List of works by Victor Nizet

2390. Avibactam Sensitizes NDM Klebsiella pneumoniae to Innate Immune Killing by Human Cathelicidin LL-37, Serum, Neutrophils, and Platelets

637. Β-Lactam (BL) Antibiotics Promote an IL-1β Response in Patients with Staphylococcus aureus Bacteremia (SaB)

A 2-year-old girl with hematemesis, melena, and splenomegaly

scientific article published on 01 October 1993

A 5-year-old girl with varicella and acute onset of fever, stridor, and respiratory distress.

scientific article published on February 1994

A 7-month-old boy with poor growth, hypercalcemia, and unusual facies

scientific article published on 01 December 1993

A Biosurveillance-driven Home Score to Guide Strep Pharyngitis Treatment

scientific article

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide

scientific journal article

A Red Blood Cell Membrane-Camouflaged Nanoparticle Counteracts Streptolysin O-Mediated Virulence Phenotypes of Invasive Group A Streptococcus

scientific article

A Staphylococcus aureus TIR domain protein virulence factor blocks TLR2-mediated NF-κB signaling.

scientific article

A Virulent Nonencapsulated Haemophilus influenzae

scientific article published on 01 January 1996

A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus

scientific article published on 16 December 2019

A bacterial pathogen co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides

scientific article

A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence

scientific article

A conserved UDP-glucose dehydrogenase encoded outside the hasABC operon contributes to capsule biogenesis in group A Streptococcus

scientific article

A group A Streptococcus ADP-ribosyltransferase toxin stimulates a protective interleukin 1β-dependent macrophage immune response

scientific article published on 10 March 2015

A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence

scientific article published on 15 January 2008

A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection

scientific article

A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence

scientific article

A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection

scientific article published on 28 February 2012

A newborn girl with watery diarrhea, weight loss, and severe metabolic acidosis

scientific article published in April 1994

A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps

scientific article

A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues

scientific article

A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria

scientific journal article

ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors.

scientific article published in December 2006

Accentuate the (Gram) positive

scientific article published on 20 February 2010

Acquisition of the Sda1-encoding bacteriophage does not enhance virulence of the serotype M1 Streptococcus pyogenes strain SF370

scientific article published on 25 March 2013

Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and IL-10 expression

scientific article published on 28 August 2014

Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus

scientific article (publication date: 26 March 2010)

Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus

scientific article

Age-Appropriate Functions and Dysfunctions of the Neonatal Neutrophil

scientific article published on 28 February 2017

Alanylation of Teichoic Acids ProtectsStaphylococcus aureusagainst Toll‐like Receptor 2–Dependent Host Defense in a Mouse Tissue Cage Infection Model

scientific article published on 10 July 2003

All major cholesterol-dependent cytolysins use glycans as cellular receptors

scientific article published on 22 May 2020

Alterations in neonatal neutrophil function attributable to increased immature forms

scientific article

Ampicillin enhances daptomycin- and cationic host defense peptide-mediated killing of ampicillin- and vancomycin-resistant Enterococcus faecium

scientific article published on 28 November 2011

An 8-day-old male infant with poor feeding, lethargy, and an elevated anion gap metabolic acidosis

scientific article published on 01 August 1993

An Experimental Group A Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model

scientific article published on 30 April 2019

Analysis of the effects of cigarette smoke on staphylococcal virulence phenotypes

scientific article published on 30 March 2015

Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus

scientific article

Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage

scientific article published on 16 June 2011

Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst

scientific article

Antibacterial drug leads targeting isoprenoid biosynthesis

scientific article

Antimicrobial and Protease Inhibitory Functions of the Human Cathelicidin (hCAP18/LL-37) Prosequence

scientific article (publication date: May 2003)

Antimicrobial peptide resistance mechanisms of human bacterial pathogens.

scientific article

Antimicrobial peptides and the skin

scientific article published on April 2004

Antimicrobial salvage therapy for persistent staphylococcal bacteremia using daptomycin plus ceftaroline.

scientific article

Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis

scientific article (publication date: 23 March 2015)

Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens

scientific article

Bacteria and phagocytes: mortal enemies

scientific article published on 10 September 2010

Bacterial Cytological Profiling (BCP) as a Rapid and Accurate Antimicrobial Susceptibility Testing Method for Staphylococcus aureus

scientific article published on 18 January 2016

Bacterial Evasion of Host Antimicrobial Peptide Defenses

scientific article published on February 2016

Bacterial and Viral Infections

scientific article published on 20 March 2010

Bacterial phenotype variants in group B streptococcal toxic shock syndrome

scientific article published on February 2009

Bacterial pore-forming cytolysins induce neuronal damage in a rat model of neonatal meningitis

scientific article

Bactericidal kinetics of marine-derived napyradiomycins against contemporary methicillin-resistant Staphylococcus aureus

scientific article

Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections

scientific article

Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence

scientific article published on 25 August 2015

Blood Group Antigen Recognition via the Group A Streptococcal M Protein Mediates Host Colonization

scientific article published on 24 January 2017

Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid

scientific article

Brain abscess caused by Streptococcus pyogenes in a previously healthy child

scientific article published on 25 October 2006

Broad-Spectrum Neutralization of Pore-Forming Toxins with Human Erythrocyte Membrane-Coated Nanosponges

scientific article published on 13 February 2018

CAMP factor is not essential for systemic virulence of Group B Streptococcus

scientific article published on 14 August 2007

Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture

scientific article published on 16 June 2017

Cathelicidins and Innate Defense Against Invasive Bacterial Infection

scientific article published on January 1, 2003

Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens

scientific article

Cefazolin and Ertapenem, a Synergistic Combination Used To Clear Persistent Staphylococcus aureus Bacteremia

scientific article published on 29 August 2016

Ceftaroline restores daptomycin activity against daptomycin-nonsusceptible vancomycin-resistant Enterococcus faecium

scientific article

Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection

scientific article published on April 2009

Cellular Activation, Phagocytosis, and Bactericidal Activity Against Group B Streptococcus Involve Parallel Myeloid Differentiation Factor 88-Dependent and Independent Signaling Pathways

scientific article published on 01 October 2002

Characterization of CA-MRSA TCH1516 exposed to nafcillin in bacteriological and physiological media

scientific article published on 26 April 2019

Characterization of in vivo expression of the human papillomavirus type 16 E4 protein in cervical biopsy tissues

scientific article

Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract

scientific article

Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions

scientific article published on September 2013

Classical β-Lactamase Inhibitors Potentiate the Activity of Daptomycin against Methicillin-Resistant Staphylococcus aureus and Colistin against Acinetobacter baumannii

scientific article

Clinical Data on Daptomycin plus Ceftaroline versus Standard of Care Monotherapy in the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia

scientific article published on 25 April 2019

Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum

scientific article

Clove Bud Oil Modulates Pathogenicity Phenotypes of the Opportunistic Human Pathogen Pseudomonas aeruginosa.

scientific article published on 21 February 2018

ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis

scientific article

Cofactors required for TLR7- and TLR9-dependent innate immune responses

scientific article published in March 2012

Coiled-Coil Irregularities and Instabilities in Group A Streptococcus M1 Are Required for Virulence

scientific article

Coiled-coil destabilizing residues in the group A Streptococcus M1 protein are required for functional interaction

scientific article published on 10 August 2016

Coiled-coil irregularities of the M1 protein structure promote M1-fibrinogen interaction and influence group A Streptococcus host cell interactions and virulence

scientific article

Collective Resistance in Microbial Communities by Intracellular Antibiotic Deactivation

scientific article

Color me bad: microbial pigments as virulence factors

scientific article published on 31 August 2009

Common etiologies and new approaches to management of poisoning in pediatric practice.

scientific article

Comparative genome-scale modelling of Staphylococcus aureus strains identifies strain-specific metabolic capabilities linked to pathogenicity

scientific article published on 10 June 2016

Component Analysis of Multipurpose Contact Lens Solutions To Enhance Activity against Pseudomonas aeruginosa and Staphylococcus aureus

scientific article published on 02 May 2016

Conquering Neutrophils

scientific article

Conserved anchorless surface proteins as group A streptococcal vaccine candidates

scientific article published on 14 April 2012

Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein

scientific article published on 05 September 2016

Correction: Relationship between Expression of the Family of M Proteins and Lipoteichoic Acid to Hydrophobicity and Biofilm Formation in Streptococcus pyogenes

scientific article published in PLoS ONE

Correction: Relationship between Expression of the Family of M Proteins and Lipoteichoic Acid to Hydrophobicity and Biofilm Formation in Streptococcus pyogenes.

scientific article published on 26 January 2009

Correction: Streptococcus pneumoniae Invades Erythrocytes and Utilizes Them to Evade Human Innate Immunity.

scientific article published on 15 January 2014

Critical role of HIF-1alpha in keratinocyte defense against bacterial infection

scientific article

Cutaneous defense mechanisms by antimicrobial peptides

scientific article

Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus

scientific article published in July 2001

Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis

scientific article

D-alanylation of teichoic acids promotes group a streptococcus antimicrobial peptide resistance, neutrophil survival, and epithelial cell invasion

scientific article

DNase Sda1 allows invasive M1T1 Group A Streptococcus to prevent TLR9-dependent recognition

scientific article

DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection

scientific article published on 15 July 2007

DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps

scientific article

Decontaminating surfaces with atomized disinfectants generated by a novel thickness-mode lithium niobate device

scientific article published in 2018

Differential Effects of Penicillin Binding Protein Deletion on the Susceptibility of Enterococcus faecium to Cationic Peptide Antibiotics

scientific article

Differential expression and intrachromosomal evolution of the sghC1q genes in zebrafish (Danio rerio).

scientific article

Differing Efficacies of Lead Group A Streptococcal Vaccine Candidates and Full-Length M Protein in Cutaneous and Invasive Disease Models

scientific article published on 14 June 2016

Differing effects of exogenous or endogenous cathelicidin on macrophage toll-like receptor signaling

scientific article published on 7 April 2009

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.

scientific article published on 21 January 2014

Discovery and characterization of sialic acid O-acetylation in group B Streptococcus

scientific article

Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass

scientific article

Discovery of a widely distributed toxin biosynthetic gene cluster

scholarly article

Disease manifestations and pathogenic mechanisms of Group A Streptococcus

scientific article

Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics

scientific article

Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing

scientific article published on 25 March 2019

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

scientific article

Effect of a bacterial pheromone peptide on host chemokine degradation in group A streptococcal necrotising soft-tissue infections

scientific article

Effects of vancomycin versus nafcillin in enhancing killing of methicillin-susceptible Staphylococcus aureus causing bacteremia by human cathelicidin LL-37.

scientific article published on 27 May 2016

Elevated serum interleukin-10 at time of hospital admission is predictive of mortality in patients with Staphylococcus aureus bacteremia.

scientific article published on 10 September 2012

EndoS2 is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and α1-acid glycoprotein.

scientific article published on October 2013

Endogenous production of antimicrobial peptides in innate immunity and human disease

scientific article

Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy

scientific article

Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions

scientific article published on 7 September 2017

Enhanced topical delivery of non-complexed molecular iodine for Methicillin-resistant Staphylococcus aureus decolonization

Enhanced topical delivery of non-complexed molecular iodine for Methicillin-resistant Staphylococcus aureus decolonization

Epidermal deletion of HIF-2α stimulates wound closure

scientific article published on 13 September 2013

Epithelial cell invasion by group B streptococci is important to virulence

scientific article published on January 1997

Erratum for Rivera-Hernandez et al., "An Experimental Group A <i>Streptococcus</i> Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model"

scientific article published on 01 December 2020

Erratum for Schooley et al., "Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection"

scholarly article by Robert T. Schooley et al published December 2018 in Antimicrobial Agents and Chemotherapy

Erratum: Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein

scientific article published on 12 June 2017

Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation

scientific article published on 17 April 2017

Evaluating Organism-Wide Changes in the Metabolome and Microbiome following a Single Dose of Antibiotic

scientific article published in 2020

Evaluation of IL-17D in Host Immunity to Group A Streptococcus Infection

scientific article published on 19 October 2020

Evaluation of Streptococcus iniae killed bacterin and live attenuated vaccines in hybrid striped bass through injection and bath immersion

scientific article

Evasion of Neutrophil Extracellular Traps by Respiratory Pathogens

scientific article published on 17 November 2016

Evidence To Support Continuation of Statin Therapy in Patients with Staphylococcus aureus Bacteremia

scientific article published on 9 January 2017

Evidence that recurrent Group A streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant Tfh cells

Evolutionary inactivation of a sialidase in group B Streptococcus

scientific article published on 29 June 2016

Examining the use of ceftaroline in the treatment of Streptococcus pneumoniae meningitis with reference to human cathelicidin LL-37.

scientific article

Experimental selection for Drosophila survival in extremely high O2 environments

scientific article

Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae

scientific article published in 2021

Extracellular virulence factors of group B Streptococci

scientific article published on May 2004

Fetal calf serum contains heat-stable nucleases that degrade neutrophil extracellular traps

scientific article published on December 2009

Fever in Children

scientific article published on 01 April 1994

Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection

scientific article

Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp.

scientific article

Fulminant bacterial meningitis complicating sphenoid sinusitis

scientific article published on December 2003

Genetic Determinants Enabling Medium-Dependent Adaptation to Nafcillin in Methicillin-Resistant Staphylococcus aureus

scientific article published on 31 March 2020

Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact

scientific article published on 30 July 2009

Genetic basis for the beta-haemolytic/cytolytic activity of group B Streptococcus

scientific article

Genetic characterization and virulence role of the RALP3/LSA locus upstream of the streptolysin s operon in invasive M1T1 Group A Streptococcus

scientific article published on 17 November 2006

Genetic locus for streptolysin S production by group A streptococcus

scientific article

Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A streptococcus M1T1 clone

scientific article

Genome-scale analysis of Methicillin-resistant Staphylococcus aureus USA300 reveals a tradeoff between pathogenesis and drug resistance.

scientific article

Genotypic and phenotypic evaluation of the evolution of high-level daptomycin nonsusceptibility in vancomycin-resistant Enterococcus faecium

scientific article published on 4 September 2012

Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules

scientific article

Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems

scientific article

Group A Streptococcal M1 Protein Provides Resistance against the Antimicrobial Activity of Histones

scientific article published on 21 February 2017

Group A Streptococcal M1 Protein Sequesters Cathelicidin to Evade Innate Immune Killing

scientific article

Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP.

scientific article published on 17 May 2018

Group A Streptococcus encounters with host macrophages

scientific article published on 11 December 2017

Group A streptococcal M protein activates the NLRP3 inflammasome

scientific article

Group A streptococcal necrotizing fasciitis complicating primary varicella: a series of fourteen patients

scientific article published on 01 July 1995

Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches.

scientific article published on 22 February 2018

Group B Streptococcal β‐Hemolysin Induces Nitric Oxide Production in Murine Macrophages

scientific article published on 30 June 2000

Group B Streptococcus Evades Host Immunity by Degrading Hyaluronan

scientific article

Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo

scientific article

Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5.

scientific article published on 13 July 2009

Group B Streptococcus β-hemolysin/cytolysin breaches maternal-fetal barriers to cause preterm birth and intrauterine fetal demise in vivo

scientific article

Group B streptococcal beta-hemolysin expression is associated with injury of lung epithelial cells.

scientific article published on September 1996

Group B streptococcal beta-hemolysin induces mortality and liver injury in experimental sepsis

scientific article published on 22 May 2002

Group B streptococcal beta-hemolysin promotes injury of lung microvascular endothelial cells

scientific article published in May 1999

Group B streptococcal beta-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis

scientific article published on September 2003

Group B streptococcal beta-hemolysin/cytolysin directly impairs cardiomyocyte viability and function

scientific article

Group B streptococcal beta-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8.

scientific article published on 3 January 2002

Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes

scientific article published on 22 September 2006

Group B streptococcal pilus proteins contribute to adherence to and invasion of brain microvascular endothelial cells

scientific article published on 13 October 2006

HIF isoforms in the skin differentially regulate systemic arterial pressure

scientific article published on 07 October 2013

HIF transcription factors, inflammation, and immunity

scientific article

HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite

scientific article published on 2 July 2007

HIF-1alpha expression regulates the bactericidal capacity of phagocytes

scientific article published on July 2005

HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination

scientific article published on 19 May 2013

HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis

scientific article

Hedgehog: linking uracil to innate defense

scientific article

Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity

scientific article

Heterogeneity of genetic pathways toward daptomycin nonsusceptibility in Staphylococcus aureus determined by adjunctive antibiotics

scientific article

Host Cathelicidin Exacerbates Group B Streptococcus Urinary Tract Infection

scientific article published on 22 April 2020

Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation

scientific article published on 28 September 2015

How group A Streptococcus circumvents host phagocyte defenses

scientific article published on February 2007

Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein

scientific article published on 27 July 2011

Human cathelicidin LL-37 resistance and increased daptomycin MIC in methicillin-resistant Staphylococcus aureus strain USA600 (ST45) are associated with increased mortality in a hospital setting

scientific article

Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera.

scientific article

Human milk oligosaccharides inhibit growth of group B Streptococcus

scientific article

Human milk oligosaccharides protect bladder epithelial cells against uropathogenic Escherichia coli invasion and cytotoxicity

scientific article published on 29 August 2013

Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1α.

scientific article published on 3 March 2015

Human transferrin confers serum resistance against Bacillus anthracis

scientific article

Hyaluronan breakdown contributes to immune defense against group A Streptococcus

scientific article

Hypoxia inducible factor (HIF) function in innate immunity and infection

scientific article

Hypoxia potentiates allergen induction of HIF-1α, chemokines, airway inflammation, TGF-β1, and airway remodeling in a mouse model

scientific article published on 21 February 2013

Hypoxia-Inducible Factor (HIF) as a Pharmacological Target for Prevention and Treatment of Infectious Diseases

scientific article

IKKbeta/NF-kappaB and the miscreant macrophage

scientific article published on 2 June 2008

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

scientific article published in Nature

IL-1β is an innate immune sensor of microbial proteolysis

scientific article published on 19 August 2016

IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

scientific article published on 19 December 2010

Identification of a streptolysin S-associated gene cluster and its role in the pathogenesis of Streptococcus iniae disease

scientific article

IgG protease Mac/IdeS is not essential for phagocyte resistance or mouse virulence of M1T1 group A Streptococcus

scientific article published on 30 July 2013

Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis

scientific article

Immunoglobulin Attenuates Streptokinase-Mediated Virulence in Streptococcus dysgalactiae Subspecies equisimilis Necrotizing Fasciitis

scientific article published in November 2017

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.

scientific article

Impairment of innate immune killing mechanisms by bacteriostatic antibiotics

scientific article published on 10 January 2007

Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections

scientific article

Improved diagnostic accuracy of group A streptococcal pharyngitis with use of real-time biosurveillance

scientific article published on September 2011

In vitro activity of daptomycin in combination with β-lactams, gentamicin, rifampin, and tigecycline against daptomycin-nonsusceptible enterococci

scientific article published on 11 May 2015

Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes

scientific article

Increased Endovascular Staphylococcus aureus Inoculum Is the Link Between Elevated Serum Interleukin 10 Concentrations and Mortality in Patients With Bacteremia

scientific article published on 16 February 2017

Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor

scientific article

Inflammasome inhibition blocks cardiac glycoside cell toxicity

scientific article published on 12 July 2019

Inflammasome/IL-1β Responses to Streptococcal Pathogens

scientific article

Influences of chloride and hypochlorite on neutrophil extracellular trap formation

scientific article published in 2012

Inhibition of Human Neutrophil Extracellular Trap (NET) Production by Propofol and Lipid Emulsion

Inhibition of Staphyloxanthin Virulence Factor Biosynthesis in Staphylococcus aureus : In Vitro, in Vivo, and Crystallographic Results †

scientific article

Innate Immune Interactions between Bacillus anthracis and Host Neutrophils

scientific article published on 22 January 2018

Innate antimicrobial peptide protects the skin from invasive bacterial infection

scientific article

Innate barriers against infection and associated disorders

scientific article published on June 2008

Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections

scholarly article

Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer

scientific article

Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps

scientific article published on 16 May 2009

Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure

scholarly article

Interaction of Antibiotics with Innate Host Defense Factors against Salmonella enterica Serotype Newport

scientific article published in November 2017

Interaction of Bacterial Exotoxins with Neutrophil Extracellular Traps: Impact for the Infected Host

scientific article

Interdependence of hypoxic and innate immune responses

scientific article published on September 2009

Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract

scientific article published on 31 May 2016

Intracellular Streptococcus pyogenes in human macrophages display an altered gene expression profile

scientific article

Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria

scientific article

Invasion of brain microvascular endothelial cells by group B streptococci

scientific article

Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB.

scientific article

Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils

scientific article published on 30 March 2016

Is a Reported Penicillin Allergy Sufficient Grounds to Forgo the Multidimensional Antimicrobial Benefits of β-Lactam Antibiotics?

scientific article published on 01 January 2019

Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster

scientific article published on 29 November 2017

Keratinocyte production of cathelicidin provides direct activity against bacterial skin pathogens

scientific article

Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis

scientific article

Late-onset group B streptococcal infection in identical twins: insight to disease pathogenesis

scientific article published on June 2002

Leukocyte inflammatory responses provoked by pneumococcal sialidase

scientific article published on 3 January 2012

Listeria monocytogenes endocarditis: case report, review of the literature, and laboratory evaluation of potential novel antibiotic synergies

scientific article published on 11 January 2018

Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State

scientific article published on February 2017

Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation.

scientific article published on 22 March 2013

Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis

scientific article

M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus

scientific article

M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition

scientific article published on 20 February 2009

M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment

scientific article

Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance

scientific article published in Nature Communications

Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management

scientific article

Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (I)

scientific article

Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (III).

scientific article

Mechanisms of group A Streptococcus resistance to reactive oxygen species

scientific article published on 10 February 2015

Methicillin-resistant Staphylococcus aureus bacterial nitric-oxide synthase affects antibiotic sensitivity and skin abscess development

scientific article published on 15 January 2013

Microbial competition between Bacillus subtilis and Staphylococcus aureus monitored by imaging mass spectrometry

scientific article

Mitochondrial missile defense

scientific article published on 01 September 2008

Modeling neuro-immune interactions during Zika virus infection

scientific article published on 17 October 2017

Molecular dynamic study of MlaC protein in Gram-negative bacteria: conformational flexibility, solvent effect and protein-phospholipid binding

scientific article published on 25 April 2016

Molecular genetic analysis of a group A Streptococcus operon encoding serum opacity factor and a novel fibronectin-binding protein, SfbX

scientific article

Molecular insight into invasive group A streptococcal disease

scientific article published on 16 September 2011

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

scientific article published on 04 February 2009

Molecular pathogenesis of neonatal group B streptococcal infection: no longer in its infancy

scientific article published in October 2004

Multidimensional Proteome Profiling of Blood-Brain Barrier Perturbation by Group B Streptococcus

scientific article published on 25 August 2020

Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infection

scientific article

Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus

scientific article

Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis

scientific article published on 20 February 2015

Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function

scientific article published on 19 December 2012

Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection

scientific article

N-terminal ArgD peptides from the classical Staphylococcus aureus Agr system have cytotoxic and proinflammatory activities

scientific article

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

scientific article published on 23 April 2008

NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation

scientific article published on 16 June 2009

Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus

scientific article published on 03 December 2013

Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity

scientific article published on 13 May 2016

NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus

scientific article published on 23 July 2007

Neuroscience: Bacteria get on your nerves.

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Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap-associated cathelicidin

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New insights into the biological effects of anthrax toxins: linking cellular to organismal responses

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Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus

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Non-Native Amino Acid Click Chemistry-Based Technology for Site-Specific Polysaccharide Conjugation to a Bacterial Protein Serving as Both Carrier and Vaccine Antigen

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Novel bacterial metabolite merochlorin A demonstrates in vitro activity against multi-drug resistant methicillin-resistant Staphylococcus aureus

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Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.

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Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid

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Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry

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Novel role for the yceGH tellurite resistance genes in the pathogenesis of Bacillus anthracis

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Novel role of the antimicrobial peptide LL-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases

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Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps

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O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence

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Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes

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On resin amino acid side chain attachment strategy for the head to tail synthesis of new glutamine containing gramicidin-S analogs and their antimicrobial activity

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Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete

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Orthopaedic manifestations of invasive group A streptococcal infections complicating primary varicella

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PHLPP1 counter-regulates STAT1-mediated inflammatory signaling

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Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.

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Papillation in Bacillus anthracis colonies: a tool for finding new mutators

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Parameters governing invasive disease propensity of non-M1 serotype group A streptococci

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Participatory Medicine: A Home Score for Streptococcal Pharyngitis

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Participatory medicine: A home score for streptococcal pharyngitis enabled by real-time biosurveillance: a cohort study

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Pathogen microevolution in high resolution

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Penicillin Binding Protein 1 Is Important in the Compensatory Response of Staphylococcus aureus to Daptomycin-Induced Membrane Damage and Is a Potential Target for β-Lactam-Daptomycin Synergy

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Penicillin-binding protein 1a promotes resistance of group B streptococcus to antimicrobial peptides

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Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection

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Pharmacological Targeting of the Host-Pathogen Interaction: Alternatives to Classical Antibiotics to Combat Drug-Resistant Superbugs

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Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics

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Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus

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Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking

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Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus

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Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing.

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Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics

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Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ.

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Profiling the effect of nafcillin on HA-MRSA D712 using bacteriological and physiological media

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Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

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Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis

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Proton-pump inhibitors do not influence clinical outcomes in patients with bacteremia

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RAB11-mediated trafficking in host-pathogen interactions

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Recent advances in understanding the molecular basis of group B Streptococcus virulence

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Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells.

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Recurrent infection progressively disables host protection against intestinal inflammation.

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Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection

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Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

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Reply to Kalil et al., "Is Daptomycin plus Ceftaroline Associated with Better Clinical Outcomes than Standard of Care Monotherapy for Staphylococcus aureus Bacteremia?"

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Retargeting pre-existing human antibodies to a bacterial pathogen with an alpha-Gal conjugated aptamer

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Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators, and role in key physiological response

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Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection

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Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae

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SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity.

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Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase.

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Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin

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Selective modulation of superantigen-induced responses by streptococcal cysteine protease

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Selectively guanidinylated aminoglycosides as antibiotics

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Serine-Aspartate Repeat Protein D Increases Staphylococcus aureus Virulence and Survival in Blood

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Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence

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Severe soft tissue infection caused by a non-beta-hemolytic Streptococcus pyogenes strain harboring a premature stop mutation in the sagC gene.

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Severity of Group B Streptococcal Arthritis Is Correlated with β‐Hemolysin Expression

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Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus

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Singly modified amikacin and tobramycin derivatives show increased rRNA A-site binding and higher potency against resistant bacteria

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Skin microbiota: a source of disease or defence?

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Specific inactivation of two immunomodulatory SIGLEC genes during human evolution

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Standard susceptibility testing overlooks potent azithromycin activity and cationic peptide synergy against MDR Stenotrophomonas maltophilia

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Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury

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Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity

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Staphylococcus aureus virulence is enhanced by secreted factors that block innate immune defenses.

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Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus.

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Strain-Specific Metabolic Requirements Revealed by a Defined Minimal Medium for Systems Analyses of Staphylococcus aureus

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Strain-associated virulence factors of Streptococcus iniae in hybrid-striped bass

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Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects

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Streptococcal Lancefield polysaccharides are critical cell wall determinants for human group IIA secreted phospholipase A2 to exert its bactericidal effects

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Streptococcal Skin Infections

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Streptococcal beta-hemolysins: genetics and role in disease pathogenesis

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Streptococcal collagen-like protein A and general stress protein 24 are immunomodulating virulence factors of group A Streptococcus

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Streptococcal inhibitor of complement promotes innate immune resistance phenotypes of invasive M1T1 group A Streptococcus

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Streptococcal toxins: role in pathogenesis and disease

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Streptococcus iniae M-like protein contributes to virulence in fish and is a target for live attenuated vaccine development

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Streptococcus iniae beta-hemolysin streptolysin S is a virulence factor in fish infection

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Streptococcus iniae capsule impairs phagocytic clearance and contributes to virulence in fish

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Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development

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Streptococcus iniae virulence is associated with a distinct genetic profile

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Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR.

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Streptococcus pneumoniae invades erythrocytes and utilizes them to evade human innate immunity

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Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells

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Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus

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Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis

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Streptolysin S and necrotising infections produced by group G streptococcus

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Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S.

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Study of streptococcal hemoprotein receptor (Shr) in iron acquisition and virulence of M1T1 group A streptococcus

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Subterfuge and sabotage: evasion of host innate defenses by invasive gram-positive bacterial pathogens

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

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Surprising synergy of dual translation inhibition vs. Acinetobacter baumannii and other multidrug-resistant bacterial pathogens

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Surviving innate immunity.

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Sword and shield: linked group B streptococcal beta-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense

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Synergistic Action of Nitric Oxide Release from Murine Macrophages Caused by Group B Streptococcal Cell Wall and β‐Hemolysin/Cytolysin

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Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms.

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Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability

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T4 Pili Promote Colonization and Immune Evasion Phenotypes of Nonencapsulated M4 Streptococcus pyogenes

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TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin

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TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens

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Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract

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Tamm-Horsfall protein protects the urinary tract against

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Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide

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Telavancin for refractory MRSA bacteraemia in intermittent haemodialysis recipients.

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The Accidental Orthodoxy of Drs. Mueller and Hinton

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The Ashwell receptor mitigates the lethal coagulopathy of sepsis

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The CXC chemokine-degrading protease SpyCep of Streptococcus pyogenes promotes its uptake into endothelial cells

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The FbaB-type fibronectin-binding protein of Streptococcus pyogenes promotes specific invasion into endothelial cells

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The GraRS regulatory system controls Staphylococcus aureus susceptibility to antimicrobial host defenses.

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The IL-8 protease SpyCEP/ScpC of group A Streptococcus promotes resistance to neutrophil killing

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The Mla pathway is critical for Pseudomonas aeruginosa resistance to outer membrane permeabilization and host innate immune clearance

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The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis

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The Selective Estrogen Receptor Modulator Raloxifene Inhibits Neutrophil Extracellular Trap Formation

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The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis

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The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps

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The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design

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The fibrinogen-binding M1 protein reduces pharyngeal cell adherence and colonization phenotypes of M1T1 group A Streptococcus

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The globally disseminated M1T1 clone of group A Streptococcus evades autophagy for intracellular replication

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The group B streptococcal serine-rich repeat 1 glycoprotein mediates penetration of the blood-brain barrier

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The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters.

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The interplay between Siglecs and sialylated pathogens

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The long noncoding RNA regulates inflammatory gene expression

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The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection

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The mammalian ionic environment dictates microbial susceptibility to antimicrobial defense peptides

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The novel polysaccharide deacetylase homologue Pdi contributes to virulence of the aquatic pathogen Streptococcus iniae

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The pore-forming protein Cry5B elicits the pathogenicity of Bacillus sp. against Caenorhabditis elegans

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The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity

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The role of group B streptococci beta-hemolysin expression in newborn lung injury

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The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-κB signaling, and inflammatory gene expression in human aortic valve cells

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The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion

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Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways

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Total synthesis and biological evaluation of marinopyrrole A and analogues

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Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone

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Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process.

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Treatment of high-level gentamicin-resistant Enterococcus faecalis endocarditis with daptomycin plus ceftaroline

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Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages

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Trigger for group A streptococcal M1T1 invasive disease

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Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes

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Understanding how leading bacterial pathogens subvert innate immunity to reveal novel therapeutic targets

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Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding

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Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes

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Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus

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Virulence role of group B Streptococcus beta-hemolysin/cytolysin in a neonatal rabbit model of early-onset pulmonary infection

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Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion

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β-Lactam antibiotics targeting PBP1 selectively enhance daptomycin activity against methicillin-resistant Staphylococcus aureus

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