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List of works by Tom Curran

A gene expression approach to mapping the functional maturation of the hippocampus

scientific article published in December 1998

A neurogenomics approach to gene expression analysis in the developing brain

scientific article published on December 2004

A protein related to extracellular matrix proteins deleted in the mouse mutant reeler

scientific article (publication date: 20 April 1995)

A transcriptome map of cellular transformation by the fos oncogene

scientific article

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

scientific article (publication date: 8 April 1988)

Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis

scientific article published in September 1998

Altered protein conformation on DNA binding by Fos and Jun.

scientific article

Alternative splicing disabled by Nova2.

scientific article published in June 2010

An enhanced immune response in mice lacking the transcription factor NFAT1.

scientific article published on May 1996

Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini

scientific article published in April 1983

Apoptosis in the nervous system: new revelations

scientific article published on January 1995

Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion

scientific article

Audiogenic seizure susceptibility in thyroid hormone receptor β-deficient mice

scientific article published on 01 August 2001

BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system

scientific article published on 28 March 2006

Barium modulates c-fos expression and post-translational modification

scientific article

Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1

scientific article (publication date: 10 April 2003)

Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence

scientific article

Brain development: integrins and the Reelin pathway

scientific article

CRK proteins selectively regulate T cell migration into inflamed tissues

scientific article

Calcium and Proto-Oncogene Involvement in the Immediate-Early Response in the Nervous System

article

Calcium as a modulator of the immediate-early gene cascade in neurons

scientific article published on December 1988

Cancer: Hedgehog's other great trick

scientific article published in Nature

Candidate product of the FBJ murine osteosarcoma virus oncogene: characterization of a 55,000-dalton phosphoprotein ⬇️

scientific article published on April 1, 1982

Cardiovascular and craniofacial defects in Crk-null mice

scientific article

Cerebellar Disorganization Characteristic of Reeler in Scrambler Mutant Mice Despite Presence of Reelin ⬇️

scientific article published on November 15, 1997

Common DNA binding site for Fos protein complexesand transcription factor AP-1

article

Components of the reelin signaling pathway are expressed in the spinal cord

scientific article published in March 2004

Continuous c-fos expression precedes programmed cell death in vivo

scientific article published on May 1993

Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling

scientific article published on September 2008

Cortical development: Cdk5 gets into sticky situations

scientific article

Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway

scientific article

Crk and CrkL are required for cell transformation by v-fos and v-ras

scientific article published on 3 January 2015

Crk proteins transduce FGF signaling to promote lens fiber cell elongation

scientific article published on 23 January 2018

Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis

scientific article

Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease

scientific article published on 17 January 2012

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity

scientific article

Crossed signals: oncogenic transcription factors

Crystal structures of the Dab homology domains of mouse disabled 1 and 2

scientific article

Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding

scientific article

DNA bending by Fos and Jun: the flexible hinge model

scientific article published in Science

Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality

scientific article

Dendritic planarity of Purkinje cells is independent of Reelin signaling

scientific article published on 15 May 2014

Design of a "minimAl" homeodomain: the N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure

scientific article published on August 1994

Detection of the reelin breakpoint in reeler mice

scientific article published in July 1996

Developmental expression of Fos-lacZ in the brains of postnatal transgenic rats

scientific article

Developmental expression of thyroid hormone receptor beta2 protein in cone photoreceptors in the mouse

scientific article published on April 2009

Developmental mouse brain gene expression maps

scientific article

Differential binding of ligands to the apolipoprotein E receptor 2.

scientific article

Differential roles for Fos and Jun in DNA-binding: redox-dependent and independent functions

scientific article published on December 1993

Dimerization and DNA binding alter phosphorylation of Fos and Jun.

scientific article

Disabled-1 interacts with a novel developmentally regulated protocadherin

scientific journal article

Disabled-1 is expressed in type AII amacrine cells in the mouse retina

scientific article published in August 2000

Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L

scientific article

Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure

article

Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord

scientific article

Energy transfer analysis of Fos-Jun dimerization and DNA binding

scientific article published on July 1994

Essential roles of Crk and CrkL in fibroblast structure and motility.

scientific article published on 28 October 2013

Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly

scientific journal article

Expression of c-fos protein in brain: metabolic mapping at the cellular level

scientific article

Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV.

scientific article published in June 1985

FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA ⬇️

scientific article published on November 1, 1982

FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product

scientific article published in May 1984

FBR murine osteosarcoma virus. II. Nucleotide sequence of the provirus reveals that the genome contains sequences acquired from two cellular genes

scientific article published in May 1984

Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL).

scientific article

Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro

scientific article published on December 1988

Fos and Jun. Oncogenic Transcription Factors ⬇️

scientific article published on 01 October 1992

Fos and Jun: the AP-1 connection

scientific article published on November 1988

Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity

scientific article

Fos-Like Immunoreactivity Induced by Seizure in Mice Is Specifically Associated With Euchromatin in Neurons

scientific article published on 01 January 1989

Fos-associated protein p39 is the product of the jun proto-oncogene

scientific article published on May 1988

Fos: an immediate-early transcription factor in neurons

scientific article published on March 1995

Fosvergnügen. The excitement of immediate-early genes

scientific article published on January 1991

From Bings to Biology: Taking a Different Path in Cancer Research ⬇️

scientific article published on July 1, 2003

Gene dosage in mice—BAC to the future

article

Gene expression profiles of mouse retinas during the second and third postnatal weeks

scientific article published on 13 June 2006

Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53.

scientific article

Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

scientific article published on 27 March 2006

Gli1 is important for medulloblastoma formation in Ptc1+/- mice

scientific article published on June 2005

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity

scientific article published on August 2012

Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain

scientific article published in September 1989

Glutamate, immediate-early genes, and cell death in the nervous system

scientific article published on May 1993

Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor

scientific article

Identification of a 39,000-dalton protein in cells transformed by the FBJ murine osteosarcoma virus

scientific article published in January 1982

Identification of redox/repair protein Ref-1 as a potent activator of p53

scientific article

Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1.

scientific article

Immediate-early genes: ten years on.

scientific article published on February 1995

Induction of c-fos during myelomonocytic differentiation and macrophage proliferation

scientific article published in Nature

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

scientific article published in December 1984

Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats

scientific article published in September 1990

Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain

scientific journal article

Isolation of an allele of reeler by insertional mutagenesis

scientific article

Isolation of the cyclosporin-sensitive T cell transcription factor NFATp

scientific journal article

Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts ⬇️

scientific article published on October 1, 1992

Loss of suppressor-of-fused function promotes tumorigenesis

scientific article published on 23 April 2007

Lost in translation: the future of cancer research?

scientific article published on July 2005

Mapping patterns of c-fos expression in the central nervous system after seizure

scientific article published on July 1987

Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor.

scientific article published on 5 April 2007

Memories of fos.

scientific article published on December 1987

Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome

scientific article

Mouse models and mouse supermodels

scientific article

Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS.

scientific article

N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone

scientific article published on September 1995

Nestin Mediates Hedgehog Pathway Tumorigenesis

scientific article

Neurobiology: Reelin mediates form and function

scientific article published on 17 November 2014

PTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young mice

scientific article published on 16 March 2011

Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains

scientific article published in Science

Patched2 modulates tumorigenesis in patched1 heterozygous mice

scientific article

Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study

scientific article published on 27 September 2013

Proto-oncogene transcription factors and epilepsy

scientific article published on September 1991

Q&A: Tom Curran on Translational Research ⬇️

scientific article published on January 26, 2012

Radial glia cells are candidate stem cells of ependymoma

scientific article

Radial glia cells are candidate stem cells of ependymoma

Redox regulation of fos and jun DNA-binding activity in vitro

scientific article published in Science

Reeler gene discrepancies

scientific article

Reeler: new tales on an old mutant mouse

scientific article published in March 1998

Reelin is a ligand for lipoprotein receptors

scientific article

Reelin mRNA expression during embryonic brain development in the chick

scientific article published on 01 July 2000

Regulation of a fos-lacZ fusion gene: a paradigm for quantitative analysis of stimulus-transcription coupling

scientific article published on July 1991

Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements

scientific article published on 01 February 1995

Regulation of proenkephalin by Fos and Jun.

scientific article published on December 1989

Regulation of proto-oncogenes in rat parotid acinar cells in vitro after stimulation of β- adrenergic receptors

article

Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene

scientific article published on August 1985

Reply to the Letter to the Editor by Diamandis

item in Clinical Cancer Research (15 January 2006)

Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer

article

Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice

scientific article published in February 2002

Role of DNA 5-methylcytosine transferase in cell transformation by fos

scientific article

Role of ion flux in the control of c-fos expression

scientific article published in Nature

Role of reelin in the control of brain development

article

Role of the reelin signaling pathway in central nervous system development

scientific article (publication date: 2001)

Selective activation of calcium permeability by aspartate in Purkinje cells

scientific article

Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies

scientific article published on April 2006

Smart transcription factors

scientific article published in Nature

Spontaneous and evoked glutamate signalling influences Fos-lacZ expression and pyramidal cell death in hippocampal slice cultures from transgenic rats

article

Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.

scientific article published on 6 February 2018

Stimulus-transcription coupling in neurons: role of cellular immediate-early genes

scientific article

Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.

scientific article published on January 1991

Structure of the FBJ Murine Osteosarcoma Virus Genome: Molecular Cloning of Its Associated Helper Virus and the Cellular Homolog of the v-fos Gene from Mouse and Human Cells ⬇️

scientific article published on May 1, 1983

Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines

scientific article

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice

scientific article published in September 2004

Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death

scientific journal article

Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics

scientific article

Temporal and spatial expression of a fos-lacZ transgene in the developing nervous system

scientific article published in November 1992

The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites

scientific article

The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose

scientific article

The Hedgehog's tale: developing strategies for targeting cancer

scientific article published on 26 May 2011

The Ketogenic Diet Does Not Affect Growth of Hedgehog Pathway Medulloblastoma in Mice

scientific article published on 20 July 2015

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

scientific article

The effects of phorbol ester and Ca ionophore on c-fos and c-myc expression and on DNA synthesis in human lymphocytes are not directly related

article

The fos gene product undergoes extensive post-translational modification in eukaryotic but not in prokaryotic cells.

scientific article

The genetic landscape of the childhood cancer medulloblastoma

scientific article

The hedgehog pathway and neurological disorders

scientific article published on January 2006

The human reelin gene: isolation, sequencing, and mapping on chromosome 7.

scientific article

The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes.

scientific article published on February 1989

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains

scientific article

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

scientific article published on August 1996

The reelin pathway modulates the structure and function of retinal synaptic circuitry

scientific article

The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions

scientific article published on May 1997

The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation

scientific article

Thyroid hormone receptor beta is essential for development of auditory function

scientific journal article

Thyrotropin regulation by thyroid hormone in thyroid hormone receptor beta-deficient mice

scientific journal article

Transcription factor interactions: basics on zippers

Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1.

scientific article published on May 2004

Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure

scientific article published in March 2008

Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins

scientific article published in May 2004

Use of fluorescence resonance energy transfer to estimate intramolecular distances in the Msx-1 homeodomain

scientific article published in November 1995

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.

scientific article

Whole-exome identifies RXRG and TH germline variants in familial isolated prolactinoma

scientific article published on 4 May 2016

Yayoi era mutation disrupts brain and muscle

scientific article published in September 1998

Zen and the art of Fos and Jun

scientific article published in Nature

c-fos and Signal Transduction In Vivo

scientific article published in October 1998

fos Oncogene

fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system

scientific article published in January 1992

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