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List of works by Melchiorre Cervello

A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells

scientific article published on 21 January 2016

A new extracellular matrix protein of the sea urchin embryo with properties of a substrate adhesion molecule

scientific article

Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells

scientific article published on 18 October 2019

Advances in targeting signal transduction pathways

scientific article

Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression

scientific article

Antitumor effects of dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, in human liver cancer cells are mediated through a reactive oxygen species-dependent mechanism

scientific article

Antitumor effects of the novel NF-kappaB inhibitor dehydroxymethyl-epoxyquinomicin on human hepatic cancer cells: analysis of synergy with cisplatin and of possible correlation with inhibition of pro-survival genes and IL-6 production.

scientific article published on April 2006

Aromatase and amphiregulin are correspondingly expressed in human liver cancer cells

scientific article

Association Between MICA Gene Variants and the Risk of Hepatitis C Virus-Induced Hepatocellular Cancer in a Sicilian Population Sample.

scientific article published on 27 March 2018

Biocompatible Lipid Nanoparticles as Carriers To Improve Curcumin Efficacy in Ovarian Cancer Treatment.

scientific article published on 23 January 2017

COX-2-dependent and COX-2-independent mode of action of celecoxib in human liver cancer cells.

scientific article published on 16 March 2011

Calcium-dependent self-aggregation of toposome, a sea urchin embryo cell adhesion molecule

scientific article published in 1992

Cancer therapy and treatments during COVID-19 era

scientific article published on 26 June 2020

Cationic Solid Lipid Nanoparticles as Non Viral Vectors for the Inhibition of Hepatocellular Carcinoma Growth by RNA Interference

scientific article published on 01 May 2018

Circulating intercellular adhesion molecule-1 in chronic hepatitis C patients with normal or elevated aminotransferase before and after alpha-interferon treatment

scientific article

Cloning and expression of a type IX-like collagen in tissues of the ascidian Ciona intestinalis.

scientific article

Correction to: Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells

scientific article

Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: possible role in tumor promotion and angiogenesis

scientific article

Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy

scientific article published on 4 March 2016

Cyclooxygenase-2 expression in chronic liver diseases and hepatocellular carcinoma: an immunohistochemical study .

scientific article published in February 2009

Cyclooxygenases in hepatocellular carcinoma.

scientific article published on August 2006

Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells

scientific article

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

scientific article

Diverse roles of GSK-3: tumor promoter-tumor suppressor, target in cancer therapy

scientific article published on 08 October 2013

Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine

scientific article published on 16 November 2012

Effects of ectopic expression of NGAL on doxorubicin sensitivity

scientific article published on October 2012

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer

scientific article published on 06 September 2016

Emerging MEK inhibitors.

scientific article published on June 2010

Emerging Raf inhibitors.

scientific article published on December 2009

Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells

scientific article

Epidemiology, risk factors, and natural history of hepatocellular carcinoma.

scientific article published in June 2002

Expression of IAPs and alternative splice variants in hepatocellular carcinoma tissues and cells

scientific article

Expression of WISPs and of their novel alternative variants in human hepatocellular carcinoma cells.

scientific article

Expression of the IAPs in multidrug resistant tumor cells

scientific article published on 01 January 2004

Frequent Alteration of the Yin Yang 1/Raf-1 Kinase Inhibitory Protein Ratio in Hepatocellular Carcinoma

scientific article published in May 2011

GSK-3 as potential target for therapeutic intervention in cancer

scientific article

GSK-3 in liver diseases: Friend or foe?

scientific article published on 14 May 2020

GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity

scientific article

Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma

scientific article

Hepatic and circulating levels of PCSK9 in morbidly obese patients: relation with severity of liver steatosis

scientific article published on 07 August 2020

Histamine and spontaneously released mast cell granules affect the cell growth of human hepatocellular carcinoma cells

scientific article

IL-6 -174G/C polymorphism and IL-6 serum levels in patients with liver cirrhosis and hepatocellular carcinoma.

scientific article

Identification of Type I and IX Collagens in the Ascidian Ciona intestinalis

Identification of an LPS-Induced Chemo-Attractive Peptide from Ciona robusta

scientific article published on 12 April 2020

Induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors.

scientific article

Induction of apoptosis by the adenosine derivative IB-MECA in parental or multidrug-resistant HL-60 leukemia cells: possible relationship to the effects on inhibitor of apoptosis protein levels

scientific article published on 26 July 2005

Induction of apoptosis by the proteasome inhibitor MG132 in human HCC cells: Possible correlation with specific caspase-dependent cleavage of beta-catenin and inhibition of beta-catenin-mediated transactivation.

scientific article published on May 2004

Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma

scientific article

Lipid nanocarriers containing sorafenib inhibit colonies formation in human hepatocarcinoma cells

scientific article published on 23 July 2015

Management of Liver Failure: From Transplantation to Cell-Based Therapy

scientific article published on June 2011

Molecular mechanisms of sorafenib action in liver cancer cells.

scientific article

Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

scientific article published on September 2012

NAIP-deltaEx10-11: a novel splice variant of the apoptosis inhibitor NAIP differently expressed in drug-sensitive and multidrug-resistant HL60 leukemia cells

scientific article

Nanoassemblies Based on Supramolecular Complexes of Nonionic Amphiphilic Cyclodextrin and Sorafenib as Effective Weapons to Kill Human HCC Cells

scientific article

Nanoparticles of a polyaspartamide-based brush copolymer for modified release of sorafenib: In vitro and in vivo evaluation

scientific article published on 13 September 2017

Nanostructured lipid carriers-containing anticancer compounds: preparation, characterization, and cytotoxicity studies

scientific article published on February 2007

New landscapes and horizons in hepatocellular carcinoma therapy

scientific article published on 04 February 2020

Novel cationic solid-lipid nanoparticles as non-viral vectors for gene delivery

scientific article published on May 2007

Novel combination of celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells

scientific article published in April 2010

Novel combination of sorafenib and celecoxib provides synergistic anti-proliferative and pro-apoptotic effects in human liver cancer cells.

scientific article

Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation

scientific article published on 21 June 2017

Pivotal roles of glycogen synthase-3 in hepatocellular carcinoma

scientific article

Poly (ADP-ribose) polymerase inhibition synergizes with the NF-κB inhibitor DHMEQ to kill hepatocellular carcinoma cells.

scientific article published on 26 July 2014

Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway.

scientific article published on 26 June 2007

Preclinical evaluation of antitumor activity of the proteasome inhibitor MLN2238 (ixazomib) in hepatocellular carcinoma cells

scientific article

Properties of sea urchin coelomocyte agglutinins

scientific article published in 1996

Prostaglandin E2 receptors and COX enzymes in human hepatocellular carcinoma: role in the regulation of cell growth.

scientific article

RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinoma

scientific article published on 04 November 2019

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance

scientific article

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health

scientific article published on March 2011

Regulation of GSK-3 activity by curcumin, berberine and resveratrol: Potential effects on multiple diseases

scientific article published on 26 May 2017

Resistance to diverse apoptotic triggers in multidrug resistant HL60 cells and its possible relationship to the expression of P-glycoprotein, Fas and of the novel anti-apoptosis factors IAP (inhibitory of apoptosis proteins).

scientific article published on June 2002

Response to antiviral therapy and hepatic expression of cyclooxygenases in chronic hepatitis C.

scientific article published in November 2007

Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells

scientific article published on 17 July 2015

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells

scientific article

Roles of NGAL and MMP-9 in the tumor microenvironment and sensitivity to targeted therapy

scientific article published on 13 August 2015

Roles of TP53 in determining therapeutic sensitivity, growth, cellular senescence, invasion and metastasis

scientific article

Roles of p53, NF-κB and the androgen receptor in controlling NGAL expression in prostate cancer cell lines

article

Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis

scientific article

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

scientific article

Significance of Autologous Interleukin-6 Production in the HA22T/VGH Cell Model of Hepatocellular Carcinoma

scientific article published in November 2006

Synthesis and characterization of polyaminoacidic polycations for gene delivery

scientific article published on 19 October 2005

Synthetic peptide-labelled micelles for active targeting of cells overexpressing EGF receptors

scientific article published on 25 June 2019

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon

scientific article

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer

scientific article published on 30 April 2020

Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma

scientific article published on 24 December 2018

Targeting breast cancer initiating cells: advances in breast cancer research and therapy

scientific article

Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.

scientific article

Targeting the cancer initiating cell: the ultimate target for cancer therapy.

scientific article published on January 2012

The Prevalence of NAFLD and Fibrosis in Bariatric Surgery Patients and the Reliability of Noninvasive Diagnostic Methods

scientific article published on 26 April 2020

The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment

scientific article published on 09 June 2020

The novel NF-κB inhibitor DHMEQ synergizes with celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism.

scientific article

The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells

scientific article published on February 2006

Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.

scientific article

Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways

scientific article

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