List of works by Osamu Takeuchi

5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival

scientific article

A spatially and temporally restricted mouse model of soft tissue sarcoma

scientific article published on 5 August 2007

Activation of MDA5 requires higher-order RNA structures generated during virus infection

scientific article

Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling

scientific article

Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex

scientific article

Akirin2-Mediated Transcriptional Control by Recruiting SWI/SNF Complex in B Cells

scientific article

Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1 ⬇️

scientific article published on November 24, 2010

Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.

scientific article published in August 2007

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells

scientific journal article

Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

scientific article published on 15 May 2013

Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA.

scientific article

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

scientific article

Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner

scientific article

Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

scientific article published on 27 March 2012

C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia

scientific journal article

CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes ⬇️

scientific article published on April 24, 2003

CD44 participates in IP-10 induction in cells in which hepatitis C virus RNA is replicating, through an interaction with Toll-like receptor 2 and hyaluronan

scientific article

Candida albicans phospholipomannan is sensed through toll-like receptors

scientific article published on 23 June 2003

Cell type-specific involvement of RIG-I in antiviral response

scientific article (publication date: July 2005)

Chromatin Remodeling and Transcriptional Control in Innate Immunity: Emergence of Akirin2 as a Novel Player

scientific article

Codon bias confers stability to human mRNAs

scientific article published on 03 September 2019

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

scientific journal article

Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling

scientific article published on 01 December 2006

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

scientific article published on 9 July 2006

Differential recognition of structural details of bacterial lipopeptides by toll-like receptors

scientific article published in December 2002

Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β.

scientific article published on 20 June 2013

Dynamics of enhancers in myeloid antigen presenting cells upon LPS stimulation.

scientific article published on 12 December 2014

Endonuclease Regnase-1/Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) in controlling immune responses and beyond

scientific article published on 20 September 2017

Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses

scientific article published on 3 June 2015

Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice

scientific article published on 27 August 2010

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

scientific journal article

Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.

scientific article published on 15 March 2013

Functional characterization of protein domains common to animal viruses and mouse.

scientific article

Genetic approaches to the study of Toll-like receptor function

scientific article

Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus

scientific article published on 01 March 2019

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

scientific article

HuR keeps interferon-β mRNA stable.

scientific article published on May 2015

Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression

scientific article

Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

scientific article

IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil

scientific article published on 29 December 2010

IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation.

scientific article published on 6 March 2013

IRF3: a molecular switch in pathogen responses

scientific article published on 19 June 2012

Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling ⬇️

scientific article published on September 26, 2010

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration

scientific article published on 22 March 2016

Innate immunity to virus infection.

scientific article published on January 2009

Interferon response induced by Toll-like receptor signaling

scientific article published in January 2004

Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis.

scientific article published in September 2005

IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18.

scientific article

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium.

scientific article published in February 2004

Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.

scientific article published on 17 October 2007

MDA5/RIG-I and virus recognition.

scientific article

Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus.

scientific article

N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation

scientific article published on 27 May 2019

NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements

scientific article published on 02 September 2019

NSD3 keeps IRF3 active.

scientific article published on 20 November 2017

Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myoca

scientific article published on 22 July 2016

Negative Regulators in Toll-like Receptor Responses ⬇️

scientific article published on November 1, 2010

Nickel ions selectively inhibit lipopolysaccharide-induced interleukin-6 production by decreasing its mRNA stability.

scientific article published on 5 March 2015

Normal Development of the Gut-Associated Lymphoid Tissue Except Peyer's Patch in MyD88-Deficient Mice

article

PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases

scientific article published on 01 May 2021

Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

scientific article published on 6 January 2017

Pathogen recognition by innate receptors.

scientific article published on 30 April 2008

Pathological role of Toll-like receptor signaling in cerebral malaria.

scientific article published on 29 November 2006

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity

scientific article published on 27 March 2014

Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways.

scientific article

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense ⬇️

scientific article published on August 19, 2010

Post-transcriptional control of immune responses and its potential application

scientific article published on 17 June 2019

Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation.

scientific article published on January 2013

Post-transcriptional regulation of immune responses by RNA binding proteins

scientific article published on 01 January 2018

Posttranscriptional control of inflammation by an RNase Regnase-1

scientific article published on January 2015

Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-1

scientific article published on 25 September 2020

Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia.

scientific article published on 25 April 2018

RNA Recognition and Immunity-Innate Immune Sensing and Its Posttranscriptional Regulation Mechanisms

scientific article published on 16 July 2020

RNA binding proteins in the control of autoimmune diseases

scientific article published on 01 June 2019

Recognition of lipopeptides by Toll-like receptors

scientific article published on 01 January 2002

Recognition of viruses by innate immunity.

scientific article published on December 2007

Regnase-1 Is an Endoribonuclease Essential for the Maintenance of Immune Homeostasis

scientific article published on May 2017

Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.

scientific article published on May 2017

Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis.

scientific article published on 10 November 2017

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

scientific journal article

Regnase-1 and Roquin regulate inflammatory mRNAs

scientific journal article

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta

scientific article

Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β

article

Role of lipoteichoic acid in the phagocyte response to group B streptococcus.

scientific article

SOCS-1 participates in negative regulation of LPS responses

scientific article published on 01 November 2002

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

scientific article published on 27 April 2008

Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan

scientific article

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

scientific article

Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP

scientific journal article

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

scientific article published in Nature

TLR9 as a key receptor for the recognition of DNA.

scientific article published on 03 January 2008

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

article

The effects of codon bias and optimality on mRNA and protein regulation

scientific article published on 30 October 2020

The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice

scientific article published on 9 November 2011

The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells

scientific article published on 01 September 2020

Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart

scientific article published on 29 November 2004

Toll-like receptor 4 mediates the antitumor host response induced by a 55-kilodalton protein isolated from Aeginetia indica L., a parasitic plant

scientific article

Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction.

scientific article published in December 2003

Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen

scientific article published on October 2002

Translation of Hepatitis A Virus IRES Is Upregulated by a Hepatic Cell-Specific Factor

scientific article published on 10 August 2018

Translation-dependent unwinding of stem-loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs

scientific article published on 01 September 2019

Translational control of mRNAs by 3'-Untranslated region binding proteins.

scientific article published on 13 March 2017

VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.

scientific article published on 19 September 2006

West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response

scientific article

Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus

scientific article published on 08 July 2013

[Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin]

scientific article published on 01 June 2016

[Roles of Toll-like receptor in host defense and the mechanism of its signal transduction]

scientific article published on 01 November 2004

p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

scientific article

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