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List of works by Tiago Fleming Outeiro

(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis.

scientific article published on 3 May 2018

A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies

scientific article

A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies

scientific article published on 22 February 2017

A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model

scientific article published on 15 January 2020

A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS.

scientific article

A2A R-induced transcriptional deregulation in astrocytes: An in vitro study

scientific article published on 22 July 2019

Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast.

scientific article published on October 2011

Alpha-Synuclein Antibody Characterization: Why Semantics Matters

scientific article published on 07 January 2021

Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson's Disease

scientific article published in January 2018

Alpha-synuclein and intracellular trafficking: impact on the spreading of Parkinson's disease pathology.

scientific article published on 25 April 2013

Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function

scientific article published on 06 August 2018

Alpha-synuclein oligomerization and aggregation: a model will always be a model

scientific article published on 09 December 2020

Alpha-synuclein: from secretion to dysfunction and death ⬇️

scientific article published on July 19, 2012

Alzheimer's disease: the quest to understand complexity.

scientific article published on January 2010

Amyloidogenesis: FlAsH illuminates Aβ aggregation.

scientific article

Analysis of Protein Oligomeric Species by Sucrose Gradients

scientific article published in January 2016

Are genetic and idiopathic forms of Parkinson's disease the same disease?

scientific article published on 08 December 2019

Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.

scientific article

Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington's and Parkinson's diseases.

scientific article published on 17 March 2011

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity

article

Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation.

scientific article published in March 2018

C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.

scientific article

Cancer and Parkinson's Disease: Common Targets, Emerging Hopes

scientific article published on 21 December 2020

Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain

scientific article

Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease.

scientific article

Cellular models of alpha-synuclein toxicity and aggregation

scientific article published on 30 July 2019

Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease.

scientific article published on April 2014

Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1

scientific article published on 03 December 2019

Contribution of Neuroepigenetics to Huntington's Disease.

scientific article published on 30 January 2017

Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics

scientific article published on 6 February 2017

Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease

scientific article

Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells.

scientific article published on 16 May 2008

Current and future therapeutic strategies for Parkinson's disease.

scientific article

Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies

scientific article published on 01 July 2019

DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization

scientific article published on 03 March 2021

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease

scientific article

DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease.

scientific article published on 26 September 2013

Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View

scientific article published on 28 March 2018

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy

scientific article published on 15 June 2019

Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin.

scientific article published on 8 July 2016

Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice ⬇️

scientific article published on July 19, 2011

Dopamine-induced conformational changes in alpha-synuclein

scientific article

Drug discovery for CNS disorders: from bench to bedside

scientific article published on 01 December 2010

Editorial on special topic: sirtuins in metabolism, aging, and disease.

scientific article published on 24 April 2012

Editorial: Molecular Chaperones and Neurodegeneration.

scientific article published on 11 October 2017

Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases

scientific article published on 01 January 2019

Effects of alpha-synuclein post-translational modifications on metal binding

scientific article published on 09 July 2019

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells

scientific article

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.

scientific article published on 05 October 2016

Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice.

scientific article published on 21 June 2012

Epigenetics in Parkinson's Disease

scientific article published in January 2017

Epigenetics in neurodegeneration: a new layer of complexity.

scientific article published on 22 August 2010

Epigenetics of the Synapse in Neurodegeneration

scientific article published on 23 August 2019

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

scientific article published on August 2012

From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease

scientific article published on 16 November 2020

Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity. ⬇️

scientific article published on 2 November 2010

Glycation in Huntington's Disease: A Possible Modifier and Target for Intervention

scientific article published on 01 January 2019

Glycation in Parkinson's disease and Alzheimer's disease

scientific article published on 4 March 2016

Glycation potentiates neurodegeneration in models of Huntington's disease.

scientific article

Guidelines and recommendations on yeast cell death nomenclature.

scientific article published in January 2018

Harnessing the power of yeast to unravel the molecular basis of neurodegeneration.

scientific article published on 08 May 2013

IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function.

scientific article published on 22 June 2017

Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice

scientific article

Identification and quantitative analysis of human transthyretin variants in human serum by Fourier transform ion-cyclotron resonance mass spectrometry.

scientific article

Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats

scientific article published on 13 January 2017

Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model

scientific article published on 28 November 2019

Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast

scientific article published on 01 December 2018

Imaging Protein Oligomerization in Neurodegeneration Using Bimolecular Fluorescence Complementation

scientific article published on 01 January 2012

Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice.

scientific article

Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice.

scientific article

Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models

scientific article published on 7 September 2017

In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies

scientific article published on 15 May 2019

Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats.

scientific article

Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions

scientific article published on 17 September 2014

Investigating targets for neuropharmacological intervention by molecular dynamics simulations

scientific article published on 13 May 2019

LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?

scientific article published on 13 May 2019

Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.

scientific article published on January 2013

Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells

scientific article

Mechanisms of disease II: cellular protein quality control.

scientific article published on March 2007

Membrane binding, internalization, and sorting of alpha-synuclein in the cell

scientific article published on 14 August 2018

Modulating Alzheimer's disease through caffeine: a putative link to epigenetics.

scientific article

Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies

scientific article published on 30 October 2019

Monitoring α-synuclein multimerization in vivo

scientific article published on 25 September 2018

Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways

scientific article published on 17 August 2016

Neurotrophic Factors as a Protective Strategy in Parkinsons Disease ⬇️

scientific article published on December 1, 2010

Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein

scientific article published on 01 January 2019

Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo.

scientific article published on 20 September 2013

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.

scientific article published on 19 March 2013

Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells.

scientific article

Pharmacological Modulators of Tau Aggregation and Spreading

scientific article published on 13 November 2020

Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models.

scientific article published on 5 April 2007

Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease.

scientific article

Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.

scientific article

Protein phosphorylation in neurodegeneration: friend or foe?

scientific article published on 13 May 2014

SARS-CoV-2 as a trigger of neurodegeneration: thinking ahead

scientific article published on 05 June 2020

SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration

scientific article published on 15 April 2020

SIRT1 and SIRT2: emerging targets in neurodegeneration

scientific article

SIRT2 in age-related neurodegenerative disorders.

scientific article published on 3 March 2018

Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells

scientific article published on 04 October 2018

Seeding variability of different alpha synuclein strains in synucleinopathies

scientific article published on 27 March 2019

Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration

scientific article published on 13 November 2018

Serum lipid alterations in GBA-associated Parkinson's disease.

scientific article

Simple is good: yeast models of neurodegeneration.

scientific article published on December 2010

Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway

scientific article published on 10 April 2017

Sirtuins: common targets in aging and in neurodegeneration.

scientific article published on October 2010

Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells

scientific article published on 22 September 2015

Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

article published in the Proceedings of the National Academy of Sciences of the United States of America

Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation

scientific article published on 19 December 2014

Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage

scientific article published on 24 March 2017

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved

scientific article published on 25 April 2019

Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies

scientific article published on 18 July 2015

Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding

scientific article published on 15 November 2018

Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes.

scientific article published on 18 October 2011

Synuclein Meeting 2019: where we are and where we need to go

scientific article published on 01 September 2019

Synucleinopathies: Where we are and where we need to go

scientific article published on 20 January 2020

Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia

scientific article published on 01 November 2019

Tau deletion promotes brain insulin resistance

scientific article

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

scientific article

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.

scientific article published on 06 September 2013

The Parkinson’s Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration

scientific article published on 19 April 2018

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.

scientific article published on 11 August 2016

The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease.

scientific article published on May 2013

The courage to change science

scientific article published on 20 February 2020

The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation.

scientific article published on 9 December 2016

The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus

scientific article published on 4 December 2017

The role of LRRK2 in cell signalling

scientific article published on 21 December 2018

The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism

scientific article published on 01 August 2019

The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1

scientific article published on 01 September 2018

The yin and yang of α-synuclein-associated epigenetics in Parkinson's disease.

scientific article published on 31 August 2016

The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival.

scientific article published on 31 October 2012

Therapeutic role of sirtuins in neurodegenerative disease.

scientific article published on 07 March 2008

Traffic jams and the complex role of α-Synuclein aggregation in Parkinson disease

scientific article published on 17 June 2016

Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism

scientific article published on 22 February 2019

Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death

scientific article

Visualization of cell-to-cell transmission of mutant huntingtin oligomers

scientific article

Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase

scientific article

Yeast models of Parkinson's disease-associated molecular pathologies.

scientific article published on 16 February 2017

Yeast-Based Screens to Target Alpha-Synuclein Toxicity

scientific article published on 01 January 2019

Zebrafish as an Animal Model for Drug Discovery in Parkinson's Disease and Other Movement Disorders: A Systematic Review.

scientific article

α-Synuclein modifies huntingtin aggregation in living cells

scientific article

α-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1

scientific article published on 11 April 2019

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B.

scientific article

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