List of works by Marco Bugliani

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets.

scientific article

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function.

scientific article published on 11 March 2015

A role for autophagy in β-cell life and death.

scientific article published on September 2009

ADCY5 couples glucose to insulin secretion in human islets

scientific article

Administering 25-hydroxyvitamin D3 in vitamin D-deficient young type 1A diabetic patients reduces reactivity against islet autoantigens

scientific article published on 09 January 2014

Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes.

scientific article published on 19 May 2012

An alternative and simple method to consistently prepare viable isolated human islets for clinical transplantation

scientific article published on 01 April 2004

Apoptotic, regenerative, and immune-related signaling in human islets from type 2 diabetes individuals.

scientific article

Are we overestimating the loss of beta cells in type 2 diabetes?

scientific article published on 01 February 2014

Atorvastatin but Not Pravastatin Impairs Mitochondrial Function in Human Pancreatic Islets and Rat β-Cells. Direct Effect of Oxidative Stress.

scientific article published on 19 September 2017

Author Correction: Atorvastatin but Not Pravastatin Impairs Mitochondrial Function in Human Pancreatic Islets and Rat β-Cells. Direct Effect of Oxidative Stress

scientific article published on 10 December 2020

Autophagy in human type 2 diabetes pancreatic beta cells.

scientific article

Beneficial effect of the nonpeptidyl low molecular weight radical scavenger IAC on cultured human islet function.

scientific article published in January 2008

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

scientific article published on 20 July 2016

Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells

scientific journal article

Co-localization of acinar markers and insulin in pancreatic cells of subjects with type 2 diabetes

scientific article

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

scientific article

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

scientific article

DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes

scientific article published on 31 January 2018

Direct effects of rosuvastatin on pancreatic human beta cells.

scientific article published on 17 March 2013

Discovery of molecular pathways mediating 1,25-dihydroxyvitamin D3 protection against cytokine-induced inflammation and damage of human and male mouse islets of Langerhans

scientific article

Effects of C-peptide on isolated human pancreatic islet cells

scientific article published on 01 March 2007

Effects of exendin-4 on islets from type 2 diabetes patients

scientific article published on 14 January 2008

Enhanced Signaling Downstream of Ribonucleic Acid-Dependent Protein Kinase-Like Kinase Potentiates Lipotoxic Endoplasmic Reticulum Stress in Human Islets.

scientific article published in February 2010

Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

scientific article

Erratum to: The p66Shc redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells

scientific article published on 01 November 2015

FGF-2b and h-PL Transform Duct and Non-Endocrine Human Pancreatic Cells into Endocrine Insulin Secreting Cells by Modulating Differentiating Genes.

scientific article

Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.

scientific article published on 9 July 2010

Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose

scientific article

Glucagon-like peptide 1 protects INS-1E mitochondria against palmitate-mediated beta-cell dysfunction: a proteomic study.

scientific article published on June 2015

Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion

scientific article published on 4 December 2017

Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation.

scientific article published on 11 August 2016

Histopathology and ex vivo insulin secretion of pancreatic islets in gestational diabetes: A case report

scientific article published on 01 September 2011

Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patients.

scientific article

In vitro use of free fatty acids bound to albumin: A comparison of protocols.

scientific article

Incretin-modulated beta cell energetics in intact islets of Langerhans

scientific article

Insulin secretory granules labelled with phogrin-fluorescent proteins show alterations in size, mobility and responsiveness to glucose stimulation in living β-cells

article

JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway

scientific article

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.

scientific article published on 16 April 2018

Lipotoxicity disrupts incretin-regulated human β cell connectivity

scientific article

Mast cells infiltrate pancreatic islets in human type 1 diabetes.

scientific article

MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion

scientific article

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells.

scientific article

Mitochondrial and ER-targeted eCALWY probes reveal high levels of free Zn2+.

scientific article published on 17 July 2014

MondoA is an Essential Glucose Responsive Transcription Factor in Human Pancreatic Beta Cells.

scientific article

Optical control of insulin release using a photoswitchable sulfonylurea

scientific article

Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets

scientific article

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets

scientific article published on 18 October 2017

Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes

scientific article published on 23 May 2017

Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.

scientific article published in November 2004

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).

scientific article published on 11 July 2017

Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion

scientific journal article

Phenylpropenoic Acid Glucoside from Rooibos Protects Pancreatic Beta Cells against Cell Death Induced by Acute Injury

scientific article

Pleiotropic effects of GIP on islet function involve osteopontin

scientific article

Prevention by metformin of alterations induced by chronic exposure to high glucose in human islet beta cells is associated with preserved ATP/ADP ratio

scientific article published on 03 January 2014

Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets.

scientific article

Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.

scientific article published on 18 November 2003

SRp55 Regulates a Splicing Network that Controls Human Pancreatic Beta Cell Function and Survival

scientific article published on 15 December 2017

The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic β-Cell Survival and Insulin Secretion.

scientific article

The beta-cell in human type 2 diabetes.

scientific article published on January 2010

The direct effects of tacrolimus and cyclosporin A on isolated human islets: A functional, survival and gene expression study.

scientific article published on September 2009

The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans

scientific article published on 16 August 2018

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

scientific article

The immunoproteasome is induced by cytokines and regulates apoptosis in human islets

scientific article published on 24 April 2017

The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.

scientific article

The pancreatic beta cells in human type 2 diabetes.

scientific article published on January 2012

The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity

scientific article published on 15 February 2018

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.

scientific article

Transcription factors of beta-cell differentiation and maturation in isolated human islets: Effects of high glucose, high free fatty acids and type 2 diabetes

scientific article published on 31 March 2006

Ultrastructural alterations of pancreatic beta cells in human diabetes mellitus.

scientific article

Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes

article

Virus-like infection induces human β cell dedifferentiation.

scientific article published on 8 February 2018

β-Cell inflammation in human type 2 diabetes and the role of autophagy.

scientific article

Paulina is supported by:

About Paulina

Help