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List of works by Holly Van Remmen

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).

scientific article

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence

scientific article published on 2 November 2016

A novel approach for screening the proteome for changes in protein conformation

scientific article published in March 2006

A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice

scientific article

Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPR(MT) and increased resistance to oxidative stress in primary cultures of fibroblasts

scientific article published on 09 May 2016

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy

scientific journal article

Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation

scientific article

Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice.

scientific article published on 2 July 2018

Age-associated alterations of the neuromuscular junction ⬇️

scientific article published on September 18, 2010

Age-dependent increases in interstitial collagenase and MAP Kinase levels are exacerbated by superoxide dismutase deficiencies

scientific article

Age-related cardiac muscle sarcopenia: Combining experimental and mathematical modeling to identify mechanisms

scientific article published on 15 December 2007

Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence

scientific article published in September 2005

Age-related loss of the DNA repair response following exposure to oxidative stress

scientific article

Butyrate prevents muscle atrophy after sciatic nerve crush

scientific article

Catalase transgenic mice: characterization and sensitivity to oxidative stress

scientific article published in February 2004

Comparative proteomics: characterization of a two-dimensional gel electrophoresis system to study the effect of aging on mitochondrial proteins

scientific article published on 01 January 2003

Comparative studies of oxidative stress and mitochondrial function in aging

scientific article published on 2 July 2010

Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels

scientific article published on 18 May 2012

Complex III releases superoxide to both sides of the inner mitochondrial membrane

scientific journal article

Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses

scientific article published on September 2014

Continuous overexpression of thioredoxin 1 enhances cancer development and does not extend maximum lifespan in male C57BL/6 mice

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

scientific article

CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

scientific article published on 31 May 2013

Current thoughts on the role of mitochondria and free radicals in the biology of aging

scientific article published on 30 January 2009

Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice

scientific article published on 10 July 2013

Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance

scientific article published in July 2008

Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria

scientific article

Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD.

scientific article

Dietary restriction attenuates the accelerated aging phenotype of Sod1(-/-) mice

scientific article published on 28 February 2013

Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

scientific article (publication date: August 2012)

Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells

scientific article published on 8 May 2006

Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction

scientific article published on 24 February 2009

Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels

scientific article published in July 2005

Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination

scientific article

Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes

scientific article published in November 2003

Emerging roles for histone deacetylases in age-related muscle atrophy.

scientific article published on 27 October 2016

Formation of 3-nitrotyrosines in carbonic anhydrase III is a sensitive marker of oxidative stress in skeletal muscle

scientific article published on April 2007

GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis

scientific article published on 6 August 2008

Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy

scientific article published on 8 October 2013

Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function

scientific article published on 05 September 2013

Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria

scientific article published on 15 May 2009

Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity

scientific article published in July 2006

Glutathione-peroxidase-1 null muscle progenitor cells are globally defective

scientific journal article

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

scientific article published on 6 March 2012

High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates

scientific article

Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia

scientific article published on 9 September 2004

Increased mitochondrial matrix-directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria

scientific article

Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

scientific article

Insulin resistance is a cellular antioxidant defense mechanism

scientific article

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

scientific article published in February 2018

Is the oxidative stress theory of aging dead?

scientific article

Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase

scientific article

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

scientific article (publication date: 16 December 2003)

Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.

scientific article published on 25 April 2018

Lifespan extension in genetically modified mice

scientific article published on 22 May 2009

Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice

scientific article published on 31 January 2016

Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts

scientific article published on 16 July 2010

Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle

scientific article published on 21 July 2016

Metabolic and Stress Response Changes Precede Disease Onset in the Spinal Cord of Mutant SOD1 ALS Mice.

scientific article published on 31 May 2019

Methionine oxidation and aging

scientific article

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity

scientific article published on 23 September 2009

Microwave & Magnetic (M2) Proteomics of a Mouse Model of Mild Traumatic Brain Injury

scientific article

Mitochondrial dysfunction in aging and longevity: a causal or protective role?

scientific article

Mitochondrial stress signaling in longevity: a new role for mitochondrial function in aging

scientific article

MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models

scientific article

MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging

scientific article

MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart

scientific article published on 11 July 2014

Moderate modulation of disease in the G93A model of ALS by the compound 2-(2-hydroxyphenyl)-benzoxazole (HBX).

scientific article

Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress.

scientific article published in December 2002

Molecular changes associated with spinal cord aging

scientific article published on 06 March 2020

Molecular events in matrix protein metabolism in the aging kidney

scientific article published on 19 October 2012

Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging

scientific article

Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress

scientific journal article

Muscle fiber type diversification during exercise and regeneration

scientific article published on 28 March 2016

Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia

scientific article published on 24 September 2021

Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice

scientific article published on 04 September 2020

Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice

scientific article published on 30 December 2013

Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.

scientific article published on 6 April 2018

Overexpression of Mn superoxide dismutase does not increase life span in mice

scientific article published on 24 July 2009

Overexpression of antioxidant enzymes in diaphragm muscle does not alter contraction-induced fatigue or recovery

scientific article

Overexpression of human SOD1 improves survival of mice susceptible to endotoxic shock

scientific article

Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase

scientific article published on 18 July 2013

Oxidative damage to DNA and aging

scientific article

Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?

scientific article

Processing of data generated by 2-dimensional gel electrophoresis for statistical analysis: missing data, normalization, and statistics

scientific article

Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates

scientific article

Protein imbalance in the development of skeletal muscle wasting in tumour-bearing mice

article

Protein misfolding, mitochondrial dysfunction and muscle loss are not directly dependent on soluble and aggregation state of mSOD1 protein in skeletal muscle of ALS.

scientific article published on 3 January 2012

Raising the antioxidant levels within mouse muscle fibres does not affect contraction-induced injury

scientific article

Rapamycin Modulates Markers of Mitochondrial Biogenesis and Fatty Acid Oxidation in the Adipose Tissue of db/db Mice

scientific article published on June 2013

Reactive Oxygen Species Differentially Regulate Bone Turnover in an Age-Specific Manner in Catalase Transgenic Female Mice

scientific article published on 12 May 2016

Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice

scientific article

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

scientific article published on 30 July 2013

Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus

scientific article

Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis

scientific article

Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance

scientific article

Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice

scientific article published on 17 May 2012

Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice

scientific article published on 5 September 2008

Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase

scientific article

Sco2 deficient mice develop increased adiposity and insulin resistance

scientific article published on 17 April 2017

Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice

scientific article published on 2 April 2015

Sod2 overexpression preserves myoblast mitochondrial mass and function, but not muscle mass with aging.

scientific article

Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health

scientific article published on 29 May 2017

The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase

scientific article

The effects of dietary restriction on oxidative stress in rodents

scientific article

The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

scientific article

The in vivo gene expression signature of oxidative stress

scientific article

The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice

scientific article

The mitochondrial theory of aging: insight from transgenic and knockout mouse models

scientific article published on 12 January 2009

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

scientific article published on 11 December 2008

The role of insulin and insulin-like growth factor-I in mammalian ageing

scientific article published in September 2004

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

scientific journal article

Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice

scientific article published on 26 August 2011

Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress

scientific article published on 7 December 2007

Transcriptional profiling of the age-related response to genotoxic stress points to differential DNA damage response with age.

scientific article published on 11 August 2009

Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis

scientific article

Trends in oxidative aging theories

scientific article (publication date: 15 August 2007)

Use of Nerve Conduction Velocity to Assess Peripheral Nerve Health in Aging Mice

scientific article

p53 Regulates oxidative stress-mediated retrograde signaling: a novel mechanism for chemotherapy-induced cardiac injury

scientific article

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