List of works - Costas Giaginis

Alternative measures of lipophilicity: from octanol-water partitioning to IAM retention.

scientific article published on August 2008

Analysis of PPAR-α/γ Activity by Combining 2-D QSAR and Molecular Simulation

scientific article published on 15 April 2013

Angiogenesis in salivary gland tumors: from clinical significance to treatment.

scientific article published on 08 May 2015

Application of quantitative structure-activity relationships for modeling drug and chemical transport across the human placenta barrier: a multivariate data analysis approach.

scientific article

Application of the ion pair concept to the n-octanol-water partitioning of cefepime and cefpirome.

scientific article published on 6 March 2006

Applying quantitative structure-activity relationship (QSAR) methodology for modeling postmortem redistribution of benzodiazepines and tricyclic antidepressants

scientific article published on 28 March 2014

Assessing drug transport across the human placental barrier: from in vivo and in vitro measurements to the ex vivo perfusion method and in silico techniques.

scientific article published on May 2011

Chromatographic behavior of zwitterionic enalapril-exploring the conditions for lipophilicity assessment.

scientific article

Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions

scientific article published on 11 October 2015

Clinical Significance of EphB4 and EphB6 Expression in Human Malignant and Benign Thyroid Lesions.

scientific article published on 30 July 2015

Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions

scientific article published on 26 October 2015

Clinical Significance of Tumor-associated Antigen RCAS1 Expression in Human Pancreatic Ductal Adenocarcinoma

scientific article published on 01 June 2008

Clinical Value of Nutritional Status in Cancer: What is its Impact and how it Affects Disease Progression and Prognosis?

scientific article published on 30 October 2017

Clinical implication of plasma neutrophil gelatinase-associated lipocalin (NGAL) concentrations in patients with advanced carotid atherosclerosis.

scientific article published in July 2010

Clinical significance of HuR expression in human malignancy.

scientific article

Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity.

scientific article published on 9 May 2008

Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma

scientific article published on 01 December 2009

Clinical significance of farnesoid X receptor expression in thyroid neoplasia.

scientific article

Clinical significance of histone deacetylase (HDAC)-1, HDAC-2, HDAC-4, and HDAC-6 expression in human malignant and benign thyroid lesions.

scientific article published on 20 July 2013

Clinical value of nutritional status in neurodegenerative diseases: What is its impact and how it affects disease progression and management?

scientific article published on 30 November 2016

Contribution to the standardization of the chromatographic conditions for the lipophilicity assessment of neutral and basic drugs

scientific article published on 29 March 2006

Correlation of Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) and Retinoid X Receptor-alpha (RXR-alpha) expression with clinical risk factors in patients with advanced carotid atherosclerosis ⬇️

scientific article published on July 1, 2011

Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implications

scientific article published on 17 June 2008

Cranberry Consumption Against Urinary Tract Infections: Clinical Stateof- the-Art and Future Perspectives

scientific article published on 01 January 2018

Cranberry as promising natural source of potential anticancer agents: current evidence and future perspectives.

scientific article published on July 2012

Current Advances in Food Science & Health Promotion (Part I)

scientific article published on 01 January 2018

Current Evidence on the Anticancer Potential of Chios Mastic Gum ⬇️

scientific article published on November 1, 2011

Current clinical status on the preventive effects of cranberry consumption against urinary tract infections.

scientific article published on July 2013

Current evidence for histone deacetylase inhibitors in pancreatic cancer.

scientific article published on February 2013

Current toxicological aspects on drug and chemical transport and metabolism across the human placental barrier ⬇️

scientific article published on July 11, 2012

Cyclin D1 and Rb protein expression and their correlation with prognosis in patients with colon cancer.

scientific article

DNA repair systems as targets of cadmium toxicity.

scientific article

Detection of dental plaque with disclosing agents in the context of preventive oral hygiene training programs

scientific article published on 10 July 2019

Diagnostic and prognostic utility of serum receptor-binding cancer antigen expressed on SiSo cells (RCAS1) levels in colon cancer patients

scientific article published on 01 April 2009

Different retention behavior of structurally diverse basic and neutral drugs in immobilized artificial membrane and reversed-phase high performance liquid chromatography: comparison with octanol-water partitioning

scientific article published on 03 April 2006

Direct injection liquid chromatography/positive ion electrospray ionization mass spectrometric quantification of methotrexate, folinic acid, folic acid and ondansetron in human serum.

scientific article published on 2 October 2009

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

scientific article published on 22 February 2018

Elevated Farnesoid X Receptor (FXR) and Retinoid X Receptors (RXRs) expression is associated with less tumor aggressiveness and favourable prognosis in patients with pancreatic adenocarcinoma

scientific article published on 01 January 2015

Elevated Hu-Antigen Receptor (HuR) Expression is Associated with Tumor Aggressiveness and Poor Prognosis but not with COX-2 Expression in Invasive Breast Carcinoma Patients

scientific article published on 14 August 2017

Enhanced TLR4 endothelial cell immunohistochemical expression in symptomatic carotid atherosclerotic plaques.

scientific article published in January 2010

Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival

scientific article

Ephrin receptor (Eph) -A1, -A2, -A4 and -A7 expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival.

scientific article published on 11 September 2013

Epithelial-Mesenchymal Transition in Non Small-cell Lung Cancer

scientific article published in April 2017

Estimating the agreement between the metabolic rate calculated from prediction equations and from a portable indirect calorimetry device: an effort to develop a new equation for predicting resting metabolic rate.

scientific article

Evaluation of FAK and Src expression in human benign and malignant thyroid lesions

scientific article published on 20 April 2010

Evaluation of cannabinoid CB1 and CB2 receptors expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients' survival.

scientific article

Evaluation of coxsackievirus and adenovirus receptor expression in human benign and malignant thyroid lesions.

scientific article

Expression and Clinical Significance of Concomitant FAK/SRC and p-Paxillin in Mobile Tongue Squamous Cell Carcinoma.

scientific article published in March 2017

Expression and Clinical Significance of FAK and Src Proteins in Human Endometrial Adenocarcinoma ⬇️

scientific article published on November 7, 2010

Expression and clinical significance of focal adhesion kinase in the two distinct histological types, intestinal and diffuse, of human gastric adenocarcinoma.

scientific article

Expression of DNA repair proteins, MSH2, MLH1 and MGMT in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients' survival

scientific article published on 01 October 2010

Expression of peroxisome proliferator activated receptor-gamma (PPAR-γ) in human non-small cell lung carcinoma: correlation with clinicopathological parameters, proliferation and apoptosis related molecules and patients' survival.

scientific article published on 18 March 2012

Expression of peroxisome proliferator-activated receptor-gamma in colon cancer: correlation with histopathological parameters, cell cycle-related molecules, and patients' survival.

scientific article published on 28 March 2007

Extracellular signal-regulated kinase (ERK) expression and activation in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival.

scientific article published on 30 March 2014

FAK and Src expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival

scientific article published on 10 April 2012

Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility.

scientific article published on 02 January 2015

Farnesoid-X Receptor (FXR) as a Promising Pharmaceutical Target in Atherosclerosis.

scientific article published on 24 January 2017

Heat Shock Protein-27, -60 and -90 expression in gastric cancer: association with clinicopathological variables and patient survival

scientific article

High Farnesoid X Receptor (FXR) expression is a strong and independent prognosticator in invasive breast carcinoma

scientific article published on 9 May 2017

Higher adherence to Mediterranean diet prior to pregnancy is associated with decreased risk for deviation from the maternal recommended gestational weight gain.

scientific article published on 14 June 2017

Histone deacetylase (HDAC)-1, -2, -4 and -6 expression in human pancreatic adenocarcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival

scientific article published on 26 October 2015

Histone deacetylase inhibitors and pancreatic cancer: are there any promising clinical trials?

scientific article published on February 2013

Histone deacetylase inhibitors as potential therapeutic agents for the treatment of malignant mesothelioma.

scientific article published on March 2013

Histone deacetylase inhibitors in oral squamous cell carcinoma treatment.

scientific article published on 12 September 2014

Histone deacetylase-1 and -2 expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival

scientific article published on 02 April 2011

Hu-antigen receptor (HuR) and cyclooxygenase-2 (COX-2) expression in human non-small-cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival.

scientific article published on 25 September 2014

Increased RCAS1 expression is associated with advanced histopathological stage and poor prognosis in patients with gastric adenocarcinoma

scientific article published on 03 September 2013

Investigation of the retention behavior of structurally diverse drugs on alpha(1) acid glycoprotein column: insight on the molecular factors involved and correlation with protein binding data

scientific article

Lipophilicity and biomimetic properties to support drug discovery.

scientific article

MCM-2 and MCM-5 expression in gastric adenocarcinoma: clinical significance and comparison with Ki-67 proliferative marker.

scientific article published on 6 August 2010

NF-κB signaling at the crossroads of inflammation and atherogenesis: searching for new therapeutic links

scientific article published on 08 July 2014

Octanol/water partitioning simulation by RP-HPLC for structurally diverse acidic drugs: comparison of three columns in the presence and absence of n-octanol as the mobile phase additive.

scientific article published in December 2013

Octanol/water partitioning simulation by reversed-phase high performance liquid chromatography for structurally diverse acidic drugs: Effect of n-octanol as mobile phase additive.

scientific article published on 9 August 2007

PPAR-gamma signaling pathway in placental development and function: a potential therapeutic target in the treatment of gestational diseases

scientific article published on 01 August 2008

Peroxisome Proliferator-Activated Receptor-gamma Ligands: Potential Pharmacological Agents for Targeting the Angiogenesis Signaling Cascade in Cancer.

scientific article published on January 2008

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: novel pharmacological agents in the treatment of ischemia reperfusion injury.

scientific article published on September 2008

Peroxisome proliferator-activated receptor-γ in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival

scientific article published on 01 February 2011

Peroxisome proliferator-activated receptors (PPARs) in the control of bone metabolism.

scientific article published on June 2007

Phosphorylated Epidermal Growth Factor Receptor Expression Is Associated With Clinicopathologic Parameters and Patient Survival in Mobile Tongue Squamous Cell Carcinoma.

scientific article published on 27 August 2016

Physicochemical profile of nimesulide. Exploring the interplay of lipophilicity, solubility and ionization.

scientific article

Platelet-activating factor (PAF) receptor expression is associated with histopathological stage and grade and patients' survival in gastric adenocarcinoma

scientific article published on 01 January 2014

Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression

scientific article published on October 2015

Pregnane X receptor (PXR) at the crossroads of human metabolism and disease.

scientific article published on March 2013

Primary extramammary invasive Paget's vulvar disease: what is the standard, what are the challenges and what is the future for radiotherapy?

scientific article

Quantitative structure-activity relationship (QSAR) methodology in forensic toxicology: modeling postmortem redistribution of structurally diverse drugs using multivariate statistics.

scientific article

Quantitative structure-activity relationships for PPAR-gamma binding and gene transactivation of tyrosine-based agonists using multivariate statistics.

scientific article published on 12 September 2008

Receptor-Binding Cancer Antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions ⬇️

scientific article published on April 1, 2012

Retention behavior of flavonoids on immobilized artificial membrane chromatography and correlation with cell-based permeability.

scientific article published on 18 October 2017

Retention of structurally diverse drugs in human serum albumin chromatography and its potential to simulate plasma protein binding

scientific article published on July 16, 2010

Salivaomics for oral diseases biomarkers detection.

scientific article published on 17 December 2015

Serum tissue inhibitor of metalloproteinase 1 and 2 (TIMP-1 and TIMP-2) levels in colorectal cancer patients: associations with clinicopathological variables and patient survival

scientific article published on 01 October 2009

Simple physicochemical properties related with lipophilicity, polarity, molecular size and ionization status exert significant impact on the transfer of drugs and chemicals into human breast milk.

scientific article

Structural basis for the design of PPAR-gamma ligands: a survey on quantitative structure- activity relationships.

scientific article

The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot †.

scientific article published on 28 October 2017

The Impact of Lipophilicity in Drug Discovery: Rapid Measurements by Means of Reversed-Phase HPLC

scientific article published on 01 January 2018

The Role of Peroxisome Proliferator-Activated Receptor-&gamma; in Breast Cancer ⬇️

scientific article published on November 1, 2012

The impact of physicochemical and molecular properties in drug design: navigation in the "drug-like" chemical space

scientific article published on 01 January 2015

The performance of 1‐ethyl‐3‐methylimidazolium tetrafluoroborate ionic liquid as mobile phase additive in HPLC‐based lipophilicity assessment ⬇️

scientific article published on August 25, 2010

The role of ephrins' receptors and ephrins' ligands in normal placental development and disease

scientific article published on 13 December 2013

Toll-like receptor 4 immunohistochemical expression is enhanced in macrophages of symptomatic carotid atherosclerotic plaques.

scientific article

List of works by Costas Giaginis

Alternative measures of lipophilicity: from octanol-water partitioning to IAM retention.

Analysis of PPAR-α/γ Activity by Combining 2-D QSAR and Molecular Simulation

Angiogenesis in salivary gland tumors: from clinical significance to treatment.

Application of quantitative structure-activity relationships for modeling drug and chemical transport across the human placenta barrier: a multivariate data analysis approach.

Application of the ion pair concept to the n-octanol-water partitioning of cefepime and cefpirome.

Applying quantitative structure-activity relationship (QSAR) methodology for modeling postmortem redistribution of benzodiazepines and tricyclic antidepressants

Assessing drug transport across the human placental barrier: from in vivo and in vitro measurements to the ex vivo perfusion method and in silico techniques.

Chromatographic behavior of zwitterionic enalapril-exploring the conditions for lipophilicity assessment.

Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions

Clinical Significance of EphB4 and EphB6 Expression in Human Malignant and Benign Thyroid Lesions.

Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions

Clinical Significance of Tumor-associated Antigen RCAS1 Expression in Human Pancreatic Ductal Adenocarcinoma

Clinical Value of Nutritional Status in Cancer: What is its Impact and how it Affects Disease Progression and Prognosis?

Clinical implication of plasma neutrophil gelatinase-associated lipocalin (NGAL) concentrations in patients with advanced carotid atherosclerosis.

Clinical significance of HuR expression in human malignancy.

Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity.

Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma

Clinical significance of farnesoid X receptor expression in thyroid neoplasia.

Clinical significance of histone deacetylase (HDAC)-1, HDAC-2, HDAC-4, and HDAC-6 expression in human malignant and benign thyroid lesions.

Clinical value of nutritional status in neurodegenerative diseases: What is its impact and how it affects disease progression and management?

Contribution to the standardization of the chromatographic conditions for the lipophilicity assessment of neutral and basic drugs

Correlation of Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) and Retinoid X Receptor-alpha (RXR-alpha) expression with clinical risk factors in patients with advanced carotid atherosclerosis ⬇️

Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implications

Cranberry Consumption Against Urinary Tract Infections: Clinical Stateof- the-Art and Future Perspectives

Cranberry as promising natural source of potential anticancer agents: current evidence and future perspectives.

Current Advances in Food Science & Health Promotion (Part I)

Current Evidence on the Anticancer Potential of Chios Mastic Gum ⬇️

Current clinical status on the preventive effects of cranberry consumption against urinary tract infections.

Current evidence for histone deacetylase inhibitors in pancreatic cancer.

Current toxicological aspects on drug and chemical transport and metabolism across the human placental barrier ⬇️

Cyclin D1 and Rb protein expression and their correlation with prognosis in patients with colon cancer.

DNA repair systems as targets of cadmium toxicity.

Detection of dental plaque with disclosing agents in the context of preventive oral hygiene training programs

Diagnostic and prognostic utility of serum receptor-binding cancer antigen expressed on SiSo cells (RCAS1) levels in colon cancer patients

Different retention behavior of structurally diverse basic and neutral drugs in immobilized artificial membrane and reversed-phase high performance liquid chromatography: comparison with octanol-water partitioning

Direct injection liquid chromatography/positive ion electrospray ionization mass spectrometric quantification of methotrexate, folinic acid, folic acid and ondansetron in human serum.

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

Elevated Farnesoid X Receptor (FXR) and Retinoid X Receptors (RXRs) expression is associated with less tumor aggressiveness and favourable prognosis in patients with pancreatic adenocarcinoma

Elevated Hu-Antigen Receptor (HuR) Expression is Associated with Tumor Aggressiveness and Poor Prognosis but not with COX-2 Expression in Invasive Breast Carcinoma Patients

Enhanced TLR4 endothelial cell immunohistochemical expression in symptomatic carotid atherosclerotic plaques.

Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival

Ephrin receptor (Eph) -A1, -A2, -A4 and -A7 expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival.

Epithelial-Mesenchymal Transition in Non Small-cell Lung Cancer

Estimating the agreement between the metabolic rate calculated from prediction equations and from a portable indirect calorimetry device: an effort to develop a new equation for predicting resting metabolic rate.

Evaluation of FAK and Src expression in human benign and malignant thyroid lesions

Evaluation of cannabinoid CB1 and CB2 receptors expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients' survival.

Evaluation of coxsackievirus and adenovirus receptor expression in human benign and malignant thyroid lesions.

Expression and Clinical Significance of Concomitant FAK/SRC and p-Paxillin in Mobile Tongue Squamous Cell Carcinoma.

Expression and Clinical Significance of FAK and Src Proteins in Human Endometrial Adenocarcinoma ⬇️

Expression and clinical significance of focal adhesion kinase in the two distinct histological types, intestinal and diffuse, of human gastric adenocarcinoma.

Expression of DNA repair proteins, MSH2, MLH1 and MGMT in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients' survival

Expression of peroxisome proliferator activated receptor-gamma (PPAR-γ) in human non-small cell lung carcinoma: correlation with clinicopathological parameters, proliferation and apoptosis related molecules and patients' survival.

Expression of peroxisome proliferator-activated receptor-gamma in colon cancer: correlation with histopathological parameters, cell cycle-related molecules, and patients' survival.

Extracellular signal-regulated kinase (ERK) expression and activation in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival.

FAK and Src expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival

Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility.

Farnesoid-X Receptor (FXR) as a Promising Pharmaceutical Target in Atherosclerosis.

Heat Shock Protein-27, -60 and -90 expression in gastric cancer: association with clinicopathological variables and patient survival

High Farnesoid X Receptor (FXR) expression is a strong and independent prognosticator in invasive breast carcinoma

Higher adherence to Mediterranean diet prior to pregnancy is associated with decreased risk for deviation from the maternal recommended gestational weight gain.

Histone deacetylase (HDAC)-1, -2, -4 and -6 expression in human pancreatic adenocarcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival

Histone deacetylase inhibitors and pancreatic cancer: are there any promising clinical trials?

Histone deacetylase inhibitors as potential therapeutic agents for the treatment of malignant mesothelioma.

Histone deacetylase inhibitors in oral squamous cell carcinoma treatment.

Histone deacetylase-1 and -2 expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival

Hu-antigen receptor (HuR) and cyclooxygenase-2 (COX-2) expression in human non-small-cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival.

Increased RCAS1 expression is associated with advanced histopathological stage and poor prognosis in patients with gastric adenocarcinoma

Investigation of the retention behavior of structurally diverse drugs on alpha(1) acid glycoprotein column: insight on the molecular factors involved and correlation with protein binding data

Lipophilicity and biomimetic properties to support drug discovery.

MCM-2 and MCM-5 expression in gastric adenocarcinoma: clinical significance and comparison with Ki-67 proliferative marker.

NF-κB signaling at the crossroads of inflammation and atherogenesis: searching for new therapeutic links

Octanol/water partitioning simulation by RP-HPLC for structurally diverse acidic drugs: comparison of three columns in the presence and absence of n-octanol as the mobile phase additive.

Octanol/water partitioning simulation by reversed-phase high performance liquid chromatography for structurally diverse acidic drugs: Effect of n-octanol as mobile phase additive.

PPAR-gamma signaling pathway in placental development and function: a potential therapeutic target in the treatment of gestational diseases

Peroxisome Proliferator-Activated Receptor-gamma Ligands: Potential Pharmacological Agents for Targeting the Angiogenesis Signaling Cascade in Cancer.

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: novel pharmacological agents in the treatment of ischemia reperfusion injury.

Peroxisome proliferator-activated receptor-γ in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival

Peroxisome proliferator-activated receptors (PPARs) in the control of bone metabolism.

Phosphorylated Epidermal Growth Factor Receptor Expression Is Associated With Clinicopathologic Parameters and Patient Survival in Mobile Tongue Squamous Cell Carcinoma.

The Role of Peroxisome Proliferator-Activated Receptor-γ in Breast Cancer ⬇️