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List of works by Tom Misteli

3D Chromosome Regulatory Landscape of Human Pluripotent Cells.

scientific article

A Deep Learning Pipeline for Nucleus Segmentation

scientific article published on 03 November 2020

A cyclophilin functions in pre-mRNA splicing

scientific article

A genome disconnect

scientific article published on 01 August 2019

A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds.

scientific article published on September 2015

A high-throughput system for segmenting nuclei using multiscale techniques.

scientific article published in May 2008

A kinetic framework for a mammalian RNA polymerase in vivo

scientific article

A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature.

scientific article

A non-random walk through the genome

scientific article

A programmable microfluidic platform for multisample injection, discretization, and droplet manipulation

scientific article published on 01 January 2020

Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs

scientific article (publication date: May 2002)

Activation of DNA damage response signaling by condensed chromatin

scientific article

Activation of the cellular DNA damage response in the absence of DNA lesions

scientific article published on 15 May 2008

Ageing-related chromatin defects through loss of the NURD complex

scientific article (publication date: October 2009)

Allele-specific nuclear positioning of the monoallelically expressed astrocyte marker GFAP

scientific article

An uncertainty principle in chromosome positioning

scientific article published on 01 August 2003

Assessment of the Utility of Gene Positioning Biomarkers in the Stratification of Prostate Cancers

scientific article published on 17 October 2019

Automatic nuclei segmentation and spatial FISH analysis for cancer detection.

scientific article published in January 2009

Automatic segmentation and supervised learning-based selection of nuclei in cancer tissue images. ⬇️

scientific article published on 31 July 2012

Biogenesis of Nuclear Bodies ⬇️

scientific article published on November 10, 2010

Blank spots on the map: some current questions on nuclear organization and genome architecture

scientific article published on 20 September 2018

Causes and consequences of nuclear gene positioning.

scientific article published on 12 April 2017

Cell biology: chromosome territories.

scientific article

Cell cycle staging of individual cells by fluorescence microscopy.

scientific article published on 29 January 2015

Chinese hamster ORC subunits dynamically associate with chromatin throughout the cell-cycle

scientific article

Chromatin in pluripotent embryonic stem cells and differentiation

scientific article

Chromatin maintenance by a molecular motor protein ⬇️

scientific article published on November 1, 2011

Chromokinesins: multitalented players in mitosis

scientific article

Chromosome positioning in the interphase nucleus

scientific article

Common features of chromatin in aging and cancer: cause or coincidence?

scientific article

Comparative analysis of 2D and 3D distance measurements to study spatial genome organization.

scientific article

Competition between histone H1 and HMGN proteins for chromatin binding sites.

scientific article

Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins

scientific article

Conservation of relative chromosome positioning in normal and cancer cells

scientific article published on October 2002

Controlled droplet discretization and manipulation using membrane displacement traps.

scientific article published on 9 October 2017

DNA damage, chromatin, and transcription: the trinity of aging ⬇️

scientific article published on August 17, 2012

Deep Imaging: the next frontier in microscopy.

scientific article

Descriptive no more: the dawn of high-throughput microscopy

scientific article

Differential in vivo binding dynamics of somatic and oocyte-specific linker histones in oocytes and during ES cell nuclear transfer

scientific article

Differential recruitment of pre-mRNA splicing factors to alternatively spliced transcripts in vivo

scientific article

Disease-specific gene repositioning in breast cancer

scientific article

Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome

scholarly article

Dynamic binding of histone H1 to chromatin in living cells

scientific article (publication date: 14 December 2000)

Effects of human sex chromosome dosage on spatial chromosome organization

scientific article published on 09 August 2018

Epigenetics in alternative pre-mRNA splicing

scientific article

Erratum: Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

scientific article published in Nature

Erratum: The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

scientific article published in Nature

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).

scientific article

Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization

scientific article published on 21 February 2019

Formation of nuclear splicing factor compartments is independent of lamins A/C.

scientific article published on 08 September 2004

Functional architecture in the cell nucleus

scientific article

Generation of cell-based systems to visualize chromosome damage and translocations in living cells

scientific article published on 25 September 2014

Genome Architecture from a Different Angle.

scientific article

Genome instability in progeria: when repair gets old

scientific article published on 01 July 2005

Genome-wide redistribution of BRD4 binding sites in transformation resistant cells

scientific article

Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins

scientific article

Global transcription in pluripotent embryonic stem cells.

scientific article published on May 2008

Good news in the nuclear envelope: loss of lamin A might be a gain

scientific article

H1FOO is coupled to the initiation of oocytic growth

scientific article

HIPMap: A High-Throughput Imaging Method for Mapping Spatial Gene Positions.

scientific article published on 15 October 2015

HiCTMap: Detection and Analysis of Chromosome Territory Structure and Position by High-throughput Imaging.

scientific article published on 2 February 2018

HiHiMap: single-cell quantitation of histones and histone posttranslational modifications across the cell cycle by high-throughput imaging

scientific article published on 14 June 2017

HiIDDD: a high-throughput imaging pipeline for the quantitative detection of DNA damage in primary human immune cells

scientific article published on 15 April 2022

HiPLA: High-throughput imaging proximity ligation assay

scientific article published on 10 November 2018

High-throughput Imaging as a versatile and unbiased discovery tool

scientific article published on 13 January 2016

Higher-order genome organization in human disease

scientific article

Histone modifications predispose genome regions to breakage and translocation

scientific article published on 23 June 2015

Human chromokinesin KIF4A functions in chromosome condensation and segregation

scientific article

Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells.

scientific article

Identification by high-throughput imaging of the histone methyltransferase EHMT2 as an epigenetic regulator of VEGFA alternative splicing

scientific article

Identification of Gene Positioning Factors Using High-Throughput Imaging Mapping

scientific article

Identification of differential protein interactors of lamin A and progerin

scientific article

Identification of mammalian protein quality control factors by high-throughput cellular imaging

scientific article

Identification of novel RNA isoforms of LMNA.

scientific article

Impairment of nuclear F-actin formation and its relevance to cellular phenotypes in Hutchinson-Gilford progeria syndrome

scientific article published on 01 December 2020

In vitro generation of human cells with cancer stem cell properties ⬇️

scientific article published on August 21, 2011

In vivo dynamics of Swi6 in yeast: evidence for a stochastic model of heterochromatin.

scientific article published on April 2004

In vivo kinetics of Cajal body components

scientific article

LINC complexes in health and disease ⬇️

scientific article published on January 1, 2010

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

scientific article

Lamin A-dependent nuclear defects in human aging

scientific article

Locus-specific and activity-independent gene repositioning during early tumorigenesis.

scientific article

Locus-specific gene repositioning in prostate cancer

scientific article

Maintenance of stable heterochromatin domains by dynamic HP1 binding

scientific article (publication date: 31 January 2003)

Mapping of protein- and chromatin-interactions at the nuclear lamina ⬇️

scientific article published on September 3, 2010

Measurement of dynamic protein binding to chromatin in vivo, using photobleaching microscopy

scientific article published in January 2004

Microfluidic on-demand droplet generation, storage, retrieval, and merging for single-cell pairing

scientific article published on 01 January 2019

Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin

scientific article

Modulation of RNA polymerase assembly dynamics in transcriptional regulation

scientific article published on May 2008

Molecular basis and biological function of variability in spatial genome organization

scientific article published on 01 September 2019

More than a splicing code: integrating the role of RNA, chromatin and non-coding RNA in alternative splicing regulation.

scientific article published on 15 April 2011

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation

scientific article published on 28 July 2017

Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin

scientific article published on May 2004

Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses

scientific article

Nuclear position modulates long-range chromatin interactions

scientific article published in 2022

Nucleolomics: an inventory of the nucleolus

scientific article published on 01 January 2002

Painting a Clearer Picture of Chromatin.

scientific article published on February 2016

Physiological importance of RNA and protein mobility in the cell nucleus

scientific article

Positional stability of single double-strand breaks in mammalian cells

scientific article published on 7 May 2007

Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins.

scientific article

Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)

scientific article

Potential Roles for Ubiquitin and the Proteasome during Ribosome Biogenesis

Potential roles for ubiquitin and the proteasome during ribosome biogenesis

scientific article

Progeria: a paradigm for translational medicine.

scientific article published in January 2014

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells

scientific article published on 01 April 2019

Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging.

scientific article published on 19 October 2017

Quantitation of GFP-fusion proteins in single living cells

scientific article

Quantitative detection of rare interphase chromosome breaks and translocations by high-throughput imaging

scientific article

Ranked retrieval of segmented nuclei for objective assessment of cancer gene repositioning

scientific article

Recruitment of dioxin receptor to active transcription sites

scientific article

RefCell: multi-dimensional analysis of image-based high-throughput screens based on 'typical cells'

scholarly article by Yang Shen published in November 2018

Regulation of alternative splicing by histone modifications

scientific article

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

scientific article (publication date: 11 July 2002)

Repression of the Antioxidant NRF2 Pathway in Premature Aging

scientific article

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

scientific article

Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis

scientific article

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases.

scientific article published on 9 August 2017

Single molecule analysis of lamin dynamics

scientific article published on 24 August 2018

SnapShot: Chromosome confirmation capture

scientific article

Spatial dynamics of chromosome translocations in living cells.

scientific article

Spatial genome organization

scientific article published on May 2004

Spatial genome organization in the formation of chromosomal translocations

scientific article published on 26 October 2006

Spatial proximity of translocation-prone gene loci in human lymphomas

scientific article published on 01 July 2003

Splicing misplaced

scientific article

SpotLearn: Convolutional Neural Network for Detection of Fluorescence In Situ Hybridization (FISH) Signals in High-Throughput Imaging Approaches.

scientific article published on 28 November 2017

Supervised learning framework for screening nuclei in tissue sections

scientific article published in January 2011

Systematic identification of pathological lamin A interactors

scientific article

Systems biology in the cell nucleus

scientific article

TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression

scientific article

The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

scientific article

The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.

scientific article published in March 2018

The biogenesis of chromosome translocations.

scientific article published on April 2014

The cell nucleus and aging: tantalizing clues and hopeful promises

scientific article published on 15 November 2005

The cellular etiology of chromosome translocations.

scientific article published on 14 March 2013

The central role of chromatin maintenance in aging

scientific article

The emerging role of nuclear architecture in DNA repair and genome maintenance

scientific article published on 11 March 2009

The lamin protein family.

scientific article

The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity

scientific article

The long reach of telomeres

scientific article

The meaning of gene positioning

scientific article

The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity

scientific article published on 13 May 2019

The road much traveled: trafficking in the cell nucleus

scientific article

Tissue-of-origin-specific gene repositioning in breast and prostate cancer.

scientific article published on 20 January 2016

Tissue-specific spatial organization of genomes

scientific article

Transcription dynamics

scientific article published on September 2009

Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4.

scientific article

Tumor formation via loss of a molecular motor protein.

scientific article published on August 2006

Ubiquitination regulates PTEN nuclear import and tumor suppression

scientific article

Visualizing Cancer

scientific article published on 01 December 2020

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