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List of works by Tyler Jacks

A Modular Assembly Platform for Rapid Generation of DNA Constructs.

scientific article published on 18 February 2016

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma.

scientific article published on 10 May 2017

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

scientific article published on 01 August 2019

A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response

scientific journal article

A mouse plasma peptide atlas as a resource for disease proteomics

scientific article published on 3 June 2008

A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo

scientific article

A spatially and temporally restricted mouse model of soft tissue sarcoma

scientific article published on 5 August 2007

A versatile reporter system for CRISPR-mediated chromosomal rearrangements.

scientific article published on 28 May 2015

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

scientific article

ARF is not required for apoptosis in Rb mutant mouse embryos

scientific article published on 01 January 2002

ARF mutation accelerates pituitary tumor development in Rb+/- mice.

scientific article

Abstract SY12-04: Multicellular spatial community featuring a novel neuronal-like malignant phenotype is enriched in pancreatic cancer after neoadjuvant chemotherapy and radiotherapy

scientific article published in 2022

Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer

scientific article published in January 2004

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

scientific journal article

Adaptive and reversible resistance to Kras inhibition in pancreatic cancer cells

scientific article published on 26 December 2017

An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation

scientific article

An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis

scientific article

Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.

scientific article published on September 2017

Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

scientific article published on 16 September 2021

Applications of the CRISPR-Cas9 system in cancer biology

scientific article

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer.

scientific article

Autophagy is required for glucose homeostasis and lung tumor maintenance

scientific article

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

scientific article published on July 2013

BRG1 loss predisposes lung cancers to replicative stress and ATR dependency

scientific article published on 20 July 2020

CRISPR-mediated direct mutation of cancer genes in the mouse liver

scientific article

CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer

scientific article published on 23 December 2019

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop ⬇️

scientific article published on July 8, 2011

Cell type-specific effects of Rb deletion in the murine retina.

scientific article published on July 2004

Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene

scientific article

Characterizing deformability and surface friction of cancer cells.

scientific article published on 22 April 2013

Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas

scientific article published on 20 December 2009

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

scientific article (publication date: 12 March 2009)

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

scientific article

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

scientific article published on 26 July 2016

Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium

scientific article published on April 2004

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers

scientific article

Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation.

scientific article published on 4 January 2018

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

scientific article published on 21 September 2015

Commensal Microbiota Promote Lung Cancer Development via γδ T Cells

scientific article published on 31 January 2019

Comparison of gene expression and DNA copy number changes in a murine model of lung cancer

scientific article published on April 2006

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

scientific article

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

scientific article

Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras

scientific article

Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q− syndrome ⬇️

scientific article published on August 26, 2011

Corrigendum: Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family

scientific article published on May 2017

Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

scientific article published in December 2017

Cre-lox-regulated conditional RNA interference from transgenes

scientific article

Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma

scientific article

Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer.

scientific article published in March 2006

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.

scientific article published on 02 September 2004

Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family

scientific article published on April 2017

Dicer1 functions as a haploinsufficient tumor suppressor

scientific article

Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma

scientific article published on July 2013

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

scientific article published on 30 March 2008

Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents

scientific article published in May 2004

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

scientific article published on 10 July 2020

Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation ⬇️

scientific article published on June 3, 2013

Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage

scientific article published on 01 May 2007

Driving Rel-iant Tregs toward an Identity Crisis

scientific article

Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma

scientific article published on July 2009

Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

scientific article published on 08 July 2020

Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

scientific article published on 16 April 2020

Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression ⬇️

scientific article published on January 18, 2011

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

scientific article

Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation

scientific article published on 13 August 2019

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

scientific article published on 3 February 2016

Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

scientific article published on 07 July 2020

Expression of tumour-specific antigens underlies cancer immunoediting ⬇️

scientific article published on February 8, 2012

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis

scientific article

Future of early detection of lung cancer: the role of mouse models

scientific article

Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing

scientific article

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

scientific article

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

scientific article published on 28 April 2016

HIF-2alpha deletion promotes Kras-driven lung tumor development.

scientific article

IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development

scientific article published on 01 December 2019

Identification of DHODH as a therapeutic target in small cell lung cancer

scientific article published on 01 November 2019

Imaging primary lung cancers in mice to study radiation biology.

scientific article

Immunology. Guilty by association

scientific article

Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations

scientific article published on 20 April 2010

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

scientific article

Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

scientific article published on October 2004

Inducible de novo expression of neoantigens in tumor cells and mice

scientific article published on 27 July 2020

Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target

scientific article published on 15 January 2013

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma.

scientific article

KRAS and YAP1 converge to regulate EMT and tumor survival

scientific article

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.

scientific article published on 2 October 2017

Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1

scientific article published on 08 June 2020

Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas

scientific article published in May 2005

LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint

scientific article published on 22 May 2014

Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes

scientific article published on 17 August 2021

Longitudinal single cell profiling of regulatory T cells identifies IL-33 as a driver of tumor immunosuppression

Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer

scientific article published on 30 September 2021

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

scientific article published on May 2016

MHC-II neoantigens shape tumour immunity and response to immunotherapy

scientific article published on 23 October 2019

Mammalian RNAi: a practical guide

scientific article published in August 2005

Marked regression of metastatic pilocytic astrocytoma during treatment with imatinib mesylate (STI-571, Gleevec): a case report and laboratory investigation

scientific article published in August 2003

Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1

scientific journal article

Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization ⬇️

scientific article published on January 8, 2002

Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development.

scientific article published in September 2005

MicroRNA expression profiles classify human cancers

scientific article (publication date: 9 June 2005)

MicroRNAs and cancer: short RNAs go a long way.

scientific article published on February 2009

Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma

scientific article published on 01 January 2006

Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

scientific article published on 01 June 2021

Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency

scientific article published on 08 August 2007

Multiple response elements and differential p53 binding control Perp expression during apoptosis

scientific article published on 01 December 2003

Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification

scientific article published on 18 January 2007

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

scientific article published on 01 December 2004

Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice

scientific article published in October 2004

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma

scientific article published on 04 October 2016

Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma

scientific article published on 21 March 2013

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

scientific article published on 10 July 2019

Nuclear factor I/B is an oncogene in small cell lung cancer

scientific article

Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer

article published in the Proceedings of the National Academy of Sciences of the United States of America

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

scientific article

PKM2, cancer metabolism, and the road ahead

scientific article published on 17 November 2016

Perp is a mediator of p53-dependent apoptosis in diverse cell types

scientific journal article

Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes

article

Progesterone receptor expression in neurofibromas.

scientific article published in February 2003

Proliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of DICER1 ⬇️

scientific article published on June 12, 2012

Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation

scientific article published in September 2005

Protocol for single-cell ATAC sequencing using combinatorial indexing in mouse lung adenocarcinoma

scientific article published on 03 June 2021

Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.

scientific article published on 29 May 2013

Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival

scientific article

RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult

scientific article published on 02 January 2004

ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice

scientific article

Rapid modelling of cooperating genetic events in cancer through somatic genome editing

scientific article

Rb and N-ras function together to control differentiation in the mouse

scientific article

Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation

scientific article published on 18 June 2019

Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo

scientific article

Recombinase-based conditional and reversible gene regulation via XTR alleles

scientific article

Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer

scientific article

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.

scientific article

Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma

scientific article published on 21 October 2009

Requirement for Rac1 in a K-ras induced lung cancer in the mouse

scientific article published in September 2007

Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation

scientific article

Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma

scientific article published on 16 June 2011

Restoration of p53 function leads to tumour regression in vivo

scientific article (publication date: 8 February 2007)

Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer

scientific article published on 01 December 2021

Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

scientific article published on 26 December 2004

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress ⬇️

scientific article published on May 9, 2011

Small RNA combination therapy for lung cancer

scientific article

SnapShot: Lung Cancer Models ⬇️

scientific article published on March 30, 2012

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

scientific article published on March 2007

Stage-specific sensitivity to p53 restoration during lung cancer progression.

scientific article

Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development

scientific article published on 19 November 2015

Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy

scientific article

Suppression of lung adenocarcinoma progression by Nkx2-1

scientific article

Suppression of non-small cell lung tumor development by the let-7 microRNA family

scientific article

Survival of pancreatic cancer cells lacking KRAS function.

scientific article

Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects

scholarly article

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

scientific article

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

scientific article (publication date: 5 November 2009)

Targeted deletion reveals an essential function for the telomere length regulator Trf1.

scientific article published in September 2003

Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters

scientific article

Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function

scientific article

Technologically advanced cancer modeling in mice ⬇️

scientific article published on February 1, 2002

The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer

scientific article published on 24 July 2020

The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion

scholarly article

The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung

scientific article published in April 2015

The differential effects of mutant p53 alleles on advanced murine lung cancer

scientific article published on 01 November 2005

The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium

scientific article published on 28 October 2005

Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment

scientific article

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

scientific article

Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras

scientific article

Treating metastatic cancer with nanotechnology

scientific article published on 23 December 2011

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

scientific article published on 01 April 2005

Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis ⬇️

scientific article published on April 21, 2011

Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling

scientific article published on 01 April 2020

Use of gene expression profiling to direct in vivo molecular imaging of lung cancer

scientific article

iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer

scientific article published on 10 August 2018

p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

scientific article

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

scientific article published in Nature

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