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List of works by Ge Lin

1-Formyl-7-hydroxy-6,7-dihydro-5 H-pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids

scientific article published on 03 June 2019

A Pair of Enantiomeric Bis- seco-abietane Diterpenoids from Cryptomeria fortunei

scientific article published on 28 November 2018

A catenary model to study transport and conjugation of baicalein, a bioactive flavonoid, in the Caco-2 cell monolayer: demonstration of substrate inhibition.

scientific article published on 2 April 2008

A generic multiple reaction monitoring based approach for plant flavonoids profiling using a triple quadrupole linear ion trap mass spectrometry.

scientific article published on 2 April 2014

A novel bone targeting delivery system carrying phytomolecule icaritin for prevention of steroid-associated osteonecrosis in rats.

scientific article published on 10 October 2017

A novel ultra-performance liquid chromatography hyphenated with quadrupole time of flight mass spectrometry method for rapid estimation of total toxic retronecine-type of pyrrolizidine alkaloids in herbs without requiring corresponding standards

scientific article published on 25 November 2014

Action of GLP-1 (7-36) amide and exendin-4 on Suncus murinus (house musk shrew) isolated ileum

scientific article published on 06 April 2007

Action of anti-tussive drugs on the emetic reflex of Suncus murinus (house musk shrew).

scientific article published on 29 December 2006

Adduct ion-targeted qualitative and quantitative analysis of polyoxypregnanes by ultra-high pressure liquid chromatography coupled with triple quadrupole mass spectrometry

scientific article published on 20 June 2017

Alkaloids from roots of Stemona sessilifolia and their antitussive activities.

scientific article published on 24 November 2008

Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa.

scientific article published on 7 October 2015

Anti-metastatic effect and mechanisms of Wenshen Zhuanggu Formula in human breast cancer cells.

scientific article

Antitussive indole alkaloids from Kopsia hainanensis.

scientific article published on 16 December 2010

Assessment of pyrrolizidine alkaloid-induced toxicity in an in vitro screening model.

scientific article published on 14 September 2013

Blood Pyrrole-Protein Adducts--A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans.

scientific article published on 23 September 2015

Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome.

scientific article

Cassane Diterpenoids from the Pericarps of Caesalpinia bonduc

scientific article published on 12 January 2016

Centrally located GLP-1 receptors modulate gastric slow waves and cardiovascular function in ferrets consistent with the induction of nausea

scientific article published on 21 April 2017

Characteristic ion clusters as determinants for the identification of pyrrolizidine alkaloid N-oxides in pyrrolizidine alkaloid-containing natural products using HPLC-MS analysis

scientific article published on 01 March 2012

Clinical application of pyrrole-hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans

scientific article published on 18 November 2020

Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae.

scientific article published on 14 December 2011

Controllable drug release and simultaneously carrier decomposition of SiO2-drug composite nanoparticles.

scientific article

Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi

scientific article published on 14 March 2019

Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity.

scientific article published on 10 September 2015

Data showing the circumvention of oxaliplatin resistance by vatalanib in colon cancer.

scientific article

Deacetylclivorine: a gender-selective metabolite of clivorine formed in female Sprague-Dawley rat liver microsomes.

scientific article published on 19 January 2007

Definitive diagnosis of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids.

scientific article published in January 2012

Determination of hepatotoxic pyrrolizidine alkaloids by on-line high performance liquid chromatography mass spectrometry with an electrospray interface ⬇️

scientific article published on 01 January 1998

Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood

article

Development of a two-layer transwell co-culture model for the in vitro investigation of pyrrolizidine alkaloid-induced hepatic sinusoidal damage

scientific article published on 02 May 2019

Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret.

scientific article published on 10 December 2014

Diterpenoids from the flowers of Rhododendron molle.

scientific article

Double loaded self-decomposable SiO₂ nanoparticles for sustained drug release

scientific article published on 01 October 2015

Effect of structural modification of α-aminoxy peptides on their intestinal absorption and transport mechanism

scientific article published on 13 June 2011

Effect of structural modification on the gastrointestinal stability and hepatic metabolism of α-aminoxy peptides

scientific article published on 18 April 2012

Effects of Radix Astragali and Radix Rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isofor

scientific article published on 18 January 2012

Establishment of a novel CYP3A4-transduced human hepatic sinusoidal endothelial cell model and its application in screening hepatotoxicity of pyrrolizidine alkaloids

scientific article published on 29 May 2020

Evidence on Integrating Pharmacokinetics to Find Truly Therapeutic Agent for Alzheimer's Disease: Comparative Pharmacokinetics and Disposition Kinetics Profiles of Stereoisomers Isorhynchophylline and Rhynchophylline in Rats

scientific article published on 03 February 2019

Extraordinary metabolic stability of peptides containing α-aminoxy acids

scientific article published on 01 October 2011

First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans.

scientific article published on 15 June 2017

Gastric myoelectric activity during cisplatin-induced acute and delayed emesis reveals a temporal impairment of slow waves in ferrets: effects not reversed by the GLP-1 receptor antagonist, exendin (9-39).

scientific article published on 16 October 2017

Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum ⬇️

scientific article published on September 22, 2010

Hepatotoxicity and Tumorigenicity Induced by Metabolic Activation of Pyrrolizidine Alkaloids in Herbs ⬇️

scientific article published on November 1, 2011

High-performance liquid chromatographic method for simultaneous determination of baicalein and baicalein 7-glucuronide in rat plasma.

scientific article published in November 2004

Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product

scientific article published on 16 October 2010

Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb, Herba Senecionis scandentis (Qianliguang).

scientific article published in January 2008

Imaging-guided delivery of RNAi for anticancer treatment

scientific article

Immunoassay approach for diagnosis of exposure to pyrrolizidine alkaloids.

scientific article published on 16 May 2017

Importance of metabolic activation study to the safe use of Chinese herbal medicines.

scientific article published on June 2012

In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of baicalein.

scientific article published on 26 August 2011

Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact

scientific article published on 9 October 2013

Insights into the central pathways involved in the emetic and behavioural responses to exendin-4 in the ferret.

scientific article

Intestinal absorbability of three Radix Puerariae isoflavones including daidzein, daidzin and puerarin ⬇️

scientific article published on November 23, 2011

Intestinal absorption of Stemona alkaloids in a Caco-2 cell model.

scientific article published in February 2006

Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids

scientific article published on 20 June 2019

Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species.

scientific article

Involvement of UDP-glucuronosyltransferases in the extensive liver and intestinal first-pass metabolism of flavonoid baicalein.

scientific article published on 16 November 2006

Lack of metabolic activation and predominant formation of an excreted metabolite of nontoxic platynecine-type pyrrolizidine alkaloids.

scientific article published on 13 December 2013

Localization of estrogen receptor ERα, ERβ and GPR30 on myenteric neurons of the gastrointestinal tract and their role in motility

scientific article published on 28 November 2018

Low oral bioavailability and pharmacokinetics of senkyunolide a, a major bioactive component in Rhizoma Chuanxiong, in the rat

scientific article published on 01 February 2007

Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites

scientific article published on 08 October 2020

Lysine Adduction by Reactive Metabolite(s) of Monocrotaline.

scientific article published on 26 January 2016

Mechanisms underlying the vasorelaxing effects of butylidenephthalide, an active constituent of Ligusticum chuanxiong, in rat isolated aorta

scientific article published on 20 March 2006

Mechanistic study on the intestinal absorption and disposition of baicalein.

scientific article published on 9 April 2007

Metabolic activation of pyrrolizidine alkaloids: insights into the structural and enzymatic basis

scientific article published on 22 May 2014

Metabolic conversion from co-existing ingredient leading to significant systemic exposure of Z-butylidenephthalide, a minor ingredient in Chuanxiong Rhizoma in rats

scientific article published on 01 June 2012

Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook.

scientific article

Mitochondrial membrane potential played crucial roles in the accumulation of berberine in HepG2 cells

scientific article published on 26 April 2019

Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir.

scientific article

Naturally occurring proteinaceous nanoparticles in Coptidis Rhizoma extract act as concentration-dependent carriers that facilitate berberine absorption

scientific article published on 29 January 2016

Olvanil, a non-pungent vanilloid enhances the gastrointestinal toxicity of cisplatin in the ferret

scientific article published on 30 November 2009

Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa

scientific article published on 12 February 2009

Pelitinib (EKB-569) targets the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer

scientific article

Pharmacokinetic interactions among major bioactive components in Radix Scutellariae via metabolic competition

scientific article published on 25 September 2012

Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma Chuanxiong, in the rat.

scientific article published on 26 November 2007

Pharmacokinetics of 2-methoxyphenylmetyrapone and 2-bromophenylmetyrapone in rats

scientific article published on 01 January 1999

Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones.

scientific article published on 19 September 2011

Phosphocreatine attenuates Gynura segetum-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway

scientific article published on 27 June 2019

Photoirradiation of dehydropyrrolizidine alkaloids--formation of reactive oxygen species and induction of lipid peroxidation

scientific article published on 22 June 2011

Polyoxypregnane steroids from the stems of Marsdenia tenacissima

scientific article published on 12 September 2014

Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity

scientific article published on 14 March 2016

Position preference on glucuronidation of mono-hydroxylflavones in human intestine

scientific article published on 22 December 2005

Post-harvest alteration of the main chemical ingredients in Ligusticum chuanxiong Hort. (Rhizoma Chuanxiong) ⬇️

scientific article published on 01 January 2007

Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells

scientific article published on 24 October 2018

Proteomic Study of Pyrrolizidine Alkaloid-Induced Hepatic Sinusoidal Obstruction Syndrome in Rats

article

Pyrrole-Hemoglobin Adducts, a More Feasible Potential Biomarker of Pyrrolizidine Alkaloid Exposure

scientific article published on 06 May 2019

Pyrrole-protein adducts - A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity

scientific article published on 14 June 2018

Pyrrolizidine Alkaloid-Protein Adducts: Potential Non-invasive Biomarkers of Pyrrolizidine Alkaloid-Induced Liver Toxicity and Exposure

scientific article published on 7 July 2016

Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides.

scientific article published on 19 September 2017

Quality assurance and safety of herbal dietary supplements.

scientific article published on April 2009

Quantitation of DNA reactive pyrrolic metabolites of senecionine - A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis

scientific article published on 13 December 2019

Rapid endosomal escape of prickly nanodiamonds: implications for gene delivery.

scientific article published on 30 June 2015

Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta

scientific article published on 20 December 2006

Reversal of P-glycoprotein-mediated multidrug resistance by a synthetic α-aminoxy peptidomimetic.

scientific article published on 2 January 2012

Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes

scientific article published on 28 March 2017

Role of intestinal first-pass metabolism of baicalein in its absorption process.

scientific article published on 22 July 2005

Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry.

scientific article

Simultaneous quantification of 12 bioactive components of Ligusticum chuanxiong Hort. by high-performance liquid chromatography

scientific article published on 01 February 2005

Simultaneous quantification of five major biologically active ingredients of saffron by high-performance liquid chromatography

scientific article (publication date: July 1999)

Structure-activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases.

scientific article

Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells.

scientific article

Sulfur Fumigation Processing of Traditional Chinese Medicinal Herbs: Beneficial or Detrimental? ⬇️

scientific article published on December 27, 2011

Sulfur fumigation reducing systemic exposure of ginsenosides and weakening immunomodulatory activity of ginseng.

scientific article published on 14 November 2016

Surface plasmon enhanced drug efficacy using core-shell Au@SiO2 nanoparticle carrier.

scientific article published on 7 March 2013

Synergistic interaction between the Ligusticum chuanxiong constituent butylidenephthalide and the nitric oxide donor sodium nitroprusside in relaxing rat isolated aorta.

scientific article published on 6 January 2009

The differential antiemetic properties of GLP-1 receptor antagonist, exendin (9-39) in Suncus murinus (house musk shrew)

scientific article published on 12 April 2014

The effects of pretreatment with glycyrrhizin and glycyrrhetinic acid on the retrorsine-induced hepatotoxicity in rats

scientific article published on 01 September 1999

The long persistence of pyrrolizidine alkaloid-derived DNA adducts in vivo: kinetic study following single and multiple exposures in male ICR mice.

scientific article published on 28 April 2016

The metabolism of piperidine-type phenothiazine antipsychotic agents. I. Sulforidazine in the rat

scientific article published on 01 March 1992

The potential of liposomes with carbonic anhydrase IX to deliver anticancer ingredients to cancer cells in vivo

scientific article

The role of formation of pyrrole-ATP synthase subunit beta adduct in pyrrolizidine alkaloid-induced hepatotoxicity

scientific article published on 22 September 2018

Time-course accumulation of main bioactive components in the rhizome of Ligusticum chuanxiong.

scientific article published in February 2006

Toxicoproteomic assessment of liver responses to acute pyrrolizidine alkaloid intoxication in rats

scientific article published on 01 April 2018

Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb-drug interactions.

scientific article

Triterpenoid saponins profiling by adducts-targeted neutral loss triggered enhanced resolution and product ion scanning using triple quadrupole linear ion trap mass spectrometry

scientific article published on 20 February 2014

Ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry based chemical profiling approach to rapidly reveal chemical transformation of sulfur-fumigated medicinal herbs, a case study on white ginseng

scientific article published on 04 February 2012

Unambiguous observation of shape effects on cellular fate of nanoparticles.

scientific article published on 28 March 2014

Vatalanib sensitizes ABCB1 and ABCG2-overexpressing multidrug resistant colon cancer cells to chemotherapy under hypoxia.

scientific article published on 20 July 2015

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