List of works - Minoru Hasegawa

A Case of Erythema Multiforme Major Developed after Sequential Use of Two Immune Checkpoint Inhibitors, Nivolumab and Ipilimumab, for Advanced Melanoma: Possible Implication of Synergistic and/or Complementary Immunomodulatory Effects.

scientific article published on 18 January 2018

A Case of Subcutaneous Sarcoidosis Occurring along the Superficial Veins of the Forearms: A Distinctive Cutaneous Manifestation Masquerading Venous Tropic Action in the Underlying Systemic Disease?

scientific article published on January 2017

A case of acute cutaneous graft-versus-host disease mimicking psoriasis vulgaris.

scientific article published in January 2008

A clue for telangiectasis in systemic sclerosis: elevated serum soluble endoglin levels in patients with the limited cutaneous form of the disease

scientific article published on 01 January 2006

A crucial role of L-selectin in C protein-induced experimental polymyositis in mice.

scientific article

A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis.

scientific article published in November 2009

A novel splenic B1 regulatory cell subset suppresses allergic disease through phosphatidylinositol 3-kinase-Akt pathway activation.

scientific article published on 29 February 2016

A rare case of chronic expanding haematoma in the occipital region mimicking a malignant soft tissue tumour

scientific article published on 09 May 2018

Abnormal natural killer cell function in systemic sclerosis: altered cytokine production and defective killing activity.

scientific article published in October 2005

Altered expression of dermokine in skin disorders

scientific article published on 31 May 2012

Anti-DNA topoisomerase II alpha autoantibodies in Japanese patients with systemic sclerosis

scientific article published on 26 October 2005

Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy.

scientific article published on 17 January 2012

Anti-topoisomerase I antibody levels as serum markers of skin sclerosis in systemic sclerosis.

scientific article

Antigen specificity of antihistone antibodies in connective tissue disease patients with anti-U1RNP antibodies

scientific article published on 13 July 2007

Antimelanoma differentiation-associated protein 5 antibody level is a novel tool for monitoring disease activity in rapidly progressive interstitial lung disease with dermatomyositis.

scientific article published on 25 July 2016

Antiphospholipid antibodies in patients with autoimmune blistering disease.

scientific article

Association of CD22 gene polymorphism with susceptibility to limited cutaneous systemic sclerosis

scientific article published on 01 March 2007

Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis

scientific article published on 25 June 2008

Association of STAT4 polymorphism with systemic sclerosis in a Japanese population

scientific article published on 01 August 2009

Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population.

scientific article

Association of the FAM167A-BLK region with systemic sclerosis

scientific article published on 01 March 2010

Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population

scientific article published on 03 December 2008

Augmented ICOS expression in patients with early diffuse cutaneous systemic sclerosis.

scientific article published on 29 September 2012

Autoantibodies against matrix metalloproteinase-1 in patients with localized scleroderma

scientific article published on 18 June 2008

Autoantibodies to RuvBL1 and RuvBL2: a novel systemic sclerosis-related antibody associated with diffuse cutaneous and skeletal muscle involvement.

scientific article published in April 2014

Autoantibodies to small ubiquitin-like modifier activating enzymes in Japanese patients with dermatomyositis: comparison with a UK Caucasian cohort

scientific article published on 26 July 2012

Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis.

scientific article published on 29 July 2009

Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis: association with pulmonary fibrosis and vascular damage.

scientific article published on 21 October 2009

Autoantibody against peroxiredoxin I, an antioxidant enzyme, in patients with systemic sclerosis: possible association with oxidative stress

scientific article published on 19 February 2007

B cells promote tumor immunity against B16F10 melanoma

scientific article published on 28 August 2014

B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells.

scientific article published on 25 March 2013

B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis

scientific article

BAFF antagonist attenuates the development of skin fibrosis in tight-skin mice

scientific article published on 21 June 2007

BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance

scientific article published on 11 July 2018

Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction

scientific article published on 23 June 2012

Biomarkers in systemic sclerosis: Their potential to predict clinical courses

scientific article

Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse.

scientific article

Blockade of Syk ameliorates the development of murine sclerodermatous chronic graft-versus-host disease

scientific article published on 12 March 2014

Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis.

scientific article published on 15 March 2018

Blockade of p38 Mitogen-Activated Protein Kinase Inhibits Murine Sclerodermatous Chronic Graft-versus-Host Disease.

scientific article published on 8 February 2017

Both Th1 and Th2 chemokines are elevated in sera of patients with autoimmune blistering diseases

scientific article published on 01 April 2006

CCL13 is a promising diagnostic marker for systemic sclerosis.

scientific article published on 11 September 2009

CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma.

scientific article published on 8 May 2008

CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling.

scientific article published on 02 July 2009

CD34-positive infantile myofibromatosis: Case report and review of hemangiopericytoma-like pattern tumors

scientific article published on 14 April 2016

Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.

scientific article published on 12 July 2010

Certolizumab pegol, a pegylated anti-TNF-α antagonist, caused de novo-onset palmoplantar pustulosis followed by generalized pustular psoriasis in a patient with rheumatoid arthritis

scientific article published on 07 September 2016

Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis.

scientific article published on 24 October 2012

Circulating γ/δ T cells in systemic sclerosis exhibit activated phenotype and enhance gene expression of proalpha2(I) collagen of fibroblasts

scientific article published on 17 October 2012

Cladophialophora bantiana infection mimicking neuromyelitis optica

scientific article published on 10 December 2018

Clinical and immunologic predictors of scleroderma renal crisis in Japanese systemic sclerosis patients with anti-RNA polymerase III autoantibodies.

scientific article published in April 2015

Clinical association of serum CD137 (4-1BB) levels in patients with systemic sclerosis

scientific article published on 05 October 2008

Clinical association of serum interleukin-17 levels in systemic sclerosis: is systemic sclerosis a Th17 disease?

scientific article published on 07 March 2008

Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study.

scientific article published in April 2011

Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity

scientific article published on 30 September 2008

Clonal expansion of Epstein-Barr virus (EBV)-infected γδ T cells in patients with chronic active EBV disease and hydroa vacciniforme-like eruptions.

scientific article published on 12 August 2012

Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome.

scientific article

Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid

scientific article published on 18 October 2006

Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis.

scientific article published in February 2009

Decreased levels of regulatory B cells in patients with systemic sclerosis: association with autoantibody production and disease activity.

scientific article

Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing.

scientific article published on 4 February 2013

Dermokine-β impairs ERK signaling through direct binding to GRP78

scientific article

Dermoscopy findings of nail fold capillaries in connective tissue diseases.

scientific article published on January 2011

Developing classification criteria for discoid lupus erythematosus: an update from the World Congress of Dermatology 2015 meeting

scientific article published on 28 February 2016

Development of classification criteria for discoid lupus erythematosus: Results of a Delphi exercise

scientific article published on 9 June 2017

Diagnostic criteria, severity classification and guideline of lichen sclerosus et atrophicus

scientific article published on 19 December 2017

Diagnostic criteria, severity classification and guidelines of localized scleroderma.

scientific article published on 23 April 2018

Dietary supplement product composed of natural ingredients as a suspected cause of erythema multiforme: A case report and identification for the confident false positivity of lymphocyte transformation test

scientific article published on 09 January 2019

Disaccharide analysis of skin glycosaminoglycan in lichen myxedematosus.

scientific article

Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.

scientific article published on 19 February 2013

E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis

scientific article published on September 2006

Effects of bisphosphonate administration on the bone mass in immune thrombocytopenic purpura patients under treatment with steroids.

scientific article

Elevated circulating TWEAK levels in systemic sclerosis: association with lower frequency of pulmonary fibrosis

scientific article published on 16 June 2009

Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases

scientific article published on 01 February 2007

Elevated serum BAFF levels in patients with systemic sclerosis: enhanced BAFF signaling in systemic sclerosis B lymphocytes

scientific article published on 01 January 2006

Elevated serum concentrations of triggering receptor expressed on myeloid cells-1 in diffuse cutaneous systemic sclerosis: association with severity of pulmonary fibrosis

scientific article published on 15 February 2010

Elevated serum insulin-like growth factor (IGF-1) and IGF binding protein-3 levels in patients with systemic sclerosis: possible role in development of fibrosis.

scientific article

Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation

scientific article published on 12 August 2010

Elevated serum levels of APRIL, but not BAFF, in patients with atopic dermatitis

scientific article published on 02 November 2007

Elevated serum placenta growth factor (PlGF) levels in patients with systemic sclerosis: a possible role in the development of skin but not lung fibrosis

scientific article published on 18 April 2010

Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1

scientific article published on 26 June 2007

Erythema induratum of Bazin which occurred after tumor necrosis factor antagonist therapy.

scientific article published on 20 January 2017

Esophageal transit scintigraphy and structured questionnaire in patients with systemic sclerosis with endoscopically proven reflux esophagitis

scientific article published on 24 October 2009

FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin.

scientific article published in June 2013

Fatal case of pancreatic panniculitis caused by occult neuroendocrine tumor in the corresponding organ: A case report and review of the published work

scientific article published on 18 October 2020

Genital herpes due to acyclovir-sensitive herpes simplex virus caused secondary and recurrent herpetic whitlows due to thymidine kinase-deficient/temperature-sensitive virus.

scientific article published in November 2007

Guideline for diagnostic criteria, severity classification and treatment of eosinophilic fasciitis.

scientific article published on 13 December 2017

High incidence of pulmonary arterial hypertension in systemic sclerosis patients with anti-centriole autoantibodies.

scientific article published on 25 October 2013

Host-derived MCP-1 and MIP-1α regulate protective anti-tumor immunity to localized and metastatic B16 melanoma

scientific article published on 26 October 2011

Human Leukocyte Antigen and Systemic Sclerosis in Japanese: The Sign of the Four Independent Protective Alleles, DRB113:02, DRB114:06, DQB103:01, and DPB102:01.

scientific article

IL-6 blockade attenuates the development of murine sclerodermatous chronic graft-versus-host disease

scientific article published on 19 July 2012

Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: an association with malignancy

scientific article published on 25 May 2006

Identification of myocardial damage in systemic sclerosis: a nuclear cardiology approach.

scientific article published on 31 August 2010

IgG4-related skin lesions in a patient with IgG4-related chronic sclerosing dacryoadenitis and sialoadenitis.

scientific article published on 15 July 2011

Impact of a new simplified disability scoring system for adult patients with localized scleroderma.

scientific article

Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts

scientific article published on 07 March 2012

Increased accumulation of extracellular thrombospondin-2 due to low degradation activity stimulates type I collagen expression in scleroderma fibroblasts

scientific article published on 03 December 2011

Increased cutaneous T-cell-attracting chemokine levels in sera from patients with systemic sclerosis

scientific article published on 29 March 2005

Increased serum interleukin 23 in patients with systemic sclerosis

scientific article published on 15 December 2007

Increased serum pentraxin 3 in patients with systemic sclerosis.

scientific article published on 27 February 2009

Inducible costimulator ligand regulates bleomycin-induced lung and skin fibrosis in a mouse model independently of the inducible costimulator/inducible costimulator ligand pathway

scientific article published on 01 June 2010

Inhibition of the Progression of Skin Inflammation, Fibrosis, and Vascular Injury by Blockade of the CX3 CL1/CX3 CR1 Pathway in Experimental Mouse Models of Systemic Sclerosis

scientific article published on 11 September 2019

Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction

scientific article published on 13 February 2007

Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice

scientific article published on 01 July 2007

Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with early systemic sclerosis: a multicentre prospective observational study.

scientific article

L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury

scientific article published on 03 February 2006

Long-term follow-up of finger passive range of motion in Japanese systemic sclerosis patients treated with self-administered stretching.

scientific article published on 18 April 2018

Low zone tolerance requires ICAM-1 expression to limit contact hypersensitivity elicitation.

scientific article published on 18 June 2009

Multiple subcutaneous cholesterol granulomas arising in eruptive vellus hair cysts: A case report and published work review of 11 cases.

scientific article

Myocardial damages in systemic sclerosis detected by gated myocardial perfusion SPECT and sympathetic imaging.

scientific article published in November 2006

Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins

scientific article published on 01 February 2012

Oropharyngeal Dysphagia in Dermatomyositis: Associations with Clinical and Laboratory Features Including Autoantibodies.

scientific article

Outline of guidelines for the management of vasculitis and vascular disorders in Japan, 2016 revised edition

scientific article

P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a p-selectin ligand and partly as an e-selectin ligand

scientific article published on 29 January 2009

Pathogenesis of systemic sclerosis: altered B cell function is the key linking systemic autoimmunity and tissue fibrosis.

scientific article

Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses.

scientific article published on May 2007

Phenotypic analysis in a case of hydroa vacciniforme-like eruptions associated with chronic active Epstein-Barr virus disease of γδ T cells ⬇️

scientific article published on January 1, 2012

Potential immunologic targets for treating fibrosis in systemic sclerosis: a review focused on leukocytes and cytokines.

scientific article published on 26 April 2012

Prevalence and clinical characteristics of anti-Mi-2 antibodies in Japanese patients with dermatomyositis.

scientific article published on 9 November 2005

Prevalence of Pruritus in Cutaneous Lupus Erythematosus: Brief Report of a Multicenter, Multinational Cross-Sectional Study

scientific article published on 25 July 2018

Preventive effects of topical washing with miconazole nitrate-containing soap to diaper candidiasis in hospitalized elderly patients: A prospective, double-blind, placebo-controlled study.

scientific article

Prospective trial for the clinical efficacy of anogenital skin care with miconazole nitrate-containing soap for diaper candidiasis

scientific article published on 06 February 2020

RXRB Is an MHC-Encoded Susceptibility Gene Associated with Anti-Topoisomerase I Antibody-Positive Systemic Sclerosis.

scientific article

Re-emergence of anti-topoisomerase I antibody with exacerbated development of skin sclerosis in a patient with systemic sclerosis.

scientific article published on 6 September 2009

Reactive hemophagocytic syndrome in a patient with polyarteritis nodosa associated with Epstein-Barr virus reactivation.

scientific article

Redefining cutaneous lupus erythematosus: a proposed international consensus approach and results of a preliminary questionnaire.

scientific article published on 26 March 2015

Reduced hypoxia risk in a systemic sclerosis patient with interstitial lung disease after long-term pulmonary rehabilitation.

scientific article

Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1

scientific article published on 01 February 2006

Serum CXCL16 concentrations correlate with the extent of skin sclerosis in patients with systemic sclerosis

scientific article published on 15 July 2009

Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study.

scientific article

Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis

scientific article published on 04 November 2010

Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis.

scientific article published on 31 January 2006

Serum pulmonary and activation-regulated chemokine/CCL18 levels in patients with systemic sclerosis: a sensitive indicator of active pulmonary fibrosis

scientific article published on 01 September 2005

Skin sclerosis as a manifestation of POEMS syndrome.

scientific article published on 23 June 2012

Successful treatment of acquired reactive perforating collagenosis with topical benzoyl peroxide: A possible therapeutic action underlying structural and metabolic turnover

scientific article published on 09 October 2019

Successful treatment of recalcitrant subcorneal pustular dermatosis with oral nicotinamide

scientific article published on 12 June 2019

Successful treatment with oral minocycline in a case with a long-standing idiopathic atrophoderma of Pasini and Pierini: Histopathological comparison with the contralateral normal skin

scientific article published on 28 August 2019

Successful treatment with sildenafil in systemic sclerosis patients with isolated pulmonary arterial hypertension: two case reports.

scientific article published on 25 May 2005

Survey of single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 2 producing loss of function potentially implicated in the pathogenesis of parakeratosis.

scientific article

TGF-β-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts

scientific article published on 29 February 2012

The clinical characteristics of juvenile-onset systemic sclerosis in Japanese patients

article published in 2014

The clinical relevance of serum antinuclear antibodies in Japanese patients with systemic sclerosis.

scientific article published on 17 January 2008

The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity.

scientific article published on 25 February 2010

The loss of MCP-1 attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer

scientific article published on 24 January 2008

The roles of chemokines in leukocyte recruitment and fibrosis in systemic sclerosis

scientific article published on May 2008