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List of works by Charles Wachihi

"How I Wish This Thing Was Initiated 100 Years Ago!" Willingness to Take Daily Oral Pre-Exposure Prophylaxis among Men Who Have Sex with Men in Kenya

scientific article

A Genetic Polymorphism of FREM1 Is Associated with Resistance against HIV Infection in the Pumwani Sex Worker Cohort ⬇️

scientific article published on August 22, 2012

A TRIM5alpha exon 2 polymorphism is associated with protection from HIV-1 infection in the Pumwani sex worker cohort

scientific article

A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers

scientific article published on October 2008

An integrative bioinformatic approach for studying escape mutations in human immunodeficiency virus type 1 gag in the Pumwani Sex Worker Cohort

scientific article

Anti-HIV-1 activity of elafin depends on its nuclear localization and altered innate immune activation in female genital epithelial cells

scientific article

Anti-HIV-1 activity of elafin is more potent than its precursor's, trappin-2, in genital epithelial cells

scientific article published on 15 February 2012

Associations of human leukocyte antigen DRB with resistance or susceptibility to HIV-1 infection in the Pumwani Sex Worker Cohort

scientific article published in May 2008

Associations of human leukocyte antigen-G with resistance and susceptibility to HIV-1 infection in the Pumwani sex worker cohort ⬇️

scientific article published on January 2, 2013

Bacterial vaginosis in HIV-infected women induces reversible alterations in the cervical immune environment

scientific article published in December 2008

Bacterial vaginosis, HIV serostatus and T-cell subset distribution in a cohort of East African commercial sex workers: retrospective analysis

scientific article

Blunted IL17/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV-exposed, seronegative female sex workers in Kenya

scientific article

CD26/dipeptidyl peptidase IV (CD26/DPPIV) is highly expressed in peripheral blood of HIV-1 exposed uninfected female sex workers

scientific article

CD4+ T cell responses in HIV-exposed seronegative women are qualitatively distinct from those in HIV-infected women

scientific article published in December 2004

Characterization of CD8 T-cell responses in HIV-1-exposed seronegative commercial sex workers from Nairobi, Kenya

scientific article

Clade-specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 clade A1 p24.

scientific article published on 16 September 2009

Correction: Enumeration of Sex Workers in the Central Business District of Nairobi, Kenya.

scientific article published on 20 November 2013

Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells

scientific article published in May 2009

Diversity and Frequencies of HLA Class I and Class II Genes of an East African Population

article

Does antiretroviral therapy initiation increase sexual risk taking in Kenyan female sex workers? A retrospective case-control study

scientific article published in April 2012

Effect of baseline HIV disease parameters on CD4+ T cell recovery after antiretroviral therapy initiation in Kenyan women

scientific article

Elevated elafin/trappin-2 in the female genital tract is associated with protection against HIV acquisition

scientific article

Enumeration of sex workers in the central business district of Nairobi, Kenya

scientific article

Epitope cross-reactivity frequently differs between central and effector memory HIV-specific CD8+ T cells

scientific article published in March 2007

Epitope mapping of HIV-specific CD8+ T cell responses by multiple immunological readouts reveals distinct specificities defined by function

scientific article

Epitope mapping of HIV-specific CD8+ T cells in a cohort dominated by clade A1 infection

scientific article

Evaluation of a quantitative real-time PCR assay to measure HIV-specific mucosal CD8+ T cell responses in the cervix

scientific article

For Protection from HIV-1 Infection, More Might Not Be Better: a Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection ⬇️

scientific article published on November 9, 2011

Full-length HIV type 1 proviral sequencing of 10 highly exposed women from Nairobi, Kenya reveals a high proportion of intersubtype recombinants.

scientific article

Genital levels of soluble immune factors with anti-HIV activity may correlate with increased HIV susceptibility

scientific article published on October 2008

HIV postexposure prophylaxis in an urban population of female sex workers in Nairobi, Kenya

scientific article

HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers

scientific article

HIV-1 clade D is associated with increased rates of CD4 decline in a Kenyan cohort

scientific article

HIV-specific CD8+ T-cell proliferation is prospectively associated with delayed disease progression.

scientific article

HIV‐exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV‐dependent host factors

scientific article

High prevalence of genetically similar HIV-1 recombinants among infected sex workers in Nairobi, Kenya

scientific article published on November 2008

Human immunodeficiency virus (HIV) type 1 proviral hypermutation correlates with CD4 count in HIV-infected women from Kenya

scientific article published on 11 June 2008

Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection

scientific article published in April 2008

IL-7Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation

scientific article published in February 2006

Identification of differentially expressed proteins in the cervical mucosa of HIV-1-resistant sex workers

scientific article published on 16 August 2008

Immunogenicity of sequences around HIV-1 protease cleavage sites: Potential targets and population coverage analysis for a HIV vaccine targeting protease cleavage sites ⬇️

scientific article published on May 10, 2013

Influence of HLA class I haplotypes on HIV-1 seroconversion and disease progression in Pumwani sex worker cohort

scientific article

Microarray analysis of HIV resistant female sex workers reveal a gene expression signature pattern reminiscent of a lowered immune activation state

scientific article

Molecular definition of vaginal microbiota in East African commercial sex workers

scientific article

Mucosal Serpin A1 and A3 Levels in HIV Highly Exposed Sero‐Negative Women are Affected by the Menstrual Cycle and Hormonal Contraceptives but are Independent of Epidemiological Confounders ⬇️

scientific article published on September 13, 2012

Negative mucosal synergy between Herpes simplex type 2 and HIV in the female genital tract

scientific article published on March 2007

Reduced cellular susceptibility to in vitro HIV infection is associated with CD4+ T cell quiescence

scientific article

Relative HIV resistance in kenyan sex workers is not due to an altered prevalence or mucosal immune impact of herpes simplex virus type 2 infection

scientific article published in September 2009

Selection, phenotyping and identification of acid and hydrogen peroxide producing bacteria from vaginal samples of Canadian and East African women

scientific article

Substantial intrapatient differences in the breadth and specificity of HIV-specific CD8+ T-cell interferon-gamma and proliferation responses

scientific article published in October 2008

The role of G protein gene GNB3 C825T polymorphism in HIV-1 acquisition, progression and immune activation

scientific article published on 3 January 2012

Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection

scientific article published in March 2008

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