List of works - Alexei S Soares

A linear relationship between crystal size and fragment binding time observed crystallographically: implications for fragment library screening using acoustic droplet ejection

scientific article

A simple technique to classify diffraction data from dynamic proteins according to individual polymorphs

scientific article published on 14 December 2020

A simple technique to reduce evaporation of crystallization droplets by using plate lids with apertures for adding liquids

scientific article

AMX – the highly automated macromolecular crystallography (17-ID-1) beamline at the NSLS-II

scientific article published in 2022

Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.

scientific article

Acoustic Methods to Monitor Protein Crystallization and to Detect Protein Crystals in Suspensions of Agarose and Lipidic Cubic Phase

scientific article

Acoustic methods for high-throughput protein crystal mounting at next-generation macromolecular crystallographic beamlines

scientific article

Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening

scientific article

Acoustically mounted microcrystals yield high-resolution X-ray structures.

scientific article

An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis

scientific article

Best practices for high data-rate macromolecular crystallography (HDRMX)

scientific article published on 09 January 2020

Computing infrastructure, software optimization, and real time analysis for high data-rate MX

Crystal Structure of a Complex between the Phosphorelay Protein YPD1 and the Response Regulator Domain of SLN1 Bound to a Phosphoryl Analog

scientific article

Crystal structures of the nitrite and nitric oxide complexes of horse heart myoglobin

scientific article published on 05 May 2006

Crystallographic characterization of the nitric oxide derivative of R-state human hemoglobin

scientific article

Determinants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with Mesotrypsin

scientific article

Estimating the diversity of peptide populations from limited sequence data

scientific article

Experimental methods for measuring accurate high-amplitude phases and their importance in isomorphous replacement experiments

scientific article published on 19 October 2005

Expression, purification and preliminary diffraction studies of CmlS

scientific article published on 26 February 2009

Expression, purification and preliminary diffraction studies of PhnP

scientific article published on 24 May 2008

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

scientific article published on 24 November 2020

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

scientific article

Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site

scientific article

Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II

scientific article published on 30 January 2019

High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density

scientific article

High-speed raster-scanning synchrotron serial microcrystallography with a high-precision piezo-scanner

scientific article published on 23 August 2018

Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes

scientific article

Hydrogen bond formation between the naturally modified nucleobase and phosphate backbone

scientific article

Integrated software for macromolecular crystallography synchrotron beamlines II: revision, robots and a database

scientific article published on 18 October 2006

Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation

scientific article

Macromolecular crystallography beamline X25 at the NSLS.

scientific article

Mail-in crystallography program at Brookhaven National Laboratory's National Synchrotron Light Source

scientific article published on 18 October 2006

Maintaining Microclimates during Nanoliter Chemical Dispensations Using Custom-Designed Source Plate Lids

scientific article published on 12 November 2015

Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2: BINDING STUDIES AND CRYSTAL STRUCTURE

scientific article

Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes

scientific article

Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates

scientific article

Optics Concept for a Pair of Undulator Beamlines for MX.

scientific article

Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors

scientific article

Quantitative assessment of peptide sequence diversity in M13 combinatorial peptide phage display libraries

scientific article

Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.

scientific article

Serial Crystallography with Multi-stage Merging of 1000's of Images

scholarly article published 24 May 2017

Small molecule inhibitors of mesotrypsin from a structure-based docking screen

scientific article

Solvent minimization induces preferential orientation and crystal clustering in serial micro-crystallography on micro-meshes, in situ plates and on a movable crystal conveyor belt

scientific article

Structural basis for NADH/NAD+ redox sensing by a Rex family repressor

scientific article

Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin

scientific article

Structural insights of non-canonical U*U pair and Hoogsteen interaction probed with Se atom

scientific article

Structure of the catalytic chain ofMethanococcus jannaschiiaspartate transcarbamoylase in a hexagonal crystal form: insights into the path of carbamoyl phosphate to the active site of the enzyme

scientific article

Structure of the dihydrolipoamide succinyltransferase catalytic domain from Escherichia coli in a novel crystal form: a tale of a common protein crystallization contaminant

scientific article published on 29 August 2019

Synthesis, structure and imaging of oligodeoxyribonucleotides with tellurium-nucleobase derivatization

scientific article

The Donald L. D. Caspar Structural Biology Symposium at Florida State University

scientific article published in December 2017

The P 2 ′ residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity

scientific article

The structures of penicillin binding protein 4 (PBP4) and PBP5 from Enterococci provide structural insights into β-lactam resistance

scientific article published in Journal of Biological Chemistry

The use of haptic interfaces and web services in crystallography: an application for a 'screen to beam' interface.

scientific article published on 11 November 2016

Three-beam interference is a sensitive measure of the efficacy of macromolecular refinement techniques ⬇️

scientific article published on September 19, 2003

Using sound pulses to solve the crystal-harvesting bottleneck

scientific article

X-ray Diffraction Measurement of Cosolvent Accessible Volume in Rhombohedral Insulin Crystals

scientific article published on 21 August 2017

List of works by Alexei S Soares

A linear relationship between crystal size and fragment binding time observed crystallographically: implications for fragment library screening using acoustic droplet ejection

A simple technique to classify diffraction data from dynamic proteins according to individual polymorphs

A simple technique to reduce evaporation of crystallization droplets by using plate lids with apertures for adding liquids

AMX – the highly automated macromolecular crystallography (17-ID-1) beamline at the NSLS-II

Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.

Acoustic Methods to Monitor Protein Crystallization and to Detect Protein Crystals in Suspensions of Agarose and Lipidic Cubic Phase

Acoustic methods for high-throughput protein crystal mounting at next-generation macromolecular crystallographic beamlines

Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening

Acoustically mounted microcrystals yield high-resolution X-ray structures.

An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis

Best practices for high data-rate macromolecular crystallography (HDRMX)

Computing infrastructure, software optimization, and real time analysis for high data-rate MX

Crystal Structure of a Complex between the Phosphorelay Protein YPD1 and the Response Regulator Domain of SLN1 Bound to a Phosphoryl Analog

Crystal structures of the nitrite and nitric oxide complexes of horse heart myoglobin

Crystallographic characterization of the nitric oxide derivative of R-state human hemoglobin

Determinants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with Mesotrypsin

Estimating the diversity of peptide populations from limited sequence data

Experimental methods for measuring accurate high-amplitude phases and their importance in isomorphous replacement experiments

Expression, purification and preliminary diffraction studies of CmlS

Expression, purification and preliminary diffraction studies of PhnP

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site

Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II

High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density

High-speed raster-scanning synchrotron serial microcrystallography with a high-precision piezo-scanner

Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes

Hydrogen bond formation between the naturally modified nucleobase and phosphate backbone

Integrated software for macromolecular crystallography synchrotron beamlines II: revision, robots and a database

Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation

Macromolecular crystallography beamline X25 at the NSLS.

Mail-in crystallography program at Brookhaven National Laboratory's National Synchrotron Light Source

Maintaining Microclimates during Nanoliter Chemical Dispensations Using Custom-Designed Source Plate Lids

Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2: BINDING STUDIES AND CRYSTAL STRUCTURE

Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes

Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates

Optics Concept for a Pair of Undulator Beamlines for MX.

Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors

Quantitative assessment of peptide sequence diversity in M13 combinatorial peptide phage display libraries

Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.

Serial Crystallography with Multi-stage Merging of 1000's of Images

Small molecule inhibitors of mesotrypsin from a structure-based docking screen

Solvent minimization induces preferential orientation and crystal clustering in serial micro-crystallography on micro-meshes, in situ plates and on a movable crystal conveyor belt

Structural basis for NADH/NAD+ redox sensing by a Rex family repressor

Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin

Structural insights of non-canonical U*U pair and Hoogsteen interaction probed with Se atom

Structure of the catalytic chain ofMethanococcus jannaschiiaspartate transcarbamoylase in a hexagonal crystal form: insights into the path of carbamoyl phosphate to the active site of the enzyme

Structure of the dihydrolipoamide succinyltransferase catalytic domain from Escherichia coli in a novel crystal form: a tale of a common protein crystallization contaminant

Synthesis, structure and imaging of oligodeoxyribonucleotides with tellurium-nucleobase derivatization

The Donald L. D. Caspar Structural Biology Symposium at Florida State University

The P 2 ′ residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity

The structures of penicillin binding protein 4 (PBP4) and PBP5 from Enterococci provide structural insights into β-lactam resistance

The use of haptic interfaces and web services in crystallography: an application for a 'screen to beam' interface.

Three-beam interference is a sensitive measure of the efficacy of macromolecular refinement techniques ⬇️

Using sound pulses to solve the crystal-harvesting bottleneck

X-ray Diffraction Measurement of Cosolvent Accessible Volume in Rhombohedral Insulin Crystals