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List of works by V. Craig Jordan

"The only true antiestrogen is no estrogen".

scientific article published on December 1990

'Who do you think you are?'.

scientific article published on 8 May 2014

3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha

scientific article published on February 2006

4-Hydroxytamoxifen, an active metabolite of tamoxifen, does not alter the radiation sensitivity of MCF-7 breast carcinoma cells irradiated in vitro

scientific article published on 01 January 1994

5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of tamoxifen in breast cancer cells

scientific article published on 7 March 2013

50th ANNIVERSARY OF THE FIRST CLINICAL TRIAL WITH ICI 46,474 (TAMOXIFEN): THEN WHAT HAPPENED?

scientific article published on 01 November 2020

A Raloxifene Withdrawal Response: Translational Research, Definitions, and Clinical Applications

scientific article published on 7 June 2016

A Retrospective: On Clinical Studies with 5-Fluorouracil

scientific article published on 01 February 2016

A STAR is born

scientific article published on 01 August 2006

A century of deciphering the control mechanisms of sex steroid action in breast and prostate cancer: the origins of targeted therapy and chemoprevention

scientific article

A comparison, at the cellular and subcellular levels, of the effects of tamoxifen and oestradiol benzoate on the immature rat uterus [proceedings] ⬇️

scientific article published on March 1, 1978

A laboratory model to explain the survival advantage observed in patients taking adjuvant tamoxifen therapy

scientific article

A mechanism of drug resistance to tamoxifen in breast cancer

scientific article published in December 2002

A model to describe how a point mutation of the estrogen receptor alters the structure-function relationship of antiestrogens

scientific article published on January 1993

A molecular model for the mechanism of acquired tamoxifen resistance in breast cancer

scientific article

A molecular strategy to control tamoxifen resistant breast cancer

scientific article published on January 1, 1992

A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity ⬇️

scientific article published on November 1, 1977

A mutant receptor as a mechanism of drug resistance to tamoxifen treatment.

scientific article published on June 1995

A naturally occurring estrogen receptor mutation results in increased estrogenicity of a tamoxifen analog

scientific article published on August 1995

A new day dawns: women without oestrogen or is a balance best?

scientific article

A novel 80 kDa human estrogen receptor containing a duplication of exons 6 and 7

scientific article

A phase I study of high-dose tamoxifen for the treatment of refractory malignant gliomas of childhood

scientific article published in July 1997

A pilot study of the effects of short-term tamoxifen therapy on Ki-67 labelling index in women with primary breast cancer

scientific article published on 01 January 2000

A prospective study of variability in mammographic density during the menstrual cycle

scientific article

A risk-benefit assessment of tamoxifen therapy

scientific article

A therapeutic withdrawal can make a strategic advance ⬇️

scientific article published on September 1, 1992

A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers.

scientific article published on 21 November 2017

A(nother) scientific strategy to prevent breast cancer in postmenopausal women by enhancing estrogen-induced apoptosis?

scientific article

ASO Author Reflections: An Optimal Biological Model for Successful Drug Discovery

scientific article published on 17 April 2019

Acceptance of tamoxifen chemoprevention by physicians and women at risk

scientific article published in May 2004

Acquired resistance to selective estrogen receptor modulators (SERMs) in clinical practice (tamoxifen & raloxifene) by selection pressure in breast cancer cell populations

scientific article

Activated estrogens and antiestrogens: a 30-year journey with David Kupfer

scientific article

Activity of the antioestrogen trioxifene against N-Nitrosomethylurea-induced rat mammary carcinomas

scientific article published on 01 August 1981

Advances in endocrine therapy for the treatment and prevention of breast cancer

scientific article published in January 2003

After the menopause: tamoxifen and other new prevention maintenance therapies

scientific article published on 01 June 1997

Agonist activity of antiestrogen-receptor complexes to regulate urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) endogenous gene expression in breast cancer cells ⬇️

scientific article published on March 13, 1998

Allosteric silencing of activating function 1 in the 4-hydroxytamoxifen estrogen receptor complex is induced by substituting glycine for aspartate at amino acid 351.

scientific article

Alteration of endocrine parameters in premenopausal women with breast cancer during long-term adjuvant therapy with tamoxifen as the single agent

scientific article published on 01 October 1991

Alternate antiestrogens and approaches to the prevention of breast cancer.

scientific article published on January 1995

An analysis of tamoxifen-stimulated human carcinomas for mutations in the AF-2 region of the estrogen receptor

scientific article published on August 1996

An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro

scientific article published on 01 April 1983

An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol

scientific article published on December 1992

An estrogen-independent MCF-7 breast cancer cell line which contains a novel 80-kilodalton estrogen receptor-related protein

scientific article

An immobilized antiestrogen binds a specific uterine protein in addition to estrogen receptor proteins

scientific article published on 01 May 1984

An overview of considerations for the testing of tamoxifen as a preventive for breast cancer

scientific article published on September 1995

Analysis of cross-resistance of the selective estrogen receptor modulators arzoxifene (LY353381) and LY117018 in tamoxifen-stimulated breast cancer xenografts.

scientific article published in August 2001

Angela M. Hartley Brodie (1934-2017).

scientific article published in August 2017

Anti-oestrogen action in experimental breast cancer.

scientific article published on January 1980

Anti-oestrogenic activity in compounds related to ethamoxytriphetol (MER 25), clomiphene and MRL 37 ⬇️

scientific article published on June 1, 1973

Antiestrogen stimulated human endometrial cancer growth: laboratory and clinical considerations ⬇️

scientific article published on April 1, 1998

Antiestrogenic Action of Raloxifene and Tamoxifen: Today and Tomorrow ⬇️

scientific article published on July 1, 1998

Antiestrogenic action of toremifene on hormone-dependent, -independent, and heterogeneous breast tumor growth in the athymic mouse

scientific article published on 01 April 1989

Antiestrogenic and antitumor properties of tamoxifen in laboratory animals

scientific article published on 01 October 1976

Antiestrogenic effect of trifluoperazine in mice.

scientific article published in June 1985

Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. Receptor interactions

scientific article

Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 2. Clinical considerations and new agents

scientific article

Antiestrogens and the reduction in circulating cholesterol

scientific article published on 01 August 1996

Antiestrogens: clinical applications of pharmacology

scientific article

Antitumor action of physiological estradiol on tamoxifen-stimulated breast tumors grown in athymic mice.

scientific article

Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model

scientific article published on 01 August 1987

Antitumor actions of toremifene in the 7,12-dimethylbenzanthracene (DMBA)-induced rat mammary tumor model

scientific article published on 01 December 1988

Apoptotic Action of 17 -Estradiol in Raloxifene-Resistant MCF-7 Cells In Vitro and In Vivo ⬇️

scientific article published on November 5, 2003

Are we giving tamoxifen for too long? ⬇️

scientific article published on 01 January 1991

Aromatase inhibitors that regulate estrogen target tissues selectively?

scientific article published in March 2004

Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells.

scientific article published on September 2006

Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levels

scientific article

Avoiding the bad and enhancing the good of soy supplements in breast cancer

scientific article published on 4 September 2014

Beyond raloxifene for the prevention of osteoporosis and breast cancer

scientific article

Binding of [3H] monohydroxytamoxifen in human breast carcinoma cytosols ⬇️

scientific article published on 01 January 1981

Biochemical pharmacology of antiestrogen action

scientific article

Bioluminescence imaging for assessment and normalization in transfected cell arrays

scientific article published on October 2007

Bone mineral density in women with breast cancer treated with adjuvant tamoxifen for at least two years

scientific article published on 01 December 1988

Breast cancer cell apoptosis with phytoestrogens is dependent on an estrogen-deprived state

scientific article (publication date: September 2014)

Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis

scientific article published on 05 December 2008

By looking back we can see the way forward: enhancing the gains achieved with antihormone therapy

scientific article published on 18 December 2008

CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations

scientific article published on 23 September 2013

Changing role of the oestrogen receptor in the life and death of breast cancer cells

scientific article published on December 2003

Characteristics of salivary profiles of oestradiol and progesterone in premenopausal women

scientific article published in July 2005

Characterization of a point mutation in the hormone binding domain of the estrogen receptor from an breast tumor ⬇️

scientific article published on May 1, 1998

Characterization of a receptor-negative, hormone-nonresponsive clone derived from a T47D human breast cancer cell line kept under estrogen-free conditions

scientific article published on November 1990

Characterization of tamoxifen stimulated MCF-7 tumor variants grown in athymic mice

scientific article published on January 1994

Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells

scientific article

Chemoprevention in the 21st century: is a balance best or should women have no estrogen at all?

scientific article published on 01 March 2005

Chemoprevention of breast cancer with selective oestrogen-receptor modulators

scientific article published on 01 January 2007

Chemoprevention of breast cancer: a model for change

scientific article published in January 2002

Chemoprevention of breast cancer: current and future prospects

scientific article

Chemoprevention with antiestrogens: the beginning of the end for breast cancer. Daniel G. Miller Lecture

scientific article published in December 2001

Chemosuppression of breast cancer with long-term tamoxifen therapy

scientific article published on January 1991

Chemosuppression of breast cancer with tamoxifen: laboratory evidence and future clinical investigations

scientific article published on January 1988

Chemotherapy is antihormonal therapy--how much proof do oncologists need?

scientific article published on 01 April 1998

Cloning and characterization of a 77-kDa oestrogen receptor isolated from a human breast cancer cell line

scientific article

Combination hormonal therapy involving aromatase inhibitors in the management of women with breast cancer

scientific article

Comparative antioestrogen action in experimental breast cancer

scientific article published on 01 January 1981

Comparison of the effects of tamoxifen and toremifene on liver and kidney tumor promotion in female rats ⬇️

scientific article published on November 1, 1995

Concerns About Methodology of a Trial Investigating Vaginal Health During Aromatase Inhibitor Therapy for Breast Cancer

Continued breast cancer risk reduction in postmenopausal women treated with raloxifene: 4-year results from the MORE trial. Multiple outcomes of raloxifene evaluation

scientific article

Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse

scientific article published on 01 February 1988

Contrasting subcellular responses to monohydroxytamoxifen and oestradiol benzoate in the immature rat uterus [proceedings]

scientific article

Control of experimental breast cancer by antioestrogenic therapies [proceedings]

scientific article

Control of experimental breast cancer by antioestrogenic therapies [proceedings]

scientific article published in April 1979

Control of the estrogen-like actions of the tamoxifen-estrogen receptor complex by the surface amino acid at position 351.

scientific article

Cooperative effect of gefitinib and fumitremorgin c on cell growth and chemosensitivity in estrogen receptor alpha negative fulvestrant-resistant MCF-7 cells.

scientific article published on November 2006

Correction to: Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis.

scientific article

Cross-resistance of triphenylethylene-type antiestrogens but not ICI 182,780 in tamoxifen-stimulated breast tumors grown in athymic mice

scientific article published on 01 December 2000

Current controversies in breast cancer management

scientific article

Cyclin dependent kinase-9 mediated transcriptional de-regulation of cMYC as a critical determinant of endocrine-therapy resistance in breast cancers

scientific article published on 06 December 2013

DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination

scientific article

Decrease in estradiol-stimulated progesterone receptor production in MCF-7 cells by epidermal growth factor and possible clinical implication for paracrine-regulated breast cancer growth

scientific article published on 01 February 1989

Defining the conformation of the estrogen receptor complex that controls estrogen-induced apoptosis in breast cancer

scientific article published on 07 March 2014

Delayed triggering of oestrogen induced apoptosis that contrasts with rapid paclitaxel-induced breast cancer cell death

scientific article published on 18 February 2014

Delayed triggering of oestrogen induced apoptosis that contrasts with rapid paclitaxel-induced breast cancer cell death

scientific article published on 6 October 2016

Deregulation of estrogen induced telomerase activity in tamoxifen-resistant breast cancer cells

scientific article

Design of an ideal hormone replacement therapy for women

scientific article

Designer Estrogens

scientific article published on 01 October 1998

Determination and pharmacology of a new hydroxylated metabolite of tamoxifen observed in patient sera during therapy for advanced breast cancer.

scientific article published on March 1983

Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer

scientific article published on 13 December 2006

Development and therapeutic options for the treatment of raloxifene-stimulated breast cancer in athymic mice

scientific article

Development of a new prevention maintenance therapy for postmenopausal women

scientific article

Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration ⬇️

scientific article published on September 15, 1988

Differences between estrogen- and antiestrogen-estrogen receptor complexes from human breast tumors identified with an antibody raised against the estrogen receptor.

scientific article published in March 1984

Differential DNase I hypersensitivity reveals factor-dependent chromatin dynamics

scientific article

Differential antiestrogen action in the immature rat uterus: a comparison of hydroxylated antiestrogens with high affinity for the estrogen receptor

scientific article published on 01 September 1983

Differing Perspectives on Breast Cancer Chemoprevention

scientific article published on 01 February 2016

Direct and reversible inhibition of estradiol-stimulated prolactin synthesis by antiestrogens in vitro

scientific article published on 01 April 1983

Distinct molecular conformations of the estrogen receptor alpha complex exploited by environmental estrogens ⬇️

scientific article published on November 1, 2003

Dose-related effects of non-steroidal antioestrogens nad oestrogens on the measurement of cytoplasmic oestrogen receptors in the rat and mouse uterus

scientific article published on July 1, 1978

Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer

scientific article published on 30 October 2020

EGF activates highly selective estrogen-responsive reporter plasmids by an ER-independent pathway

scientific article published on 01 January 2000

Early breast cancer

scientific article published in The Lancet

Effect of Chronic Administration of Mestranol, Tamoxifen, and Toremifene on Hepatic Ploidy in Rats ⬇️

scientific article published on June 1, 1998

Effect of oestradiol benzoate, tamoxifen and monohydroxytamoxifen on immature rat uterine progesterone receptor synthesis and endometrial cell division ⬇️

scientific article published on 01 July 1979

Effect of raloxifene on salivary sex steroid concentrations in premenopausal women

scientific article published on 01 December 2006

Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa101) in athymic mice

scientific article published on 01 June 1990

Effect of submandibular gland removal on carcinogen induced rat mammary tumors

scientific article published on 01 April 1987

Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata

scientific article published on 01 June 1976

Effects of a new clinically relevant antiestrogen (GW5638) related to tamoxifen on breast and endometrial cancer growth in vivo

scientific article

Effects of angiogenesis inhibitor TNP-470 on tamoxifen-stimulated MCF-7 breast tumors in nude mice

scientific article published on 01 July 2000

Effects of chronic administration of tamoxifen and toremifene on DNA adducts in rat liver, kidney, and uterus.

scientific article published in April 1997

Effects of low dose tamoxifen on normal breast tissue from premenopausal women ⬇️

scientific article published on May 1, 2003

Effects of raloxifene after tamoxifen on breast and endometrial tumor growth in athymic mice

scientific article published in February 2002

Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver

scientific article published on 01 April 1995

Effects of tamoxifen in relation to breast cancer

scientific article published on 01 June 1977

Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer

scientific article published on March 26, 1992

Effects of tamoxifen on cardiovascular risk factors in postmenopausal women

scientific article published on 01 December 1991

Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial

scientific article (publication date: 21 June 2006)

Effects of the Antiestrogens Tamoxifen, Toremifene, and ICI 182,780 on Endometrial Cancer Growth ⬇️

scientific article published on October 21, 1998

Effects of the new selective estrogen receptor modulator LY353381.HCl (Arzoxifene) on human endometrial cancer growth in athymic mice.

scientific article published in December 2001

Effects of type I and II interferons on cultured human breast cells: interaction with estrogen receptors and with tamoxifen

scientific article

Emerging principles for the development of resistance to antihormonal therapy: implications for the clinical utility of fulvestrant

scientific article published on 7 November 2006

Endocrine effects of adjuvant chemotherapy and long-term tamoxifen administration on node-positive patients with breast cancer

scientific article published on 01 January 1987

Endocrine status of premenopausal node-positive breast cancer patients following adjuvant chemotherapy and long-term tamoxifen

scientific article published on 01 February 1988

Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.

scientific article published on 8 May 2018

Endoxifen: The End, or Are We at the Beginning?

scientific article published on 30 August 2017

Enhanced growth of an estrogen receptor-negative endometrial adenocarcinoma by estradiol in athymic mice

scientific article published on 01 September 1989

Estradiol-stimulated growth of MCF-7 tumors implanted in athymic mice: a model to study the tumoristatic action of tamoxifen

scientific article

Estrogen Activity in Plastic Products: Yang et al. Respond.

scientific article

Estrogen Deprivation Therapy in Ovarian Cancer: An Opportunity

scientific article published on 23 May 2016

Estrogen Receptors as Therapeutic Targets in Breast Cancer

scientific article (publication date: February 2006)

Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time ⬇️

scientific article published on October 19, 2011

Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells

scholarly article

Estrogen receptor alpha mediated induction of the transforming growth factor alpha gene by estradiol and 4-hydroxytamoxifen in MDA-MB-231 breast cancer cells

scientific article

Estrogen receptor as a target for the prevention of breast cancer

scientific article

Estrogen receptor distribution in enucleated breast cancer cell lines

scientific article published in June 1988

Estrogen receptor expression and sensitivity to paclitaxel in breast cancer

scientific article published on 18 May 2004

Estrogen receptor mutations found in breast cancer metastases integrated with the molecular pharmacology of selective ER modulators.

scientific article published on 2 April 2015

Estrogen receptor-mediated direct and indirect antitumor effects of tamoxifen

scientific article published on 01 November 1990

Estrogen receptors as therapeutic targets in breast cancer

scientific article

Estrogen receptors in BRCA1-mutant breast cancer: now you see them, now you don't

scientific article published on 13 November 2007

Estrogen regulation of X-box binding protein-1 and its role in estrogen induced growth of breast and endometrial cancer cells ⬇️

scientific article published on August 1, 2010

Estrogen regulation of apoptosis: how can one hormone stimulate and inhibit?

scientific article published on 29 May 2009

Estrogen, selective estrogen receptor modulation, and coronary heart disease: something or nothing

scientific article

Estrogen-Induced Apoptosis in Breast Cancers Is Phenocopied by Blocking Dephosphorylation of Eukaryotic Initiation Factor 2 Alpha (eIF2α) Protein

scientific article published on 17 January 2019

Estrogen-induced apoptosis in a breast cancer model resistant to long-term estrogen withdrawal

scientific article

Estrogen-mediated mechanisms to control the growth and apoptosis of breast cancer cells: a translational research success story

scientific article published on January 2013

Estrogen-related receptor alpha1 transcriptional activities are regulated in part via the ErbB2/HER2 signaling pathway

scientific article published in January 2007

Estrogen-related receptors as emerging targets in cancer and metabolic disorders

scientific article

Estrogen-stimulated prolactin synthesis in vitro. Classification of agonist, partial agonist, and antagonist actions based on structure

scientific article published on September 1984

Estrogenic actions of RU486 in hormone-responsive MCF-7 human breast cancer cells

scientific article published on 01 June 1993

Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor ⬇️

scientific article published on 01 March 1997

Estrogenic activity of phenol red ⬇️

scientific article published on 01 June 1988

Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2.

scientific article published on March 2004

Estrogenic potential of progestins in oral contraceptives to stimulate human breast cancer cell proliferation ⬇️

scientific article published on December 1, 1992

Evaluation of tamoxifen plus letrozole with assessment of pharmacokinetic interaction in postmenopausal women with metastatic breast cancer

scientific article published on 01 July 1999

Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model

scientific article published on 01 February 1980

Evidence for the metabolic activation of non-steroidal antioestrogens: a study of structure-activity relationships

scientific article

Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen

scientific article published on 7 November 2007

Experimental treatment of oestrogen receptor (ER) positive breast cancer with tamoxifen and brivanib alaninate, a VEGFR-2/FGFR-1 kinase inhibitor: a potential clinical application of angiogenesis inhibitors

scientific article

Exploiting the apoptotic actions of oestrogen to reverse antihormonal drug resistance in oestrogen receptor positive breast cancer patients

scientific article published on 24 August 2007

Expression of estrogen receptor alpha with a Tet-off adenoviral system induces G0/G1 cell cycle arrest in SKBr3 breast cancer cells.

scientific article

Four decades of discovery in breast cancer research and treatment--an interview with V. Craig Jordan. Interview by Marc Poirot

scientific article published in January 2011

Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer

scientific article

Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor

scientific article published in August 2002

Growth Stimulation and Differential Regulation of Transforming Growth Factor-β1 (TGFβ1), TGFβ2, and TGFβ3 Messenger RNA Levels by Norethindrone in MCF-7 Human Breast Cancer Cells ⬇️

scientific article published on August 1, 1991

Growth factor regulation by tamoxifen is demonstrated in patients with breast cancer

scientific article published on 01 July 1993

Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor

scientific article

Gynecologic complications associated with long-term adjuvant tamoxifen therapy for breast cancer

scientific article published on May 1, 1992

Gynecologic effects of tamoxifen and the association with endometrial carcinoma ⬇️

scientific article published on June 1, 1995

Health and safety inspections

scientific article published on 01 December 1977

Hormonal strategies for breast cancer: a new focus on the estrogen receptor as a therapeutic target

scientific article published on June 1, 1992

Hormonal therapy for breast cancer. An update

scientific article

Hormone receptor assays: clinical usefulness in the management of carcinoma of the breast

scientific article

How PERK kinase conveys stress signals to nuclear factor-κB to mediate estrogen-induced apoptosis in breast cancer cells?

scholarly article by Ping Fan & V. Craig Jordan published 13 August 2018 in Cell Death and Disease

How is tamoxifen's action subverted?

scientific article

How safe is tamoxifen?

scientific article published in November 1993

Human recombinant interferon-beta SER and tamoxifen: growth suppressive effects for the human breast carcinoma MCF-7 grown in the athymic mouse

scientific article published on January 1993

Identification of gene regulation patterns underlying both oestrogen- and tamoxifen-stimulated cell growth through global gene expression profiling in breast cancer cells.

scientific article

Immune-deficient animals to study "hormone-dependent" breast and endometrial cancer

scientific article published on 01 January 1989

Implications of tamoxifen metabolism in the athymic mouse for the study of antitumor effects upon human breast cancer xenografts

scientific article published on 01 December 1989

Importance of the alkylaminoethoxy side-chain for the estrogenic and antiestrogenic actions of tamoxifen and trioxifene in the immature rat uterus

scientific article published on 01 August 1982

Improvements in tumor targeting, survivorship, and chemoprevention pioneered by tamoxifen. A personal perspective.

scientific article published on May 2006

In vitro estrogenic actions in rat and human cells of hydroxylated derivatives of D16726 (zindoxifene), an agent with known antimammary cancer activity in vivo

scientific article

In vitro regulation of vascular endothelial growth factor by estrogens and antiestrogens in estrogen-receptor positive breast cancer

scientific article published on January 2002

In vitro study of the effect of raloxifene on lipid metabolism compared with tamoxifen

scientific article published on 01 September 2000

Increasing the number of tandem estrogen response elements increases the estrogenic activity of a tamoxifen analogue

scientific article published on 01 May 1995

Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene and idoxifene in female Sprague-Dawley rats.

scientific article

Influence of Estradiol and Tamoxifen on Susceptibility of Human Breast Cancer Cell Lines to Lysis by Lymphokine-Activated Killer Cells ⬇️

scientific article published on 01 January 1992

Influence of the length and positioning of the antiestrogenic side chain of endoxifen and 4-hydroxytamoxifen on gene activation and growth of estrogen receptor positive cancer cells

scientific article

Inhibition of BET proteins impairs estrogen-mediated growth and transcription in breast cancers by pausing RNA polymerase advancement.

scientific article published on 27 February 2015

Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells

scientific article published on 30 October 2013

Inhibition of cell division and stimulation of progesterone receptor synthesis in rat oestrogen target tissues by non-steroidal antioestrogens

scientific article published on 01 January 1979

Inhibition of hormone-dependent and independent breast cancer cell growth in vivo and in vitro with the antiestrogen toremifene and recombinant human interferon-alpha 2

scientific article published on 01 February 1990

Inhibition of oestradiol binding to mouse uterine and vaginal oestrogen receptors by triphenylethylenes ⬇️

scientific article published on January 1, 1975

Inhibition of oestrogen-stimulated prolactin release by anti-oestrogens ⬇️

scientific article published on 01 April 1975

Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens.

scientific article

Inhibition of the uterotropic activity of estrogens and antiestrogens by the short acting antiestrogen LY117018

scientific article published on 01 August 1983

Integration of Downstream Signals of Insulin-like Growth Factor-1 Receptor by Endoplasmic Reticulum Stress for Estrogen-Induced Growth or Apoptosis in Breast Cancer Cells

scientific article published on 26 June 2015

Interaction of [3H] estradiol - and [3H] monohydroxytamoxifen-estrogen receptor complexes with a monoclonal antibody

scientific article published on 01 January 1983

Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8-trichlorodibenzofuran with estrogen receptor alpha

scientific article published on April 2004

International Union of Pharmacology. LXIV. Estrogen receptors

scientific article

Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation

scientific article published on December 2005

Introducing a new section to Breast Cancer Research: Endocrinology and hormone therapy ⬇️

scientific article published on August 26, 2003

Introduction to a special edition in Steroids of nuclear hormone receptor modulators

scientific article published on 02 July 2014

Investigation of the mechanism of tamoxifen-stimulated breast tumor growth with nonisomerizable analogues of tamoxifen and metabolites.

scientific article published in May 1993

Irreversible loss of the oestrogen receptor in T47D breast cancer cells following prolonged oestrogen deprivation

scientific article

Is tamoxifen the Rosetta stone for breast cancer?

scientific article published in March 2003

Laboratory Models of Breast and Endometrial Cancer to Deveiop Strategies for Antiestrogen Therapy

Laboratory evidence to support the use of long-term adjuvant tamoxifen therapy for breast cancer

scientific article published on 01 January 1989

Laboratory models of breast and endometrial cancer to develop strategies for antiestrogen therapy.

scientific article published in January 1998

Laboratory models of breast cancer to aid the elucidation of antiestrogen action

scientific article published on March 1987

Laboratory studies on the mode of action and application of antiestrogen for breast cancer therapy.

scientific article published on January 1988

Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: problems and potential for future clinical applications

scientific article published on January 1983

Legislation and hospitals

scientific article published on 01 November 1971

Letters to the Editor

scientific article published in July 2012

Linking estrogen-induced apoptosis with decreases in mortality following long-term adjuvant tamoxifen therapy

scientific article

Long-term Adjuvant Tamoxifen Therapy and Decreases in Contralateral Breast Cancer

scientific article published on 01 February 2017

Long-term adjuvant tamoxifen study: clinical update

scientific article published on 01 January 1987

Long-term adjuvant tamoxifen therapy for breast cancer

scientific article published on May 1990

Long-term adjuvant tamoxifen therapy for breast cancer: the prelude to prevention

scientific article published on March 1990

Long-term adjuvant therapy with tamoxifen: effects on sex hormone binding globulin and antithrombin III

scientific article published on 01 August 1987

Long-term tamoxifen adjuvant therapy in node-positive breast cancer: a metabolic and pilot clinical study

scientific article published on 01 January 1984

Long-term tamoxifen therapy for breast cancer

scientific article

Long-term tamoxifen therapy to control or to prevent breast cancer: laboratory concept to clinical trials

scientific article published on January 1988

Low-dose estrogen therapy to reverse acquired antihormonal resistance in the treatment of breast cancer

scientific article published on April 2008

MCT-1 oncogene contributes to increased in vivo tumorigenicity of MCF7 cells by promotion of angiogenesis and inhibition of apoptosis

scientific article published on December 2005

MICoA, a novel metastasis-associated protein 1 (MTA1) interacting protein coactivator, regulates estrogen receptor-alpha transactivation functions

scientific article (publication date: 23 May 2003)

Mechanisms underlying differential response to estrogen-induced apoptosis in long-term estrogen-deprived breast cancer cells

scientific article

Medroxyprogesterone acetate and metastases: of mice and (wo)men

scientific article published in May 2005

Metabolism of steroid-modifying anticancer agents

scientific article published on January 1988

Metabolism of tamoxifen and its uterotrophic activity.

scientific article

Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance ⬇️

scientific article published on January 1, 1982

Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient ⬇️

scientific article published on 01 January 1991

Models and Mechanisms of Acquired Antihormone Resistance in Breast Cancer: Significant Clinical Progress Despite Limitations

scientific article published on February 2012

Models of hormone resistance in vitro and in vivo.

scientific article published on January 2006

Modulating therapeutic effects of the c-Src inhibitor via oestrogen receptor and human epidermal growth factor receptor 2 in breast cancer cell lines ⬇️

scientific article published on June 2, 2012

Modulation of estrogen receptor alpha function and stability by tamoxifen and a critical amino acid (Asp-538) in helix 12.

scientific article published on 20 December 2002

Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells

scientific article published on 12 February 2018

Modulation of nuclear oestrogen receptor levels by oestrogen and antioestrogen [proceedings]

scientific article published on January 1980

Modulation of rat uterine steroid hormone receptors by estrogen and antiestrogen

scientific article published on 01 December 1980

Molecular Mechanism for Breast Cancer Incidence in the Women's Health Initiative

scientific article published on 15 July 2020

Molecular biology of the estrogen receptor aids in the understanding of tamoxifen resistance and breast cancer prevention with raloxifene.

scientific article

Molecular classification of estrogens.

scientific article

Molecular classification of selective oestrogen receptor modulators on the basis of gene expression profiles of breast cancer cells expressing oestrogen receptor alpha

scientific article published on August 2002

Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen

scientific article

Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells

scientific article published on May 2013

Molecular mechanisms of antiestrogen action in breast cancer

scientific article published on January 1994

Molecular mechanisms of resistance to tamoxifen therapy in breast cancer

scientific article

Molecular modulation of estrogen-induced apoptosis by synthetic progestins in hormone replacement therapy: an insight into the women's health initiative study

scientific article

Most Plastic Products Release Estrogenic Chemicals: A Potential Health Problem That Can Be Solved ⬇️

scientific article published on March 2, 2011

Moving Precision Oncology Forward Amid Myths and Misconceptions

scientific article published in December 2018

Mutations of the estrogen receptor in endometrial carcinoma: evidence of an association with high tumor grade

scientific article published on 01 November 1996

New hypotheses and opportunities in endocrine therapy: amplification of oestrogen-induced apoptosis

scientific article

New insights into acquired endocrine resistance of breast cancer

scientific article published on 19 June 2019

New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer

scientific article published on 27 July 2007

New strategies for the treatment of breast cancer

scientific article published in January 2001

Node-negative breast cancer: tamoxifen and chemosuppression

scientific article published on 01 June 1990

Nomegestrol acetate, a clinically useful 19-norprogesterone derivative which lacks estrogenic activity

scientific article

Nonsteroidal antiestrogens: Their biological effects and potential mechanisms of action ⬇️

scientific article published on March 1, 1978

Norgestrel and gestodene stimulate breast cancer cell growth through an oestrogen receptor mediated mechanism

scientific article published in May 1993

Novel antitumor effect of estradiol in athymic mice injected with a T47D breast cancer cell line overexpressing protein kinase Calpha.

scientific article

Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer

scientific article

Nuclear [3H]4-hydroxytamoxifen (4-OHTAM)- and [3H]estradiol (E2)-estrogen receptor complexes in the MCF-7 breast cancer and GH3 pituitary tumor cell lines

scientific article published on 01 July 1984

Obesity and male breast cancer: provocative parallels? ⬇️

scientific article published on 4 June 2015

Oestradiol regulation of the components of the plasminogen-plasmin system in MDA-MB-231 human breast cancer cells stably expressing the oestrogen receptor ⬇️

scientific article published on July 1, 1998

Oestrogen is bad for patients with breast cancer?

scientific article

Oestrogenic and antioestrogenic actions in a series of triphenylbut-1-enes: modulation of prolactin synthesis in vitro

scientific article published in January 1986

Opportunities and challenges of long term anti-estrogenic adjuvant therapy: treatment forever or intermittently?

scientific article published on 10 March 2017

Optimising endocrine approaches for the chemoprevention of breast cancer beyond the Study of Tamoxifen and Raloxifene (STAR) trial

scientific article published on 24 October 2006

Optimizing the antihormonal treatment and prevention of breast cancer

scientific article published on January 2007

Overexpression of CEACAM6 promotes migration and invasion of oestrogen-deprived breast cancer cells

scientific article published on 07 July 2008

Overview from the International Conference on Long-Term Tamoxifen Therapy for Breast Cancer

scientific article published on February 19, 1992

Pak up your breast tumor--and grow!

scientific article published on 01 May 2006

Paradoxical Action of Fulvestrant in Estradiol-Induced Regression of Tamoxifen-Stimulated Breast Cancer ⬇️

scientific article published on November 5, 2003

Paradoxical Clinical Effect of Estrogen on Breast Cancer Risk: A “New” Biology of Estrogen-induced Apoptosis ⬇️

scientific article published on April 10, 2011

Paradoxical regulation of estrogen-dependent growth factor gene expression in estrogen receptor (ER)-negative human breast cancer cells stably expressing ER

scientific article published on 01 July 1994

Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest.

scientific article

Pharmacological relevance of endoxifen in a laboratory simulation of breast cancer in postmenopausal patients

scientific article

Pharmacology and Molecular Mechanisms of Clinically-Relevant Estrogen Estetrol and Estrogen Mimic BMI-135 for Endocrine-Resistant Breast Cancer Treatment

scientific article published on 12 August 2020

Pharmacology of tamoxifen in laboratory animals.

scientific article published on June 1980

Phase II enzyme expression in rat liver in response to the antiestrogen tamoxifen

scientific article published on August 1996

Point mutation of estrogen receptor (ER) in the ligand-binding domain changes the pharmacology of antiestrogens in ER-negative breast cancer cells stably expressing complementary DNAs for ER.

scientific article published on December 1992

Possible mechanisms for the agonist actions of tamoxifen and the antagonist actions of MER-25 (ethamoxytriphetol) in the mouse uterus

scientific article published in August 1985

Possible mechanisms in the emergence of tamoxifen-resistant breast cancer ⬇️

scientific article published on August 1, 1995

Potential of endogenous estrogen receptor beta to influence the selective ER modulator ERbeta complex.

scientific article published on August 2005

Potential of l-buthionine sulfoximine to enhance the apoptotic action of estradiol to reverse acquired antihormonal resistance in metastatic breast cancer

scientific article

Potential of selective estrogen receptor modulators as treatments and preventives of breast cancer

scientific article published on June 2009

Preclinical studies with toremifene as an antitumor agent.

scientific article published on August 1990

Prelude to breast cancer prevention with an antiestrogen

scientific article published on September 1990

Preventing Breast Cancer with Tamoxifen ⬇️

scientific article published on September 15, 1998

Problems with the progesterone receptor in practice?

scientific article published on 23 April 2007

Profiles of miRNAs matched to biology in aromatase inhibitor resistant breast cancer

scientific article published on 17 September 2016

Progesterone and Synthetic Progestin Controversies

scientific article published on 01 October 2015

Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward

scientific article published on June 2006

Progress in endocrine approaches to the treatment and prevention of breast cancer ⬇️

scientific article published on October 5, 2011

Progress in the prevention of breast cancer: concept to reality

scientific article

Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner

scientific article

Prolonged adjuvant tamoxifen: a beginning not the end.

scientific article published on July 1991

Prolonged antioestrogenic activity of ICI 46, 474 in the ovariectomized mouse ⬇️

scientific article published on February 1, 1975

Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer

scientific article published in June 2001

Proteomic analysis of pathways involved in estrogen-induced growth and apoptosis of breast cancer cells.

scientific article

Proven value of translational research with appropriate animal models to advance breast cancer treatment and save lives: the tamoxifen tale

scientific article

Questions about Tamoxifen and the Future Use of Antiestrogens.

scientific article published on January 1998

RESPONSE

scientific article published on 01 January 2000

Raloxifene as a multifunctional medicine? Current trials will show whether it is effective in both osteoporosis and breast cancer

scientific article published on August 1999

Raloxifene-stimulated experimental breast cancer with the paradoxical actions of estrogen to promote or prevent tumor growth: a unifying concept in anti-hormone resistance.

scientific article

Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer

scientific article published on 11 November 2020

Rapid development of tamoxifen-stimulated mutant p53 breast tumors (T47D) in athymic mice.

scientific article published in November 2000

Rat uterine growth and induction of progesterone receptor without estrogen receptor translocation.

scientific article

Re: Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17 beta-estradiol and the two faces of Janus: sex steroids as mediators of both cell proliferation and cell death

scientific article published in August 2002

Re: Trends in Use of Adjuvant Multi-Agent Chemotherapy and Tamoxifen for Breast Cancer in the United States: 1975-1999 ⬇️

scientific article published on May 7, 2003

Reduced antioestrogenic activity in derivatives of tamoxifen unable to undergo metabolic p-hydroxylation [proceedings]

scientific article

Regulation of estrogen target genes and growth by selective estrogen-receptor modulators in endometrial cancer cells

scientific article

Regulation of the levels of three transforming growth factor beta mRNAs by estrogen and their effects on the proliferation of human breast cancer cells

scientific article published on 01 November 1993

Resistance to paclitaxel therapy is related with Bcl-2 expression through an estrogen receptor mediated pathway in breast cancer.

scientific article

Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells stably transfected with ER alpha

scientific article published in May 2003

Rethinking Extended Adjuvant Antiestrogen Therapy to Increase Survivorship in Breast Cancer

scientific article published on 16 November 2017

Reversal of tamoxifen resistant breast cancer by low dose estrogen therapy

scientific article

Reversal of the antitumor effects of tamoxifen by progesterone in the 7,12-dimethylbenzanthracene-induced rat mammary carcinoma model

scientific article published on 01 October 1987

Reversible control of oestradiol-stimulated growth of MCF-7 tumours by tamoxifen in the athymic mouse ⬇️

scientific article published on December 1, 1991

Risk factors and the prevention of breast cancer with tamoxifen.

scientific article published on January 1993

Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer

scientific article

Role of antiestrogens and aromatase inhibitors in breast cancer treatment

scientific article

Role of tamoxifen in the long-term treatment and prevention of breast cancer

scientific article published on September 1988

Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro

scientific article published in December 2002

SERMs for the treatment and prevention of breast cancer

scientific article published on September 2007

SERMs: meeting the promise of multifunctional medicines

scientific article published on March 2007

Safety of tamoxifen

scientific article published on May 1994

Scientific rationale for postmenopause delay in the use of conjugated equine estrogens among postmenopausal women that causes reduction in breast cancer incidence and mortality

scientific article

Selective estrogen modulators as an anticancer tool: mechanisms of efficiency and resistance.

scientific article published on January 2008

Selective estrogen receptor modulation and reduction in risk of breast cancer, osteoporosis, and coronary heart disease

scientific article

Selective estrogen receptor modulation: a personal perspective.

scientific article

Selective estrogen receptor modulation: concept and consequences in cancer

scientific article published on March 2004

Selective estrogen receptor modulators (SERMS) and their roles in breast cancer prevention

scientific article

Selective estrogen receptor modulators (SERMs): mechanisms of anticarcinogenesis and drug resistance

scientific article

Selective estrogen receptor modulators and phytoestrogens

scientific article published on 08 October 2008

Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade

scientific article

Selective estrogen-induced apoptosis in breast cancer

scientific article

Selective estrogen-receptor modulators and antihormonal resistance in breast cancer

scientific article

Selective oestrogen receptor modulation: molecular pharmacology for the millennium

scientific article

Selective oestrogen receptor modulation: molecular pharmacology for the millennium

scientific article published on 01 December 1999

Sensitivity and insensitivity of breast cancer to tamoxifen.

scientific article

Sex steroid induced apoptosis as a rational strategy to treat anti-hormone resistant breast and prostate cancer

scientific article published on May 2016

Should adjuvant tamoxifen therapy be stopped at 5 years?

scientific article published on May 1996

Should clinicians be concerned about the carcinogenic potential of tamoxifen?

scientific article published on January 1994

Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor alpha complex.

scientific article published in May 2001

Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D6 genotypes

scientific article

Species-specific pharmacology of antiestrogens: role of metabolism

scientific article published on 01 April 1987

Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells.

scientific article published on October 2003

Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines

scientific article published on September 2000

Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines

scientific article published on 22 September 2016

Steroid receptors and their role in the biology and control of breast cancer growth

scientific article published on December 2006

Stimulation of breast cancer cells in vitro by the environmental estrogen enterolactone and the phytoestrogen equol

scientific article published on 01 November 1987

Strategies for breast cancer therapy with antiestrogens

scientific article published on January 1987

Structural components necessary for the antiestrogenic activity of tamoxifen

scientific article

Structural derivatives of tamoxifen and oestradiol 3-methyl ether as potential alkylating antioestrogens ⬇️

scientific article published on 01 February 1981

Structural requirements for the pharmacological activity of nonsteroidal antiestrogens in vitro.

scientific article published on September 1984

Structure-activity relationships of estrogens

scientific article

Structure-function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen

scientific article

Structure-function relationships of hydroxylated metabolites of tamoxifen that control the proliferation of estrogen-responsive T47D breast cancer cells in vitro.

scientific article published on November 1990

Structure-function relationships of the raloxifene-estrogen receptor-alpha complex for regulating transforming growth factor-alpha expression in breast cancer cells

scientific article

Structure–Activity Relationships for Triphenylethylene Antiestrogens on Hepatic Phase-I and Phase-II Enzyme Expression ⬇️

scientific article published on August 1, 1998

Studies of tamoxifen as a promoter of hepatocarcinogenesis in female Fischer F344 rats

scientific article published on January 1994

Studies on the mechanism of action of the nonsteroidal antioestrogen tamoxifen (I.C.I. 46,474) in the rat.

scientific article published on April 1977

Subcellular effects of monohydroxytamoxifen in the rat uterus: steroid receptors and mitosis

scientific article published on June 1980

Successful Targeted Therapies for Breast Cancer: the Worcester Foundation and Future Opportunities in Women's Health

article

Suppression of Nuclear Factor-κB by Glucocorticoid Receptor Blocks Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells

scientific article published on 11 September 2019

Suppression of mouse mammary tumorigenesis by long-term tamoxifen therapy

scientific article published on 01 April 1991

Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor ⬇️

scientific article published on March 1, 1975

Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer

scientific article

Tamoxifen Decreases Mortality, but How?

scientific article

Tamoxifen Goes Forward Alone

scientific article published in 2013

Tamoxifen Metabolism and Breast Cancer Recurrence: A Question Unanswered by CYPTAM

scientific article published on 18 June 2019

Tamoxifen Resistance Trumped and Oral Selective Estrogen Receptor Degraders Arrive

scientific article published on 19 April 2018

Tamoxifen and contralateral breast cancer

scientific article

Tamoxifen and endometrial cancer

scientific article published on 01 April 1989

Tamoxifen and endometrial cancer

scientific article published on 01 October 1988

Tamoxifen and endometrial cancer: from experiment to patient.

scientific article published on January 1996

Tamoxifen and endometrial cancer: tamoxifen effects on the human female genital tract

scientific article published on 01 August 1997

Tamoxifen and tumorigenicity: a predictable concern

scientific article published on 01 May 1995

Tamoxifen as an anti-tumour agent: role of oestradiol and prolactin

scientific article

Tamoxifen as the first targeted long-term adjuvant therapy for breast cancer

scientific article

Tamoxifen for breast cancer prevention

scientific article published on 01 February 1995

Tamoxifen for the prevention of breast cancer in the high-risk woman

scientific article

Tamoxifen in liver disease: potential exacerbation of hepatic dysfunction

scientific article published in October 1998

Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague-Dawley rats

scientific article published in July 1994

Tamoxifen inhibits lipoprotein activity: in vivo and in vitro studies

scientific article published on 01 January 2000

Tamoxifen or raloxifene for breast cancer chemoprevention: a tale of two choices--point

scientific article published in November 2007

Tamoxifen prophylaxis

scientific article published on 01 January 1986

Tamoxifen regulates cell fate through mitochondrial estrogen receptor beta in breast cancer ⬇️

scientific article published on August 20, 2012

Tamoxifen to prevent breast cancer

scientific article

Tamoxifen to raloxifene and beyond

scientific article

Tamoxifen treatment for breast cancer: concept to gold standard.

scientific article published on February 1997

Tamoxifen, Raloxifene, and the Prevention of Breast Cancer1

Tamoxifen, raloxifene, and the prevention of breast cancer

scientific article

Tamoxifen-induced increase in the potential doubling time of MCF-7 xenografts as determined by bromodeoxyuridine labeling and flow cytometry

scientific article published on 01 September 1993

Tamoxifen: From breast cancer therapy to the design of a postmenopausal prevention maintenance therapy ⬇️

scientific article published on January 1, 1997

Tamoxifen: a most unlikely pioneering medicine

scientific article

Tamoxifen: a personal retrospective.

scientific article published in September 2000

Tamoxifen: catalyst for the change to targeted therapy

scientific article

Tamoxifen: from breast cancer therapy to the design of a postmenopausal prevention maintenance therapy

scientific article published on January 1997

Tamoxifen: the herald of a new era of preventive therapeutics

scientific article published on 01 June 1997

Tamoxifen: too much of a good thing?

scientific article published on 01 September 1999

Tamoxifen: toxicities and drug resistance during the treatment and prevention of breast cancer

scientific article

Targeted Antiestrogens to Prevent Breast Cancer

scientific article published on 01 October 1999

Targeted anti-estrogens to treat and prevent diseases in women

scientific article published on May 1996

Targeted antiestrogens

scientific article published on January 1997

Targeted hormone therapy for breast cancer

scientific article

Targeted therapies: Any surprises from selective oestrogen-receptor modulators?

scientific article

Targeting Peroxisome Proliferator-Activated Receptor γ to Increase Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells

scientific article published on 17 September 2018

Targeting antihormone resistance in breast cancer: a simple solution

scientific article

Targeting oestrogen to kill the cancer but not the patient

scientific article published on March 2004

Targeting of tamoxifen to enhance antitumour action for the treatment and prevention of breast cancer: the 'personalised' approach?

scientific article published on 09 July 2009

Telling details of breast-cancer recurrence

scientific article published in January 2018

The 38th David A. Karnofsky lecture: the paradoxical actions of estrogen in breast cancer--survival or death?

scientific article published on 2 June 2008

The 4Ps of Breast Cancer Chemoprevention: Putting Proven Principles into Practice

scientific article published on 28 February 2017

The Effect of Raloxifene on Risk of Breast Cancer in Postmenopausal Women

scientific article (publication date: 16 June 1999)

The Effect of Raloxifene on Risk of Breast Cancer in Postmenopausal Women: Results From the MORE Randomized Trial

The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.

scientific article

The Paradox of Oestradiol-Induced Breast Cancer Cell Growth and Apoptosis

scientific article published on May 2009

The SERM Saga, Something from Nothing: American Cancer Society/SSO Basic Science Lecture

scientific article published on 25 March 2019

The Selective Estrogen Receptor Modulator Bazedoxifene Inhibits Hormone-Independent Breast Cancer Cell Growth and Down-Regulates Estrogen Receptor α and Cyclin D1 ⬇️

scientific article published on July 7, 2011

The St. Gallen Prize Lecture 2011: evolution of long-term adjuvant anti-hormone therapy: consequences and opportunities

scientific article

The Structure-Function Relationship of Angular Estrogens and Estrogen Receptor Alpha to Initiate Estrogen-Induced Apoptosis in Breast Cancer Cells

scientific article published on 03 May 2020

The Study of Letrozole Extension (SOLE) revisited

scientific article published in February 2018

The antitumour activity of tamoxifen and monohydroxytamoxifen: a comparative study in the rat [proceedings]

scientific article

The apoptotic action of estrogen following exhaustive antihormonal therapy: a new clinical treatment strategy

scientific article

The binding of [3H]-oestradiol-17 beta in the immature rat uterus during the sequential administration of non-steroidal anti-oestrogens ⬇️

scientific article published on February 1, 1979

The biological role of estrogen receptors alpha and beta in cancer

scientific article published on April 2004

The biological significance of the interaction of estrogen agonists and antagonists with the estrogen receptor

scientific article published on December 1990

The conformation of the estrogen receptor directs estrogen-induced apoptosis in breast cancer: a hypothesis ⬇️

scientific article published on March 1, 2011

The consequences of exhaustive antiestrogen therapy in breast cancer: estrogen-induced tumor cell death

scientific article published in September 2004

The control of hormone-dependent breast cancer growth--are we talking about estrogen alone?

scientific article published on August 1988

The current status of breast cancer chemoprevention: a star is born

scientific article published on 01 January 2007

The development of tamoxifen for breast cancer therapy: a tribute to the late Arthur L. Walpole

scientific article published on July 1988

The discovery and development of selective estrogen receptor modulators (SERMs) for clinical practice

scientific article

The duration of adjuvant tamoxifen therapy ⬇️

scientific article published on 01 January 1998

The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation

scientific article (publication date: 16 June 1999)

The effect of tamoxifen and two of its non-isomerizable fixed-ring analogs on multistage rat hepatocarcinogenesis

scientific article published on March 1996

The effects of intermittent progesterone upon tamoxifen inhibition of tumor growth in the 7,12-dimethylbenzanthracene rat mammary tumor model

scientific article published on 01 September 1993

The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain

scientific article published on January 1994

The estrogen receptor: a logical target for the prevention of breast cancer with antiestrogens

scientific article

The estrogen receptor: a model for molecular medicine.

scientific article

The estrogenic activity of synthetic progestins used in oral contraceptives.

scientific article

The evolution of nonsteroidal antiestrogens to become selective estrogen receptor modulators

scientific article

The evolution of tamoxifen therapy in breast cancer: selective oestrogen-receptor modulators and downregulators

scientific article

The evolving role of endocrine therapy for the treatment and prevention of breast cancer

scientific article published on January 1, 2002

The evolving role of endocrine therapy for treatment and prevention of breast cancer.

scientific article

The forgotten group at risk for breast cancer

scientific article published on 01 August 1990

The inhibition of prolactin synthesis in GH3 rat pituitary tumor cells by monohydroxytamoxifen is associated with changes in the properties of the estrogen receptor

scientific article published on January 1984

The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor.

scientific article published on September 1999

The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor ⬇️

scientific article published on 01 May 1998

The modulation of estrogen-induced apoptosis as an interpretation of the women's health initiative trials

scientific article published on 23 December 2015

The molecular, cellular and clinical consequences of targeting the estrogen receptor following estrogen deprivation therapy

scientific article published on 5 June 2015

The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer

scientific article published on 22 October 2014

The oestrogen-like effect of 4-hydroxytamoxifen on induction of transforming growth factor alpha mRNA in MDA-MB-231 breast cancer cells stably expressing the oestrogen receptor ⬇️

scientific article published on June 1, 1998

The paracrine stimulation of MCF-7 cells by MDA-MB-231 cells: possible role in antiestrogen failure

scientific article published on March 1989

The past, present, and future of selective estrogen receptor modulation

scientific article

The rise of raloxifene and the fall of invasive breast cancer

scientific article published on 10 June 2008

The role of estrogen receptor mutations in tamoxifen-stimulated breast cancer ⬇️

scientific article published on June 1, 1997

The role of tamoxifen in the treatment and prevention of breast cancer

scientific article published on May 1, 1992

The science of selective estrogen receptor modulators: concept to clinical practice

scientific article published on September 2006

The secrets of selective estrogen receptor modulation: cell-specific coregulation

scientific article

The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3.

scientific article

The strategic use of antiestrogens to control the development and growth of breast cancer.

scientific article

The ups and downs of the estrogen receptor

scientific article published on 01 January 2003

Third annual William L. McGuire Memorial Lecture. "Studies on the estrogen receptor in breast cancer"--20 years as a target for the treatment and prevention of cancer

scientific article published on January 1995

Toremifene as an anticancer agent

scientific article published on 01 January 1990

Transfection of human estrogen receptor (ER) cDNA into ER-negative mammalian cell lines

scientific article published on December 1994

Trastuzumab therapy for tamoxifen-stimulated endometrial cancer

scientific article published on September 2005

Treatment of Postmenopausal Breast Cancer with Selective Estrogen Receptor Modulators (SERMs).

scientific article published on January 2005

Treatment of osteoporosis and reduction in risk of invasive breast cancer in postmenopausal women with raloxifene ⬇️

scientific article published on February 7, 2011

Tumoristatic action of tamoxifen: experimental evidence for clinical application in stage I and II breast cancer

scientific article

Understanding the Antiestrogenic Actions of Raloxifene and a Mechanism of Drug Resistance to Tamoxifen.

scientific article published in April 1998

Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing breast cancer

scientific article

What if tamoxifen (ICI 46,474) had been found to produce rat liver tumors in 1973? A personal perspective

scientific article

William L. McGuire Memorial Symposium. Drug resistance to tamoxifen during breast cancer therapy

scientific article published on January 1993

c-Src modulates estrogen-induced stress and apoptosis in estrogen-deprived breast cancer cells

scientific article published on 23 May 2013

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