List of works - Valeria Pittalà

(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties

scientific article published on 8 December 2017

(+)-cis-N-Ethyleneamino-N-normetazocine Derivatives. Novel and Selective σ Ligands with Antagonist Properties ⬇️

scientific article published on May 7, 1998

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors.

scientific article published on 14 November 2005

3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective alpha(1)-adrenoceptor ligands.

scientific article

5-HT7 receptor ligands: recent developments and potential therapeutic applications.

scientific article

A facile synthesis of new 2-carboxamido-3-carboxythiophene and 4,5,6,7-tetrahydro-2-carboxamido-3-carboxythieno[2,3-c]pyridine derivatives as potential endothelin receptors ligands.

scientific article published in September 2005

A focus on heme oxygenase-1 (HO-1) inhibitors

scientific article published on January 2013

Analysis of mechanisms for memory enhancement using novel and potent 5-HT1A receptor ligands.

scientific article published on 29 April 2015

Antioxidant activity and phenolic content of microwave-assisted Solanum melongena extracts

scientific article published on 09 February 2014

Antioxidant properties of hydroxycinnamic acids: a review of structure- activity relationships

scientific article published in January 2013

Antitumor properties of substituted (αE)-α-(1H-indol-3-ylmethylene)benzeneacetic acids or amides.

scientific article published on 27 June 2013

Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors

scientific article published on 21 September 2017

Curcumin⁻Copper Complex Nanoparticles for the Management of Triple-Negative Breast Cancer

scientific article published on 01 November 2018

Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR.

scientific article published on 28 June 2016

Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis

scientific article published on 27 August 2018

Effects of Novel Nitric Oxide-Releasing Molecules against Oxidative Stress on Retinal Pigmented Epithelial Cells

scientific article published on 12 October 2017

Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions.

scientific article

Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation.

scientific article published on 19 February 2015

Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties.

scientific article published on 26 June 2013

Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors.

scientific article published on 14 July 2017

Heme Oxygenase Inhibition Sensitizes Neuroblastoma Cells to Carfilzomib

scientific article published on 10 June 2018

Heme Oxygenase-1 Inhibition Sensitizes Human Prostate Cancer Cells towards Glucose Deprivation and Metformin-Mediated Cell Death.

scientific article published on 27 May 2019

Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors

scientific article published on 17 September 2019

Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia.

scientific article published on 20 July 2017

High affinity ligands and potent antagonists for the α1D-adrenergic receptor. Novel 3,8-disubstituted [1]benzothieno[3,2-d]pyrimidine derivatives.

scientific article

Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands

scientific article published on 25 August 2017

Identification of potentially potent Heme Oxygenase-1 inhibitors through 3D-QSAR coupled to scaffold hopping analysis.

scientific article

Latest advances towards the discovery of 5-HT(7) receptor ligands

scientific article

New 1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives: analogues of HEAT as ligands for the alpha1-adrenergic receptor subtypes.

scientific article published on 2 May 2006

New Arylethanolimidazole Derivatives as HO-1 Inhibitors with Cytotoxicity against MCF-7 Breast Cancer Cells

scientific article published on 11 March 2020

New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT7 and 5-HT1A receptor ligands: Synthesis, structure-activity relationships, and molecular modeling studies

scientific article published on 27 December 2016

New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation

scientific article

New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: high affinity ligands for the alpha(1)-adrenoceptor subtypes

scientific article published on 05 October 2006

Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity

scientific article published on 20 November 2018

Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands for α₁-adrenoceptor subtypes.

scientific article

Novel Caffeic Acid Phenethyl Ester (Cape) Analogues as Inducers of Heme Oxygenase-1.

scientific article published on 10 February 2017

Novel Heme Oxygenase-1 (HO-1) Inducers Based on Dimethyl Fumarate Structure

scientific article published on 15 December 2020

Novel Sigma Receptor Ligand-Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect.

scientific article published on 27 November 2017

Novel Sigma-1 receptor antagonists: from opioids to small molecules: what is new?

scientific article published on 29 November 2017

Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation

scientific article published on 18 May 2018

Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.

scientific article published on 7 April 2015

Novel inhibitors of nitric oxide synthase with antioxidant properties

scientific article published on 11 January 2012

Nrf2 as regulator of innate immunity: A molecular Swiss army knife!

scientific article published on 22 December 2017

Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors

scientific article published on 9 February 2018

Progress in the development of more effective and safer analgesics for pain management

scientific article published on 16 September 2019

Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application

scientific article published on 12 February 2019

Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats

scientific article published on 17 May 2019

Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents.

scientific article

Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries.

scientific article published on 30 June 2017

S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands

scientific article (publication date: 2017)

Serotonin 5-HT3 and 5-HT4 ligands: an update of medicinal chemistry research in the last few years.

scientific article published on January 2010

Structure–Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update

scientific article published on 05 June 2018

Structure–activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT7 and 5-HT1A receptor ligands

scientific article published on 07 August 2014

Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF-7 and MDA-MB-231

scholarly article in Journal of Chemistry, 2017

Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands

scientific article published on 17 April 2020

Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands

scientific article published on 25 February 2015

Synthesis and endothelin receptor binding affinity of a novel class of 2-substituted-4-aryl-3-quinolinecarboxylic acid derivatives.

scientific article published in March 2008

Synthesis and endothelin receptors binding affinity of new 1,3,5- substituted pyrrole-2-carboxylic acid derivatives

scientific article published in January 2015

Synthesis and evaluation of haloperidol metabolite II prodrugs as anticancer agents.

scientific article published on 4 September 2017

Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors

scientific article published on 21 June 2011

Synthesis of 1,2,4-triazole derivatives: binding properties on endothelin receptors.

scientific article published in November 2007

Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands.

scientific article published in April 2005

Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.

scientific article published on 4 July 2008

Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands

scientific article published on 21 April 2019

Targeting STATs in neuroinflammation: The road less traveled!

scientific article published on 11 December 2018

Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines

scientific article published on 17 September 2018

The Effect of Silver Nanoparticles on Learning, Memory and Social Interaction in BALB/C Mice

scientific article published on 08 January 2019

The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis

scientific article published in January 2023

Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity

scientific article

[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT7 receptor

scientific article published on 10 September 2019

List of works by Valeria Pittalà

(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties

(+)-cis-N-Ethyleneamino-N-normetazocine Derivatives. Novel and Selective σ Ligands with Antagonist Properties ⬇️

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors.

3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective alpha(1)-adrenoceptor ligands.

5-HT7 receptor ligands: recent developments and potential therapeutic applications.

A facile synthesis of new 2-carboxamido-3-carboxythiophene and 4,5,6,7-tetrahydro-2-carboxamido-3-carboxythieno[2,3-c]pyridine derivatives as potential endothelin receptors ligands.

A focus on heme oxygenase-1 (HO-1) inhibitors

Analysis of mechanisms for memory enhancement using novel and potent 5-HT1A receptor ligands.

Antioxidant activity and phenolic content of microwave-assisted Solanum melongena extracts

Antioxidant properties of hydroxycinnamic acids: a review of structure- activity relationships

Antitumor properties of substituted (αE)-α-(1H-indol-3-ylmethylene)benzeneacetic acids or amides.

Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors

Curcumin⁻Copper Complex Nanoparticles for the Management of Triple-Negative Breast Cancer

Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR.

Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis

Effects of Novel Nitric Oxide-Releasing Molecules against Oxidative Stress on Retinal Pigmented Epithelial Cells

Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions.

Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation.

Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties.

Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors.

Heme Oxygenase Inhibition Sensitizes Neuroblastoma Cells to Carfilzomib

Heme Oxygenase-1 Inhibition Sensitizes Human Prostate Cancer Cells towards Glucose Deprivation and Metformin-Mediated Cell Death.

Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors

Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia.

High affinity ligands and potent antagonists for the α1D-adrenergic receptor. Novel 3,8-disubstituted [1]benzothieno[3,2-d]pyrimidine derivatives.

Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands

Identification of potentially potent Heme Oxygenase-1 inhibitors through 3D-QSAR coupled to scaffold hopping analysis.

Latest advances towards the discovery of 5-HT(7) receptor ligands

New 1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives: analogues of HEAT as ligands for the alpha1-adrenergic receptor subtypes.

New Arylethanolimidazole Derivatives as HO-1 Inhibitors with Cytotoxicity against MCF-7 Breast Cancer Cells

New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT7 and 5-HT1A receptor ligands: Synthesis, structure-activity relationships, and molecular modeling studies

New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation

New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: high affinity ligands for the alpha(1)-adrenoceptor subtypes

Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity

Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands for α₁-adrenoceptor subtypes.

Novel Caffeic Acid Phenethyl Ester (Cape) Analogues as Inducers of Heme Oxygenase-1.

Novel Heme Oxygenase-1 (HO-1) Inducers Based on Dimethyl Fumarate Structure

Novel Sigma Receptor Ligand-Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect.

Novel Sigma-1 receptor antagonists: from opioids to small molecules: what is new?

Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation

Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.

Novel inhibitors of nitric oxide synthase with antioxidant properties

Nrf2 as regulator of innate immunity: A molecular Swiss army knife!

Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors

Progress in the development of more effective and safer analgesics for pain management

Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application

Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats

Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents.

Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries.

S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands

Serotonin 5-HT3 and 5-HT4 ligands: an update of medicinal chemistry research in the last few years.

Structure–Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update

Structure–activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT7 and 5-HT1A receptor ligands

Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF-7 and MDA-MB-231

Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands

Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands

Synthesis and endothelin receptor binding affinity of a novel class of 2-substituted-4-aryl-3-quinolinecarboxylic acid derivatives.

Synthesis and endothelin receptors binding affinity of new 1,3,5- substituted pyrrole-2-carboxylic acid derivatives

Synthesis and evaluation of haloperidol metabolite II prodrugs as anticancer agents.

Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors

Synthesis of 1,2,4-triazole derivatives: binding properties on endothelin receptors.

Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands.

Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.

Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands

Targeting STATs in neuroinflammation: The road less traveled!

Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines

The Effect of Silver Nanoparticles on Learning, Memory and Social Interaction in BALB/C Mice

The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis

Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity

[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT7 receptor