List of works - Huaiyu Yang

4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.

scientific article published on 15 May 2009

A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel

scientific article published on 9 March 2018

A Theoretical Model for Calculating Voltage Sensitivity of Ion Channels and the Application on Kv1.2 Potassium Channel ⬇️

scientific article published on April 18, 2012

An allosteric ligand-binding site in the extracellular cap of K2P channels

scientific article

Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels.

scientific article

Binding competition to the POPG lipid bilayer of Ca2+, Mg2+, Na+, and K+ in different ion mixtures and biological implication

scientific article published on 10 January 2013

Computer-Aided Drug Discovery and Design Targeting Ion Channels.

scientific article published on 15 March 2016

Conformational transition and energy landscape of ErbB4 activated by neuregulin1β: one microsecond molecular dynamics simulations

scientific article published on 24 February 2012

Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y1 receptor antagonists

scientific article published on 06 September 2018

Detailed mechanism for AmtB conducting NH4+/NH3: molecular dynamics simulations.

scientific article published on 10 November 2006

Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling

scientific article published on 11 January 2008

Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating

scientific article

Dynamic States of the Ligand-Free Class A G Protein-Coupled Receptor Extracellular Side

scientific article published on 24 July 2018

Effects of Na+, K+, and Ca2+ on the structures of anionic lipid bilayers and biological implication

scientific article published on 02 December 2010

Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse

scientific article published on 14 December 2020

Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism

scientific article (publication date: July 2009)

Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation

scientific article

Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

scientific article

Molecular dynamics simulations on the mechanism of transporting methylamine and ammonia by ammonium transporter AmtB.

scientific article published on 26 October 2010

N-glycosylation of the β2 adrenergic receptor regulates receptor function by modulating dimerization

scientific article published on 3 May 2017

Progress in studies of structure, mechanism and antagonists interaction of GPCR co-receptors for HIV.

scientific article

Selective N-glycan editing on living cell surfaces to probe glycoconjugate function

scientific article published on 01 June 2020

Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models

scientific article published on 01 November 2019

Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel

scientific article published on 16 January 2019

TREK Channel Family Activator with a Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation

scientific article published on 24 March 2020

The Mechanism by Which Luteolin Disrupts the Cytoplasmic Membrane of Methicillin-Resistant Staphylococcus aureus

scientific article

The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels.

scientific article published on 17 September 2014

Two-quartet G-quadruplexes formed by DNA sequences containing four contiguous GG runs

scientific article published on 24 February 2015

Varied Probability of Staying Collapsed/Extended at the Conformational Equilibrium of Monomeric Aβ40 and Aβ42

scientific article

List of works by Huaiyu Yang

4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.

A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel

A Theoretical Model for Calculating Voltage Sensitivity of Ion Channels and the Application on Kv1.2 Potassium Channel ⬇️

An allosteric ligand-binding site in the extracellular cap of K2P channels

Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels.

Binding competition to the POPG lipid bilayer of Ca2+, Mg2+, Na+, and K+ in different ion mixtures and biological implication

Computer-Aided Drug Discovery and Design Targeting Ion Channels.

Conformational transition and energy landscape of ErbB4 activated by neuregulin1β: one microsecond molecular dynamics simulations

Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y1 receptor antagonists

Detailed mechanism for AmtB conducting NH4+/NH3: molecular dynamics simulations.

Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling

Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating

Dynamic States of the Ligand-Free Class A G Protein-Coupled Receptor Extracellular Side

Effects of Na+, K+, and Ca2+ on the structures of anionic lipid bilayers and biological implication

Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse

Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism

Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation

Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

Molecular dynamics simulations on the mechanism of transporting methylamine and ammonia by ammonium transporter AmtB.

N-glycosylation of the β2 adrenergic receptor regulates receptor function by modulating dimerization

Progress in studies of structure, mechanism and antagonists interaction of GPCR co-receptors for HIV.

Selective N-glycan editing on living cell surfaces to probe glycoconjugate function

Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models

Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel

TREK Channel Family Activator with a Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation

The Mechanism by Which Luteolin Disrupts the Cytoplasmic Membrane of Methicillin-Resistant Staphylococcus aureus

The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels.

Two-quartet G-quadruplexes formed by DNA sequences containing four contiguous GG runs

Varied Probability of Staying Collapsed/Extended at the Conformational Equilibrium of Monomeric Aβ40 and Aβ42