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List of works by Luca Agnelli

A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: an integrated genomics approach reveals a wide gene dosage effect

scientific article published in July 2009

A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias.

scientific article

A compendium of long non-coding RNAs transcriptional fingerprint in multiple myeloma.

scientific article published on 26 April 2018

B-cell receptor configuration and adverse cytogenetics are associated with autoimmune hemolytic anemia in chronic lymphocytic leukemia

scientific article published on 31 October 2012

Biological and clinical relevance of miRNA expression signatures in primary plasma cell leukemia.

scientific article

Bone osteoblastic and mesenchymal stromal cells lack primarily tumoral features in multiple myeloma patients

scientific article published on 20 May 2010

Characterization of oncogene dysregulation in multiple myeloma by combined FISH and DNA microarray analyses

scientific article published on 01 February 2005

Chromosome 2p gain in monoclonal B-cell lymphocytosis and in early stage chronic lymphocytic leukemia.

scientific article published on 9 October 2012

Correction: miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma.

scientific article

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target.

scientific article published on 6 June 2016

Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients.

scientific article

Distinct lncRNA transcriptional fingerprints characterize progressive stages of multiple myeloma.

scientific article

Distinct patterns of global promoter methylation in early stage chronic lymphocytic leukemia

scientific article published on 18 December 2013

Distinct transcriptional profiles characterize bone microenvironment mesenchymal cells rather than osteoblasts in relationship with multiple myeloma bone disease.

scientific article published on 4 December 2009

Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity.

scientific article published on 22 February 2018

Expanding the repertoire of miRNAs and miRNA-offset RNAs expressed in multiple myeloma by small RNA deep sequencing

scientific article published on 19 February 2019

Expression Pattern and Biological Significance of the lncRNA ST3GAL6-AS1 in Multiple Myeloma

scientific article published on 25 March 2020

Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes.

scientific article

Galectin-1 suppression delineates a new strategy to inhibit myeloma-induced angiogenesis and tumoral growth in vivo

scientific article published on 17 June 2016

Gene expression profiling of plasma cell dyscrasias reveals molecular patterns associated with distinct IGH translocations in multiple myeloma

article

Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms

scientific article

Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with changes in transcriptional profiles

article

HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients.

scientific article published on 23 November 2010

Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction.

scientific article published on 24 January 2013

IL21R expressing CD14+CD16+ monocytes expand in multiple myeloma patients leading to increased osteoclasts.

scientific article

Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphoma

scientific article

Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts

scientific article

Identification of microRNA expression patterns and definition of a microRNA/mRNA regulatory network in distinct molecular groups of multiple myeloma.

scientific article published in December 2009

Identification of primary MAFB target genes in multiple myeloma.

scientific article

Immune thrombocytopenia in patients with chronic lymphocytic leukemia is associated with stereotyped B-cell receptors.

scientific article

Immunoreactivity for cyclin D1 is a reliable marker of gene aberration in plasma cell myeloma but does not specify patients prognosis

article

Impact of host genes and strand selection on miRNA and miRNA* expression.

scientific article

Improved risk stratification in myeloma using a microRNA-based classifier.

scientific article published on 30 May 2013

In Silico Characterization of miRNA and Long Non-Coding RNA Interplay in Multiple Myeloma.

scientific article published on 29 November 2016

Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation.

scientific article published on 6 January 2012

Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma

scientific article published on 27 May 2015

Integration of transcriptional and mutational data simplifies the stratification of peripheral T-cell lymphoma

scientific article published on 19 March 2019

Integrative genomic analysis reveals distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma

scientific article published on 01 January 2007

Integrative genomics analyses reveal molecularly distinct subgroups of B-cell chronic lymphocytic leukemia patients with 13q14 deletion.

scientific article published on 14 October 2010

Integrative high-resolution microarray analysis of human myeloma cell lines reveals deregulated miRNA expression associated with allelic imbalances and gene expression profiles.

scientific article published on June 2009

Long Non-Coding RNAs in Multiple Myeloma

scientific article published in February 2018

Long non-coding RNA NEAT1 shows high expression unrelated to molecular features and clinical outcome in multiple myeloma

scientific article published on 13 September 2018

Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma

scientific article published on 19 August 2019

Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine

scientific article

Molecular and transcriptional characterization of 17p loss in B-cell chronic lymphocytic leukemia

scientific article published on 01 September 2008

Molecular and transcriptional characterization of the novel 17p11.2-p12 amplicon in multiple myeloma.

scientific article published on December 2007

Molecular characterization of human multiple myeloma cell lines by integrative genomics: insights into the biology of the disease.

scientific article published on March 2007

Molecular classification of multiple myeloma: a distinct transcriptional profile characterizes patients expressing CCND1 and negative for 14q32 translocations.

scientific article

Molecular spectrum of BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias: implication for MEK-ERK pathway activation

scientific article

Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability

scientific article published on 05 November 2020

Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells.

scientific article

NEAT1 Long Isoform Is Highly Expressed in Chronic Lymphocytic Leukemia Irrespectively of Cytogenetic Groups or Clinical Outcome

scientific article published on 13 March 2020

Overexpression of HOXB7 and homeobox genes characterizes multiple myeloma patients lacking the major primary immunoglobulin heavy chain locus translocations

article

Relevance of Ras gene mutations in the context of the molecular heterogeneity of multiple myeloma.

scientific article published on March 2007

Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.

scientific article

Small nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia

scientific article

The expression pattern of small nucleolar and small Cajal body-specific RNAs characterizes distinct molecular subtypes of multiple myeloma.

scientific article

The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide.

scientific article published on 25 October 2010

Transcriptional characterization of a prospective series of primary plasma cell leukemia revealed signatures associated with tumor progression and poorer outcome.

scientific article published on 18 April 2013

Transcriptional features of multiple myeloma patients with chromosome 1q gain

scientific article published on 22 February 2007

Upregulation of translational machinery and distinct genetic subgroups characterise hyperdiploidy in multiple myeloma

scientific article

lncRNA profiling in early-stage chronic lymphocytic leukemia identifies transcriptional fingerprints with relevance in clinical outcome

scientific article published on 9 September 2016

miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma.

scientific article published on 08 February 2016

microRNAome Expression in Chronic Lymphocytic Leukemia: Comparison with Normal B-cell Subsets and Correlations with Prognostic and Clinical Parameters

scientific article published on 10 June 2014

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