List of works - Helen M Sheldrake

Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

scientific article

Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.

scientific article published on January 2009

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins

scientific article published on 15 April 2013

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

scientific article published on 27 June 2019

Function and antagonism of beta3 integrins in the development of cancer therapy.

scientific article published on June 2009

Functionalized cyclobutenes via multicomponent thermal [2 + 2] cycloaddition reactions

scientific article published on 01 September 2005

Intramolecular thermal stepwise [2 + 2] cycloadditions: investigation of a stereoselective synthesis of [n.2.0]-bicyclolactones

scientific article published on 20 September 2016

Kinetic and thermodynamic control of axial chirality in biaryl-derived fused oxazolidine lactams exploiting a centre-axis relay of unit efficiency.

scientific article published in August 2007

Manganese(III) acetate mediated synthesis of oxygen heterocycles. Influence of copper(II) salts on product distribution.

scientific article published on 2 March 2004

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

scientific article published on 14 October 2011

RGD-Binding Integrins in Head and Neck Cancers

scientific article

RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis.

scientific article published on 26 October 2012

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

scientific article published on 26 July 2013

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity

scientific article published on 30 September 2015

Strategies to inhibit tumor associated integrin receptors: rationale for dual and multi-antagonists.

scientific article published on 07 March 2014

Synthesis of the originally proposed structures of elatenyne and an enyne from Laurencia majuscula

scientific article published on 20 November 2008

The changing faces of halogenated marine natural products: total synthesis of the reported structures of elatenyne and an enyne from Laurencia majuscula

scientific article published on 01 November 2006

List of works by Helen M Sheldrake