List of works - Shafaat Rabbani

A KDR-binding peptide (ST100,059) can block angiogenesis, melanoma tumor growth and metastasis in vitro and in vivo.

scientific article

A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis

scientific article published on 01 January 2005

A common promoter hypomethylation signature in invasive breast, liver and prostate cancer cell lines reveals novel targets involved in cancer invasiveness.

scientific article published on 22 September 2015

A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo.

scientific article published on September 2006

A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGFβ-mediated breast cancer cell migration and invasion.

scientific article

A synthetic 15-mer peptide (PCK3145) derived from prostate secretory protein can reduce tumor growth, experimental skeletal metastases, and malignancy-associated hypercalcemia

scientific article published on 01 August 2004

Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo.

scientific article published on September 2006

An anti-urokinase plasminogen activator receptor antibody (ATN-658) blocks prostate cancer invasion, migration, growth, and experimental skeletal metastasis in vitro and in vivo.

scientific article published on October 2010

Binding and internalization of NGR-peptide-targeted liposomal doxorubicin (TVT-DOX) in CD13-expressing cells and its antitumor effects.

scientific article

Contribution of the 37-kDa laminin receptor precursor in the anti-metastatic PSP94-derived peptide PCK3145 cell surface binding.

scientific article published on 2 June 2006

Cyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasion

scientific article

DNA Methylation Readers and Cancer: Mechanistic and Therapeutic Applications

scientific article published on 11 June 2019

DNA demethylation and cancer: therapeutic implications.

scientific article published in August 2004

DNA methylation signatures of Prostate Cancer in peripheral T-cells

scientific article published on 23 June 2020

DNA methylation signatures of breast cancer in peripheral T-cells.

scientific article

Demethylation of urokinase promoter as a prognostic marker in patients with breast carcinoma.

scientific article published on May 2004

Effect of Herceptin on the development and progression of skeletal metastases in a xenograft model of human breast cancer

scientific article published on 01 October 2005

Effect of nucleoside analogue BCH-4556 on prostate cancer growth and metastases in vitro and in vivo ⬇️

scientific article published on August 1, 1998

Evaluating distant metastases in breast cancer: from biology to outcomes.

scientific article published on December 2007

Expression and characterization of recombinant rat parathyroid hormone-related peptide (1–141) and an amino-terminally-truncated analogue (38–141) ⬇️

scientific article published on June 20, 1997

Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation

scientific journal article

Expression of adenylate cyclase-coupled osseous parathyroid hormone and parathyroid hormone-like peptide receptors in Xenopus oocytes ⬇️

scientific article published on March 15, 1991

Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets

article

Hypomethylation of urokinase (uPA) promoter in breast and prostate cancer: prognostic and therapeutic implications.

scientific article

Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal Women

scientific article published on 20 July 2018

Induction in human osteoblastic cells (SaOS2) of the early response genesfos, jun, andmyc by the amino terminal fragment (ATF) of urokinase ⬇️

scientific article published on 01 August 1997

Induction of parathyroid hormone-related peptide by the Ras oncogene: role of Ras farnesylation inhibitors as potential therapeutic agents for hypercalcemia of malignancy ⬇️

scientific article published on October 15, 1997

Inhibition of MMP-9 secretion by the anti-metastatic PSP94-derived peptide PCK3145 requires cell surface laminin receptor signaling.

scientific article published on April 2006

Inhibition of processing of parathyroid hormone‐related peptide by anti‐sense furin: Effect in vitro and in vivo on rat leydig (H‐500) tumor cells ⬇️

scientific article published on 01 October 1995

LRP5 knockdown: effect on prostate cancer invasion growth and skeletal metastasis in vitro and in vivo.

scientific article published on 5 September 2013

Metalloproteases and urokinase in angiogenesis and tumor progression

scientific article published on January 1, 1998

Methyl donor S-adenosylmethionine (SAM) supplementation attenuates breast cancer growth, invasion, and metastasis in vivo; therapeutic and chemopreventive applications

scientific article published on 26 December 2017

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications.

scientific article

Nucleotide and (derived) amino acid sequence of a novel peptide from a rat (hypercalcemic) Leydig cell tumor

scientific article published on December 29, 1992

Over-production of parathyroid hormone-related peptide results in increased osteolytic skeletal metastasis by prostate cancer cells in vivo

scientific article published on 01 January 1999

PEGylated DX-1000: pharmacokinetics and antineoplastic activity of a specific plasmin inhibitor.

scientific article

Pharmacological methyl group donors block skeletal metastasis in vitro and in vivo.

scientific article

Prevention of breast cancer growth, invasion, and metastasis by antiestrogen tamoxifen alone or in combination with urokinase inhibitor B-428 ⬇️

scientific article published on August 15, 1997

Regulation in vivo of the growth of Leydig cell tumors by antisense ribonucleic acid for parathyroid hormone-related peptide ⬇️

scientific article published on December 1, 1995

Regulation of parathyroid hormone-related peptide by estradiol: effect on tumor growth and metastasis in vitro and in vivo.

scientific article

Regulation of urokinase production by androgens in human prostate cancer cells: effect on tumor growth and metastases in vivo

scientific article published on 01 September 1999

Reversal of hypercalcemia with the vitamin D analogue EB1089 in a human model of squamous cancer.

scientific article published on July 1999

Role of Epigenetics in Cancer Initiation and Progression ⬇️

scientific article published on January 1, 2011

Role of urokinase (uPA) and its receptor (uPAR) in invasion and metastasis of hormone-dependent malignancies ⬇️

scientific article published on April 1, 1998

S-adenosylmethionine blocks osteosarcoma cells proliferation and invasion in vitro and tumor metastasis in vivo: therapeutic and diagnostic clinical applications

scientific article published on 26 January 2015

S-adenosylmethionine in combination with decitabine shows enhanced anti-cancer effects in repressing breast cancer growth and metastasis

scientific article published on 28 July 2020

SKI-606 (Bosutinib) blocks prostate cancer invasion, growth, and metastasis in vitro and in vivo through regulation of genes involved in cancer growth and skeletal metastasis.

scientific article

Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.

scientific article

Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells

scientific article published on 01 July 1999

Structural requirements for the growth factor activity of the amino-terminal domain of urokinase ⬇️

scientific article published on July 15, 1992

Studies of the molecular biology of parathyroid hormone-like peptide

scientific article published on January 1, 1992

Studies on the pathogenesis of osteoblastic metastases by prostate cancer

scientific article published on January 1, 1992

Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness

scientific article

Targeting DNA Hypomethylation in Malignancy by Epigenetic Therapies

scientific article published on 01 January 2019

The urokinase plasminogen activator receptor (UPAR) is preferentially induced by nerve growth factor in PC12 pheochromocytoma cells and is required for NGF-driven differentiation.

scientific article published on January 2000

Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications.

scientific article published on September 2004

List of works by Shafaat Rabbani

A KDR-binding peptide (ST100,059) can block angiogenesis, melanoma tumor growth and metastasis in vitro and in vivo.

A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis

A common promoter hypomethylation signature in invasive breast, liver and prostate cancer cell lines reveals novel targets involved in cancer invasiveness.

A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo.

A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGFβ-mediated breast cancer cell migration and invasion.

A synthetic 15-mer peptide (PCK3145) derived from prostate secretory protein can reduce tumor growth, experimental skeletal metastases, and malignancy-associated hypercalcemia

Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo.

An anti-urokinase plasminogen activator receptor antibody (ATN-658) blocks prostate cancer invasion, migration, growth, and experimental skeletal metastasis in vitro and in vivo.

Binding and internalization of NGR-peptide-targeted liposomal doxorubicin (TVT-DOX) in CD13-expressing cells and its antitumor effects.

Contribution of the 37-kDa laminin receptor precursor in the anti-metastatic PSP94-derived peptide PCK3145 cell surface binding.

Cyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasion

DNA Methylation Readers and Cancer: Mechanistic and Therapeutic Applications

DNA demethylation and cancer: therapeutic implications.

DNA methylation signatures of Prostate Cancer in peripheral T-cells

DNA methylation signatures of breast cancer in peripheral T-cells.

Demethylation of urokinase promoter as a prognostic marker in patients with breast carcinoma.

Effect of Herceptin on the development and progression of skeletal metastases in a xenograft model of human breast cancer

Effect of nucleoside analogue BCH-4556 on prostate cancer growth and metastases in vitro and in vivo ⬇️

Evaluating distant metastases in breast cancer: from biology to outcomes.

Expression and characterization of recombinant rat parathyroid hormone-related peptide (1–141) and an amino-terminally-truncated analogue (38–141) ⬇️

Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation

Expression of adenylate cyclase-coupled osseous parathyroid hormone and parathyroid hormone-like peptide receptors in Xenopus oocytes ⬇️

Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets

Hypomethylation of urokinase (uPA) promoter in breast and prostate cancer: prognostic and therapeutic implications.

Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal Women

Induction in human osteoblastic cells (SaOS2) of the early response genesfos, jun, andmyc by the amino terminal fragment (ATF) of urokinase ⬇️

Induction of parathyroid hormone-related peptide by the Ras oncogene: role of Ras farnesylation inhibitors as potential therapeutic agents for hypercalcemia of malignancy ⬇️

Inhibition of MMP-9 secretion by the anti-metastatic PSP94-derived peptide PCK3145 requires cell surface laminin receptor signaling.

Inhibition of processing of parathyroid hormone‐related peptide by anti‐sense furin: Effect in vitro and in vivo on rat leydig (H‐500) tumor cells ⬇️

LRP5 knockdown: effect on prostate cancer invasion growth and skeletal metastasis in vitro and in vivo.

Metalloproteases and urokinase in angiogenesis and tumor progression

Methyl donor S-adenosylmethionine (SAM) supplementation attenuates breast cancer growth, invasion, and metastasis in vivo; therapeutic and chemopreventive applications

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications.

Nucleotide and (derived) amino acid sequence of a novel peptide from a rat (hypercalcemic) Leydig cell tumor

Over-production of parathyroid hormone-related peptide results in increased osteolytic skeletal metastasis by prostate cancer cells in vivo

PEGylated DX-1000: pharmacokinetics and antineoplastic activity of a specific plasmin inhibitor.

Pharmacological methyl group donors block skeletal metastasis in vitro and in vivo.

Prevention of breast cancer growth, invasion, and metastasis by antiestrogen tamoxifen alone or in combination with urokinase inhibitor B-428 ⬇️

Regulation in vivo of the growth of Leydig cell tumors by antisense ribonucleic acid for parathyroid hormone-related peptide ⬇️

Regulation of parathyroid hormone-related peptide by estradiol: effect on tumor growth and metastasis in vitro and in vivo.

Regulation of urokinase production by androgens in human prostate cancer cells: effect on tumor growth and metastases in vivo

Reversal of hypercalcemia with the vitamin D analogue EB1089 in a human model of squamous cancer.

Role of Epigenetics in Cancer Initiation and Progression ⬇️

Role of urokinase (uPA) and its receptor (uPAR) in invasion and metastasis of hormone-dependent malignancies ⬇️

S-adenosylmethionine blocks osteosarcoma cells proliferation and invasion in vitro and tumor metastasis in vivo: therapeutic and diagnostic clinical applications

S-adenosylmethionine in combination with decitabine shows enhanced anti-cancer effects in repressing breast cancer growth and metastasis

SKI-606 (Bosutinib) blocks prostate cancer invasion, growth, and metastasis in vitro and in vivo through regulation of genes involved in cancer growth and skeletal metastasis.

Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.

Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells

Structural requirements for the growth factor activity of the amino-terminal domain of urokinase ⬇️

Studies of the molecular biology of parathyroid hormone-like peptide

Studies on the pathogenesis of osteoblastic metastases by prostate cancer

Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness

Targeting DNA Hypomethylation in Malignancy by Epigenetic Therapies

The urokinase plasminogen activator receptor (UPAR) is preferentially induced by nerve growth factor in PC12 pheochromocytoma cells and is required for NGF-driven differentiation.

Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications.