List of works - Shaheen Khan

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways.

scientific article

A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression

scientific journal article

A new locus for nonsyndromic deafness DFNB49 maps to chromosome 5q12.3-q14.1.

scientific article

A new locus for nonsyndromic deafness DFNB51 maps to chromosome 11p13-p12.

scientific article

Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth

scientific article

Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48.

scientific article

Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells.

scientific article published on September 2006

Autosomal recessive nonsyndromic deafness locus DFNB63 at chromosome 11q13.2-q13.3.

scientific article

Challenges and solutions for gene identification in the presence of familial locus heterogeneity

scientific article

Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells

scientific article

Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice

scientific article

DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1.

scientific article published on 12 February 2005

DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis

scientific article

Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function

scientific article (publication date: March 2002)

Fatty Acid Amide Hydrolase Regulates Peripheral B Cell Receptor Revision, Polyreactivity, and B1 Cells in Lupus.

scientific article

Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74

scientific article

Genetic analysis through OtoSeq of Pakistani families segregating prelingual hearing loss

scientific article

Global genetic insight contributed by consanguineous Pakistani families segregating hearing loss

article

Inframe deletion of human ESPN is associated with deafness, vestibulopathy and vision impairment

scientific article published on 23 March 2018

Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens.

scientific article published on 23 February 2008

Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42

scientific article

MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary

scientific article published on 11 April 2019

Melanoma models for the next generation of therapies

Molecular and clinical studies of X-linked deafness among Pakistani families

scientific article

Molecular genetics of MARVELD2 and clinical phenotype in Pakistani and Slovak families segregating DFNB49 hearing loss

scientific article

Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.

scientific article published on 4 May 2006

Mutation spectrum of MYO7A and evaluation of a novel nonsyndromic deafness DFNB2 allele with residual function

scientific article published in April 2008

Mutational Spectrum of MYO15A and the Molecular Mechanisms of DFNB3 Human Deafness

scientific article

Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse

scientific article published on 28 March 2018

Mutations in TBC1D24, a gene associated with epilepsy, also cause nonsyndromic deafness DFNB86.

scientific article published on January 2014

Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness

scientific article

Mutations of GIPC3 cause nonsyndromic hearing loss DFNB72 but not DFNB81 that also maps to chromosome 19p

scientific article published on 10 June 2011

Mutations of MYO6 are associated with recessive deafness, DFNB37

scientific article

Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome

scientific article

Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus

scientific article

Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39.

scientific article

Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways

scientific article published on 01 January 2007

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

scientific article published on 01 June 2016

Phenotypic variability of CLDN14 mutations causing DFNB29 hearing loss in the Pakistani population ⬇️

scientific article published on December 13, 2012

RNA sequencing reveals the consequences of a novel insertion in dedicator of cytokinesis-8.

scientific article published on 13 February 2016

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity.

scientific article published on 16 February 2016

Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells.

scientific article

Single-Cell RNA-Sequencing of Peripheral Blood Mononuclear Cells with ddSEQ

scientific article published on 01 January 2019

Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79

scientific article

Targeting NR4A1 (TR3) in cancer cells and tumors ⬇️

scientific article published on 05 January 2011

The autosomal recessive nonsyndromic deafness locus DFNB72 is located on chromosome 19p13.3.

scientific article published on 10 August 2007

Tricellulin is a tight-junction protein necessary for hearing

scientific article

Variable expressivity of FGF3 mutations associated with deafness and LAMM syndrome

scientific article

List of works by Shaheen Khan

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways.

A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression

A new locus for nonsyndromic deafness DFNB49 maps to chromosome 5q12.3-q14.1.

A new locus for nonsyndromic deafness DFNB51 maps to chromosome 11p13-p12.

Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth

Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48.

Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells.

Autosomal recessive nonsyndromic deafness locus DFNB63 at chromosome 11q13.2-q13.3.

Challenges and solutions for gene identification in the presence of familial locus heterogeneity

Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells

Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice

DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1.

DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis

Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function

Fatty Acid Amide Hydrolase Regulates Peripheral B Cell Receptor Revision, Polyreactivity, and B1 Cells in Lupus.

Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74

Genetic analysis through OtoSeq of Pakistani families segregating prelingual hearing loss

Global genetic insight contributed by consanguineous Pakistani families segregating hearing loss

Inframe deletion of human ESPN is associated with deafness, vestibulopathy and vision impairment

Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens.

Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42

MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary

Melanoma models for the next generation of therapies

Molecular and clinical studies of X-linked deafness among Pakistani families

Molecular genetics of MARVELD2 and clinical phenotype in Pakistani and Slovak families segregating DFNB49 hearing loss

Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.

Mutation spectrum of MYO7A and evaluation of a novel nonsyndromic deafness DFNB2 allele with residual function

Mutational Spectrum of MYO15A and the Molecular Mechanisms of DFNB3 Human Deafness

Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse

Mutations in TBC1D24, a gene associated with epilepsy, also cause nonsyndromic deafness DFNB86.

Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness

Mutations of GIPC3 cause nonsyndromic hearing loss DFNB72 but not DFNB81 that also maps to chromosome 19p

Mutations of MYO6 are associated with recessive deafness, DFNB37

Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome

Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus

Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39.

Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

Phenotypic variability of CLDN14 mutations causing DFNB29 hearing loss in the Pakistani population ⬇️

RNA sequencing reveals the consequences of a novel insertion in dedicator of cytokinesis-8.

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity.

Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells.

Single-Cell RNA-Sequencing of Peripheral Blood Mononuclear Cells with ddSEQ

Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79

Targeting NR4A1 (TR3) in cancer cells and tumors ⬇️

The autosomal recessive nonsyndromic deafness locus DFNB72 is located on chromosome 19p13.3.

Tricellulin is a tight-junction protein necessary for hearing

Variable expressivity of FGF3 mutations associated with deafness and LAMM syndrome