List of works by Ana J García-Sáez

7th Tuscany Retreat on Cancer Research: genetic profiling, resistance mechanism and novel treatment concepts in cancer.

scientific article published on 16 December 2011

A new perspective on membrane-embedded Bax oligomers using DEER and bioresistant orthogonal spin labels

scientific article published on 10 September 2019

A single herpesvirus protein can mediate vesicle formation in the nuclear envelope

scientific article published on 20 January 2015

Apoptotic foci at mitochondria: in and around Bax pores

scientific article

Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprins

scientific article published on 18 September 2020

Assembling the puzzle: Oligomerization of α-pore forming proteins in membranes

scientific article

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers

scientific article published on 22 July 2015

Automated analysis of giant unilamellar vesicles using circular Hough transformation.

scientific article published on 18 February 2014

BCL-2-family protein tBID can act as a BAX-like effector of apoptosis

scientific article published on 21 December 2021

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores.

scientific article published on 18 January 2016

Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species

scientific article

Cardiolipin effects on membrane structure and dynamics.

scientific article

DRP1 interacts directly with BAX to induce its activation and apoptosis

scientific article published on 13 January 2022

Destabilization exerted by peptides derived from the membrane-proximal external region of HIV-1 gp41 in lipid vesicles supporting fluid phase coexistence.

scientific article published on 18 February 2011

Determinants of BH3 Sequence Specificity for the Disruption of Bcl-xL/cBid Complexes in Membranes.

scientific article published on 7 February 2017

Differences in activity of actinoporins are related with the hydrophobicity of their N-terminus

scientific article

Drp1 modulates mitochondrial stress responses to mitotic arrest

scientific article published on 19 March 2020

Drp1 polymerization stabilizes curved tubular membranes similar to those of constricted mitochondria.

scientific article published on 19 December 2017

Dynamic interaction of cBid with detergents, liposomes and mitochondria.

scientific article

Dynamin-related protein 1 (Drp1) promotes structural intermediates of membrane division

scientific article

Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim

scientific article published on 12 June 2019

Fluorescence correlation spectroscopy for the study of membrane dynamics and organization in giant unilamellar vesicles

scientific article published on 01 January 2010

Formation of disulfide bridges drives oligomerization, membrane pore formation, and translocation of fibroblast growth factor 2 to cell surfaces.

scientific article published on 18 February 2015

Giant unilamellar vesicles (GUVs) as a new tool for analysis of caspase-8/Bid-FL complex binding to cardiolipin and its functional activity.

scientific article

Lipids glue BAK dimers together

scientific article published on 29 September 2020

MERLIN: a novel BRET-based proximity biosensor for studying mitochondria-ER contact sites

scientific article published on 09 December 2019

MIM through MOM: the awakening of Bax and Bak pores

scientific article published on 22 August 2018

MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF

scientific article published on 02 June 2021

Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.

scientific article published on January 2013

Membrane Disintegration Caused by the Steroid Saponin Digitonin Is Related to the Presence of Cholesterol.

scientific article published on 9 November 2015

Membrane promotes tBID interaction with BCL(XL).

scientific article published on 11 October 2009

Membrane-insertion fragments of Bcl-xL, Bax, and Bid

scientific article published on 01 August 2004

Membranes in motion: mitochondrial dynamics and their role in apoptosis.

scientific article published on March 2014

Mitochondrial alterations in apoptosis.

scientific article published on 13 April 2014

Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization

scientific article published on 03 January 2020

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

More Than a Pore: The Interplay of Pore-Forming Proteins and Lipid Membranes.

scientific article published on 19 June 2015

New biophysical methods to study the membrane activity of Bcl-2 proteins.

scientific article

Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores

scientific article published on 01 March 2006

Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins

scientific article published on 18 March 2005

Peptides in apoptosis research.

scientific article

Permeabilization of the Outer Mitochondrial Membrane by Bcl-2 Proteins ⬇️

scientific article published on January 1, 2010

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion.

scientific article

Pore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM.

scientific article

Pore formation in regulated cell death

scientific article published on 30 October 2020

Pores formed by Baxα5 relax to a smaller size and keep at equilibrium ⬇️

scientific article published on November 3, 2010

Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size

scientific article published on 7 October 2013

Quantitative analysis of super-resolved structures using ASAP

scientific article published on 01 July 2019

Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation.

scientific article published on 13 July 2017

Scanning fluorescence correlation spectroscopy on biomembranes.

scientific article

Single event visualization of unconventional secretion of FGF2

scientific article published on 23 November 2018

Structural model of active Bax at the membrane.

scientific article published on 30 October 2014

TAT-RasGAP<sub>317-326</sub> kills cells by targeting inner-leaflet-enriched phospholipids

scientific article published on 30 November 2020

The Mysteries around the BCL-2 Family Member BOK

scientific article published on 04 December 2020

Toxicity of an α-pore-forming toxin depends on the assembly mechanism on the target membrane as revealed by single molecule imaging

scientific article published on 18 December 2014

cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities.

scientific article published on 25 February 2016

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