List of works - Reem K Arafa

Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines

scientific article published on 27 February 2019

Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues

scientific article

Azaterphenyl diamidines as antileishmanial agents

scientific article published on 30 October 2007

Design and molecular modeling of novel P38α MAPK inhibitors targeting breast cancer, synthesized from oxygen heterocyclic natural compounds

scientific article published on 15 February 2019

Design and synthesis of novel benzopyran-2-one derivatives of expected antimicrobial activity through DNA gyrase-B inhibition.

scientific article published in November 2008

Design, synthesis and molecular docking of novel N,N-dimethylbenzenesulfonamide derivatives as potential antiproliferative agents.

scientific article published on 3 October 2013

Design, synthesis and potential anti-proliferative activity of some novel 4-aminoquinoline derivatives

scientific article published on September 2014

Design, synthesis and structure-activity relationship of novel semi-synthetic flavonoids as antiproliferative agents.

scientific article

Discovery of a Novel Dibromoquinoline Compound Exhibiting Potent Antifungal and Antivirulence Activity That Targets Metal Ion Homeostasis

scientific article

In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi.

scientific article published on 25 January 2010

In vitro anticancer screening and radiosensitizing evaluation of some new quinolines and pyrimido[4,5-b]quinolines bearing a sulfonamide moiety ⬇️

scientific article published on May 12, 2010

Induced topological changes in DNA complexes: influence of DNA sequences and small molecule structures. ⬇️

scientific article

Molecular determinants for DNA minor groove recognition: design of a bis-guanidinium derivative of ethidium that is highly selective for AT-rich DNA sequences.

scientific article published in February 2005

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

scientific article published on 08 August 2016

New 1-phthalazinone Scaffold based Compounds: Design, Synthesis, Cytotoxicity and Protein Kinase Inhibition Activity

scientific article published on 01 January 2018

New benzenesulfonamide scaffold-based cytotoxic agents: Design, synthesis, cell viability, apoptotic activity and radioactive tracing studies

scientific article published on 11 January 2020

New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies

scientific article published on 10 September 2019

New thiobarbituric acid scaffold-based small molecules: Synthesis, cytotoxicity, 2D-QSAR, pharmacophore modelling and in-silico ADME screening

scientific article published on 23 January 2019

Novel heterocyclic-fused pyrimidine derivatives: synthesis, molecular modeling and pharmacological screening.

scientific article published on 12 September 2013

Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.

scientific article published on 29 February 2008

Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling

scientific article published on 19 September 2014

Personalized Medicine and Resurrected Hopes for the Management of Alzheimer's Disease: A Modular Approach Based on GSK-3β Inhibitors.

scientific article published on January 2017

Preparation and nanoformulation of new quinolone scaffold-based anticancer agents: Enhancing solubility for better cellular delivery

scientific article

Synthesis and antiproliferative activity of monocationic arylthiophene derivatives

scientific article published on 2 December 2016

Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.

scientific article published on 18 October 2007

Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents ⬇️

scientific article published on March 16, 2013

Synthesis, DNA Affinity, and Antiprotozoal Activity of Linear Dications: Terphenyl Diamidines and Analogues

scientific article published on 01 August 2006

Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.

scientific article

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines.

scientific article published on 11 March 2016

Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

scientific article published on 07 April 2016

Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides.

scientific article published on 14 January 2014

Targeting homologous recombination (HR) repair mechanism for cancer treatment: discovery of new potential UCHL-3 inhibitors via virtual screening, molecular dynamics and binding mode analysis

scientific article published on 27 August 2020

The molecular basis of cytotoxicity of α-spinasterol from Ganoderma Resinaceum: induction of apoptosis and overexpression of p53 in breast and ovarian cancer cell lines.

scientific article published on 16 November 2017

Trypanocidal activity and selectivity in vitro of aromatic amidine compounds upon bloodstream and intracellular forms of Trypanosoma cruzi ⬇️

scientific article published on November 11, 2010

Visnagin and benzofuran scaffold-based molecules as selective cyclooxygenase-2 inhibitors with anti-inflammatory and analgesic properties: design, synthesis and molecular docking

scientific article published on 08 April 2019

List of works by Reem K Arafa

Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines

Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues

Azaterphenyl diamidines as antileishmanial agents

Design and molecular modeling of novel P38α MAPK inhibitors targeting breast cancer, synthesized from oxygen heterocyclic natural compounds

Design and synthesis of novel benzopyran-2-one derivatives of expected antimicrobial activity through DNA gyrase-B inhibition.

Design, synthesis and molecular docking of novel N,N-dimethylbenzenesulfonamide derivatives as potential antiproliferative agents.

Design, synthesis and potential anti-proliferative activity of some novel 4-aminoquinoline derivatives

Design, synthesis and structure-activity relationship of novel semi-synthetic flavonoids as antiproliferative agents.

Discovery of a Novel Dibromoquinoline Compound Exhibiting Potent Antifungal and Antivirulence Activity That Targets Metal Ion Homeostasis

In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi.

In vitro anticancer screening and radiosensitizing evaluation of some new quinolines and pyrimido[4,5-b]quinolines bearing a sulfonamide moiety ⬇️

Induced topological changes in DNA complexes: influence of DNA sequences and small molecule structures. ⬇️

Molecular determinants for DNA minor groove recognition: design of a bis-guanidinium derivative of ethidium that is highly selective for AT-rich DNA sequences.

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

New 1-phthalazinone Scaffold based Compounds: Design, Synthesis, Cytotoxicity and Protein Kinase Inhibition Activity

New benzenesulfonamide scaffold-based cytotoxic agents: Design, synthesis, cell viability, apoptotic activity and radioactive tracing studies

New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies

New thiobarbituric acid scaffold-based small molecules: Synthesis, cytotoxicity, 2D-QSAR, pharmacophore modelling and in-silico ADME screening

Novel heterocyclic-fused pyrimidine derivatives: synthesis, molecular modeling and pharmacological screening.

Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.

Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling

Personalized Medicine and Resurrected Hopes for the Management of Alzheimer's Disease: A Modular Approach Based on GSK-3β Inhibitors.

Preparation and nanoformulation of new quinolone scaffold-based anticancer agents: Enhancing solubility for better cellular delivery

Synthesis and antiproliferative activity of monocationic arylthiophene derivatives

Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.

Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents ⬇️

Synthesis, DNA Affinity, and Antiprotozoal Activity of Linear Dications: Terphenyl Diamidines and Analogues

Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines.

Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides.

Targeting homologous recombination (HR) repair mechanism for cancer treatment: discovery of new potential UCHL-3 inhibitors via virtual screening, molecular dynamics and binding mode analysis

The molecular basis of cytotoxicity of α-spinasterol from Ganoderma Resinaceum: induction of apoptosis and overexpression of p53 in breast and ovarian cancer cell lines.

Trypanocidal activity and selectivity in vitro of aromatic amidine compounds upon bloodstream and intracellular forms of Trypanosoma cruzi ⬇️

Visnagin and benzofuran scaffold-based molecules as selective cyclooxygenase-2 inhibitors with anti-inflammatory and analgesic properties: design, synthesis and molecular docking