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List of works by Kazunori Hamamura

A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3.

scientific article published on 08 April 2016

Attenuation of malignant phenotypes of breast cancer cells through eIF2α-mediated downregulation of Rac1 signaling.

scientific article published on 2 April 2014

Bidirectional communication between sensory neurons and osteoblasts in an in vitro coculture system.

scientific article published on 17 January 2017

Biosignals modulated by tumor-associated carbohydrate antigens: novel targets for cancer therapy.

scientific article published on November 2006

Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis.

scientific article published on May 2015

Conditioned medium from rat dental pulp reduces the number of osteoclasts via attenuation of adhesiveness in osteoclast precursors

scientific article published on 09 July 2018

Deficiency of GD3 Synthase in Mice Resulting in the Attenuation of Bone Loss with Aging

scientific article published on 10 June 2019

Deletion of Gb3 Synthase in Mice Resulted in the Attenuation of Bone Formation via Decrease in Osteoblasts

scientific article published on 18 September 2019

Differential roles of gangliosides in malignant properties of melanomas

scientific article published in PLoS ONE

Disialyl gangliosides enhance tumor phenotypes with differential modalities.

scientific article published on 05 July 2012

Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells ⬇️

scientific article published on July 1, 2013

Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3.

scientific article published on 16 July 2012

Essential roles of integrin-mediated signaling for the enhancement of malignant properties of melanomas based on the expression of GD3.

scientific article

Fine tuning of cell signals by glycosylation ⬇️

scientific article published on May 22, 2012

Functional Activation of Src Family Kinase Yes Protein Is Essential for the Enhanced Malignant Properties of Human Melanoma Cells Expressing Ganglioside GD3 ⬇️

scientific article published on March 31, 2011

GM1 / GD1b / GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line.

scientific article published on September 2010

Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells.

scientific article

Guanabenz Downregulates Inflammatory Responses via eIF2α Dependent and Independent Signaling

scientific article published on 5 May 2016

In vitro and in silico analysis of an inhibitory mechanism of osteoclastogenesis by salubrinal and guanabenz

scientific article published on 27 November 2014

Knee loading reduces MMP13 activity in the mouse cartilage

scientific article

Lengthening of mouse hindlimbs with joint loading.

scientific article

Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x ⬇️

scientific article published on December 15, 2012

MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus

scientific article published on 9 September 2015

Model-based comparative prediction of transcription-factor binding motifs in anabolic responses in bone.

scientific article published on December 2007

Molecules in the signaling pathway activated by gangliosides can be targets of therapeutics for malignant melanomas.

scientific article published on August 2008

New era of research on cancer-associated glycosphingolipids

scientific article published on 29 April 2019

Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside GD3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties.

scientific article published on 31 January 2007

Positive feedback loop between PI3K-Akt-mTORC1 signaling and the lipogenic pathway boosts Akt signaling: induction of the lipogenic pathway by a melanoma antigen.

scientific article published in June 2011

Potential applications of pulsating joint loading in sports medicine.

scientific article published on January 2009

Predicting and validating the pathway of Wnt3a-driven suppression of osteoclastogenesis

scientific article

Proteomic analysis of ganglioside-associated membrane molecules: substantial basis for molecular clustering.

scientific article published on October 2012

Reduction in Migratory Phenotype in a Metastasized Breast Cancer Cell Line via Downregulation of S100A4 and GRM3.

scientific article

RhoA-mediated signaling in mechanotransduction of osteoblasts.

journal article published in 2012

Role of miR-222-3p in c-Src-Mediated Regulation of Osteoclastogenesis

scientific article published on 16 February 2016

Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis

scientific article

Salubrinal improves mechanical properties of the femur in osteogenesis imperfecta mice

scientific article published on October 2016

Salubrinal promotes healing of surgical wounds in rat femurs.

scientific article

Salubrinal reduces expression and activity of MMP13 in chondrocytes.

scientific article published on 7 March 2013

Stress to endoplasmic reticulum of mouse osteoblasts induces apoptosis and transcriptional activation for bone remodeling.

scientific article published on 2 April 2007

Suppressed invasive and migratory behaviors of SW1353 chondrosarcoma cells through the regulation of Src, Rac1 GTPase, and MMP13.

scientific article published on 21 August 2015

Suppression of osteoclastogenesis through phosphorylation of eukaryotic translation initiation factor 2 alpha.

scientific article published on 28 March 2013

Suppression of osteoclastogenesis via α2-adrenergic receptors.

scientific article published on 9 March 2018

Systemic administration of low-dose naltrexone increases bone mass due to blockade of opioid growth factor receptor signaling in mice osteoblasts

scientific article published on 28 March 2019

Systems analysis of bone remodelling as a homeostatic regulator.

scientific article

Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9.

scientific article published on 27 June 2013

pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen.

scientific article published on 28 January 2012

α1B -Adrenoceptor signalling regulates bone formation through the up-regulation of CCAAT/enhancer-binding protein δ expression in osteoblasts.

scientific article published on 10 January 2016

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