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List of works by Matthew Whiteman

5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons

scientific article

A Reevaluation of the Peroxynitrite Scavenging Activity of Some Dietary Phenolics

scientific article published in 2000

A high-throughput and sensitive methodology for the quantification of urinary 8-hydroxy-2'-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase extraction

scientific article

AP39, A Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo

scientific article

AP39, a mitochondria-targeting hydrogen sulfide (H2 S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling

scientific article published on 8 December 2016

AP39, a mitochondrially targeted hydrogen sulfide donor, exerts protective effects in a rat model of renal ischemia–reperfusion

article published in 2015

AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

scientific article

Alone NO Longer

scientific article published in 2016

Anti-oxidative stress effects of Herba leonuri on ischemic rat hearts

scientific article published in May 2005

Antioxidant Action of Ergothioneine: Assessment of Its Ability to Scavenge Peroxynitrite

article

Antipsoriatic activity of GYY4137 (a slow-releasing hydrogen sulphide donor) microemulsion system using a mouse skin model of psoriasis

Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels

scientific article published on 5 May 2008

Boron-Doped Diamond Dual-Plate Deep-Microtrench Device for Generator-Collector Sulfide Sensing

Cardioprotection by H2S Donors: Nitric Oxide-Dependent and ‑Independent Mechanisms

scientific article published on 24 June 2016

Catching tau in the act.

scientific article published in April 2003

Cell guidance in tissue engineering: SDF-1 mediates site-directed homing of mesenchymal stem cells within three-dimensional polycaprolactone scaffolds

scientific article published in November 2007

Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide

scientific article published on 28 April 2008

Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines

scientific article

Chlorinative stress: an under appreciated mediator of neurodegeneration?

scientific article published on 7 September 2006

Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons

scientific article published on March 2004

Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons

scientific article published on 12 June 2006

Contrasting Effects of ‘Fast’ and ‘Slow’ Releasing H2S Donors on β Cell Viability in the DiabeticMilieu

Cytochrome bc(1) regulates the mitochondrial permeability transition by two distinct pathways

scientific article published on 10 September 2004

Daily therapy with a slow-releasing H2S donor GYY4137 enables early functional recovery and ameliorates renal injury associated with urinary obstruction

scientific article published on 6 March 2018

Detection and measurement of reactive oxygen intermediates in mitochondria and cells

scientific article

Determination of S-nitrosothiols in biological and clinical samples using electron paramagnetic resonance spectrometry with spin trapping

scientific article published on January 2008

Dexamethasone inhibits lipopolysaccharide-induced hydrogen sulphide biosynthesis in intact cells and in an animal model of endotoxic shock

scientific article

Distinct mechanisms of cardioprotection by different hydrogen sulfide donors

Do mitochondria make nitric oxide? no?

scientific article published in June 2004

Early induction of calpains in rotenone-mediated neuronal apoptosis

scientific article published on 10 January 2006

Effects of a Novel Triphenylphosphonium Derivatised Anethole Dithiolethione Hydrogen Sulfide (H2S) Donor, AP39, on Cardiac Ion Channels and on Haemodynamic Parameters in Normotensive and Hypertensive Rats in Vivo

Effects of mitochondria-targeted and non-targeted hydrogen sulphide donors on platelet aggregation

Effects of natural products on ischemic heart diseases and cardiovascular system.

scientific article

Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools ⬇️

scientific article published on December 1, 2011

Evaluation of a Novel Mitochondria-targeted Peptide-based H 2 S Donor Compound (RTP-10) in Hyperglycaemia-induced Microvascular Endothelial Cell Dysfunction

Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide

article

Factors affecting the ascorbate- and phenolic-dependent generation of hydrogen peroxide in Dulbecco's Modified Eagles Medium

scientific article published on October 2003

GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Ameliorates Renal Damage Associated with Chronic Obstructive Uropathy

scientific article published on 10 May 2016

GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.

scientific article published on 15 April 2009

Gene profiling reveals hydrogen sulphide recruits death signaling via the N‐methyl‐D‐aspartate receptor identifying commonalities with excitotoxicity ⬇️

scientific article published on May 1, 2011

Glial metabolism of quercetin reduces its neurotoxic potential

scientific article published on 23 July 2008

H2S during circulatory shock: some unresolved questions

scientific article

HOCl causes necrotic cell death in human monocyte derived macrophages through calcium dependent calpain activation ⬇️

scientific article published on October 10, 2011

Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion

scientific article published on 21 January 2018

Hydrogen Sulfide Inhibits Proliferation and Release of IL-8 from Human Airway Smooth Muscle Cells

Hydrogen Sulfide Is an Endogenous Stimulator of Mitochondrial DNA Repair

Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages

scientific article published on 13 June 2016

Hydrogen Sulfide and Nitric Oxide Crosstalk: Evidence for Hydrogen Sulfide Mediated Nitric Oxide Production from Nitrite

article

Hydrogen Sulfide and Reactive Friends: The Interplay with Reactive Oxygen Species and Nitric Oxide Signalling Pathways

article

Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising

scientific article published on January 2011

Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability?

scientific article published on March 2009

Hydrogen sulfide attenuates opioid dependence by suppression of adenylate cyclase/cAMP pathway

scientific article published on 11 July 2013

Hydrogen sulfide induced neuronal death occurs via glutamate receptor and is associated with calpain activation and lysosomal rupture in mouse primary cortical neurons

article by Nam Sang Cheung et al published September 2007 in Neuropharmacology

Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells

scientific article published on 4 February 2011

Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse

scientific article published on 29 April 2005

Hydrogen sulfide signaling: interactions with nitric oxide and reactive oxygen species

scientific article published on 17 March 2015

Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway

scientific article published in October 2007

Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?

scientific article

Hypochlorous Acid-Induced Base Modifications in Isolated Calf Thymus DNA

Hypochlorous Acid-Induced DNA Base Modification: Potentiation by Nitrite: Biomarkers of DNA Damage by Reactive Oxygen Species

article

Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes

scientific article published in September 2006

Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: role of mitochondrial permeability transition

scientific article

Increased iron staining in the cerebral cortex of cholesterol fed rabbits

scientific article published in April 2004

Inducible Synthesis of the Gaseous Mediator Hydrogen Sulfide (H2S) by Human Resident Joint Cells and BoneDerived Mesenchymal Progenitor Cells

Inhibition of hypochlorous acid-induced cellular toxicity by nitrite

scientific article

Inhibition of hypochlorous acid-induced oxidative reactions by nitrite: is nitrite an antioxidant?

scientific article published in April 2003

Inhibition of peroxynitrite-mediated cellular toxicity, tyrosine nitration, and alpha1-antiproteinase inactivation by 3-mercapto-2-methylpentan-1-ol, a novel compound isolated from Allium cepa

scientific article (publication date: 7 March 2003)

Inhibitory action of novel hydrogen sulfide donors on bovine isolated posterior ciliary arteries

scientific article published on 4 April 2015

Inhibitory regulation of platelets by hydrogen sulphide

Intracellular glutathione protects human monocyte-derived macrophages from hypochlorite damage ⬇️

scientific article published on March 24, 2012

Investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137

Investigating the generation of hydrogen sulphide from the phosphinodithioate slow-release donor GYY4137: Novel products and experimental tools

Involvement of Potassium Channels and Calcium-Independent Mechanisms in Hydrogen Sulfide-Induced Relaxation of Rat Mesenteric Small Arteries.

scientific article

Is Hydrogen Sulfide a Regulator of Nitric Oxide Bioavailability in the Vasculature?

Is antioxidant potential of the mitochondrial targeted ubiquinone derivative MitoQ conserved in cells lacking mtDNA?

scientific article published in March 2008

Lack of tyrosine nitration by hypochlorous acid in the presence of physiological concentrations of nitrite. Implications for the role of nitryl chloride in tyrosine nitration in vivo

scientific article published on 9 December 2002

Leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats: role of nitric oxide and hydrogen sulfide

scientific article published on 24 January 2014

Loss of 3-Nitrotyrosine on Exposure to Hypochlorous Acid: Implications for the Use of 3-Nitrotyrosine as a Bio-markerin Vivo

article

Loss of 3-chlorotyrosine by inflammatory oxidants: implications for the use of 3-chlorotyrosine as a bio-marker in vivo

scientific article published on 9 April 2008

Loss of oxidized and chlorinated bases in DNA treated with reactive oxygen species: implications for assessment of oxidative damage in vivo

scientific article published in August 2002

MP19-09 DAILY HYDROGEN SULFIDE THERAPY DURING PROLONGED URETERIC OBSTRUCTION ENABLES EARLY RENAL RECOVERY FOLLOWING DECOMPRESSION

MP58-18 EXOGENOUS HYDROGEN SULFIDE TREATMENT REDUCES RENAL FIBROSIS ASSOCIATED WITH CHRONIC URETERAL OBSTRUCTION BY ATTENUATING EPITHELIAL-MESENCHYMAL TRANSITION

Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

scientific article

Mechanism of cell death induced by an antioxidant extract of Cratoxylum cochinchinense (YCT) in Jurkat T cells: the role of reactive oxygen species and calcium

scientific article published on June 2004

Mercaptoethylguanidine inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expressions induced in rats after fluid-percussion brain injury

scientific article

Metabolic, Cardiac, and Renal Effects of the Slow Hydrogen Sulfide-Releasing Molecule GYY4137 During Resuscitated Septic Shock in Swine with Pre-Existing Coronary Artery Disease

scientific article published on 19 January 2017

Mitochondria-Targeted Hydrogen Sulfide Donors Protect Microvascular Endothelial Cells from Hyperglycaemia-Inducted Metabolic Changes and Oxidative Damage

Mitochondria-targeted Hydrogen Sulfide (H 2 S), but not Untargeted H 2 S, Reverses Ventricular Arrhythmia at Reperfusion

article published in 2017

Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2.

scientific article published in July 2018

Mitochondria-targeting hydrogen sulfide donors prolong healthspan: lifespan ratio in Caenorhabditis elegans

Modulation of peroxynitrite-induced fibroblast injury by hesperetin: A role for intracellular scavenging and modulation of ERK signalling

scientific article published in 2006

Multifaceted role of nitric oxide in an in vitro mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signalling cascades

scientific article published on January 2012

Nitric oxide protects against mitochondrial permeabilization induced by glutathione depletion: role of S-nitrosylation?

scientific article published on 10 November 2005

Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat

scientific article published on April 2006

Nitrite-mediated protection against hypochlorous acid-induced chondrocyte toxicity: a novel cytoprotective role of nitric oxide in the inflamed joint?

scientific article published in November 2003

Novel Mitochondria-Targeted Hydrogen Sulfide (H2S) Donors AP39 and AP123 Attenuate Hyperglycaemia-Induced Oxidative Stress and Loss of Bioenergetics in Microvascular Endothelial Cells

Novel Slow Releasing Hydrogen Sulfide (H2S) Donor Compounds Inhibit Endothelial Dysfunction Induced by TNF-α, Oxidative and Nitrosative Stress

OP08 The hydrogen sulfide donor GYY4137 attenuates transient receptor potential vanilloid 1 (TRPV1) antagonist-mediated hyperthermia

OP16 Hydrogen sulfide inhibits human platelet aggregation

OP23 Role of hydrogen sulfide in leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats

OP27 H2S and heme oxygenase: A possible co-operation against diabetic nephropathy

OP28 Is hydrogen sulfide involved in mediating functional effects of dietary nitrate ingestion in humans?

article published in 2013

Oltipraz-induced phase 2 enzyme response conserved in cells lacking mitochondrial DNA.

scientific article published on November 2005

Oxidative damage in mitochondrial DNA is not extensive

scientific article published in May 2005

Oxidative stress in autoimmune rheumatic diseases

article published in 2018

P103 Effects of fast and slow H2S donors on rat hemodynamic parameters

P104 Inhibition of platelet aggregation in vitro and in vivo by the H2S releasing compound GYY4137

P12 The complex effects of a slow-releasing hydrogen sulifde donor (GYY4137) in a model of inflammatory arthritis and in primary human cartilage cells

P14 Comparing the differential effects of novel, slow-release H2S donors on inflammatory mediators and cell proliferation in human joint and immune cells

P21

scholarly article

P22

P44 Does the slow-releasing hydrogen sulfide donor GYY4137 controls inflammation and pruritogen responses in mouse skin?

article

P58 Potential anti-atherogenic effects of hydrogen-sulfide releasing molecules

P63 Hydrogen sulfide – a novel guardian of the endothelial glycocalyx?

P65 Characterising the effect of novel slow-release H2S donors on pro-inflammatory enzyme activity in human cartilage cells

P89 Inhibition of endogenous hydrogen sulfide production decreases hypoxia induced erythropoietin release

P99 Hydrogen-sulfide releasing molecules inhibit intraplaque hemorrhage-associated oxidative burst in the human atheroma and subsequent endothelial reactions

PL03 Expression of H2S-catalyzing enzymes during “acute chronic disease”

PL04 Modulation of inflammatory and vascular signalling by novel slow release and mitochondria-targeted H2S donors

Peroxynitrite mediates calcium-dependent mitochondrial dysfunction and cell death via activation of calpains

scientific article published in July 2004

Pharmacological actions of the slow release hydrogen sulfide donor GYY4137 on phenylephrine-induced tone in isolated bovine ciliary artery

scientific article published on 18 October 2013

Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137.

scientific article published on July 2016

Pharmacological tools for hydrogen sulphide research: a brief, introductory guide for beginners

scientific article

Potentiation of Methyl Aminolevulinate (MAL)-Induced Photodynamic Therapy (PDT) Killing of Skin Cancer Cells by Mitochondria-Targeted Hydrogen Sulfide (H2S) Donors

Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice

scientific article published in May 2004

Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis

scientific article published on 30 June 2005

RT01, A Novel Derivative of the Mitochondria-targeted Hydrogen Sulfide Donor AP39, Reversed Hyperglycaemia-induced Mitochondrial Dysfunction in Murine Brain Microvascular Endothelial Cells

Reaction of the Radical Pair NO2•and CO3•-with 2-[6-(4‘-Amino)phenoxy-3H-xanthen-3-on-9-yl]benzoic Acid (APF)

Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide

scientific article published on 17 March 2011

S3-1 H2S in inflammation: Time for resolution?

Slow release hydrogen sulfide donors and inflammation: A novel therapeutic opportunity

Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis

scientific article published in August 2005

Sulfite-mediated oxidative stress in kidney cells

scientific article published in February 2004

Temporal transcriptomic profiling reveals cellular targets that govern survival in HOCl-mediated neuronal apoptosis ⬇️

scientific article published on September 15, 2010

The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: role of mitcohondrial [correction mitochondrial] complex III.

scientific article published on 29 August 2003

The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages

scientific article

The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction

scientific article published on 5 December 2007

The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro

scientific article published on 23 August 2016

The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'?

scientific article published on August 2004

The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways

scientific article

The reaction of flavonoid metabolites with peroxynitrite

scientific article published in 2006

The redox regulation of intermediary metabolism by a superoxide-aconitase rheostat

scientific article

The role of H2S bioavailability in endothelial dysfunction

scientific article

The slow-releasing hydrogen sulphide donor, GYY4137, exhibits novel anti-skin symptoms of psoriasis and related itch

Therapeutic potential of hydrogen sulfide donors

Therapeutic potential of mitochondria-targeted hydrogen sulphide donors

Vascular Guidance: Microstructural Scaffold Patterning for Inductive Neovascularization ⬇️

scientific article published on December 1, 2010

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