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List of works by R David G Theakston

1st International Congress on Envenomations and their Treatments Institut Pasteur, Paris, 7-9 June, 1995.

scientific article

6-Phosphogluconate dehydrogenase activity in malaria-infected erythrocytes

scientific article published in January 1973

A bite by a carpet viper (Echis carinatus) in a research institute

scientific article published on 01 January 1990

A clinical study of viper bite poisoning

scientific article

A humane alternative to the measurement of the lethal effects (ld50) of non-neurotoxic venoms using hens' eggs ⬇️

scientific article published on July 1, 1998

A list of animal toxins and some other natural products with biological activity

scientific article published on May 2002

A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa

scientific article published on July 2003

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

scientific article

A technique for the cytochemical demonstration in the electron microscope of glucose-6-phosphate dehydrogenase activity in erythrocytes of malaria-infected animals

scientific article published on April 1973

Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities

scientific article

An electron cytochemical study of 6-phosphogluconate dehydrogenase activity in infected erythrocytes during malaria

scientific article published in August 1973

An electron cytochemical study of glucose-6-phosphate dehydrogenase activity in erythrocytes of malaria-infected mice, monkeys and chickens ⬇️

scientific article published on June 22, 1971

An electron cytochemical study of glucose-6-phosphate dehydrogenase activity in malaria-infected erythrocytes

scientific article published on January 1, 1971

An in vivo but insensate model for the evaluation of antivenoms (ED(50)) using fertile hens' eggs

scientific article

An investigation of the coagulant activity of the venom of the saw-scaled viper (Echis carinatus) from Saudi Arabia

scientific article published on October 1988

An investigation of venom secretion by the venom gland cells of the carpet viper (Echis carinatus).

scientific article published in January 1986

An objective approach to antivenom therapy and assessment of first aid measures in snake bite

scientific article published on October 1, 1997

An open, randomized comparative trial of two antivenoms for the treatment of envenoming by Sri Lankan Russell's viper (Daboia russelii russelii).

scientific article

Antibody zymography: a novel adaptation of zymography to determine the protease-neutralising potential of specific antibodies and snake antivenoms

scientific article published on September 2004

Antigenic relationships and relative immunogenicities of isolated metalloproteinases from Echis ocellatus venom

scientific article published on April 2005

Antivenom reactions and complement depletion in snake bite

scientific article

Antivenomic assessment of the immunological reactivity of EchiTAb-Plus-ICP, an antivenom for the treatment of snakebite envenoming in sub-Saharan Africa

scientific article

Antivenoms: A list of hyperimmune sera currently available for the treatment of envenoming by bites and stings ⬇️

scientific article published on January 1, 1991

Apparent marked reduction in early antivenom reactions compared to historical controls: was it prophylaxis or method of administration?

scientific article

Approximate LD50 determinations of snake venoms using eight to ten experimental animals

scientific article published in January 1986

Bacteriological studies of the venom and mouth cavities of wild Malayan pit vipers (Calloselasma rhodostoma) in southern Thailand

scientific article published on November 1990

Bioinformatics and multiepitope DNA immunization to design rational snake antivenom

scientific article published in June 2006

Bites by the Monocled Cobra, Naja kaouthia, in Chittagong Division, Bangladesh: Epidemiology, Clinical Features of Envenoming and Management of 70 Identified Cases

scientific article

Bites by the Philippine cobra (Naja naja philippinensis): prominent neurotoxicity with minimal local signs

scientific article

Book Reviews

Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy

scientific article

Changes in coagulation effects by venoms of Crotalus atrox as snakes age

scientific article published on September 1, 1978

Characterisation of a monoclonal antibody capable of neutralising the haemorrhagic activity of West African Echis carinatus (carpet viper) venom

scientific article published on January 1988

Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis

scientific article

Characterization of a monomeric disintegrin, ocellatusin, present in the venom of the Nigerian carpet viper, Echis ocellatus

scientific article published in February 2002

Characterization of a novel protein from Proatheris superciliaris venom: proatherocytin, a 34-kDa platelet receptor PAR1 agonist

scientific article published on October 2005

Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage.

scientific article

Cloning of a prothrombin activator-like metalloproteinase from the West African saw-scaled viper, Echis ocellatus ⬇️

scientific article published on November 1, 2003

Coagulopathy and haemorrhage in human victims of Bothrops jararaca envenoming in Brazil

scientific article

Coagulopathy following lethal and non-lethal envenoming of humans by the South American rattlesnake (Crotalus durissus) in Brazil

scientific article

Combining mitochondrial DNA sequences and morphological data to infer species boundaries: phylogeography of lanceheaded pitvipers in the Brazilian Atlantic forest, and the status of Bothrops pradoi (Squamata: Serpentes: Viperidae)

article

Comments on the ultrastructure of human erythrocytes infected with Plasmodium malariae

scientific article published in September 1970

Comparison of the potency of three Brazilian Bothrops antivenoms using in vivo rodent and in vitro assays. BIASG (Butantan Institute Antivenom Study Group)

scientific article published on October 1, 1992

Comparison of the purity and efficacy of affinity purified avian antivenoms with commercial equine crotalid antivenoms

scientific article published on September 1, 1992

Confronting the neglected problem of snake bite envenoming: the need for a global partnership

scientific article

Crotaline snake bite in the Ecuadorian Amazon: randomised double blind comparative trial of three South American polyspecific antivenoms

scientific article

Crystallization and preliminary diffraction data of BaP1, a haemorrhagic metalloproteinase from Bothrops asper snake venom

scientific article

Cytochemical observations on Plasmodium berghei and P. gallinaceum

scientific article published on 01 January 1969

Cytotoxic substances in sera from P. knowlesi-infected rhesus monkeys

scientific article published in January 1973

Defibrination syndrome following snake bite by a North African saw-scaled viper (Echis carinatus pyramidum)

scientific article

Detection of antibodies to myotoxin a and prairie rattlesnake (Crotalus viridis viridis) venom in three antisera using enzyme-linked immunosorbent assay and immunodiffusion

scientific article published on January 1983

Development of alpha-neurotoxin antibodies in patients envenomed by the monocellate Thai cobra (Naja kaouthia).

scientific article

Development of simple standard assay procedures for the characterization of snake venom

scientific article published on January 1983

Diagnosis of snakebite and the importance of immunological tests in venom research

scientific article

Distinctive epidemiologic and clinical features of common krait (Bungarus caeruleus) bites in Sri Lanka

scientific article published on 01 September 2008

Divided dose intramuscular regimen and single dose subcutaneous regimen for chloroquine: plasma concentrations and toxicity in patients with malaria

scientific article

Effects of three novel metalloproteinases from the venom of the West African saw-scaled viper, Echis ocellatus on blood coagulation and platelets

scientific article published on 7 April 2005

Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without β-propiolactone, in the treatment of Bothrops asper bites in Colombia

scientific article published on 12 May 2006

Electron cytochemical study on glucose-6-phosphate dehydrogenase activity in erythrocytes of Aotus monkeys infected with Plasmodium falciparum ⬇️

scientific article published on January 1, 1971

Electron microscope autoradiographic studies on the effect of chloroquine on the uptake of nucleosides by Plasmodium berghei ⬇️

scientific article published on January 1, 1971

Electrophoresis of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in erythrocytes from malaria-infected animals ⬇️

scientific article published on June 1, 1977

Electrospray mass spectrometry of Malayan pit viper (Calloselasma rhodostoma) venom ⬇️

scientific article published on 01 December 1992

Envenoming after carpet viper (Echis ocellatus) bite during pregnancy: timely use of effective antivenom improves maternal and foetal outcomes

scientific article

Envenoming by Bothrops jararaca in Brazil: association between venom antigenaemia and severity at admission to hospital

scientific article published in May 2003

Envenoming by the common krait (Bungarus caeruleus) and Sri Lankan cobra (Naja naja naja): efficacy and complications of therapy with Haffkine antivenom

scientific article published on March 1990

Enzyme-linked immunosorbent assay of venom-antibodies in human victims of snake bite

scientific article published on June 1, 1981

Epidemiological studies of snake bite in French Guiana

scientific article

Experimental assessment of a new, low-cost antivenom for treatment of carpet viper (Echis ocellatus) envenoming ⬇️

scientific article published on March 1, 1995

Experimental evaluation of ovine antisera to Thai cobra (Naja kaouthia) venom and its alpha-neurotoxin

scientific article

Facial swelling in a pony attributable to an adder bite

scientific article published on July 1992

Failure of 3,4-diaminopyridine and edrophonium to produce significant clinical benefit in neurotoxicity following the bite of Papuan taipan (Oxyuranus scutellatus canni).

scientific article published in July 1995

Failure of chloramphenicol prophylaxis to reduce the frequency of abscess formation as a complication of envenoming by Bothrops snakes in Brazil: a double-blind randomized controlled trial.

scientific article published in September 2004

Frequent and potentially fatal envenoming by hump-nosed pit vipers (Hypnale hypnale and H. nepa) in Sri Lanka: lack of effective antivenom

scientific article published on 02 May 2008

Functional expression and purification of recombinant Tx1, a sodium channel blocker neurotoxin from the venom of the Brazilian "armed" spider, Phoneutria nigriventer

scientific article

Further electron autoradiographic and cytochemical studies on malaria parasites

scientific article published in January 1969

Gene expression in Echis carinatus (carpet viper) venom glands following milking

scientific article

Glucose-6-phosphate and 6-phosphogluconate dehydrogenase activities human erythrocytes infected with Plasmodium falciparum

scientific article

Haematological evaluation of patients bitten by the jararaca, Bothrops jararaca, in Brazil

scientific article

High incidence of bites and stings by snakes and other animals among rubber tappers and Amazonian Indians of the Juruá Valley, Acre State, Brazil

scientific article published on February 1996

High incidence of early anaphylactoid reaction to SAIMR polyvalent snake antivenom ⬇️

scientific article published on January 1, 1998

Identification of sites in the cysteine-rich domain of the class P-III snake venom metalloproteinases responsible for inhibition of platelet function

scientific article published in August 2003

Immunization against Echis ocellatus (carpet viper) venom using liposomes incorporating immunostimulants: role of lipopolysaccharide in conferring protection in a mouse model

scientific article published on May 1993

In vitro procoagulant and anticoagulant properties of Naja naja naja venom ⬇️

scientific article published on September 1, 2003

Insights into the mechanism of haemorrhage caused by snake venom metalloproteinases

scientific article published on June 1996

Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara

scientific article published on 7 April 2006

Jararhagin ECD-containing disintegrin domain: expression in escherichia coli and inhibition of the platelet-collagen interaction

scientific article published on 01 September 1999

Life-threatening envenoming by the Saharan horned viper (Cerastes cerastes) causing micro-angiopathic haemolysis, coagulopathy and acute renal failure: clinical cases and review

scientific article

Liposomal immunisation against snake venoms

scientific article published in January 1985

Malumfashi Endemic Diseases Research Project, XIII. Epidemiology of human encounters with the spitting cobra, Naja nigricollis, in the Malumfashi area of northern Nigeria

scientific article

Mass spectrophotometric evidence for P-III/P-IV metalloproteinases in the venom of the Boomslang (Dispholidus typus).

scientific article

Molecular cloning of phospholipases A(2) from venom glands of Echis carpet vipers

scientific article

Neurotoxicity and haemostatic disturbances in patients envenomed by the Papuan black snake (Pseudechis papuanus).

scientific article

Neurotoxicity, anticoagulant activity and evidence of rhabdomyolysis in patients bitten by death adders (Acanthophis sp.) in southern Papua New Guinea

scientific article published in January 1996

Neurotoxicity, haemostatic disturbances and haemolytic anaemia after a bite by a Tunisian saw-scaled or carpet viper (Echis 'pyramidum'-complex): failure of antivenom treatment

scientific article published in August 1994

Neutralisation of venom-induced haemorrhage by IgG from camels and llamas immunised with viper venom and also by endogenous, non-IgG components in camelid sera

scientific article published on 15 December 2005

Neutralization of the haemorrhagic activities of viperine snake venoms and venom metalloproteinases using synthetic peptide inhibitors and chelators

scientific article published on 30 November 2006

New techniques in antivenom production and active immunization against snake venoms

scientific article published on July 1989

Novel sequences encoding venom C-type lectins are conserved in phylogenetically and geographically distinct Echis and Bitis viper species ⬇️

scientific article published on October 2, 2003

Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa

scientific article

Paralysis, rhabdomyolysis and haemolysis caused by bites of Russell's viper (Vipera russelli pulchella) in Sri Lanka: failure of Indian (Haffkine) antivenom

scientific article

Platelet aggregation in patients bitten by the Brazilian snake Bothrops jararaca

scientific article

Polyspecific snake antivenom may help in antivenom crisis

scientific article

Pre-clinical and preliminary dose-finding and safety studies to identify candidate antivenoms for treatment of envenoming by saw-scaled or carpet vipers (Echis ocellatus) in northern Nigeria

scientific article published on 27 October 2009

Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa

scientific article published on 21 August 2009

Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms.

scientific article published on July 2004

Preliminary trial of a new polyspecific antivenom in Nigeria

scientific article published on June 1988

Processing of pro-tumor necrosis factor-alpha by venom metalloproteinases: a hypothesis explaining local tissue damage following snake bite

scientific article

Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom

scientific article published in November 2003

Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family

scientific article

Randomised Controlled Double-Blind Non-Inferiority Trial of Two Antivenoms for Saw-Scaled or Carpet Viper (Echis ocellatus) Envenoming in Nigeria ⬇️

scientific article published on July 27, 2010

Rapid isolation and partial characterization of two phospholipases from Kenyan Echis carinatus leakeyi (Leakey's saw-scaled viper) venom ⬇️

scientific article published on January 1, 1991

Report of a WHO workshop on the standardization and control of antivenoms

scientific article

Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin

scientific article

Seasnake bites in a freshwater lake

scientific article published in July 1985

Sequence of the cDNA coding for the lethal neurotoxin Tx1 from the Brazilian "armed" spider Phoneutria nigriventer predicts the synthesis and processing of a preprotoxin

scientific article published on July 1993

Simultaneous GeneGun immunisation with plasmids encoding antigen and GM-CSF: significant enhancement of murine antivenom IgG1 titres

scientific article published on March 2002

Snake Venom Poisoning

scientific article published in February 1984

Snake antivenoms

scientific article

Snake bite in Chittagong Division, Bangladesh: a study of bitten patients who developed no signs of systemic envenoming

article

Snake bites by the Papuan taipan (Oxyuranus scutellatus canni): paralysis, hemostatic and electrocardiographic abnormalities, and effects of antivenom

scientific article

Snake venom antibodies in Ecuadorian Indians

scientific article published on 01 October 1981

Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering

scientific article published in June 2003

Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the pan-African EchiTAb-Plus-ICP antivenom by antivenomics and neutralization approaches

scientific article published on 31 January 2011

Snake venoms in science and clinical medicine. 2. Applied immunology in snake venom research

scientific article published on November 1989

Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins

scientific article published in February 2004

Syndromic approach to treatment of snake bite in Sri Lanka based on results of a prospective national hospital-based survey of patients envenomed by identified snakes

scientific article published on 01 October 2009

Systemic haemorrhage in rats induced by a haemorrhagic fraction from Bothrops jararaca venom

scientific article

The African challenge

scientific article published in April 2002

The application of immunoassay techniques, including enzyme-linked immunosorbent assay (ELISA), to snake venom research

scientific article published on January 1983

The conserved structure of snake venom toxins confers extensive immunological cross-reactivity to toxin-specific antibody

scientific article published on March 2003

The effect of jararhagin, a metalloproteinase from Bothrops jararaca venom, on pro-inflammatory cytokines released by murine peritoneal adherent cells

scientific article published in October 2001

The fine structure ofPlasmodium vinckei, a malaria parasite of rodents ⬇️

scientific article published in March 1968

The greater black krait (Bungarus niger), a newly recognized cause of neuro-myotoxic snake bite envenoming in Bangladesh

scientific article published on 20 September 2010

The management of snake bite

scientific article published on January 1983

The purification and partial characterisation of two novel metalloproteinases from the venom of the West African carpet viper, Echis ocellatus.

scientific article published on July 2003

The role of phospholipases A2 in the stimulation of neutrophil motility by cobra venoms

scientific article published in March 2003

The role of venom haemorrhagin in spontaneous bleeding in Bothrops jararaca envenoming. Butantan Institute Antivenom Study Group

scientific article published on April 2, 1992

The ultrastructural distribution of cytochrome oxidase activity in Plasmodium Berghei and P. Gallinaceum

scientific article published in May 1969

The ultrastructure of Plasmodium falciparum in splenectomized Aotus trivirgatus monkeys

scientific article published in December 1969

The use of hens' eggs as an alternative to the conventional in vivo rodent assay for antidotes to haemorrhagic venoms ⬇️

scientific article published on September 1, 1997

Traditional treatments for snake bite in a rural African community

scientific article published in December 1997

Treatment of snake bites by Bothrops species and Lachesis muta in Ecuador: laboratory screening of candidate antivenoms

scientific article published on September 1995

Ultrastructural localisation of NADH- and NADPH-dehydrogenases in the erythrocytic stages of the rodent malaria parasite, Plasmodium berghei

scientific article published in April 1970

Ultrastructural studies of the effects of malarial toxic factors on normal mouse tissues

scientific article published on January 1, 1971

Use of liposomes for protective immunisation against Crotalus durissus (tropical rattlesnake) venom

scientific article published on January 1989

Use of liposomes for protective immunisation in sheep against Echis carinatus snake venom

scientific article published in January 1985

Use of microarrays for investigating the subtoxic effects of snake venoms: insights into venom-induced apoptosis in human umbilical vein endothelial cells

scientific article

Venom antibody levels in a patient bitten by a young puff adder (Bitis arietans) during a world record attempt

scientific article published in June 1985

Venom production in snake venom gland cells cultured in vitro

scientific article

Venomous Bites and Stings

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