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List of works by Manuel A F V Gonçalves

Adeno-associated virus: from defective virus to effective vector

scientific article

Adenoviral Vectors Meet Gene Editing: A Rising Partnership for the Genomic Engineering of Human Stem Cells and Their Progeny

scientific article published on 13 April 2020

Adenoviral vector DNA for accurate genome editing with engineered nucleases.

scientific article published on 24 August 2014

Adenoviral vector delivery of RNA-guided CRISPR/Cas9 nuclease complexes induces targeted mutagenesis in a diverse array of human cells

scientific article published on 29 May 2014

Adenoviral vectors encoding CRISPR/Cas9 multiplexes rescue dystrophin synthesis in unselected populations of DMD muscle cells.

scientific article

Adenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors.

scientific article

Adenovirus: from foe to friend.

scientific article

Broadening the reach and investigating the potential of prime editors through fully viral gene-deleted adenoviral vector delivery

scientific article published on 01 November 2021

Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells.

scientific article

Construction and characterization of adenoviral vectors for the delivery of TALENs into human cells.

scientific article published on 20 February 2014

Correction of Recessive Dystrophic Epidermolysis Bullosa by Transposon-Mediated Integration of COL7A1 in Transplantable Patient-Derived Primary Keratinocytes.

scientific article published on 24 December 2016

DNA, RNA, and Protein Tools for Editing the Genetic Information in Human Cells

scientific article published on 04 August 2018

Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells.

scientific article published on 28 December 2012

Endowing human adenovirus serotype 5 vectors with fiber domains of species B greatly enhances gene transfer into human mesenchymal stem cells.

scientific article published on November 2005

Engineered Viruses as Genome Editing Devices

scientific article

Expanding the editable genome and CRISPR-Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking

scientific article published on 01 January 2020

Genetic complementation of human muscle cells via directed stem cell fusion

scientific article published on 04 March 2008

Genome editing at the crossroads of delivery, specificity, and fidelity

scientific article

High-Capacity Adenoviral Vectors Permit Robust and Versatile Testing of DMD Gene Repair Tools and Strategies in Human Cells

scientific article published on 02 April 2020

Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells.

scientific article published on 11 December 2012

Histone deacetylase inhibition rescues gene knockout levels achieved with integrase-defective lentiviral vectors encoding zinc-finger nucleases.

scientific article published on 29 October 2013

Human mesenchymal stem cells ectopically expressing full-length dystrophin can complement Duchenne muscular dystrophy myotubes by cell fusion.

scientific article published in December 2005

In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting

scientific article published on 22 September 2017

Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components

scientific article published on 03 January 2020

Intronic SMCHD1 variants in FSHD: testing the potential for CRISPR-Cas9 genome editing

scientific article published on 01 November 2019

Long-term contribution of human bone marrow mesenchymal stromal cells to skeletal muscle regeneration in mice

scientific article published on 18 August 2010

Modular and excisable molecular switch for the induction of gene expression by the yeast FLP recombinase

scientific article published on 01 December 2006

Myogenic properties of human mesenchymal stem cells derived from three different sources.

scientific article published on 7 June 2011

Nonspaced inverted DNA repeats are preferential targets for homology-directed gene repair in mammalian cells.

scientific article

Probing the impact of chromatin conformation on genome editing tools.

scientific article published on 8 June 2016

Rapid and sensitive lentivirus vector-based conditional gene expression assay to monitor and quantify cell fusion activity

scientific article

Selection-free gene repair after adenoviral vector transduction of designer nucleases: rescue of dystrophin synthesis in DMD muscle cell populations.

scientific article published on 13 January 2016

Stimulation of homology-directed gene targeting at an endogenous human locus by a nicking endonuclease.

scientific article published on 03 August 2009

Targeted chromosomal insertion of large DNA into the human genome by a fiber-modified high-capacity adenovirus-based vector system.

scientific article

Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination

scientific article published on 13 June 2013

The Chromatin Structure Differentially Impacts High-Specificity CRISPR-Cas9 Nuclease Strategies.

scientific article published on 12 August 2017

The Chromatin Structure of CRISPR-Cas9 Target DNA Controls the Balance between Mutagenic and Homology-Directed Gene-Editing Events

article

The emerging role of viral vectors as vehicles for DMD gene editing

scientific article

Transcription factor rational design improves directed differentiation of human mesenchymal stem cells into skeletal myocytes.

scientific article

Transduction of myogenic cells by retargeted dual high-capacity hybrid viral vectors: robust dystrophin synthesis in duchenne muscular dystrophy muscle cells.

scientific article published on 26 January 2006

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