List of works - Kazuyoshi Hosomichi

A BAC-based contig map of the cynomolgus macaque (Macaca fascicularis) major histocompatibility complex genomic region.

scientific article

A Bead-based Normalization for Uniform Sequencing depth (BeNUS) protocol for multi-samples sequencing exemplified by HLA-B.

scientific article

A de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia identified using whole exome sequencing

scientific article published on 22 December 2015

A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis.

scientific article

A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan

scientific article

A toddler with phylloid-type pigmentary mosaicism and ambiguous genitalia resulting from trisomy 14 induced by a der(Y)t(Y;14)

scientific article published on 25 September 2020

AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway.

scientific article published on 5 August 2017

Aggregation of rare/low-frequency variants of the mitochondria respiratory chain-related proteins in rheumatoid arthritis patients.

scientific article published on 28 May 2015

Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus

scientific article

BG1 has a major role in MHC-linked resistance to malignant lymphoma in the chicken.

scientific article published on 11 September 2009

Basic characterization of 90 kDa heat shock protein genes HSP90AA1, HSP90AB1, HSP90B1 and TRAP1 expressed in Japanese quail (Coturnix japonica).

scientific article published in August 2010

CRISPR/Cas9-mediated gene knockout in the mouse brain using in utero electroporation

scientific article

Comparative genome analysis of the major histocompatibility complex (MHC) class I B/C segments in primates elucidated by genomic sequencing in common marmoset (Callithrix jacchus)

article

Comparative genomic analysis of two avian (quail and chicken) MHC regions.

scientific article published on June 2004

Comprehensive Comparison of Novel Bovine Leukemia Virus (BLV) Integration Sites between B-Cell Lymphoma Lines BLSC-KU1 and BLSC-KU17 Using the Viral DNA Capture High-Throughput Sequencing Method

scientific article published on 07 May 2022

Comprehensive Genetic Exploration of Fused Teeth by Whole Exome Sequencing

scientific article published in 2022

Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing.

scientific article published on 23 February 2017

Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel

scientific article published on 26 February 2016

Comprehensive microbiome analysis of tonsillar crypts in IgA nephropathy.

scientific article published on 28 September 2016

Correction of the HLA-DQB1*04:01:01 sequence at position 79 in exon 1.

scientific article published on 18 November 2015

Detection of ancestry informative HLA alleles confirms the admixed origins of Japanese population.

scientific article

Dysbiotic gut microbiota in pancreatic cancer patients form correlation networks with the oral microbiota and prognostic factors

scientific article published on 15 June 2021

Evolutionary relations of Hexanchiformes deep-sea sharks elucidated by whole mitochondrial genome sequences

scientific article (publication date: 2013)

Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A24:02: the same deletion observed in other A24 alleles and A*23:01 allele.

scientific article published on 26 April 2011

Exome resequencing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in Japanese

scientific article

Exome sequencing identifies novel rheumatoid arthritis-susceptible variants in the BTNL2.

scientific article published on 31 January 2013

Exploration of genetic factors determining cleft side in a pair of monozygotic twins with mirror-image cleft lip and palate using whole-genome sequencing and comparison of craniofacial morphology

scientific article published on 19 August 2018

Folding of the Cerebral Cortex Requires Cdk5 in Upper-Layer Neurons in Gyrencephalic Mammals.

scientific article published in August 2017

Gene expression profiling reveals distinct molecular signatures associated with the rupture of intracranial aneurysm

scientific article published on 17 June 2014

Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population

scientific article published on 28 January 2019

Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout

scientific article published on 8 July 2019

Genome-wide linkage and exome analyses identify variants of HMCN1 for splenic epidermoid cyst

scientific article

Germline Variants of Prostate Cancer in Japanese Families.

scientific article

HLA-A allele associations with viral MER9-LTR nucleotide sequences at two distinct loci within the MHC alpha block.

scientific article

High Order Formation and Evolution of Hornerin in Primates

scientific article published on 01 December 2018

Identification of a novel variant of the RET proto-oncogene in a novel family with Hirschsprung's disease.

scientific article

Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia.

scientific article published on 23 February 2017

Immune-Mediated Hematopoietic Failure after Allogeneic Hematopoietic Stem Cell Transplantation: A Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism.

scientific article published on 28 August 2017

Localized astrogenesis regulates gyrification of the cerebral cortex

scientific article published on 11 March 2022

Molecular characterization of an intact p53 pathway subtype in high-grade serous ovarian cancer

scientific article published on 2 December 2014

Multiple common and rare variants of ABCG2 cause gout

scientific article published on 29 August 2017

New PCNT candidate missense variant in a patient with oral and maxillofacial osteodysplasia: a case report

scientific article published on 16 July 2019

Next-generation sequencing analysis identifies genomic alterations in pathological morphologies: A case of pulmonary carcinosarcoma harboring EGFR mutations

scientific article published on 31 May 2018

Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese

scientific article published on 05 August 2019

No novel, high penetrant gene might remain to be found in Japanese patients with unknown MODY.

scientific article published on 18 April 2018

Novel cynomolgus macaque MHC-DPB1 polymorphisms in three South-East Asian populations

scientific article published on 01 April 2006

Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease

scientific article published on 23 August 2018

Orthognathic surgery induces genome-wide changes longitudinally in DNA methylation in saliva

scientific article published on 15 November 2018

Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).

scientific article

Possible association between dysfunction of vitamin D binding protein (GC Globulin) and migraine attacks

scientific article

Primary analysis of DNA polymorphisms in the TRIM region (MHC subregion) of the Japanese quail, Coturnix japonica.

scientific article

RXRB Is an MHC-Encoded Susceptibility Gene Associated with Anti-Topoisomerase I Antibody-Positive Systemic Sclerosis.

scientific article

Rapid and cost-effective high-throughput sequencing for identification of germline mutations of BRCA1 and BRCA2.

scientific article

Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients

scientific article published on 21 May 2015

Structure and evolution of the filaggrin gene repeated region in primates

scientific article

Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia

scientific article published on 01 May 2018

TRIM39 and RNF39 are associated with Behçet's disease independently of HLA-B∗51 and -A∗26

scientific article published on 27 September 2010

The <i>Gallus gallus</i> RJF reference genome reveals an MHCY haplotype organized in gene blocks that contain 107 loci including 45 specialized, polymorphic MHC class I loci, 41 C-type lectin-like loci, and other loci amid hundreds of transposable e

scientific article published in 2022

The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity

scientific article published on 22 June 2021

The amphioxus genome illuminates vertebrate origins and cephalochordate biology

scientific article

The impact of next-generation sequencing technologies on HLA research

scientific article (publication date: November 2015)

The major histocompatibility complex (Mhc) class IIB region has greater genomic structural flexibility and diversity in the quail than the chicken.

scientific article

Whole-exome sequencing analysis of supernumerary teeth occurrence in Japanese individuals.

scientific article published on 26 January 2017

Whole-genome sequencing in a pair of monozygotic twins with discordant cleft lip and palate subtypes

scientific article published on 10 July 2018

List of works by Kazuyoshi Hosomichi

A BAC-based contig map of the cynomolgus macaque (Macaca fascicularis) major histocompatibility complex genomic region.

A Bead-based Normalization for Uniform Sequencing depth (BeNUS) protocol for multi-samples sequencing exemplified by HLA-B.

A de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia identified using whole exome sequencing

A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis.

A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan

A toddler with phylloid-type pigmentary mosaicism and ambiguous genitalia resulting from trisomy 14 induced by a der(Y)t(Y;14)

AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway.

Aggregation of rare/low-frequency variants of the mitochondria respiratory chain-related proteins in rheumatoid arthritis patients.

Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus

BG1 has a major role in MHC-linked resistance to malignant lymphoma in the chicken.

Basic characterization of 90 kDa heat shock protein genes HSP90AA1, HSP90AB1, HSP90B1 and TRAP1 expressed in Japanese quail (Coturnix japonica).

CRISPR/Cas9-mediated gene knockout in the mouse brain using in utero electroporation

Comparative genome analysis of the major histocompatibility complex (MHC) class I B/C segments in primates elucidated by genomic sequencing in common marmoset (Callithrix jacchus)

Comparative genomic analysis of two avian (quail and chicken) MHC regions.

Comprehensive Comparison of Novel Bovine Leukemia Virus (BLV) Integration Sites between B-Cell Lymphoma Lines BLSC-KU1 and BLSC-KU17 Using the Viral DNA Capture High-Throughput Sequencing Method

Comprehensive Genetic Exploration of Fused Teeth by Whole Exome Sequencing

Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing.

Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel

Comprehensive microbiome analysis of tonsillar crypts in IgA nephropathy.

Correction of the HLA-DQB1*04:01:01 sequence at position 79 in exon 1.

Detection of ancestry informative HLA alleles confirms the admixed origins of Japanese population.

Dysbiotic gut microbiota in pancreatic cancer patients form correlation networks with the oral microbiota and prognostic factors

Evolutionary relations of Hexanchiformes deep-sea sharks elucidated by whole mitochondrial genome sequences

Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A*24:02: the same deletion observed in other A*24 alleles and A*23:01 allele.

Exome resequencing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in Japanese

Exome sequencing identifies novel rheumatoid arthritis-susceptible variants in the BTNL2.

Exploration of genetic factors determining cleft side in a pair of monozygotic twins with mirror-image cleft lip and palate using whole-genome sequencing and comparison of craniofacial morphology

Folding of the Cerebral Cortex Requires Cdk5 in Upper-Layer Neurons in Gyrencephalic Mammals.

Gene expression profiling reveals distinct molecular signatures associated with the rupture of intracranial aneurysm

Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population

Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout

Genome-wide linkage and exome analyses identify variants of HMCN1 for splenic epidermoid cyst

Germline Variants of Prostate Cancer in Japanese Families.

HLA-A allele associations with viral MER9-LTR nucleotide sequences at two distinct loci within the MHC alpha block.

High Order Formation and Evolution of Hornerin in Primates

Identification of a novel variant of the RET proto-oncogene in a novel family with Hirschsprung's disease.

Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia.

Immune-Mediated Hematopoietic Failure after Allogeneic Hematopoietic Stem Cell Transplantation: A Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism.

Localized astrogenesis regulates gyrification of the cerebral cortex

Molecular characterization of an intact p53 pathway subtype in high-grade serous ovarian cancer

Multiple common and rare variants of ABCG2 cause gout

New PCNT candidate missense variant in a patient with oral and maxillofacial osteodysplasia: a case report

Next-generation sequencing analysis identifies genomic alterations in pathological morphologies: A case of pulmonary carcinosarcoma harboring EGFR mutations

Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese

No novel, high penetrant gene might remain to be found in Japanese patients with unknown MODY.

Novel cynomolgus macaque MHC-DPB1 polymorphisms in three South-East Asian populations

Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease

Orthognathic surgery induces genome-wide changes longitudinally in DNA methylation in saliva

Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).

Possible association between dysfunction of vitamin D binding protein (GC Globulin) and migraine attacks

Primary analysis of DNA polymorphisms in the TRIM region (MHC subregion) of the Japanese quail, Coturnix japonica.

RXRB Is an MHC-Encoded Susceptibility Gene Associated with Anti-Topoisomerase I Antibody-Positive Systemic Sclerosis.

Rapid and cost-effective high-throughput sequencing for identification of germline mutations of BRCA1 and BRCA2.

Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients

Structure and evolution of the filaggrin gene repeated region in primates

Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia

TRIM39 and RNF39 are associated with Behçet's disease independently of HLA-B∗51 and -A∗26

The <i>Gallus gallus</i> RJF reference genome reveals an MHCY haplotype organized in gene blocks that contain 107 loci including 45 specialized, polymorphic MHC class I loci, 41 C-type lectin-like loci, and other loci amid hundreds of transposable e

The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity

The amphioxus genome illuminates vertebrate origins and cephalochordate biology

The impact of next-generation sequencing technologies on HLA research

The major histocompatibility complex (Mhc) class IIB region has greater genomic structural flexibility and diversity in the quail than the chicken.

Whole-exome sequencing analysis of supernumerary teeth occurrence in Japanese individuals.

Whole-genome sequencing in a pair of monozygotic twins with discordant cleft lip and palate subtypes

Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A24:02: the same deletion observed in other A24 alleles and A*23:01 allele.