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List of works by Yasuhiro Uno

A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine

scientific article published on 4 April 2016

A newly developed DNA microarray is useful to assess induction of cytochromes p450 in the cynomolgus monkey.

scientific article

A novel CYP2A26 identified in cynomolgus monkey liver metabolizes coumarin.

scientific article published on September 2010

A null allele impairs function of CYP2C76 gene in cynomolgus monkeys: a possible genetic tool for generation of a better animal model in drug metabolism.

scientific article

Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).

scientific article

Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation.

scientific article

Alprazolam as an in vivo probe for studying induction of CYP3A in cynomolgus monkeys.

scientific article published on 28 June 2010

Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver

scientific article published on 31 January 2018

Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing

scientific article published on May 2016

Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies

scientific article

Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models

scientific article published on 16 October 2017

CYP1B1 is Polymorphic in Cynomolgus and Rhesus Macaques

scientific article published on 06 May 2011

CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey

scientific article published on 9 November 2010

CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques

scientific article published on 15 July 2014

CYP2C76 deficiency is embryonic lethal in cynomolgus macaques: The potential role of CYP2C76 in early embryogenesis

scientific article published on 27 October 2016

CYP2C76 non-synonymous variants in cynomolgus and rhesus macaques.

scientific article

CYP2C76-mediated species difference in drug metabolism: a comparison of pitavastatin metabolism between monkeys and humans

scientific article published on 01 January 2007

CYP2D44 polymorphisms in cynomolgus and rhesus macaques.

scientific article

CYP2G2, pseudogenized in human, is expressed in nasal mucosa of cynomolgus monkey and encodes a functional drug-metabolizing enzyme.

scientific article published on 28 December 2010

Caffeine 7-N-demethylation and C-8-oxidation mediated by liver microsomal cytochrome P450 enzymes in common marmosets.

scientific article published on 27 October 2015

Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism?

scientific article published on 14 July 2007

Characterization of feline cytochrome P450 2B6.

scientific article published on 9 March 2016

Characterization of microsomal glutathione S-transferases MGST1, MGST2, and MGST3 in cynomolgus macaque.

scientific article published on 19 June 2013

Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter ⬇️

scientific article published on October 29, 2003

Cloning and expression of a novel catechol-O-methyltransferase in common marmosets

scientific article

Cloning and tissue expression of cytochrome P450 2S1, 4V2, 7A1, 7B1, 8B1, 24A1, 26A1, 26C1, 27A1, 39A1, and 51A1 in marmosets

scientific article published on 26 December 2019

Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans

scientific article published on January 2010

Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase

scientific article published on 06 May 2015

Corrigendum to "Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9" [Drug Metab Pharmacokinet 30 (2015) 130-132].

scientific article

CpG site degeneration triggered by the loss of functional constraint created a highly polymorphic macaque drug-metabolizing gene, CYP1A2.

scientific article

Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan.

scientific article published on 25 May 2010

Cytochrome P450 1A1, 2C9, 2C19, and 3A4 polymorphisms account for inter-individual variability of toxicological drug metabolism in cynomolgus macaques

scientific article published on 19 November 2018

Cytochrome P450 metabolic activities in the small intestine of cynomolgus macaques bred in Cambodia, China, and Indonesia.

scientific article

Development of a genotyping tool for a functionally relevant CYP2C19 allele (Phe100Asn, Ala103Val and Ile112Leu) in cynomolgus macaques.

scientific article published on 21 August 2015

Development of a new device for artificial insemination in cynomolgus macaques

scientific article published on 17 June 2016

Development of genotyping method for functionally relevant variants of cytochromes P450 in cynomolgus macaques

scientific article

Differences in Intestinal Hydrolytic Activities between Cynomolgus Monkeys and Humans: Evaluation of Substrate Specificities Using Recombinant Carboxylesterase 2 Isozymes.

scientific article published on 25 July 2016

Different metabolites of human hepatotoxic pyrazolopyrimidine derivative 5-n-butyl-pyrazolo[1,5-a]pyrimidine produced by human, rat and monkey cytochrome P450 1A2 and liver microsomes.

scientific article published on 9 November 2011

Discovery of Genetic Variants in CYP1D1: Implication for Functional Integrity of CYP1D1 in Cynomolgus Macaques and Rhesus Macaques ⬇️

scientific article published on August 16, 2011

Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs.

scientific article published on 10 May 2014

Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models

scientific article published on 13 June 2017

Effect of Estradiol on Gene Expression Profile in Cynomolgus Macaque Liver: Implications for Drug-Metabolizing Enzymes ⬇️

scientific article published on August 2, 2011

Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19.

scientific article published on 7 July 2017

Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450

scientific article published on 19 February 2014

Evaluation of 89 compounds for identification of substrates for cynomolgus monkey CYP2C76, a new bupropion/nifedipine oxidase

scientific article published on 15 October 2014

Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney

scientific article published on 25 September 2018

Expression levels of microRNAs that are potential cytochrome P450 regulators in cynomolgus macaques

scientific article published on 11 November 2019

Expression of cytochrome P450 regulators in cynomolgus macaque

scientific article

Expression of cytochromes p450 in fetal, infant, and juvenile liver of cynomolgus macaques.

scientific article published on 16 August 2011

Expression of two novel cytochrome P450 3A131 and 3A132 in liver and small intestine of domestic cats.

scientific article published on 28 June 2011

Expression profile of early estradiol-responsive genes in cynomolgus macaque liver: implications for drug-metabolizing enzymes.

scientific article published on 21 February 2012

Expression profile of hepatic genes in cynomolgus macaques bred in Cambodia, China, and Indonesia: implications for cytochrome P450 genes.

scientific article

Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques

scientific article published on 02 March 2019

Functional characterization and tissue expression of marmoset cytochrome P450 2E1.

scientific article

Functional characterization for polymorphic organic anion transporting polypeptides (OATP/SLCO1B1, 1B3, 2B1) of monkeys recombinantly expressed with various OATP probes

scientific article published on 10 February 2019

Functional expression and comparative characterization of four feline P450 cytochromes using fluorescent substrates.

scientific article published on 14 November 2016

Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques

scientific article published on 06 December 2018

Genetic Variants of Glutathione S-Transferase GSTT1 and GSTT2 in Cynomolgus Macaques: Identification of GSTT Substrates and Functionally Relevant Alleles

scientific article published on 13 September 2018

Genetic diversity of cytochrome P450 1A2 with different metabolic activities in domestic cats

scientific article published on 21 May 2019

Genetic diversity of cytochrome P450 2A with different metabolic activities in domestic cats

scientific article published on 21 May 2019

Genetic diversity of cytochrome P450 3A with different metabolic activity in domestic cats ⬇️

scientific article published on 04 March 2019

Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9.

scientific article published on 19 October 2014

Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans.

scientific article

Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.

scientific article published on 12 November 2009

Genetic variants of UDP-glucuronosyltransferases 1A1, 1A6, and 1A9 in cynomolgus and rhesus macaques

scientific article published on 19 August 2020

Genomic structure and transcript variants of the bovine DAZL gene.

scientific article

Hepatic expression of cytochrome P450 enzymes in non-human primate species.

scientific article published on 29 June 2017

Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate

scientific article published on June 2010

Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling.

scientific article

Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.

scientific article

Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys

scientific article published on 13 December 2019

Identification and analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1 and CYP51A1 in cynomolgus macaques

scientific article

Identification and characterization of CYP2B6 cDNA in cynomolgus macaques (Macaca fascicularis).

scientific article

Identification and characterization of CYP2C18 in the cynomolgus macaque (Macaca fascicularis).

scientific article published on 25 November 2009

Identification and functional characterization of novel feline cytochrome P450 2A

scientific article published on 30 December 2014

Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors

scientific article published on 18 November 2015

Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys.

scientific article

Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys

scientific article

Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine.

scientific article

Importance of cynomolgus monkeys in development of monoclonal antibody drugs.

scientific article published on 20 March 2018

In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants

scientific article published on 05 April 2018

In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9.

scientific article published on 15 July 2016

Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers.

scientific article published on 20 April 2016

Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques

scientific article published on 7 February 2015

Large-scale analysis of Macaca fascicularis transcripts and inference of genetic divergence between M. fascicularis and M. mulatta

scientific article published on 24 February 2008

Limited expression of functional cytochrome p450 2c subtypes in the liver and small intestine of domestic cats

scientific article published on 13 July 2018

Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function.

scientific article published on 09 February 2011

Marmoset Cytochrome P450 2B6, a Propofol Hydroxylase Expressed in Liver

scientific article published on 8 February 2018

Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and Testosterone

scientific article

Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase.

scientific article published on 3 March 2017

Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan

scientific article published on 24 March 2015

Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine.

scientific article published on 22 February 2016

Marmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid ω-hydroxylase expressed in liver and kidney tissues.

scientific article published on 20 July 2016

Marmoset pulmonary cytochrome P450 2F1 oxidizes biphenyl and 7-ethoxycoumarin and hepatic human P450 substrates

scientific article published on 8 July 2017

Metabolism of P450 Probe Substrates by Cynomolgus Monkey CYP2C76

scientific article published on 14 July 2011

Molecular Cloning and Characterization of Marmoset Aldehyde Oxidase

scientific article published on 9 May 2017

Molecular Cloning, Tissue Distribution, and Functional Characterization of Marmoset Cytochrome P450 1A1, 1A2, and 1B1.

scientific article

Molecular and Functional Characterization of N-Acetyltransferases NAT1 and NAT2 in Cynomolgus Macaque

scholarly article by Yasuhiro Uno et al published 25 October 2018 in Chemical Research in Toxicology

Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques

scientific article published on 23 June 2018

Molecular and functional characterization of cytosolic sulfotransferases in cynomolgus macaque

scientific article published on 14 May 2019

Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque.

scientific article published on 23 April 2013

Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques

scientific article published on 24 March 2018

Molecular characterization of functional UDP-glucuronosyltransferases 1A and 2B in common marmosets

scientific article published on 10 December 2019

Molecular cloning and tissue distribution of a novel marmoset ABC transporter

scientific article published on 23 October 2017

Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation

scientific article published on 03 October 2012

Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline

scientific article published on 16 May 2013

Natural selection in the TLR-related genes in the course of primate evolution

article

Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey

scientific article

Non-synonymous genetic variants of flavin-containing monooxygenase 3 (FMO3) in cynomolgus macaques

scientific article published on 07 September 2018

Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets.

scientific article published on 15 September 2016

Polymorphisms of CYP2D17 in cynomolgus and rhesus macaques: an evidence of the genetic basis for the variability of CYP2D-dependent drug metabolism.

scientific article published in July 2014

Polymorphisms of cytochrome P450 2B6 (CYP2B6 ) in cynomolgus and rhesus macaques

scientific article published on 22 February 2018

Polymorphisms of neonatal Fc receptor in cynomolgus and rhesus macaques.

scientific article

Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide.

scientific article published on 7 September 2016

Progesterone Hydroxylation by Cytochromes P450 2C and 3A Enzymes in Marmoset Liver Microsomes

scientific article published in August 2017

Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing

scientific article (publication date: 2014)

R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys.

scientific article published on 30 January 2017

Regio- and Stereo-Selective Oxidation of a Cardiovascular Drug, Metoprolol, Mediated by Cytochrome P450 2D and 3A Enzymes in Marmoset Livers

scientific article published on 11 May 2017

Regional distribution of cytochrome p450 mRNA expression in the liver and small intestine of cynomolgus monkeys

scientific article published on 01 January 2010

Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys.

scientific article

Sex- and age-dependent gene expression in human liver: An implication for drug-metabolizing enzymes

scientific article published on 27 October 2016

Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances

scientific article published on 8 September 2015

Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (Callithrix jacchus).

scientific article

Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo.

scientific article

Strong Induction of Cytochrome P450 1A/3A, But not P450 2B, in Cultured Hepatocytes from Common Marmosets and Cynomolgus Monkeys by Typical Human P450 Inducing Agents.

scientific article published on 14 November 2016

Structural organization and chromosomal location of the chicken alpha-amylase gene family.

scientific article published on 13 October 2005

Substrate Selectivities and Catalytic Activities of Marmoset Liver Cytochrome P450 2A6 Differed from Those of Human P450 2A6.

scientific article published on 9 April 2015

Survey of Drug Oxidation Activities in Liver and Intestine Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

article

Systematic characterization of glutathione S-transferases in common marmosets

scientific article published on 04 February 2020

Systematic identification and characterization of carboxylesterases in cynomolgus macaques

scientific article published on 25 September 2014

Systematic identification and characterization of glutathione S-transferases in cynomolgus macaque.

scientific article published on July 2013

Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines.

scientific article published on 22 April 2017

The marmoset cytochrome P450 superfamily: Sequence/phylogenetic analyses, genomic structure, and catalytic function

scientific article published on 18 November 2019

Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes.

scientific article published on 15 June 2016

mRNA levels of drug-metabolizing enzymes in 11 brain regions of cynomolgus macaques

scientific article published on 31 December 2019

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