List of works - Massimo Morbidelli

A Colloidal Description of Intermolecular Interactions Driving Fibril-Fibril Aggregation of a Model Amphiphilic Peptide.

scientific article

A biodistribution study of PEGylated PCL-based nanoparticles in C57BL/6 mice bearing B16/F10 melanoma.

scientific article

A continuum theory for multicomponent chromatography modeling.

scientific article published on 22 March 2016

A multiscale view of therapeutic protein aggregation: a colloid science perspective.

scientific article published on March 2015

A new flow cell and chemometric protocol for implementing in-line Raman spectroscopy in chromatography

scientific article published on 28 May 2019

A new generation of predictive models: The added value of hybrid models for manufacturing processes of therapeutic proteins

scientific article published on 21 July 2019

A two level hierarchical model of protein retention in ion exchange chromatography.

scientific article

Adaptation for survival: phenotype and transcriptome response of CHO cells to elevated stress induced by agitation and sparging.

scientific article published on 16 September 2014

Adsorption Behavior of Charge Isoforms of Monoclonal Antibodies on Strong Cation Exchangers

scientific article

Aggregate breakup in a contracting nozzle

scientific article published on 01 January 2010

Aggregation kinetics of coalescing polymer colloids.

scientific article

Aggregation mechanism of an IgG2 and two IgG1 monoclonal antibodies at low pH: from oligomers to larger aggregates.

scientific article

Aggregation stability of a monoclonal antibody during downstream processing

scientific article published on 30 March 2011

Analysis of site-specific N-glycan remodeling in the endoplasmic reticulum and the Golgi

scientific article

Application of asymmetric flow-field flow fractionation to the characterization of colloidal dispersions undergoing aggregation.

scientific article

Application of mixed mode resins for the purification of antibodies

scientific article published on 25 June 2010

Application of polymeric macroporous supports for temperature-responsive chromatography of pharmaceuticals.

scientific article published on 19 June 2015

Behavior of human serum albumin on strong cation exchange resins: I. experimental analysis.

scientific article published on 26 June 2010

Behavior of human serum albumin on strong cation exchange resins: II. model analysis

scientific article published on 01 July 2010

Biocompatible Polymer Nanoformulation To Improve the Release and Safety of a Drug Mimic Molecule Detectable via ICP-MS.

scientific article

Bioprocessing in the Digital Age: The Role of Process Models

scientific article published on 23 September 2019

Bottle-grade polyethylene furanoate from ring-opening polymerisation of cyclic oligomers

scientific article published in Nature Communications

Breakup of dense colloidal aggregates under hydrodynamic stresses

scientific article published on 03 June 2009

Calixarene-immobilized monolithic cryogels for preparative protein chromatography

scientific article published on 16 May 2018

Cell culture process metabolomics together with multivariate data analysis tools opens new routes for bioprocess development and glycosylation prediction

scientific article published on 04 May 2020

Chromatographic behavior of a polyclonal antibody mixture on a strong cation exchanger column. Part II: Adsorption modelling.

scientific article published on 17 October 2008

Closed loop control of the multi-column solvent gradient purification process

scientific article published on 06 October 2011

Comparison of batch and continuous multi-column protein A capture processes by optimal design.

scientific article published on 15 March 2016

Conductive framework of inverse opal structure for sulfur cathode in lithium-sulfur batteries

scientific article

Continuous and Integrated Expression and Purification of Recombinant Antibodies

scientific article published on 01 January 2018

Continuous counter-current chromatography for capture and polishing steps in biopharmaceutical production

scientific article published on 4 July 2016

Continuous integrated manufacturing of therapeutic proteins

scientific article published on 28 December 2017

Contribution of Electrostatics in the Fibril Stability of a Model Ionic-Complementary Peptide

scientific article published on 23 November 2015

Controlling the time evolution of mAb N-linked glycosylation - Part II: Model-based predictions.

scientific article

Controlling the time evolution of mAb N-linked glycosylation, Part I: Microbioreactor experiments.

scientific article

Core-Shell Morphology of Redispersible Powders in Polymer-Cement Waterproof Mortars

scientific article published on 10 October 2018

Decision Tree-PLS (DT-PLS) algorithm for the development of process: Specific local prediction models

scientific article published on 25 April 2019

Design and operation of a continuous integrated monoclonal antibody production process.

scientific article published on 10 July 2017

Determination of the maximum operating range of hydrodynamic stress in mammalian cell culture

scientific article published on 18 December 2014

Development of a Scale-Down Model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions.

scientific article published on 7 December 2012

Development of a shake tube-based scale-down model for perfusion cultures

scientific article published on 10 September 2018

Distributed pore model for bio-molecule chromatography.

scientific article published on 30 April 2013

Doping reversed-phase media for improved peptide purification.

scientific article published on 13 April 2015

Effect of SiO₂ Nanoparticles on the Performance of PVdF-HFP/Ionic Liquid Separator for Lithium-Ion Batteries

scientific article published on 08 November 2018

Effect of high pH column regeneration on the separation performances in reversed phase chromatography of peptides.

scientific article published on 27 March 2010

Effect of polyol sugars on the stabilization of monoclonal antibodies

scientific article published on 27 December 2014

Effect of primary particle morphology on the structure of gels formed in intense turbulent shear

scientific article published on 01 May 2010

Effect of repulsive interactions on the rate of doublet formation of colloidal nanoparticles in the presence of convective transport.

scientific article published on 8 December 2010

Effect of surface properties of elastomer colloids on their coalescence and aggregation kinetics

scientific article published on 01 October 2009

Effect of surfactants on shear-induced gelation and gel morphology of soft strawberry-like particles

scientific article published on 04 May 2011

Effect of temperature on high shear-induced gelation of charge-stabilized colloids without adding electrolytes

scientific article published on 01 February 2010

Effects of Coalescence on Shear-Induced Gelation of Colloids

scientific article published on 30 January 2017

Electrostatic model for protein adsorption in ion-exchange chromatography and application to monoclonal antibodies, lysozyme and chymotrypsinogen A

scientific article published on 30 June 2010

End-to-End Self-Assembly of RADA 16-I Nanofibrils in Aqueous Solutions ⬇️

scientific article published on April 3, 2012

Enhanced process understanding and multivariate prediction of the relationship between cell culture process and monoclonal antibody quality.

scientific article published on 27 May 2017

Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

scientific article published on 28 August 2014

Experimental Evaluation of the Impact of Intrinsic Process Parameters on the Performance of a Continuous Chromatographic Polishing Unit (MCSGP)

scientific article published on 02 May 2019

Experimental design of a twin-column countercurrent gradient purification process.

scientific article published on 23 February 2017

Experimental implementation of automatic 'cycle to cycle' control to a nonlinear chiral simulated moving bed separation.

scientific article published in February 2010

Fate of PLA and PCL-Based Polymeric Nanocarriers in Cellular and Animal Models of Triple-Negative Breast Cancer.

scientific article published on 20 January 2016

Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data.

scientific article

Flow-induced aggregation and breakup of particle clusters controlled by surface nanoroughness

scientific article

Fractal-like structures in colloid science.

scientific article published on 10 May 2016

Fragmentation of amyloid fibrils occurs in preferential positions depending on the environmental conditions.

scientific article published on 20 March 2015

High shear-induced gelation of charge-stabilized colloids in a microchannel without adding electrolytes

scientific article published on 01 April 2009

High-throughput nucleoside phosphate monitoring in mammalian cell fed-batch cultivation using quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

scientific article

High-throughput profiling of nucleotides and nucleotide sugars to evaluate their impact on antibody N-glycosylation

scientific article

Hybrid-EKF: Hybrid Model coupled with Extended Kalman Filter for real-time monitoring and control of mammalian cell culture

scientific article published on 21 May 2020

Impact of aggregate formation on the viscosity of protein solutions.

scientific article

Improved Performance in Mammalian Cell Perfusion Cultures by Growth Inhibition

scientific article published on 04 June 2018

In vitro aggregation behavior of a non-amyloidogenic λ light chain dimer deriving from U266 multiple myeloma cells.

scientific article

Increasing the activity of monoclonal antibody therapeutics by continuous chromatography (MCSGP)

scientific article published on 01 November 2010

Induction of mammalian cell death by simple shear and extensional flows.

scientific article

Influence of protein/glycan interaction on site-specific glycan heterogeneity.

scientific article

Influence of the pore size of reversed phase materials on peptide purification processes.

scientific article published on 12 March 2011

Insights into pH-induced metabolic switch by flux balance analysis

scientific article published on 30 January 2015

Integrated multiplatform method for in vitro quantitative assessment of cellular uptake for fluorescent polymer nanoparticles.

scientific article published on January 2014

Integrated process for high conversion and high yield protein PEGylation

scientific article published on 06 March 2016

Interplay between Aggregation and Coalescence of Polymeric Particles: Experimental and Modeling Insights.

scientific article published on 14 August 2015

Introduction to "Fundamentals of Preparative and Nonlinear Chromatography" by G. Guiochon, A. Felinger, D.G. Shirazi [Elsevier, Amsterdam, 2nd ed., 2006, Ch. 1]

scientific article published on 31 March 2016

Investigation of size, surface charge, PEGylation degree and concentration on the cellular uptake of polymer nanoparticles

scientific article

Kinetic analysis of the multistep aggregation mechanism of monoclonal antibodies.

scientific article published on 28 August 2014

Kinetics and cluster morphology evolution of shear-driven aggregation of well-stabilized colloids.

scientific article

Kinetics of Monoclonal Antibody Aggregation from Dilute toward Concentrated Conditions.

scientific article

Linear isotherm determination from linear gradient elution experiments.

scientific article published on 2 December 2014

Longitudinal tracking of human fetal cells labeled with super paramagnetic iron oxide nanoparticles in the brain of mice with motor neuron disease

scientific article

Macroporous Polymer⁻Protein Hybrid Materials for Antibody Purification by Combination of Reactive Gelation and Click-Chemistry

scientific article published on 14 May 2019

Macroporous polymer particles via reactive gelation under shear: effect of primary particle properties and operating parameters

scientific article published on 12 November 2014

Mass transfer coefficients determination from linear gradient elution experiments

scientific article published on 2 December 2014

Microarray-based MALDI-TOF mass spectrometry enables monitoring of monoclonal antibody production in batch and perfusion cell cultures.

scientific article published on 17 December 2015

Minimizing hydrodynamic stress in mammalian cell culture through the lobed Taylor‐Couette bioreactor ⬇️

scientific article published on August 15, 2011

Model assisted comparison of Protein A resins and multi-column chromatography for capture processes

scientific article published on 27 August 2018

Model assisted process characterization and validation for a continuous two-column protein A capture process

article

Model based adaptive control of a continuous capture process for monoclonal antibodies production.

scientific article

Model simulation and experimental verification of a cation-exchange IgG capture step in batch and continuous chromatography

scientific article published on 12 June 2011

Model-based description of peptide retention on doped reversed-phase media.

scientific article

Model-based design of peptide chromatographic purification processes

scientific article published on 09 February 2013

Model-based design space determination of peptide chromatographic purification processes.

scientific article published on 8 February 2013

Model-based high-throughput design of ion exchange protein chromatography.

scientific article published on 25 June 2016

Model-based prediction of monoclonal antibody retention in ion-exchange chromatography.

scientific article

Modeling of ion-pairing effect in peptide reversed-phase chromatography ⬇️

scientific article published on June 12, 2012

Modeling of mixed-mode chromatography of peptides

scientific article published on 22 January 2013

Modeling the nonlinear behavior of a bioactive peptide in reversed-phase gradient elution chromatography

scientific article published on 19 December 2019

Modulation and modeling of monoclonal antibody N-linked glycosylation in mammalian cell perfusion reactors.

scientific article published on 14 April 2017

Monitoring of antibody glycosylation pattern based on microarray MALDI-TOF mass spectrometry

scientific article published on 28 June 2019

Multifraction separation in countercurrent chromatography (MCSGP)

scientific article published on 22 April 2013

NMR Metabolomics for Stem Cell type discrimination.

scientific article published on 17 November 2017

On the role of salt type and concentration on the stability behavior of a monoclonal antibody solution.

scientific article

Online control of the twin-column countercurrent solvent gradient process for biochromatography.

scientific article published on 3 April 2013

Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture

scientific article published on 26 August 2015

PEGylated Nanoparticles Obtained through Emulsion Polymerization as Paclitaxel Carriers

scientific article published in December 2015

Papers presented at SPICA 2008, the International Symposium on Preparative and Industrial Chromatography and Allied Techniques. Foreword

scientific article published on 30 May 2009

Perfusion cell culture for the production of conjugated recombinant fusion proteins reduces clipping and quality heterogeneity compared to batch-mode processes

scientific article published on 15 June 2019

Perfusion mammalian cell culture for recombinant protein manufacturing - A critical review

scientific article published on 05 May 2018

Perfusive ion-exchange chromatographic materials with high capacity

scientific article published on 01 December 2014

Pilot-scale verification of maximum tolerable hydrodynamic stress for mammalian cell culture

scientific article published on 5 December 2015

Polymer nanoparticles for the intravenous delivery of anticancer drugs: the checkpoints on the road from the synthesis to clinical translation

scientific article published on 01 December 2018

Polymeric nanoparticle system to target activated microglia/macrophages in spinal cord injury

scientific article published on 10 November 2013

Population balance modeling of antibodies aggregation kinetics.

scientific article

Population-balance description of shear-induced clustering, gelation and suspension viscosity in sheared DLVO colloids.

scientific article

Preparation of macroporous methacrylate-based monoliths for chromatographic applications by the Reactive Gelation Process

scientific article published on 01 July 2010

Preparation of perfusive chromatographic materials via shear-induced reactive gelation.

scientific article published on 12 January 2018

Process design and development of a mammalian cell perfusion culture in shake-tube and benchtop bioreactors

scientific article published on 19 May 2019

Process for Continuous Fab Production by Digestion of IgG

scientific article published on 24 July 2019

Process for protein PEGylation

scientific article published on 14 February 2014

Process intensification by frontal chromatography: Performance comparison of resin and membrane adsorber for monovalent antibody aggregate removal

scientific article published on 11 December 2019

Process performance and product quality in an integrated continuous antibody production process.

scientific article published on 6 August 2016

Process-wide control and automation of an integrated continuous manufacturing platform for antibodies

scientific article published on 05 February 2020

Protein adsorption in polyelectrolyte brush type cation-exchangers.

scientific article published on 13 October 2016

Protein adsorption on ion exchange resins and monoclonal antibody charge variant modulation.

scientific article

Proteomic analysis of micro-scale bioreactors as scale-down model for a mAb producing CHO industrial fed-batch platform

scientific article published on 30 April 2018

Purification of Human Monoclonal Antibodies and Their Fragments

scientific article published on 01 January 2019

Purification of human monoclonal antibodies and their fragments

scientific article published on 01 January 2014

Readily prepared biodegradable nanoparticles to formulate poorly water soluble drugs improving their pharmacological properties: The example of trabectedin

scientific article published on 7 March 2018

Recovery of Mineral Oil from Underground Electrical Cables

scientific article published on 03 July 2019

Recovery of monosaccharides from lignocellulosic hydrolysates by ion exclusion chromatography.

scientific article

Reduction of surface charges during coalescence of elastomer particles

scientific article published on 01 July 2010

Relating saturation capacity to charge density in strong cation exchangers.

scientific article

Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody.

scientific article

Role of cosolutes in the aggregation kinetics of monoclonal antibodies

scientific article published on 2 October 2014

Role of counterion association in colloidal stability.

scientific article

Role of the ligand density in cation exchange materials for the purification of proteins

scientific article published on 10 February 2010

Role of urea on recombinant Apo A-I stability and its utilization in anion exchange chromatography.

scientific article

Selective nanovector mediated treatment of activated proinflammatory microglia/macrophages in spinal cord injury.

scientific article published on 18 October 2013

Self-Assembling PCL-Based Nanoparticles as PTX Solubility Enhancer Excipients

scientific article published on 25 July 2018

Semi-continuous scale-down models for clone and operating parameter screening in perfusion bioreactors

scientific article published on 13 March 2019

Sequential Multivariate Cell Culture Modeling at Multiple Scales Supports Systematic Shaping of a Monoclonal Antibody Toward a Quality Target

scientific article

Shear-Driven Solidification of Dilute Colloidal Suspensions

scientific article published on 29 March 2011

Shear-Induced Reactive Gelation

scientific article published on 21 October 2015

Shear-driven aggregation of binary colloids for randomly distributing nanoparticles in a matrix

scientific article published on 01 April 2016

Shear-induced gelation of soft strawberry-like particles in the presence of polymeric P(BA-b-AA) surfactants

scientific article published on 01 November 2012

Shear-induced reaction-limited aggregation kinetics of brownian particles at arbitrary concentrations.

scientific article published in April 2010

Simulation model for overloaded monoclonal antibody variants separations in ion-exchange chromatography.

scientific article

Simulation of porosity decrease with protein adsorption using the distributed pore model.

scientific article published on 8 September 2013

Small interfering RNA delivery through positively charged polymer nanoparticles.

scientific article published on 18 February 2016

Snapshotted glass and gel transitions of stable colloidal dispersions after shear-driven aggregation in a microchannel

scientific article published on 01 February 2015

Stability and gelation behavior of bovine serum albumin pre-aggregates in the presence of calcium chloride

scientific article published on 01 March 2012

Strong cation exchange monoliths for HPLC by Reactive Gelation

scientific article published on 28 July 2011

Strong cation-exchange chromatography of proteins on a sulfoalkylated monolithic cryogel.

scientific article published on 2 February 2015

Structure and kinetics of shear aggregation in turbulent flows. I. Early stage of aggregation

scientific article published on 01 August 2010

Synthesis of Water-Based Dispersions of Polymer/TiO₂ Hybrid Nanospheres

scientific article published on 28 August 2015

Synthesis of hetero-nanoclusters: the case of polymer-magnetite systems.

scientific article published on 21 February 2014

Synthesis of macroporous polymer particles using reactive gelation under shear

scientific article published on 05 June 2014

Synthesis of surfactant free PCL-PEG brushed nanoparticles with tunable degradation kinetics.

scientific article published on 21 June 2013

The role of ion-pairing in peak deformations in overloaded reversed-phase chromatography of peptides.

scientific article published on 15 September 2010

Theory of activated-rate processes under shear with application to shear-induced aggregation of colloids.

scientific article published on 16 November 2009

Thermoresponsive Stability of Colloids in Butyl Acetate/Ethanol Binary Solvent Realized by Grafting Linear Acrylate Copolymers.

scientific article published on 7 September 2017

Tracking of Fluorescently Labeled Polymer Particles Reveals Surface Effects during Shear-Controlled Aggregation.

scientific article published on 20 November 2017

Transcriptome and proteome analysis of steady-state in a perfusion CHO cell culture process

scientific article published on 07 May 2019

Twin-column CaptureSMB: a novel cyclic process for protein A affinity chromatography

scientific article published on 21 February 2015

Two step capture and purification of IgG2 using multicolumn countercurrent solvent gradient purification (MCSGP)

scientific article published on 01 December 2010

Understanding mAb aggregation during low pH viral inactivation and subsequent neutralization

scientific article published on 11 December 2019

Uniform distribution of graphene oxide sheets into a poly-vinylidene fluoride nanoparticle matrix through shear-driven aggregation.

scientific article published on 23 June 2016

Viscosity scaling in concentrated dispersions and its impact on colloidal aggregation.

scientific article published on 4 September 2015

List of works by Massimo Morbidelli

A Colloidal Description of Intermolecular Interactions Driving Fibril-Fibril Aggregation of a Model Amphiphilic Peptide.

A biodistribution study of PEGylated PCL-based nanoparticles in C57BL/6 mice bearing B16/F10 melanoma.

A continuum theory for multicomponent chromatography modeling.

A multiscale view of therapeutic protein aggregation: a colloid science perspective.

A new flow cell and chemometric protocol for implementing in-line Raman spectroscopy in chromatography

A new generation of predictive models: The added value of hybrid models for manufacturing processes of therapeutic proteins

A two level hierarchical model of protein retention in ion exchange chromatography.

Adaptation for survival: phenotype and transcriptome response of CHO cells to elevated stress induced by agitation and sparging.

Adsorption Behavior of Charge Isoforms of Monoclonal Antibodies on Strong Cation Exchangers

Aggregate breakup in a contracting nozzle

Aggregation kinetics of coalescing polymer colloids.

Aggregation mechanism of an IgG2 and two IgG1 monoclonal antibodies at low pH: from oligomers to larger aggregates.

Aggregation stability of a monoclonal antibody during downstream processing

Analysis of site-specific N-glycan remodeling in the endoplasmic reticulum and the Golgi

Application of asymmetric flow-field flow fractionation to the characterization of colloidal dispersions undergoing aggregation.

Application of mixed mode resins for the purification of antibodies

Application of polymeric macroporous supports for temperature-responsive chromatography of pharmaceuticals.

Behavior of human serum albumin on strong cation exchange resins: I. experimental analysis.

Behavior of human serum albumin on strong cation exchange resins: II. model analysis

Biocompatible Polymer Nanoformulation To Improve the Release and Safety of a Drug Mimic Molecule Detectable via ICP-MS.

Bioprocessing in the Digital Age: The Role of Process Models

Bottle-grade polyethylene furanoate from ring-opening polymerisation of cyclic oligomers

Breakup of dense colloidal aggregates under hydrodynamic stresses

Calixarene-immobilized monolithic cryogels for preparative protein chromatography

Cell culture process metabolomics together with multivariate data analysis tools opens new routes for bioprocess development and glycosylation prediction

Chromatographic behavior of a polyclonal antibody mixture on a strong cation exchanger column. Part II: Adsorption modelling.

Closed loop control of the multi-column solvent gradient purification process

Comparison of batch and continuous multi-column protein A capture processes by optimal design.

Conductive framework of inverse opal structure for sulfur cathode in lithium-sulfur batteries

Continuous and Integrated Expression and Purification of Recombinant Antibodies

Continuous counter-current chromatography for capture and polishing steps in biopharmaceutical production

Continuous integrated manufacturing of therapeutic proteins

Contribution of Electrostatics in the Fibril Stability of a Model Ionic-Complementary Peptide

Controlling the time evolution of mAb N-linked glycosylation - Part II: Model-based predictions.

Controlling the time evolution of mAb N-linked glycosylation, Part I: Microbioreactor experiments.

Core-Shell Morphology of Redispersible Powders in Polymer-Cement Waterproof Mortars

Decision Tree-PLS (DT-PLS) algorithm for the development of process: Specific local prediction models

Design and operation of a continuous integrated monoclonal antibody production process.

Determination of the maximum operating range of hydrodynamic stress in mammalian cell culture

Development of a Scale-Down Model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions.

Development of a shake tube-based scale-down model for perfusion cultures

Distributed pore model for bio-molecule chromatography.

Doping reversed-phase media for improved peptide purification.

Effect of SiO₂ Nanoparticles on the Performance of PVdF-HFP/Ionic Liquid Separator for Lithium-Ion Batteries

Effect of high pH column regeneration on the separation performances in reversed phase chromatography of peptides.

Effect of polyol sugars on the stabilization of monoclonal antibodies

Effect of primary particle morphology on the structure of gels formed in intense turbulent shear

Effect of repulsive interactions on the rate of doublet formation of colloidal nanoparticles in the presence of convective transport.

Effect of surface properties of elastomer colloids on their coalescence and aggregation kinetics

Effect of surfactants on shear-induced gelation and gel morphology of soft strawberry-like particles

Effect of temperature on high shear-induced gelation of charge-stabilized colloids without adding electrolytes

Effects of Coalescence on Shear-Induced Gelation of Colloids

Electrostatic model for protein adsorption in ion-exchange chromatography and application to monoclonal antibodies, lysozyme and chymotrypsinogen A

End-to-End Self-Assembly of RADA 16-I Nanofibrils in Aqueous Solutions ⬇️

Enhanced process understanding and multivariate prediction of the relationship between cell culture process and monoclonal antibody quality.

Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

Experimental Evaluation of the Impact of Intrinsic Process Parameters on the Performance of a Continuous Chromatographic Polishing Unit (MCSGP)

Experimental design of a twin-column countercurrent gradient purification process.

Experimental implementation of automatic 'cycle to cycle' control to a nonlinear chiral simulated moving bed separation.

Fate of PLA and PCL-Based Polymeric Nanocarriers in Cellular and Animal Models of Triple-Negative Breast Cancer.

Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data.

Flow-induced aggregation and breakup of particle clusters controlled by surface nanoroughness

Fractal-like structures in colloid science.

Fragmentation of amyloid fibrils occurs in preferential positions depending on the environmental conditions.

High shear-induced gelation of charge-stabilized colloids in a microchannel without adding electrolytes

High-throughput nucleoside phosphate monitoring in mammalian cell fed-batch cultivation using quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

High-throughput profiling of nucleotides and nucleotide sugars to evaluate their impact on antibody N-glycosylation

Hybrid-EKF: Hybrid Model coupled with Extended Kalman Filter for real-time monitoring and control of mammalian cell culture

Impact of aggregate formation on the viscosity of protein solutions.

Improved Performance in Mammalian Cell Perfusion Cultures by Growth Inhibition

In vitro aggregation behavior of a non-amyloidogenic λ light chain dimer deriving from U266 multiple myeloma cells.

Increasing the activity of monoclonal antibody therapeutics by continuous chromatography (MCSGP)

Induction of mammalian cell death by simple shear and extensional flows.

Influence of protein/glycan interaction on site-specific glycan heterogeneity.

Influence of the pore size of reversed phase materials on peptide purification processes.

Insights into pH-induced metabolic switch by flux balance analysis

Integrated multiplatform method for in vitro quantitative assessment of cellular uptake for fluorescent polymer nanoparticles.

Integrated process for high conversion and high yield protein PEGylation

Interplay between Aggregation and Coalescence of Polymeric Particles: Experimental and Modeling Insights.