List of works by Marcelo E Bigal

A Phase I, Open-Label, Single-Dose Safety, Pharmacokinetic, and Tolerability Study of the Sumatriptan Iontophoretic Transdermal System in Adolescent Migraine Patients

scientific article published on 29 July 2016

A randomized double-blind study comparing rizatriptan, dexamethasone, and the combination of both in the acute treatment of menstrually related migraine

scientific article

ADHD and mental health status in Brazilian school-age children

scientific article published on 4 June 2012

Acute migraine medications and evolution from episodic to chronic migraine: a longitudinal population-based study

scientific article

Acute migraine treatment with rizatriptan in real world settings - focusing on treatment strategy, effectiveness, and behavior

scientific article published on February 2009

Adherence to acute migraine medication: what does it mean, why does it matter?

scientific article published on 08 October 2009

Advances in the pharmacologic treatment of tension-type headache

scientific article

Age-dependent prevalence and clinical features of migraine

scientific article

Are sleep onset/maintenance difficulties associated with medical or psychiatric comorbidities in nondemented community-dwelling older adults?

scientific article published on 15 April 2013

Assessment of adverse events associated with triptans--methods of assessment influence the results

scientific article published in November 2004

Assessment of migraine disability using the migraine disability assessment (MIDAS) questionnaire: a comparison of chronic migraine with episodic migraine

scientific article published on 01 April 2003

BMS-927711 for the acute treatment of migraine

scientific article published on 13 August 2013

Balance Impairments in Different Subgroups of Patients With Migraine

scientific article published on 19 December 2016

Barriers to satisfactory migraine outcomes. What have we learned, where do we stand?

scientific article published on 06 April 2009

Behavioral and emotional symptoms and primary headaches in children: a population-based study

scientific article published on 17 September 2012

Botulinum neurotoxin type A in the preventive treatment of refractory headache: a review of 100 consecutive cases

scientific article published in September 2004

Burden of migraine in Brazil: estimate of cost of migraine to the public health system and an analytical study of the cost-effectiveness of a stratified model of care

scientific article published in July 2003

Calcitonin gene-related peptide (CGRP) and migraine current understanding and state of development

scientific article published on 12 July 2013

Cerebral Venous Thrombosis and Headache--A Case-Series

scientific article published in June 2015

Cervical mobility in women with migraine

scientific article published on 9 September 2008

Childhood periodic syndromes: a population-based study

scientific article published in December 2010

Chronic daily headache: identification of factors associated with induction and transformation

scientific article published in July 2002

Chronic daily headache: is analgesic overuse a cause or a consequence?

scientific article published on 01 July 2003

Chronic disorders with episodic manifestations: focus on epilepsy and migraine

scientific article

Chronic migraine in the population: burden, diagnosis, and satisfaction with treatment

scientific article published in August 2008

Chronic pain and depression in the quality of life of women with migraine--a controlled study

scientific article published on 14 February 2012

Chronic pain and obesity in elderly people: results from the Einstein aging study

scientific article

Clinical course in migraine: conceptualizing migraine transformation

scientific article published on September 2008

Clinical trials update--2012: year in review--a comment

scientific article published in June 2013

Comorbidity of migraine

scientific article

Concepts and mechanisms of migraine chronification

scientific article published on January 2008

Concurrent functional and structural cortical alterations in migraine

scientific article published on 23 May 2012

Correlation of increase in phosphene threshold with reduction of migraine frequency: a comment

scientific article

Cutaneous allodynia in the migraine population

scientific article published on February 2008

Development of a simple menstrual migraine screening tool for obstetric and gynecology clinics: the menstrual migraine assessment tool

scientific article

Diagnostic evaluation and treatment of trigeminal neuralgia

scientific article published on August 2009

Do women with migraine have higher prevalence of temporomandibular disorders?

scientific article published on 2 November 2012

Efficacy and safety of topiramate for the treatment of chronic migraine: a randomized, double-blind, placebo-controlled trial.

scientific article

Efficacy of three drugs in the treatment of migrainous aura: a randomized placebo-controlled study

scientific article

Elevated saliva calcitonin gene-related peptide levels during acute migraine predict therapeutic response to rizatriptan

scientific article published in October 2009

Emerging drugs for migraine prophylaxis and treatment.

scientific article published on 4 May 2006

Ergotamine and dihydroergotamine: a review

scientific article

Evaluation of cardiovascular parameters in cynomolgus monkeys following IV administration of LBR-101, a monoclonal antibody against calcitonin gene-related peptide

scientific article published on 21 May 2014

Excellent Tolerability But Relatively Low Initial Clinical Efficacy of Telcagepant in Migraine: A Response

article

Excessive acute migraine medication use and migraine progression

scientific article

Excessive opioid use and the development of chronic migraine

scientific article (publication date: April 2009)

Factors associated with triptan use in episodic migraine: results from the American Migraine Prevalence and Prevention Study

scientific article published in February 2012

Fremanezumab as Add-On Treatment for Patients Treated With Other Migraine Preventive Medicines

scientific article published on September 2017

Fremanezumab for preventive treatment of migraine: Functional status on headache-free days

scholarly article by Juliana VanderPluym et al published 18 September 2018 in Neurology

Fremanezumab for the Preventive Treatment of Chronic Migraine

scientific article published in November 2017

From LBR-101 to Fremanezumab for Migraine

article by Marcelo E Bigal et al published 11 October 2018 in CNS Drugs

Functional Balance Deterioration on Daily Activities in Patients With Migraine: A Controlled Study.

scientific article published in February 2018

Headache and hemodialysis: a prospective study.

scientific article published in February 2003

Headache and hemodialysis: evaluation of the possible triggering factors and of the treatment

scientific article published in September 2002

Headache and symptoms of temporomandibular disorder: an epidemiological study

scientific article

Headache as a real disease.

scientific article published in May 2008

Headache attributed to hypothyroidism

scientific article published on August 2007

Headache classification and aspects of reproductive life in young women

scientific article published in January 2014

Headache: triumphs in translational research

scientific article

Headaches attributable to infectious diseases

scientific article published on August 2010

Hemicrania continua: a report of ten new cases

scientific article published on September 2002

Impact of recent prior opioid use on rizatriptan efficacy. A post hoc pooled analysis

scientific article

Insulin metabolism is altered in migraineurs. A new pathogenic mechanism for migraine? A comment

scientific article published in April 2008

Intramuscular diclofenac in the acute treatment of migraine: a double-blind placebo controlled study

scientific article

Intranasal medications for the treatment of migraine and cluster headache

scientific article published in January 2004

Intravenous dipyrone in the acute treatment of migraine without aura and migraine with aura: a randomized, double blind, placebo controlled study

scientific article published on October 2002

Is there an inherent limit to acute migraine treatment efficacy?

scientific article published on 10 October 2009

Key concepts of migraine postdrome: a qualitative study to develop a post-migraine questionnaire

scientific article published on January 2011

Levetiracetam in the preventive treatmentof transformed migraine: A prospective, open-label, pilot study

scientific article published on May 2005

Looking to the future: research designs for study of headache disease progression

scientific article published on January 2008

Memantine in the preventive treatment of refractory migraine

scientific article published in October 2008

Migraine and behavior in children: influence of maternal headache frequency

scientific article

Migraine and cardiovascular disease

scientific article published on February 2011

Migraine and cardiovascular disease: systematic review and meta-analysis

scientific article

Migraine and intranasal contact point headache: is there any connection?

scientific article published on August 2006

Migraine and migraine subtypes in preadolescent children: association with school performance

scientific article published on October 2012

Migraine and vestibular symptoms--identifying clinical features that predict "vestibular migraine".

scientific article published on 7 June 2011

Migraine at all ages

scientific article published on June 2006

Migraine attacks the Basal Ganglia

scientific article

Migraine chronification

scientific article published on April 2011

Migraine chronification--concept and risk factors

scientific article published on October 2009

Migraine in the elderly: a comparison with migraine in young adults.

scientific article published in February 2006

Migraine in the pediatric population--evolving concepts

scientific article

Migraine in the triptan era: lessons from epidemiology, pathophysiology, and clinical science

scientific article published on February 2009

Migraine in the triptan era: progresses achieved, lessons learned and future developments

scientific article published on June 2009

Migraine is the most prevalent primary headache in individuals with temporomandibular disorders

scientific article published in June 2010

Migraine treatment and placebo effect

scientific article published on March 2010

Migraine treatment with rizatriptan and almotriptan: a crossover study

scientific article

Migraine with aura versus migraine without aura: pain intensity and associated symptom intensities after placebo.

scientific article published in October 2002

Migraine: epidemiology, impact, and risk factors for progression

scientific article

Modifiable risk factors for migraine progression

scientific article published on October 2006

Modifiable risk factors for migraine progression (or for chronic daily headaches)--clinical lessons

scientific article published on October 2006

Monoclonal antibodies for migraine: preventing calcitonin gene-related peptide activity

scientific article published on May 2014

Naratriptan in the preventive treatment of refractory chronic migraine: a review of 27 cases

scientific article

Naratriptan in the preventive treatment of refractory transformed migraine: a prospective pilot study

scientific article published in November 2005

Neuromodulators for the treatment of headache disorders and fibromyalgia

scientific article published on October 2008

New and emerging prophylactic agents for migraine

scientific article

New developments in migraine prophylaxis

scientific article

New migraine preventive options: an update with pathophysiological considerations

scientific article

New onset headache in a woman with recurrent ear infections

scientific article published in March 2005

Obesity and chronic daily headache

scientific article

Obesity and migraine: a population study

scientific article published on 14 December 2005

Obesity, migraine, and chronic migraine: possible mechanisms of interaction

scientific article published on May 2007

Opioid therapy and headache: a cause and a cure

scientific article

Overuse of acute migraine medications and migraine chronification

scientific article published on August 2009

Patterns of use of triptans and reasons for switching them in a tertiary care migraine population

scientific article

Post-traumatic stress disorder in episodic and chronic migraine.

scientific article published in April 2008

Prevalence and burden of headaches as assessed by the health family program

scientific article published on 21 February 2012

Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents

scientific article

Primary Headaches in an Elderly Population Seeking Medical Care for Cognitive Decline

scientific article

Prophylactic migraine therapy: emerging treatment options

scientific article published on June 2004

Proton spectroscopy in patients with post-traumatic headache attributed to mild head injury

scientific article

Psychosocial adjustment of children with migraine and tension-type headache - a nationwide study

scientific article published on 6 February 2015

Putative mechanisms of the relationship between obesity and migraine progression

scientific article published on June 2008

Rates and predictors of starting a triptan: results from the American Migraine Prevalence and Prevention Study

scientific article published on October 2010

Re: chronic daily headache in children and adolescents presenting to tertiary headache clinics

scientific article published on 01 April 2003

Response to 'comments on results of Scher et al. pertaining to nonprescription caffeine-containing combination analgesics'.

scientific article published on December 2010

Role of melatonin in the pathophysiology of migraine: implications for treatment

scientific article

Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program

scientific article

Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study

scientific article published on 29 September 2015

Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study.

scientific article

Satisfaction with current migraine therapy: experience from 3 centers in US and Sweden

scientific article

Screening and behavioral management: obesity and weight management

scientific article published on January 2008

Side-locked headache as the chief complaint of inflammatory orbital pseudotumor (myositic form): a case report

scientific article published on April 2006

Sleep onset/maintenance difficulties and cognitive function in nondemented older adults: the role of cognitive reserve

scientific article published on 09 February 2012

Study of the use of analgesics by patients with headache at a specialized outpatient clinic (ACEF).

scientific article published on July 2015

Subcortical lesions in migraine: are they related to mitochondrial dysfunction?

scientific article published in October 2006

Sumatriptan Iontophoretic Transdermal System Reduces Treatment-Emergent Nausea and Is Effective in Patients With and Without Nausea at Baseline - Results From a Randomized Controlled Trial

scientific article published on 14 July 2015

Sumatriptan: a decade of use and experience in the treatment of migraine

scientific article

Sustained reductions in migraine days, moderate-to-severe headache days and days with acute medication use for HFEM and CM patients taking fremanezumab: Post-hoc analyses from phase 2 trials.

scientific article published in January 2018

Symptoms of temporomandibular disorders in the population: an epidemiological study

scientific article published on January 1, 2010

TEV-48125 for the preventive treatment of chronic migraine: Efficacy at early time points

scientific article published on 08 June 2016

TEV-48125: a review of a monoclonal CGRP antibody in development for the preventive treatment of migraine

scientific article

Target doses and titration schedules for migraine preventive medications

scientific article published on January 2006

Temporomandibular disorders and migraine chronification

scientific article published on August 2009

Ten lessons on the epidemiology of migraine

scientific article published on April 2007

Tension-type headache: classification and diagnosis

scientific article

The burden of migraine in the United States: current and emerging perspectives on disease management and economic analysis

scientific article published on 30 July 2008

The clinical spectrum of migraine

scientific article published on 01 January 2003

The differential diagnosis of chronic daily headaches: an algorithm-based approach

scientific article published on 23 October 2007

The effect of weather on headache

scientific article

The epidemiology and impact of migraine

scientific article published on March 2004

The epidemiology of migraine.

scientific article

The epidemiology, burden, and comorbidities of migraine

scientific article published on May 2009

The medical management of migraine

scientific article published on March 2004

The metabolic headaches

scientific article published on August 2008

The paradoxical effects of analgesics and the development of chronic migraine

scientific article published on June 2011

The preventive treatment of migraine

scientific article published on July 2006

The prognosis of migraine

scientific article

The social impact and burden of headache

scientific article published on January 1, 2010

The triptan formulations : how to match patients and products

scientific article

The triptan formulations: a critical evaluation

scientific article

The triptans

scientific article

Therapeutic antibodies against CGRP or its receptor

scientific article published on June 2015

Tinnitus in migraine: an allodynic symptom secondary to abnormal cortical functioning?

scientific article published in September 2005

Topiramate plus nortriptyline in the preventive treatment of migraine: a controlled study for nonresponders

scientific article published on 19 October 2011

Topiramate treatment of chronic migraine: a randomized, placebo-controlled trial of quality of life and other efficacy measures

scientific article published in September 2009

Toward an epidemiology of refractory migraine: current knowledge and issues for future research

scientific article published on 9 May 2008

Treatment of comorbid migraine and temporomandibular disorders: a factorial, double-blind, randomized, placebo-controlled study

scientific article published in September 2013

Treatment of comorbidities of chronic daily headache

scientific article

Triptan use as a function of cardiovascular risk. A population-based study

scientific article published on 21 December 2009

Uncommon headache syndromes in the pediatric population

scientific article published on August 2011

What predicts the change from episodic to chronic migraine?

scientific article published on June 2009

When migraine progresses: transformed or chronic migraine

scientific article

Why does sleep stop migraine?

scientific article published on October 2013

Zolmitriptan (Zomig).

scientific article

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