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List of works by Lauren O Bakaletz

4. Microbiology, Immunology, Biochemistry, and Vaccination

article published in 1989

4C. Interaction between Middle Ear and Inner Ear in Otitis Media

scientific article published in 2005

A Protein E-PilA Fusion Protein Shows Vaccine Potential against Nontypeable Haemophilus influenzae in Mice and Chinchillas

scientific article published on 23 July 2019

A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae

scientific article

A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin

scientific article published on 15 October 2007

A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media

scientific article published on 20 November 2006

A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media

scientific article

Adherence of Nontypeable Haemophilus influenzae to Cells and Substrates of the Airway Is Differentially Regulated by Individual ModA Phasevarions

scientific article published in 2023

Anatomy of the nasal cavity in the chinchilla

scientific article

Antibodies against the DNABII protein integration host factor (IHF) inhibit sinus implant biofilms

scientific article published on 17 July 2019

Antibodies against the Majority Subunit (PilA) of the Type IV Pilus of Nontypeable Haemophilus influenzae Disperse Moraxella catarrhalis from a Dual-Species Biofilm

scientific article published in 2018

Antibodies against the majority subunit of type IV Pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media

scientific article published on 15 February 2015

Antibodies directed against integration host factor mediate biofilm clearance from Nasopore

scientific article

Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens

scientific article

Bacterial biofilms in otitis media: evidence and relevance

scientific article published on October 2007

Bacterial biofilms in the upper airway - evidence for role in pathology and implications for treatment of otitis media ⬇️

scientific article published on May 27, 2012

Biofilm Biology and Vaccine Strategies for Otitis Media Due to Nontypeable Haemophilus influenzae

Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages

scientific article

Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins

scientific article published on 29 June 2011

Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein

scientific article

Biological Roles of Nontypeable Haemophilus influenzae Type IV Pilus Proteins Encoded by the pil and com Operons ⬇️

scientific article published on February 10, 2012

COPD-Related Modification to the Airway Epithelium Permits Intracellular Residence of Nontypeable Haemophilus influenzae and May Be Potentiated by Macrolide Arrest of Autophagy

scientific article published on 04 June 2020

Chinchilla and murine models of upper respiratory tract infections with respiratory syncytial virus

scientific article

Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention

scientific article published on August 2009

Closed Complete Genome Sequences of Two Nontypeable Haemophilus influenzae Strains Containing Novel Alleles from the Sputum of Patients with Chronic Obstructive Pulmonary Disease

scholarly article published July 2018

Complete Genome Sequence of Moraxella catarrhalis Strain CCRI-195ME, Isolated from the Middle Ear.

scientific article

Contribution of Moraxella catarrhalis type IV pili to nasopharyngeal colonization and biofilm formation

scientific article published on October 2007

Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children

scientific article

DNABII proteins play a central role in UPEC biofilm structure

scientific article published on 16 April 2015

Demonstration of Type IV pilus expression and a twitching phenotype by Haemophilus influenzae

scientific article

Detection and characterization of pediatric serum antibody to the OMP P5-homologous adhesin of nontypeable Haemophilus influenzae during acute otitis media

scientific article published on 01 October 2002

Developing a nontypeable Haemophilus influenzae (NTHi) vaccine

scientific article

Developing animal models for polymicrobial diseases

scientific article published on July 2004

Development of a chinchilla model to allow direct, continuous, biophotonic imaging of bioluminescent nontypeable Haemophilus influenzae during experimental otitis media

scientific article

Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo

scientific article

Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells

scientific article published on 26 December 2007

Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses

scientific article published on 17 August 2018

Efficacy of the 26-kilodalton outer membrane protein and two P5 fimbrin-derived immunogens to induce clearance of nontypeable Haemophilus influenzae from the rat middle ear and lungs as well as from the chinchilla middle ear and nasopharynx

scientific article published on August 2003

Enhanced Probiotic Potential of Lactobacillus reuteri When Delivered as a Biofilm on Dextranomer Microspheres That Contain Beneficial Cargo

scientific article published on 27 March 2017

Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae

article

Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates

scientific article published on 22 August 2009

Epitope-specific immune recognition of the nontypeable Haemophilus influenzae outer membrane protein 26.

scientific article published on 4 January 2013

Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms

scientific article published on 19 August 2014

Expression of the Nontypeable Haemophilus influenzae Type IV Pilus Is Stimulated by Coculture with Host Respiratory Tract Epithelial Cells

scientific article published on 18 November 2019

Expression, purification, crystallization and preliminary crystallographic analysis of PilA from the nontypeableHaemophilus influenzaetype IV pilus ⬇️

scientific article published on February 22, 2012

Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae

scientific article published on 19 December 2017

Extracellular DNA within a nontypeable Haemophilus influenzae-induced biofilm binds human beta defensin-3 and reduces its antimicrobial activity

scientific article published on 22 August 2012

First Otitis Media and Pneumococcal Conjugate Vaccine Serotypes in Infants

scientific article published on 01 December 2018

Genomic Sequence of an Otitis Media Isolate of Nontypeable Haemophilus influenzae: Comparative Study with H. influenzae Serotype d, Strain KW20

scientific article

Haemophilus influenzae and oxidative stress

scientific article published on 28 March 2012

Heme Utilization by Nontypeable Haemophilus influenzae Is Essential and Dependent on Sap Transporter Function ⬇️

scientific article published on March 25, 2011

High-Depth RNA-Seq Data Sets for Studying Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae

article

Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway.

scientific article published on 2 March 2004

Identification of biofilms in post-tympanostomy tube otorrhea

scientific article

Immunization with a Biofilm-Disrupting Nontypeable Haemophilus influenzae Vaccine Antigen Did Not Alter the Gut Microbiome in Chinchillas, Unlike Oral Delivery of a Broad-Spectrum Antibiotic Commonly Used for Otitis Media

scientific article published on 15 April 2020

Immunopathogenesis of polymicrobial otitis media

scientific article

Impact of protein D-containing pneumococcal conjugate vaccines on non-typeable Haemophilus influenzae acute otitis media and carriage

scientific article published on 2 June 2017

Improving patient care via development of a protein-based diagnostic test for microbe-specific detection of chronic rhinosinusitis

scientific article

In vitro biofilm formation in an 8-well chamber slide

scientific article published on 20 January 2011

Innate Immunity and the Role of Defensins in Otitis Media ⬇️

scientific article published on December 1, 2011

Innate immune defenses: finding a new way to calm the storm

scientific article published on 16 September 2008

Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae

scientific article published on 9 February 2016

Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization

scientific article published on 22 October 2012

Mapping the anatomy of respiratory syncytial virus infection of the upper airways in chinchillas (Chinchilla lanigera).

scientific article

Microbial interactions in the respiratory tract

scientific article published on October 2009

Mixed pneumococcal-nontypeable Haemophilus influenzae otitis media is a distinct clinical entity with unique epidemiologic characteristics and pneumococcal serotype distribution

scientific article published on 10 July 2013

ModA2 Phasevarion Switching in Nontypeable Haemophilus influenzae Increases the Severity of Experimental Otitis Media

scientific article

ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media.

scientific article

Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo

scientific article published on 16 June 2016

Monoclonal antibodies that target extracellular DNABII proteins or the type IV pilus of nontypeable Haemophilus influenzae (NTHI) worked additively to disrupt 2-genera biofilms

scientific article published in 2022

Moraxella catarrhalis Restriction-Modification Systems are Associated with Phylogenetic Lineage and Disease

scientific article published on 01 November 2018

Natural antigenic differences in the functionally equivalent extracellular DNABII proteins of bacterial biofilms provide a means for targeted biofilm therapeutics.

scientific article published on 14 March 2016

Nontypeable <i>Haemophilus influenzae</i> newly released (NRel) from biofilms by antibody-mediated dispersal <i>versus</i> antibody-mediated disruption are phenotypically distinct

scientific article published on 18 November 2020

Nontypeable Haemophilus influenzae (NTHi)

scientific article published on 21 May 2018

Nontypeable Haemophilus influenzae Responds to Virus-Infected Cells with a Significant Increase in Type IV Pilus Expression

scientific article published on 27 May 2020

Nontypeable Haemophilus influenzae Type IV pilus mediates augmented adherence to rhinovirus-infected human airway epithelial cells

scientific article published on 15 June 2020

Nontypeable Haemophilus influenzae adheres to intercellular adhesion molecule 1 (ICAM-1) on respiratory epithelial cells and upregulates ICAM-1 expression.

scientific article

Nontypeable Haemophilus influenzae as a pathogen in children

scientific article published on January 2009

Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media

scientific article

Nontypeable Haemophilus influenzae releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery

scientific article published on 10 July 2017

Panel 3: Recent advances in anatomy, pathology, and cell biology in relation to otitis media pathogenesis

scientific article

Panel 4: Recent advances in otitis media in molecular biology, biochemistry, genetics, and animal models

scientific article

Panel 6: Vaccines

scientific article

Panel 6: Vaccines

Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates

scientific article published on May 2004

Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae

scientific article published on 27 March 2006

Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies

scientific article published on 13 February 2018

Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media

scientific article

Prevention of early episodes of otitis media by pneumococcal vaccines might reduce progression to complex disease

scientific article published on April 2016

Protection against Development of Otitis Media Induced by Nontypeable Haemophilus influenzae by Both Active and Passive Immunization in a Chinchilla Model of Virus-Bacterium Superinfection

scientific article published in October 1999

Recent advances in otitis media. 3. Animal models; anatomy and pathology; pathogenesis; cell biology and genetics.

scientific article

Recent advances in otitis media. 4. Anatomy, cell biology, pathology, and animal models.

scientific article

Recent advances in otitis media. 4A. Molecular biology

scientific article

Recent advances in otitis media. 4B. Biochemistry

scientific article

Recent advances in otitis media. 4C. Interaction between middle ear and inner ear in otitis media

scientific article

Recent advances in otitis media. 5. Microbiology and immunology.

scientific article

Recent advances in otitis media. 5. Molecular biology and biochemistry.

scientific article

Recent advances in otitis media. 6. Microbiology and immunology

scientific article

Recent advances in otitis media. 6. Vaccine

scientific article

Recent advances in otitis media. 7. Vaccine

scientific article

Redirecting the immune response towards immunoprotective domains of a DNABII protein resolves experimental otitis media

scientific article published on 14 October 2019

Reduced severity of middle ear infection caused by nontypeable Haemophilus influenzae lacking the hemoglobin/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media.

scientific article published in January 2004

Replication of respiratory syncytial virus is inhibited by the host defense molecule viperin

scientific article

Respiratory Syncytial Virus Promotes Moraxella catarrhalis-Induced Ascending Experimental Otitis Media ⬇️

scientific article published on June 29, 2012

Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzae

scientific article published on 02 June 2009

Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear.

scientific article published on June 2005

Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms.

scientific article

Selection and Counterselection of Hia Expression Reveals a Key Role for Phase-Variable Expression of Hia in Infection Caused by Nontypeable Haemophilus influenzae

scientific article

Selection for phase variation of LOS biosynthetic genes frequently occurs in progression of non-typeable Haemophilus influenzae infection from the nasopharynx to the middle ear of human patients.

scientific article

Skin Microbiota in Obese Women at Risk for Surgical Site Infection After Cesarean Delivery.

scientific article

Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein

scientific article

Targeting a bacterial DNABII protein with a chimeric peptide immunogen or humanised monoclonal antibody to prevent or treat recalcitrant biofilm-mediated infections

scientific article published on 27 June 2020

Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis

scientific article published on 17 November 2012

Targeting the HUβ protein prevents Porphyromonas gingivalis from entering into pre-existing biofilms

scientific article published on 5 February 2018

The Chinchilla Research Resource Database: resource for an otolaryngology disease model.

scientific article

The DNABII family of proteins is comprised of the only nucleoid associated proteins required for nontypeable Haemophilus influenzae biofilm structure

scientific article published on 12 December 2017

The HMW2 adhesin of non-typeable Haemophilus influenzae is a human-adapted lectin that mediates high-affinity binding to 2-6 linked N-acetylneuraminic acid glycans

scholarly article by John M Atack published in September 2018

The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils

scientific article

The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media

scientific article published on 09 December 2019

The OxyR regulon in nontypeable Haemophilus influenzae

scientific article published on December 2006

The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract

scientific article published on 23 July 2007

The extracellular DNA lattice of bacterial biofilms is structurally related to Holliday junction recombination intermediates

scientific article published on 25 November 2019

The fourth surface-exposed region of the outer membrane protein P5-homologous adhesin of nontypable Haemophilus influenzae is an immunodominant but nonprotective decoying epitope

scientific article published in August 2003

The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant

scientific article

The multifunctional host defense peptide SPLUNC1 is critical for homeostasis of the mammalian upper airway

scientific article

Therapeutic Transcutaneous Immunization with a Band-Aid Vaccine Resolves Experimental Otitis Media

scientific article published on 27 May 2015

Tracking the tissue distribution of marker dye following intranasal delivery in mice and chinchillas: a multifactorial analysis of parameters affecting nasal retention

scientific article published in August 2002

Transcutaneous Immunization with a Band-Aid Prevents Experimental Otitis Media in a Polymicrobial Model

scientific article published on 5 April 2017

Transcutaneous immunization with a nontypeable Haemophilus influenzae dual adhesin-directed immunogen induces durable and boostable immunity

scientific article published on 27 January 2020

Type IV Pilus Expression Is Upregulated in Nontypeable Haemophilus influenzae Biofilms Formed at the Temperature of the Human Nasopharynx

scientific article

Use of the Chinchilla Model for Nasopharyngeal Colonization To Study Gene Expression by Moraxella catarrhalis ⬇️

scientific article published on December 19, 2011

Vaccines for otitis media: proposals for overcoming obstacles to progress

scientific article

Viral-bacterial co-infections in the respiratory tract

scientific article published on 7 December 2016

What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention

scientific article published on 21 April 2016

Z-form extracellular DNA is a structural component of the bacterial biofilm matrix

scientific article published in 2021

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