List of works - Todd Golub

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

scientific article

MicroRNA expression profiles classify human cancers

scientific article (publication date: 9 June 2005)

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

scientific article

Mutational heterogeneity in cancer and the search for new cancer-associated genes

scientific article

The landscape of somatic copy-number alteration across human cancers

scientific article

Next-generation characterization of the Cancer Cell Line Encyclopedia

scientific article published on 08 May 2019

Discovery and saturation analysis of cancer genes across 21 tumour types

scientific article

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

scientific article (publication date: April 2005)

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals

scientific article

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

scientific article (publication date: 16 December 2010)

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

scientific article published on January 1, 2002

Initial genome sequencing and analysis of multiple myeloma

scientific article

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

scientific article published on 03 December 2001

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

scientific article (publication date: 7 July 2005)

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

scientific article published on 16 July 2006

The genomic complexity of primary human prostate cancer

scientific article

Gene expression in fixed tissues and outcome in hepatocellular carcinoma.

scientific article

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

scientific article

Sequence analysis of mutations and translocations across breast cancer subtypes

scientific article

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

scientific article

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

scientific article (publication date: 11 December 2007)

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

scientific article

Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

scientific article

Punctuated evolution of prostate cancer genomes

scientific article published on April 2013

Gene expression correlates of clinical prostate cancer behavior

article

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

scientific article

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

scientific article

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 30 September 2014

Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

scientific article published in March 2006

Metagenes and molecular pattern discovery using matrix factorization

scholarly article

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

RETRACTED scientific article

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

scientific article

Stem cell gene expression programs influence clinical outcome in human leukemia.

scientific article published on 28 August 2011

Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy

scientific article published in January 2014

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

scientific article

Lin28 promotes transformation and is associated with advanced human malignancies

scientific article published on 31 May 2009

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

scientific article

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response

article

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

scientific article published on 24 March 2013

Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma

scientific article published on September 2009

Melanoma genome sequencing reveals frequent PREX2 mutations

scientific article

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

scientific article

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.

scientific article

Highly parallel identification of essential genes in cancer cells

scholarly article

Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

scientific article

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

scientific article published in November 2017

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

scientific article published on 28 September 2006

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

scientific article published on 02 February 2011

Dicer1 functions as a haploinsufficient tumor suppressor

scientific article

Altered microRNA expression in human heart disease

scientific article published on 21 August 2007

List of works by Todd Golub

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

MicroRNA expression profiles classify human cancers

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

Mutational heterogeneity in cancer and the search for new cancer-associated genes

The landscape of somatic copy-number alteration across human cancers

Next-generation characterization of the Cancer Cell Line Encyclopedia

Discovery and saturation analysis of cancer genes across 21 tumour types

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

Initial genome sequencing and analysis of multiple myeloma

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

The genomic complexity of primary human prostate cancer

Gene expression in fixed tissues and outcome in hepatocellular carcinoma.

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

Sequence analysis of mutations and translocations across breast cancer subtypes

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

Punctuated evolution of prostate cancer genomes

Gene expression correlates of clinical prostate cancer behavior

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

Metagenes and molecular pattern discovery using matrix factorization

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

Stem cell gene expression programs influence clinical outcome in human leukemia.

Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

Lin28 promotes transformation and is associated with advanced human malignancies

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma

Melanoma genome sequencing reveals frequent PREX2 mutations

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.

Highly parallel identification of essential genes in cancer cells

Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

Dicer1 functions as a haploinsufficient tumor suppressor

Altered microRNA expression in human heart disease