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List of works by Todd Golub

15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.

scientific article

334 A Functional Screen Identifies miRNAs that Induce Radioresistance in Glioblastomas

scientific article published on August 2016

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations.

scientific article published on 11 April 2018

A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1

scientific article

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

scientific article published in November 2017

A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay

scientific article

A first-generation pediatric cancer dependency map

scientific article published on 22 March 2021

A functional screen identifies miRs that induce radioresistance in glioblastomas

scientific article

A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.

scientific article

A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer

scientific article

A metastasis map of human cancer cell lines

scientific article published on 09 December 2020

A method for high-throughput gene expression signature analysis

scientific article published on January 2006

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

scientific article

A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia

scientific article

A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers

scientific article

A strategy for oligonucleotide microarray probe reduction

scientific article

A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer.

scientific article

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility

scientific article

AACR Cancer Progress Report 2012 ⬇️

scientific article published on September 11, 2012

Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei

scientific article

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

scientific article (publication date: April 2005)

Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

scientific article published on 01 January 2019

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

scientific article published on 20 December 2019

Altered microRNA expression in human heart disease

scientific article published on 21 August 2007

Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers

scientific article

An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray.

scientific article published on 8 March 2005

An ecosystem of cancer cell line factories to support a cancer dependency map.

scientific article published on 16 June 2015

An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome

scientific article

An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis

scientific article

Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer

scientific article

Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells

scientific article published on December 2004

Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

scientific article published on 27 January 2021

Application of oligonucleotide microarrays to assess the biological effects of neoadjuvant imatinib mesylate treatment for localized prostate cancer

scientific article published in January 2006

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

scientific article (publication date: 11 December 2007)

Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer.

scientific article published on 3 January 2018

Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations

scientific article published on 25 June 2020

Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

scientific article published on 01 December 2019

Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress

scientific article published on 01 July 2019

Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

article

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

scientific article published in 2022

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

scientific article

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

scientific article

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

scientific article (publication date: 16 December 2010)

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

scientific article published on 4 December 2017

CXCR4 pathway associated with family history of melanoma

scientific article

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

scientific article published on 18 May 2020

Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency ⬇️

scientific article published on April 17, 2012

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

scientific article

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

scientific article

Comment on "The consensus coding sequences of human breast and colorectal cancers".

scientific article

Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling.

scientific article published on 30 October 2017

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

scientific article

Comprehensive assessment of cancer missense mutation clustering in protein structures

scientific article

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

scientific article

Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.

scientific article

Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF

scientific article

Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER breast cancer

DIPG-06. REDEFINING THE CELLULAR ARCHITECTURE OF DIFFUSE MIDLINE GLIOMAS WITH H3 K27M MUTATIONS THROUGH LARGE-SCALE SINGLE-CELL ANALYSES.

scientific article

DNA microarrays in clinical oncology

scientific article

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

scientific article published on 7 November 2016

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.

scientific article published on March 2017

Defining a Cancer Dependency Map.

scientific article

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

scientific article published in April 2018

Dicer1 functions as a haploinsufficient tumor suppressor

scientific article

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning ⬇️

scientific article published on January 1, 2002

Direct evidence for a polygenic etiology in familial multiple myeloma

scientific article published on 07 April 2017

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

scientific article published on 20 January 2020

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

scientific article

Discovery and saturation analysis of cancer genes across 21 tumour types

scientific article

Discovery of Inhibitors of Anti-Apoptotic Protein A1 ⬇️

scientific article published on July 27, 2012

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.

scholarly article

Drug and disease signature integration identifies synergistic combinations in glioblastoma

scientific article published in Nature Communications

Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma.

scientific article

Empirical Bayes analysis of quantitative proteomics experiments

scientific article

Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma

scientific article

Erratum: Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

scientific article published in Nature

Erratum: Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

scientific article published on 16 September 2015

Erratum: Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia

article

Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection

scientific article published on September 2017

Estimating dataset size requirements for classifying DNA microarray data

scientific article

Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer

scientific article

Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map.

scientific article

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

scientific article published on 24 March 2013

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

scientific article

Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype

scientific article

Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma

scientific article (publication date: May 2006)

Expression profiling of archival tumors for long-term health studies

scientific article

Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation

scientific article

FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS

scientific article published on 01 April 2021

GENE-22. RE-PROGRAMING CHROMATIN WITH A BIFUNCTIONAL LSD1/HDAC INHIBITOR INDUCES THERAPEUTIC DIFFERENTIATION IN DIPG

Gefitinib induces myeloid differentiation of acute myeloid leukemia

scientific article published on 5 July 2005

Gene expression correlates of clinical prostate cancer behavior

article

Gene expression in fixed tissues and outcome in hepatocellular carcinoma.

scientific article

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

scientific article published on 28 September 2006

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

scientific article

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance

scientific article published on 28 September 2006

Gene expression-based classification of malignant gliomas correlates better with survival than histological classification.

scientific article published in April 2003

Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation

scientific article published on 08 February 2004

Gene expression-based screening for inhibitors of PDGFR signaling

scientific article published on March 2008

Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

scientific article

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

scientific article

Genetic and transcriptional evolution alters cancer cell line drug response

scientific article published in August 2018

Genetic interrogation of circulating multiple myeloma cells at single-cell resolution

scientific article

Genetic modifiers of EGFR dependence in non-small cell lung cancer

scientific article

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

scientific article published on 3 June 2016

Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma

scientific article

Genomic approaches to hematologic malignancies

scientific article published on 20 May 2004

Genomic evolution of cancer models: perils and opportunities

scientific article published on 01 February 2019

HG-110SINGLE-CELL TRANSCRIPTOME ANALYSIS IN PEDIATRIC HEMISPHERIC AND MIDLINE HIGH-GRADE GLIOMAS.

scientific article published on 30 May 2016

High-throughput Phenotyping of Lung Cancer Somatic Mutations

scientific article published on 28 July 2016

High-throughput Phenotyping of Lung Cancer Somatic Mutations

scientific article published in December 2017

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

scientific article

Highly parallel identification of essential genes in cancer cells

scholarly article

IFN-alpha-stimulated genes and Epstein-Barr virus gene expression distinguish WHO type II and III nasopharyngeal carcinomas

scientific article published in January 2007

Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells

scientific article published on 17 June 2008

Identification of AML1-ETO modulators by chemical genomics

scientific article

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

scientific article

Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells

scientific article published on August 2008

Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.

scholarly article

Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

scientific article published in December 2007

Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells

scientific article published on 15 November 2002

Identification of prostate cancer modifier pathways using parental strain expression mapping

scholarly article

Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.

scientific article published on June 2007

Identifying the proteins to which small-molecule probes and drugs bind in cells

scholarly article

Imaging of multiple mRNA targets using quantum dot based in situ hybridization and spectral deconvolution in clinical biopsies

scientific article published on 31 July 2006

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

scientific article published in Nature Communications

Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

scientific article published in March 2006

Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification

scientific article published in February 2003

Initial genome sequencing and analysis of multiple myeloma

scientific article

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

scientific article

Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis

scientific article

Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma.

scientific article published on September 2012

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

scientific article

Integrative genome comparison of primary and metastatic melanomas

scientific article

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

scientific article (publication date: 7 July 2005)

Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma

scientific article published on September 2009

LACTB is a tumour suppressor that modulates lipid metabolism and cell state

scientific article

LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures

scientific article

Large-scale chemical dissection of mitochondrial function

scientific article

Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome

scientific article

Lin28 promotes transformation and is associated with advanced human malignancies

scientific article published on 31 May 2009

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

scientific article published on 09 September 2019

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

scientific article published on 03 December 2001

MLL-rearranged leukemias: insights from gene expression profiling ⬇️

scientific article published on October 1, 2003

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

scientific article

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

scientific article published on 11 February 2016

Melanoma genome sequencing reveals frequent PREX2 mutations

scientific article

Metagenes and molecular pattern discovery using matrix factorization

scholarly article

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer

scientific article published on September 2009

MicroRNA expression profiles classify human cancers

scientific article (publication date: 9 June 2005)

MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia

scholarly article

MicroRNA miR-125a controls hematopoietic stem cell number

scientific article

MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes

scientific article

MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a

scientific article published on 13 February 2011

MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors

scientific article

Mitochondrial metabolism promotes adaptation to proteotoxic stress

scientific article published on 27 May 2019

Modeling genomic diversity and tumor dependency in malignant melanoma

scientific article published on February 2008

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response

article

Molecular sampling of prostate cancer: a dilemma for predicting disease progression

scientific article

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

article

Multiplex cytological profiling assay to measure diverse cellular states

scientific article (publication date: 2013)

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

scientific article published on 27 August 2020

Mutational heterogeneity in cancer and the search for new cancer-associated genes

scientific article

NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes

scientific article

Next-generation characterization of the Cancer Cell Line Encyclopedia

scientific article published on 08 May 2019

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.

scientific article published on 4 February 2015

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

scientific article

Noncanonical open reading frames encode functional proteins essential for cancer cell survival

scientific article published on 28 January 2021

PDTM-04. REDEFINING THE CELLULAR ARCHITECTURE OF DIFFUSE MIDLINE GLIOMAS WITH H3 K27M MUTATIONS THROUGH LARGE-SCALE SINGLE-CELL ANALYSES

PTPS-06SINGLE-CELL TRANSCRIPTOME ANALYSIS IN PEDIATRIC HIGH-GRADE GLIOMA.

scientific article

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 30 September 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

scientific article published on 11 November 2014

Patient-derived xenografts undergo mouse-specific tumor evolution.

scientific article published on 9 October 2017

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

scientific article published on September 2017

Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies

scientific article published on 18 January 2024

Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance

scientific article published in November 2002

Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosis

scientific article published on 17 January 2013

Prolonged therapy for hepatitis C with low-dose peginterferon.

scientific article published in March 2009

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

scientific article

Protection of tissue physicochemical properties using polyfunctional crosslinkers.

scientific article

Proteomic and genetic approaches identify Syk as an AML target

scientific article

Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

article

Punctuated evolution of prostate cancer genomes

scientific article published on April 2013

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

RETRACTED scientific article

Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG

scientific article published on 17 October 2019

Recurrent and functional regulatory mutations in breast cancer

scientific article published on 28 June 2017

Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice.

scientific article

Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

scientific article published in Nature

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

scientific article

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

scientific article published on 02 February 2011

STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability ⬇️

scientific article published on February 9, 2012

SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas

scientific article published on June 2013

Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors.

scientific article published on 6 November 2017

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

article

Semiautomated multiplexed quantum dot-based in situ hybridization and spectral deconvolution

scientific article

Sensitive detection of minimal residual disease in patients treated for early-stage breast cancer

scientific article published on 13 March 2020

Sequence analysis of mutations and translocations across breast cancer subtypes

scientific article

Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma

scientific article

Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program

scientific article

Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)

scientific article published on 11 November 2014

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

scientific article published on 2 November 2016

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

scientific article published on 01 July 2019

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

scientific article published on 01 August 2019

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing

scientific article

Stem cell gene expression programs influence clinical outcome in human leukemia.

scientific article published on 28 August 2011

Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP

scientific article published on 18 July 2019

Subclass mapping: identifying common subtypes in independent disease data sets

scientific article

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

scientific article published on 01 December 2020

Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles

scientific article

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals

scientific article

Targetable genetic features of primary testicular and primary central nervous system lymphomas

scientific article published on 23 December 2015

The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research

scientific article published on 10 February 2020

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

scientific article published on 03 June 2020

The Drug Repurposing Hub: a next-generation drug library and information resource

scientific article (publication date: 7 April 2017)

The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts

scientific article

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

scientific article published on 24 November 2017

The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1

scientific article

The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2

scientific article

The genomic complexity of primary human prostate cancer

scientific article

The genomic landscape of juvenile myelomonocytic leukemia

scientific article

The genomic landscape of pediatric Ewing sarcoma

scientific article

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

scientific article

The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis

scientific article published on 04 July 2016

The landscape of somatic copy-number alteration across human cancers

scientific article

The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection

scientific article published on 22 May 2017

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.

scientific article

Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.

scientific article published on 7 February 2018

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state

scientific article

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

scientific article

Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling

scientific article published on December 2006

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

scientific article published on 16 July 2006

Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory

scientific article

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

scientific article published on 10 April 2019

Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

scientific article

Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy

scientific article published in January 2014

mRNA expression signature of Gleason grade predicts lethal prostate cancer

scientific article published on 2 May 2011

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

scientific article

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells

scientific article published on 20 January 2016

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

scientific article published on April 2016

microRNA expression during trophectoderm specification

scientific article published on 3 July 2009

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