List of works - Osamu Takeuchi

Pattern Recognition Receptors and Inflammation

scientific article (publication date: 19 March 2010)

Cell type-specific involvement of RIG-I in antiviral response

scientific article (publication date: July 2005)

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

article

Innate immunity to virus infection.

scientific article published on January 2009

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

scientific article

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

scientific article published on November 15, 2001

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

scientific article

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

scientific article published in Nature

MDA5/RIG-I and virus recognition.

scientific article

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

scientific article published on December 3, 2010

SOCS-1 participates in negative regulation of LPS responses

scientific article published on 01 November 2002

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

scientific article published on 9 July 2006

Activation of MDA5 requires higher-order RNA structures generated during virus infection

scientific article

C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia

scientific journal article

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta

scientific article

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

scientific article published on 27 April 2008

A spatially and temporally restricted mouse model of soft tissue sarcoma

scientific article published on 5 August 2007

Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.

scientific article published in August 2007

Recognition of viruses by innate immunity.

scientific article published on December 2007

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

TLR9 as a key receptor for the recognition of DNA.

scientific article published on 03 January 2008

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

scientific journal article

Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction.

scientific article published in December 2003

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

scientific journal article

p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

scientific article

Pathogen recognition by innate receptors.

scientific article published on 30 April 2008

Plasmodium bergheiInfection in Mice Induces Liver Injury by an IL-12- and Toll-Like Receptor/Myeloid Differentiation Factor 88-Dependent Mechanism

scientific article published on November 15, 2001

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

scientific journal article

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

scientific article

Candida albicans phospholipomannan is sensed through toll-like receptors

scientific article published on 23 June 2003

West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response

scientific article

Differential recognition of structural details of bacterial lipopeptides by toll-like receptors

scientific article published in December 2002

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells

scientific journal article

Pathological role of Toll-like receptor signaling in cerebral malaria.

scientific article published on 29 November 2006

Recognition of lipopeptides by Toll-like receptors

scientific article published on 01 January 2002

Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.

scientific article published on 17 October 2007

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

scientific article published on August 19, 2010

Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan

scientific article

Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1

scientific article published on November 24, 2010

Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β

article

Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

scientific article published on 15 May 2013

Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β.

scientific article published on 20 June 2013

Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

scientific article published on 27 March 2012

Role of lipoteichoic acid in the phagocyte response to group B streptococcus.

scientific article

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity

scientific article published on 27 March 2014

Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways.

scientific article

The TRAF-associated protein TANK facilitates cross-talk within the IκB kinase family during Toll-like receptor signaling

scientific article published on September 23, 2011

The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice

scientific article published on 9 November 2011

Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis.

scientific article published in September 2005

CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes

scientific article published on April 24, 2003

List of works by Osamu Takeuchi

Pattern Recognition Receptors and Inflammation

Cell type-specific involvement of RIG-I in antiviral response

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

Innate immunity to virus infection.

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

MDA5/RIG-I and virus recognition.

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

SOCS-1 participates in negative regulation of LPS responses

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

Activation of MDA5 requires higher-order RNA structures generated during virus infection

C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

A spatially and temporally restricted mouse model of soft tissue sarcoma

Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.

Recognition of viruses by innate immunity.

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

TLR9 as a key receptor for the recognition of DNA.

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction.

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

Pathogen recognition by innate receptors.

Plasmodium bergheiInfection in Mice Induces Liver Injury by an IL-12- and Toll-Like Receptor/Myeloid Differentiation Factor 88-Dependent Mechanism

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

Candida albicans phospholipomannan is sensed through toll-like receptors

West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response

Differential recognition of structural details of bacterial lipopeptides by toll-like receptors

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells

Pathological role of Toll-like receptor signaling in cerebral malaria.

Recognition of lipopeptides by Toll-like receptors

Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan

Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1

Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β

Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β.

Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

Role of lipoteichoic acid in the phagocyte response to group B streptococcus.

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity

Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways.

The TRAF-associated protein TANK facilitates cross-talk within the IκB kinase family during Toll-like receptor signaling

The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice

Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis.

CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes