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List of works by Stephen T Safrany

3-position modification of myo-inositol 1,4,5-trisphosphate: consequences for intracellular Ca2+ mobilisation and enzyme recognition.

scientific article

A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity.

scientific article published on 02 March 2016

A comparison between muscarinic receptor occupancy, inositol 1,4,5-trisphosphate accumulation and Ca2+ mobilization in permeabilized SH-SY5Y neuroblastoma cells

scientific article

A novel mechanism for the anticancer activity of aspirin and salicylates

scientific article published on 29 January 2019

Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor

scientific article

Are fluoxetine's effects due to sigma-1 receptor agonism?

scientific article

Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the PH domain of protein kinase Balpha.

scientific article published on July 2008

Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells ⬇️

scientific article published on October 15, 1997

Ca2(+)-mobilising properties of synthetic fluoro-analogues of myo-inositol 1,4,5-trisphosphate and their interaction with myo-inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase

scientific article published on December 1990

Characterisation of a bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) from Drosophila melanogaster.

scientific article published on 24 January 2007

Characterizing Enzymes of the Diphosphoinositol Polyphosphate Phosphohydrolase (DIPP) Family

scientific article published on 01 January 2020

Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases

scientific article

Dipentylammonium Binds to the Sigma-1 Receptor and Protects Against Glutamate Toxicity, Attenuates Dopamine Toxicity and Potentiates Neurite Outgrowth in Various Cultured Cell Lines

article

Diphosphoinositol polyphosphates: the final frontier for inositide research?

scientific article

Disruption and overexpression of the Schizosaccharomyces pombe aps1 gene, and effects on growth rate, morphology and intracellular diadenosine 5',5"'-P1,P5-pentaphosphate and diphosphoinositol polyphosphate concentrations

scientific article published on February 2003

Fibrinogen - a possible extracellular target for inositol phosphates

scientific article published on December 2012

Interaction of synthetic D-6-deoxy-myo-inositol 1,4,5-trisphosphate with the Ca2(+)-releasing D-myo-inositol 1,4,5-trisphosphate receptor, and the metabolic enzymes 5-phosphatase and 3-kinase

scientific article published on 01 January 1991

Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase ⬇️

scientific article published on November 15, 1997

Muscarinic receptors, phosphoinositide metabolism and intracellular calcium in neuronal cells

scientific article

Neuronal muscarinic receptors and phosphoinositide metabolism ⬇️

scientific article published on April 1, 1991

Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate

scientific article (publication date: 6 December 2002)

Protocols for regulation and study of diphosphoinositol polyphosphates.

scientific article published on September 2004

Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression

scientific article published on 08 June 2020

Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

scientific article published on July 2004

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

scientific article published on 30 September 2004

Synthetic D- and L-enantiomers of 2,2-difluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate interact differently with myo-inositol 1,4,5-trisphosphate binding proteins: identification of a potent small molecule 3-kinase inhibitor

scientific article published on January 1, 1992

The Cytotoxicity and Synergistic Potential of Aspirin and Aspirin Analogues Towards Oesophageal and Colorectal Cancer

scientific article published on 01 January 2019

The g5R (D250) gene of African swine fever virus encodes a Nudix hydrolase that preferentially degrades diphosphoinositol polyphosphates

scientific article published on February 2002

The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups

scientific article published in December 2005

Turnover of bis-diphosphoinositol tetrakisphosphate in a smooth muscle cell line is regulated by beta 2-adrenergic receptors through a cAMP-mediated, A-kinase-independent mechanism ⬇️

scientific article published on March 16, 1998

Understanding inositol pyrophosphate metabolism and function: kinetic characterization of the DIPPs

scientific article published on 08 September 2013

Viral Activation of Interleukin-15 (IL-15): Characterization of a Virus-Inducible Element in the IL-15 Promoter Region

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