List of works - Nia Lowri Thomas

A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment ⬇️

scientific article published on July 16, 2012

Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain.

scientific article published on 08 September 2016

Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors.

scientific article published on 19 November 2014

Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death.

scientific article

Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor.

scientific article published on 30 May 2016

FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease

scientific article

Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death.

scientific article

Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function

scientific article published on 20 February 2020

Insights into the gating mechanism of the ryanodine-modified human cardiac Ca2+-release channel (ryanodine receptor 2).

scientific article

Investigations of the Contribution of a Putative Glycine Hinge to Ryanodine Receptor Channel Gating ⬇️

scientific article published on April 30, 2013

Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia

scientific article published on November 2016

Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?

scientific article published on 01 November 2006

Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction.

scientific article published on 02 February 2010

Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction.

scientific article

Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.

scientific article

Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level.

scientific article published on January 2012

The mechanism of flecainide action in CPVT does not involve a direct effect on RyR2.

scientific article published on 3 February 2015

Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating

scientific article published on 05 October 2016

List of works by Nia Lowri Thomas

A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment ⬇️

Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain.

Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors.

Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death.

Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor.

FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease

Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death.

Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function

Insights into the gating mechanism of the ryanodine-modified human cardiac Ca2+-release channel (ryanodine receptor 2).

Investigations of the Contribution of a Putative Glycine Hinge to Ryanodine Receptor Channel Gating ⬇️

Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia

Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?

Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction.

Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction.

Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.

Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level.

The mechanism of flecainide action in CPVT does not involve a direct effect on RyR2.

Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating