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List of works by Victor Velculescu

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

A machine learning approach for somatic mutation discovery

scientific article published on 01 September 2018

A multidimensional analysis of genes mutated in breast and colorectal cancers

scientific article

ATM mutations in patients with hereditary pancreatic cancer

scientific article published on 29 December 2011

Abstract 2482: Key tumor suppressor genes inactivated by promoter methylation and somatic mutations in head and neck cancer

article

Abstract B1-62: Bumphunting analysis identifies PAX5 promoter methylation and p53 somatic mutations in genomic instability pathways linked to very poor survival in head and neck cancer

Abstract LB-75: Blood-based molecular detection of acquired resistance to anti-EGFR therapies in colorectal cancer patients

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

scientific article

Allelic Variation in Human Gene Expression

scientific article published in Science

American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond—Lessons Learned and Member Institutions’ Perspectives

scientific article published in November 2018

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

scientific article

An integrated genomic analysis of human glioblastoma multiforme

scientific article

BRAF Mutations Occur Infrequently in Ovarian Cancer but Suggest Responsiveness to BRAF and MEK Inhibition

scientific article published on 14 June 2018

Beyond genomics: critical evaluation of cell line utility for ovarian cancer research

scientific article

Blood-based analyses of cancer: circulating tumor cells and circulating tumor DNA

scientific article (publication date: June 2014)

Cancer DNA in the Circulation: The Liquid Biopsy

scientific article published in October 2017

Cancer detection using whole-genome sequencing of cell free DNA.

scientific article published on August 2013

Cancer genome landscapes

scientific article

Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations

scientific article published on 04 August 2009

Changes in gene expression associated with developmental arrest and longevity in Caenorhabditis elegans.

scientific article

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

scientific article

Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations.

scientific article published in September 2017

Circulating Tumor DNA as a Clinical Test in Resected Pancreatic Cancer

scientific article published on 29 May 2019

Circulating Tumor DNA for Mutation Detection and Identification of Mechanisms of Resistance in Non-Small Cell Lung Cancer.

scientific article published on 24 March 2017

Circulating tumor DNA analysis as a real-time method for monitoring tumor burden in melanoma patients undergoing treatment with immune checkpoint blockade

scientific article published on 16 December 2014

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

scientific article

Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors

scientific article

Clinical study of genomic drivers in pancreatic ductal adenocarcinoma

scientific article published on 18 July 2017

Colorectal cancer: mutations in a signalling pathway

scientific article published in August 2005

Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness

scientific article published on 24 January 2019

Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models

scientific article published on 24 July 2020

Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma

scientific article

Comparative lesion sequencing provides insights into tumor evolution

scholarly article

Compartmental Analysis of T-cell Clonal Dynamics as a Function of Pathologic Response to Neoadjuvant PD-1 Blockade in Resectable Non-Small Cell Lung Cancer

scientific article published on 21 November 2019

Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma

scientific article published on 08 September 2020

Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma

scientific article published on 05 December 2020

Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis

scientific article

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

scientific article

Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

article

DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors

scientific article

Defining the blueprint of the cancer genome

scientific article

Design and analysis issues in genome-wide somatic mutation studies of cancer

scientific article published on 23 August 2008

Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing

scientific article

Detection of circulating tumor DNA in early- and late-stage human malignancies

scientific article (publication date: 19 February 2014)

Development of personalized tumor biomarkers using massively parallel sequencing

scientific article

Diagnostic strategies towards clinical implementation of liquid biopsy RAS/BRAF circulating tumor DNA analyses in patients with metastatic colorectal cancer

scientific article published on 19 September 2020

Digital karyotyping

scientific article

Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients

scientific article

Digital karyotyping.

scientific article

Direct detection of early-stage cancers using circulating tumor DNA.

scientific article published in August 2017

Discoveries: an innovative platform for publishing cutting-edge research discoveries in medicine, biology and chemistry

scientific article published on 31 December 2013

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

scientific article

Distinct epigenetic changes in the stromal cells of breast cancers

scientific article published on 10 July 2005

Dynamics of Tumor and Immune Responses during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

scientific article published on 12 December 2018

Early Noninvasive Detection of Response to Targeted Therapy in Non-Small Cell Lung Cancer

scientific article published on 20 December 2018

Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

scientific article published in November 2017

Epitope landscape in breast and colorectal cancer

scientific article published in February 2008

Essay: Amersham Pharmacia Biotech & Science prize. Tantalizing transcriptomes--SAGE and its use in global gene expression analysis

scientific article published in November 1999

Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.

scientific article published on 29 August 2016

Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

scientific article published on 28 December 2016

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

scientific article

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

scientific article (publication date: 26 August 2011)

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

scientific article

Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS.

scientific article published on 21 December 2012

Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer

scientific article

Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma

scientific article published on 06 April 2009

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma

scientific article

Functional Synergies yet Distinct Modulators Affected by Genetic Alterations in Common Human Cancers

scientific article published on 11 March 2011

Ganitumab (AMG 479) inhibits IGF-II-dependent ovarian cancer growth and potentiates platinum-based chemotherapy

scientific article

Gene expression analysis goes digital

scientific article published in August 2007

Genes expressed in human tumor endothelium

scientific article

Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing

scientific article

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

scientific article

Genetic mutations associated with cigarette smoking in pancreatic cancer

scientific article

Genetic progression and the waiting time to cancer

scientific article

Genome-wide cell-free DNA fragmentation in patients with cancer

scientific article published on 29 May 2019

Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types

scientific article published on 09 August 2019

Genome-wide linkage scan for colorectal cancer susceptibility genes supports linkage to chromosome 3q.

scientific article

Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes

scientific article

Genomic and Immunological Tumor Profiling Identifies Targetable Pathways and Extensive CD8+/PDL1+ Immune Infiltration in Inflammatory Breast Cancer Tumors

scientific article published on 19 April 2016

Genomic characterization of malignant progression in neoplastic pancreatic cysts

scientific article published on 14 August 2020

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.

scientific article published in June 2001

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

scientific article

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

scientific article

High frequency of mutations of the PIK3CA gene in human cancers

scientific article (publication date: 23 April 2004)

High grade serous ovarian carcinomas originate in the fallopian tube.

scientific article

High-Throughput Prediction of MHC Class I and II Neoantigens with MHCnuggets

scientific article published on 23 December 2019

Homozygous deletion of MKK4 in ovarian serous carcinoma

scientific article

IDH1 and IDH2 mutations in gliomas

scientific article

Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid

scientific article

Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T

scientific article

Identification of microbial DNA in human cancer

scientific article

Identifying tumor origin using a gene expression-based classification map.

scientific article

Implications of micro-RNA profiling for cancer diagnosis.

scientific article published on October 2006

Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers

scholarly article

Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

scientific article

Inactivation of hCDC4 can cause chromosomal instability

scientific article published on March 2004

Inherited Rare, Deleterious Variants in ATM Increase Lung Adenocarcinoma Risk

scientific article published on 28 August 2020

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA.

scientific article published on October 2013

Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines

scientific article published on 01 November 2018

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers

scientific article

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

scientific article

Integrated next-generation sequencing and avatar mouse models for personalized cancer treatment

scientific article

Integrative Tumor and Immune Cell Multi-omic Analyses Predict Response to Immune Checkpoint Blockade in Melanoma

scientific article published on 17 November 2020

International network of cancer genome projects

scientific article

Ipilimumab plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer.

scientific article published on 19 June 2018

Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer

scientific article

Large-scale identification of novel transcripts in the human genome

scientific article published on 31 January 2007

Low-grade serous carcinomas of the ovary contain very few point mutations

scientific article

Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer

scientific article published on 13 January 2020

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

scientific article published on June 2005

Mutant metabolic enzymes are at the origin of gliomas

scientific article published on December 2009

Mutational analysis of gene families in human cancer

scientific article (publication date: February 2005)

Mutational analysis of the tyrosine kinome in colorectal cancers

scientific article (publication date: 9 May 2003)

Mutational analysis of the tyrosine phosphatome in colorectal cancers

scientific article

Mutations in CIC and FUBP1 contribute to human oligodendroglioma

scientific article (publication date: 9 September 2011)

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer.

scientific article published on 16 April 2018

Neoadjuvant nivolumab plus ipilimumab in resectable non-small cell lung cancer

scientific article published on 01 September 2020

Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade

scientific article published on 10 September 2019

Notch1 mutations are drivers of oral tumorigenesis

scientific article

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

scientific article published on 20 June 2016

Oncogenic mutations of PIK3CA in human cancers

scientific article published on 12 October 2004

PRL-3 expression in metastatic cancers

scientific article (publication date: 15 November 2003)

Patient-oriented gene set analysis for cancer mutation data

scientific article

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

article

Personalized genomic analyses for cancer mutation discovery and interpretation

scientific article published on April 2015

Phase I Study of Rapid Alternation of Sunitinib and Regorafenib for the Treatment of Tyrosine Kinase Inhibitor Refractory Gastrointestinal Stromal Tumors

scientific article published on 30 August 2019

Precancer Atlas to Drive Precision Prevention Trials.

scientific article

Prevalence of somatic alterations in the colorectal cancer cell genome

scientific article

Q&A: Victor Velculescu. Out for blood

scientific article published in May 2015

RAF/RAS oncogenes and mismatch-repair status

scientific article published in Nature

Rapid characterization of candidate biomarkers for pancreatic cancer using cell microarrays (CMAs).

scientific article

Recurrent KRAS codon 146 mutations in human colorectal cancer

scientific article published on August 2006

SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer

scientific article

Sensitive digital quantification of DNA methylation in clinical samples

scientific article

Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms

scientific article published on 26 July 2006

Serial Assessment of Human Tumor Burdens in Mice by the Analysis of Circulating DNA

article

Sodium ion channel mutations in glioblastoma patients correlate with shorter survival

scientific article published on 11 February 2011

Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes

scientific article

Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types

scientific article

Somatic mutations of EGFR in colorectal cancers and glioblastomas

scientific article published in December 2004

Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers

scientific article

Somatic mutations of PPP2R1A in ovarian and uterine carcinomas

scientific article

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

scientific article published on 25 March 2013

The Effect of Preservative and Temperature on the Analysis of Circulating Tumor DNA.

scientific article published on 8 November 2016

The Mutation-Associated Neoantigen Functional Expansion of Specific T Cells (MANAFEST) Assay: A Sensitive Platform for Monitoring Antitumor Immunity

scientific article published on 12 June 2018

The PIK3CA gene is mutated with high frequency in human breast cancers.

scientific article

The antisense transcriptomes of human cells

scientific article

The colorectal microRNAome

scientific article

The consensus coding sequences of human breast and colorectal cancers

scientific article

The genetic landscape of the childhood cancer medulloblastoma

scientific article

The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT.

scientific article

The genomic landscape of response to EGFR blockade in colorectal cancer.

scientific article published on 30 September 2015

The genomic landscapes of human breast and colorectal cancers

scientific article

The intersection of basic science and health policy: a conversation with Victor Velculescu. Interview by Barbara J. Culliton

scientific article

The predictive capacity of personal genome sequencing

scientific article published on 02 April 2012

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

scientific article

Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer

scientific article published on 31 May 2013

Three classes of genes mutated in colorectal cancers with chromosomal instability

scientific article published in May 2004

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

Transcriptome PETs: A genome's best friends

Understanding the Enemy ⬇️

scientific article published on August 31, 2011

Using the transcriptome to annotate the genome

scientific article

WAF1, a potential mediator of p53 tumor suppression

scientific article (publication date: 19 November 1993)

White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer

scientific article published on 27 January 2020

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