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List of works by Antti Hakkarainen

31Phosphorus magnetic resonance spectroscopy of the liver for evaluating inflammation and fibrosis in autoimmune hepatitis.

scientific article published on 17 April 2017

Adipocyte morphology and implications for metabolic derangements in acquired obesity

scientific article

Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity.

scientific article published on 26 May 2017

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

scientific article

ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity

scientific article published on 2 February 2016

Association of intramyocellular, intraperitoneal and liver fat with glucose tolerance in severely obese adolescents

scientific article published on 28 June 2010

Biomarkers and prediction of myocardial triglyceride content in non-diabetic men.

scientific article

Bone marrow fat unsaturation in young adults is not affected by present or childhood obesity, but increases with age: A pilot study.

scientific article

CB1 blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans ⬇️

scientific article published on July 17, 2012

Cardiac steatosis and left ventricular function in men with metabolic syndrome.

scientific article

Cardiac steatosis associates with visceral obesity in nondiabetic obese men

scientific article published on 15 February 2013

Cardiac steatosis in patients with dilated cardiomyopathy

scientific article published on 24 April 2014

Characterising metabolically healthy obesity in weight-discordant monozygotic twins

scientific article published on 8 October 2013

Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome

scientific article published in Scientific Reports

Characterizing human adipose tissue lipids by long echo time 1H-MRS in vivo at 1.5 Tesla: validation by gas chromatography.

scientific article

Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity

scientific article published on 22 August 2010

Comparison of the relative contributions of intra-abdominal and liver fat to components of the metabolic syndrome

scientific article published on 10 June 2010

DNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs.

scientific article

Decrease in circulating fibroblast growth factor 21 after an oral fat load is related to postprandial triglyceride-rich lipoproteins and liver fat.

scientific article published on 21 December 2011

Deep subcutaneous adipose tissue is more saturated than superficial subcutaneous adipose tissue.

scientific article published on 29 May 2012

Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects

scientific article published on 21 July 2011

Ectopic fat depots and left ventricular function in nondiabetic men with nonalcoholic fatty liver disease

scientific article published on 30 December 2014

Effects of insulin therapy on liver fat content and hepatic insulin sensitivity in patients with type 2 diabetes

scientific article published on 07 November 2006

Electrocardiographic changes associated with insulin resistance.

scientific article published in November 2013

Epicardial Fat, Cardiac Dimensions, and Low-Grade Inflammation in Young Adult Monozygotic Twins Discordant for Obesity

scientific article published on 10 February 2012

F13A1 transglutaminase expression in human adipose tissue increases in acquired excess weight and associates with inflammatory status of adipocytes

scientific article published on 21 November 2020

Fat accumulates preferentially in the right rather than the left liver lobe in non-diabetic subjects

scientific article published on 23 August 2017

Frontal Cortex Myo-Inositol Is Associated with Sleep and Depression in Adolescents: A Proton Magnetic Resonance Spectroscopy Study

scientific article published on 10 August 2017

Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men.

scientific article published on 18 March 2017

GLP-1 responses are heritable and blunted in acquired obesity with high liver fat and insulin resistance.

scientific article published on 29 August 2013

Gene expression profile of subcutaneous adipose tissue in BMI-discordant monozygotic twin pairs unravels molecular and clinical changes associated with sub-types of obesity

scientific article published on 25 April 2017

Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects

scientific article

Global and Widespread Local White Matter Abnormalities in Juvenile Neuronal Ceroid Lipofuscinosis

scientific article published on 31 May 2018

Hepatic lipogenesis and a marker of hepatic lipid oxidation, predict postprandial responses of triglyceride-rich lipoproteins.

scientific article published on 28 May 2014

Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids

scientific article published on 22 August 2019

Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease

scientific article published on 12 March 2020

Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity.

scientific article

Increased coagulation factor VIII, IX, XI and XII activities in non-alcoholic fatty liver disease.

scientific article

Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal Obesity: Multicenter Tracer Kinetic Study.

scientific article published on 27 August 2015

Liver Fat and Insulin Sensitivity Define Metabolite Profiles During a Glucose Tolerance Test in Young Adult Twins.

scientific article published on 3 November 2016

Liver fat but not other adiposity measures influence circulating FGF21 levels in healthy young adult twins.

scientific article published in December 2010

Metabolic imaging of human cognition: an fMRI/1H-MRS study of brain lactate response to silent word generation

scientific article

Metabolic profile of liver damage in non-cirrhotic virus C and autoimmune hepatitis: A proton decoupled 31P-MRS study

scientific article published on 10 January 2017

Metabolic syndrome associates with left atrial dysfunction

scientific article published on 21 February 2018

Metabolism of sex steroids is influenced by acquired adiposity-A study of young adult male monozygotic twin pairs

scientific article published on 12 June 2017

Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight: a Big Mac challenge

scientific article

Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men.

scientific article published on 11 January 2016

Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins.

scientific article published on 12 October 2016

Modified Atkins diet induces subacute selective ragged-red-fiber lysis in mitochondrial myopathy patients.

scientific article published on 19 September 2016

Nonalcoholic fatty liver disease: detection of elevated nicotinamide adenine dinucleotide phosphate with in vivo 3.0-T 31P MR spectroscopy with proton decoupling

scientific article published on August 2010

Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins.

scientific article published on 17 November 2015

Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans.

scientific article published on 8 December 2016

Paradoxical dissociation between hepatic fat content and de novo lipogenesis due to PNPLA3 sequence variant.

scientific article

Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD.

scientific article published on 02 March 2017

Physical activity, cardiorespiratory fitness, and metabolic outcomes in monozygotic twin pairs discordant for body mass index.

scientific article published on 23 August 2017

Plasma metabolites reveal distinct profiles associating with different metabolic risk factors in monozygotic twin pairs

scientific article published on 15 June 2018

Postprandial metabolism of apolipoproteins B48, B100, C-III and E in humans with APOC3 loss-of-function mutations

scientific article published in 2022

Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids

scientific article published on 04 July 2013

Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) - an 11-Year Prospective Study.

scientific article published on 6 November 2017

Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects.

scientific article published on 10 September 2009

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

scientific article published on 29 May 2018

Stimulus-induced brain lactate: effects of aging and prolonged wakefulness.

scientific article

Targeting low- or high-normal Carbon dioxide, Oxygen, and Mean arterial pressure After Cardiac Arrest and REsuscitation: study protocol for a randomized pilot trial.

scientific article published on 30 October 2017

The PNPLA3-I148M variant confers an antiatherogenic lipid profile in insulin-resistant patients

scientific article published on 16 October 2020

The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue

scientific article published on 09 May 2020

Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Subcutaneous Adipose Tissue and Adipocytes in Acquired Obesity

scientific article

Weight Loss Is Associated With Increased NAD(+)/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue.

scientific article published on 13 January 2016

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