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List of works by Jeremy R. Lohman

4-Methylideneimidazole-5-One-Containing Aminomutases in Enediyne Biosynthesis

scientific article published on January 1, 2012

A new member of the 4-methylideneimidazole-5-one–containing aminomutase family from the enediyne kedarcidin biosynthetic pathway ⬇️

scientific article published on April 30, 2013

Activity of Fatty Acid Biosynthesis Initiating Ketosynthase FabH with Acetyl/Malonyl-oxa/aza(dethia)CoAs

scientific article published on 10 January 2023

Atomic resolution structures ofEscherichia coliandBacillus anthracismalate synthase A: Comparison with isoform G and implications for structure-based drug discovery

scientific article

Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes

scientific article published on 31 January 2014

C-S bond cleavage by a polyketide synthase domain

scientific article

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. ⬇️

scientific article published on 29 January 2013

Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.

scientific article

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis

scientific article published on 30 August 2017

Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892

scientific article

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.

scientific article

Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027

scientific article

Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase ⬇️

scientific article

Development of a family of redox-sensitive green fluorescent protein indicators for use in relatively oxidizing subcellular environments

scientific article

Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis

scientific article

Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.

scientific article

Kinetic folding of Haloferax volcanii and Escherichia coli dihydrofolate reductases: haloadaptation by unfolded state destabilization at high ionic strength.

scientific article published on 3 January 2008

Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species

scientific article

P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities

scientific article

PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates

scientific article published on 17 January 2018

Post-Polyketide Synthase Steps in Iso-migrastatin Biosynthesis, Featuring Tailoring Enzymes with Broad Substrate Specificity ⬇️

scientific article published on February 11, 2013

Strain Prioritization and Genome Mining for Enediyne Natural Products

scientific article (publication date: 20 December 2016)

Strain prioritization for natural product discovery by a high-throughput real-time PCR method.

scientific article

Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.

scientific article published on 13 March 2018

Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases

scientific article published on 29 September 2015

Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog Fold ⬇️

scientific article published on January 24, 2013

Structures of LnmK, a Bifunctional Acyltransferase/Decarboxylase, with Substrate Analogues Reveal the Basis for Selectivity and Stereospecificity

scientific article published on 22 January 2021

Structures of chloramphenicol acetyltransferase III and E. coli β-ketoacylsynthase III co-crystallized with partially hydrolysed acetyl-oxa(dethia)CoA

scientific article published on 24 August 2022

Substrate Enolate Intermediate and Mimic Captured in the Active Site of Streptomyces coelicolor Methylmalonyl-CoA Epimerase

scholarly article

Sulfonate/Nitro Bearing Methylmalonyl-Thioester Isosteres Applied to Methylmalonyl-CoA Decarboxylase Structure-Function Studies

scientific article published on 19 March 2019

The LnmK Bifunctional Acyltransferase/Decarboxylase Specifying (2R)-Methylmalonyl-CoA and Employing Substrate-Assisted Catalysis for Polyketide Biosynthesis

scientific article published on 23 October 2020

The Missing C-17 O-Methyltransferase in Geldanamycin Biosynthesis ⬇️

scientific article published on June 17, 2011

The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins

scientific article

The effect of salts on the activity and stability of Escherichia coli and Haloferax volcanii dihydrofolate reductases.

scientific article

Utilizing the GAAA Tetraloop/Receptor To Facilitate Crystal Packing and Determination of the Structure of a CUG RNA Helix ⬇️

scientific article published on October 12, 2012

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