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List of works by Vern L. Schramm

8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases

scientific article

A Complex of Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase, Transition State Analogue, and Nucleophilic Water Identified by Mass Spectrometry ⬇️

scientific article published on January 12, 2012

A High-Affinity Adenosine Kinase from Anopheles gambiae

scientific article

A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori

scientific article

A beta-fluoroamine inhibitor of purine nucleoside phosphorylase

scientific article published in September 2008

A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT

scientific article

A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers

scientific article published on 4 June 2007

Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase

scientific article published on 3 July 2003

Activating the phosphate nucleophile at the catalytic site of purine nucleoside phosphorylase: a vibrational spectroscopic study.

scientific article

Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.

scientific article

Active site contacts in the purine nucleoside phosphorylase--hypoxanthine complex by NMR and ab initio calculations.

scientific article published in December 2004

Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase

scientific article

Acyclic Ribooxacarbenium Ion Mimics as Transition State Analogues of Human and Malarial Purine Nucleoside Phosphorylases

scientific article published on 11 May 2007

Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

scientific article published on 5 March 2013

Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase

scientific article published on June 2009

Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase

scientific article

Anopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition

scientific article

Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase

scientific article published on 10 March 2011

Assignment of downfield proton resonances in purine nucleoside phosphorylase immucillin-H complex by saturation-transferred NOEs.

scientific article

Atomic detail of chemical transformation at the transition state of an enzymatic reaction

scientific article

Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase

scientific article

Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases

scientific article published on 6 February 2008

Binding Isotope Effects for para-Aminobenzoic Acid with Dihydropteroate Synthase from Staphylococcus aureus and Plasmodium falciparum

scientific article

Binding isotope effects: boon and bane

scientific article

Catalytic site conformations in human PNP by 19F-NMR and crystallography

scientific article

Catalytic site cooperativity in dimeric methylthioadenosine nucleosidase

scientific article published on 21 February 2014

Characterizing DNA Methyltransferases With An Ultrasensitive Luciferase-Linked Continuous Assay ⬇️

scientific article published on May 16, 2011

Circular DNA and DNA/RNA hybrid molecules as scaffolds for ricin inhibitor design

scientific article

Climate change and the integrity of science

scientific article

Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration

scientific article

Conformational Dynamics in Human Purine Nucleoside Phosphorylase with Reactants and Transition-State Analogues ⬇️

scientific article published on October 11, 2010

Conformational Freedom in Tight Binding Enzymatic Transition-State Analogues ⬇️

scientific article published on 08 August 2013

Conformational states of human purine nucleoside phosphorylase at rest, at work, and with transition state analogues

scientific article

Continuous Fluorescence Assays for Reactions Involving Adenine

scientific article

Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase

scientific article published on September 2010

Detecting ricin: sensitive luminescent assay for ricin A-chain ribosome depurination kinetics

scientific article

Detection of an abasic site in RNA with stem-loop DNA beacons: application to an activity assay for Ricin Toxin A-Chain

scientific article

Distortional binding of transition state analogs to human purine nucleoside phosphorylase probed by magic angle spinning solid-state NMR.

scientific article published on 16 September 2013

Effect of dietary p-aminobenzoic acid on murine Plasmodium yoelii infection

scientific article published on 14 November 2003

Electrophilic aromatic selenylation: new OPRT inhibitors

scientific article

Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.

scientific article published on 16 June 2005

Enhanced Antibiotic Discovery by PROSPECTing

scientific article published on 09 August 2019

Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.

scientific article published on 7 November 2011

Enzymatic Transition States and Drug Design

scientific article published on 18 October 2018

Enzymatic transition states and dynamic motion in barrier crossing

scientific article

Enzyme homologues have distinct reaction paths through their transition states

scientific article

Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum.

scientific article published on 17 September 2008

Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.

scientific article

Femtomolar inhibitors bind to 5'-methylthioadenosine nucleosidases with favorable enthalpy and entropy.

scientific article

Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli

scientific article published on 04 March 2005

Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme

scientific article published on 7 November 2011

Four generations of transition-state analogues for human purine nucleoside phosphorylase.

scientific article

Ground-State Destabilization in Orotate Phosphoribosyltransferases by Binding Isotope Effects ⬇️

scientific article published on May 6, 2011

Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.

scientific article

Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase.

scientific article

Human DNMT1 transition state structure

scientific article published on 29 February 2016

Hydride Transfer in DHFR by Transition Path Sampling, Kinetic Isotope Effects, and Heavy Enzyme Studies

scientific article published on 10 December 2015

Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis

scientific article (publication date: December 2015)

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro

scientific article

Immucillins in Infectious Diseases

scientific article

Immucillins in custom catalytic-site cavities

scientific article published on 19 August 2008

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

scientific article

Inhibition and Structure of Trichomonas vaginalis Purine Nucleoside Phosphorylase with Picomolar Transition State Analogues †

scientific article

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues

scientific article published on 01 November 2021

Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state.

scientific article

Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states

scientific article

Insight into catalytically relevant correlated motions in human purine nucleoside phosphorylase

scientific article published in January 2006

Intracellular rebinding of transition-state analogues provides extended in vivo inhibition lifetimes on human purine nucleoside phosphorylase.

scientific article published on 9 August 2017

Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels.

scientific article published on 18 June 2018

Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases

scientific article published in May 2003

Isotope-specific and amino acid-specific heavy atom substitutions alter barrier crossing in human purine nucleoside phosphorylase

scientific article

Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N-Methyltransferase.

scientific article published on 20 December 2016

Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Plasmodium falciparum.

scientific article published on 13 November 2017

Leaving Group Activation and Pyrophosphate Ionic State at the Catalytic Site of Plasmodium falciparum Orotate Phosphoribosyltransferase ⬇️

scientific article published on November 10, 2010

Loop-tryptophan human purine nucleoside phosphorylase reveals submillisecond protein dynamics

scientific article

Luciferase-based assay for adenosine: application to S-adenosyl-L-homocysteine hydrolase.

scientific article published on 28 March 2012

Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity

scientific article (publication date: September 2012)

Mass Modulation of Protein Dynamics Associated with Barrier Crossing in Purine Nucleoside Phosphorylase

scientific article published on December 2012

Mechanism-based inhibitors of CD38: a mammalian cyclic ADP-ribose synthetase

scientific article published in July 2002

Methylthioadenosine Deaminase in an Alternative Quorum Sensing Pathway in Pseudomonas aeruginosa

scientific article

Methylthioinosine Phosphorylase from Pseudomonas aeruginosa . Structure and Annotation of a Novel Enzyme in Quorum Sensing ⬇️

scientific article published on January 25, 2011

Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics

scientific article published on 29 February 2016

Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase †

scientific article

New Antibiotic Candidates against Helicobacter pylori

scientific article

Oligonucleotide transition state analogues of saporin L3.

scientific article

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase

scientific article (publication date: 27 May 2003)

Phosphate activation in the ground state of purine nucleoside phosphorylase

scientific article

Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases

scientific article

Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A

scientific article

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model

scientific article (publication date: 2011)

Plasmodium falciparum purine nucleoside phosphorylase is critical for viability of malaria parasites

scientific article published on 28 October 2008

Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function

scientific article published on 23 February 2004

Promoting Vibrations and the Function of Enzymes. Emerging Theoretical and Experimental Convergence

scientific article published on 2 April 2018

Promoting vibrations in human purine nucleoside phosphorylase. A molecular dynamics and hybrid quantum mechanical/molecular mechanical study

scientific article published in December 2004

Protein Mass-Modulated Effects in Alkaline Phosphatase

scientific article published on 07 January 2021

Protein mass-modulated effects in the catalytic mechanism of dihydrofolate reductase: beyond promoting vibrations

scientific article

Purine and Pyrimidine Pathways as Targets in Plasmodium falciparum ⬇️

scientific article published on January 1, 2011

Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase

scientific article published on 12 November 2001

Pyrophosphate activation in hypoxanthine--guanine phosphoribosyltransferase with transition state analogue

scientific article

Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases

scientific article published on June 2010

Remote mutations alter transition-state structure of human purine nucleoside phosphorylase

scientific article

Remote mutations and active site dynamics correlate with catalytic properties of purine nucleoside phosphorylase

scientific article published on 30 January 2008

Ribocation transition state capture and rebound in human purine nucleoside phosphorylase

scientific article published in September 2009

Ribosyl geometry in the transition state of Streptococcus pneumoniae methylthioadenosine nucleosidase from the 3'-(2)H kinetic isotope effect

scientific article published on 12 August 2008

Ricin A-chain activity on stem-loop and unstructured DNA substrates

scientific article

Ricin A-chain substrate specificity in RNA, DNA, and hybrid stem-loop structures

scientific article

SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates

scientific article published on April 2004

Salmonella enterica MTAN at 1.36 Å Resolution: A Structure-Based Design of Tailored Transition State Analogs

scientific article

Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase

scientific article published on July 2005

Second-sphere amino acids contribute to transition-state structure in bovine purine nucleoside phosphorylase

scientific article

Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase

scientific article published on 28 March 2019

Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry

scientific article published in August 2003

Small molecule inhibitors targeting the interaction of ricin toxin A subunit with ribosomes

scientific article published on 19 May 2020

Soapwort Saporin L3 Expression in Yeast, Mutagenesis, and RNA Substrate Specificity

scientific article

Structural Insights into Intermediate Steps in the Sir2 Deacetylation Reaction

scientific article

Structural and Metabolic Specificity of Methylthiocoformycin for Malarial Adenosine Deaminases

scientific article

Structural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine pathway.

scientific article (publication date: 14 November 2014)

Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase

scientific article published on 01 May 2006

Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

scientific article published on 03 March 2005

Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae

scientific article published on October 2006

Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases

scientific article published on 26 January 2006

Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1

scientific article published on 24 March 2022

Synthesis of 5'-methylthio coformycins: specific inhibitors for malarial adenosine deaminase

scientific article published on 8 May 2007

Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases

Synthesis of a Transition State Analogue Inhibitor of Purine Nucleoside Phosphorylase via the Mannich Reaction

scientific article published on 01 October 2003

Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase

scientific article published on 27 November 2017

Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase

scientific article published in November 2003

Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins

scientific article (publication date: 11 March 2005)

Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase

scientific article

The Immucillins: Design, Synthesis and Application of Transition- State Analogues.

scientific article published on 20 August 2015

The Transition-State Structure for Human MAT2A from Isotope Effects.

scientific article published on 7 September 2017

The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase

The transition to magic bullets – transition state analogue drug design

scientific article published on 28 August 2018

Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase

scientific article published on 8 November 2013

Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase

scientific article published on February 2009

Tight binding enantiomers of pre-clinical drug candidates

scientific article

Transition Path Sampling Study of the Reaction Catalyzed by Purine Nucleoside Phosphorylase

scientific article

Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

scientific article published on 24 August 2017

Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases

scientific article published on 11 February 2020

Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase.

scientific article published on 5 September 2017

Transition State Structure and Inhibition of Rv0091, a 5'-Deoxyadenosine/5'-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

scientific article published on 28 March 2016

Transition State Structure of RNA Depurination by Saporin L3.

scientific article

Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing

scientific article

Transition state analogue discrimination by related purine nucleoside phosphorylases

scientific article

Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes

scientific article published in January 2007

Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics

scientific article

Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum

scientific article published on 13 November 2001

Transition state analogues in quorum sensing and SAM recycling

scientific article published on January 2008

Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins

scientific article

Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases

scientific article published on 24 October 2013

Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein

scientific article published in October 2009

Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases.

scientific article published in February 2004

Transition state analysis of the arsenolytic depyrimidination of thymidine by human thymidine phosphorylase

scientific article published on 3 February 2011

Transition state analysis of thymidine hydrolysis by human thymidine phosphorylase

scientific article published on September 2010

Transition state structure for ADP-ribosylation of eukaryotic elongation factor 2 catalyzed by diphtheria toxin

scientific article published in February 2004

Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues

scientific article

Transition state structure of E. coli tRNA-specific adenosine deaminase

scientific article published on 2 February 2008

Transition states and inhibitors of the purine nucleoside phosphorylase family

scientific article

Transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases

scientific article published on April 2009

Transition states of native and drug-resistant HIV-1 protease are the same

scientific article

Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase

scientific article published on 19 October 2018

Transition-State Analogues of Phenylethanolamine N-methyltransferase

scientific article published on 23 July 2020

Transition-State Analysis of Trypanosoma cruzi Uridine Phosphorylase-Catalyzed Arsenolysis of Uridine ⬇️

scientific article published on June 3, 2011

Transition-State Inhibitors of Purine Salvage and Other Prospective Enzyme Targets in Malaria ⬇️

scientific article published on July 1, 2013

Transition-state analysis of 2-O-acetyl-ADP-ribose hydrolysis by human macrodomain 1.

scientific article

Transition-state analysis of S. pneumoniae 5'-methylthioadenosine nucleosidase

scientific article published on 14 February 2007

Transition-state interactions revealed in purine nucleoside phosphorylase by binding isotope effects

scientific article published on 30 January 2008

Transition-state structure of human 5'-methylthioadenosine phosphorylase

scientific article published on November 2006

Transition-state structure of neisseria meningitides 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

scientific article published on 23 October 2007

Transition-state variation in human, bovine, and Plasmodium falciparum adenosine deaminases

scientific article published on 31 May 2007

Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.

scientific article published on 08 October 2009

Tryptophan-free human PNP reveals catalytic site interactions

scientific article published on 13 February 2008

Uridine Phosphorylase from Trypanosoma cruzi: Kinetic and Chemical Mechanisms ⬇️

scientific article published on September 27, 2011

Vinyldeoxyadenosine in a sarcin-ricin RNA loop and its binding to ricin toxin a-chain

scientific article published on 4 May 2007

l -Enantiomers of Transition State Analogue Inhibitors Bound to Human Purine Nucleoside Phosphorylase

scientific article

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