List of works - Anne Y Saiki

DNA cleavage activities of Staphylococcus aureus gyrase and topoisomerase IV stimulated by quinolones and 2-pyridones.

scientific article published on July 1999

Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction

scientific article

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development

scientific article

Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C

scientific article published on 20 August 2019

Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction

scientific article

From bacterial genomes to novel antibacterial agents: discovery, characterization, and antibacterial activity of compounds that bind to HI0065 (YjeE) from Haemophilus influenzae

scientific article published on 01 June 2007

Identifying the determinants of response to MDM2 inhibition.

scientific article

Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors.

scientific article published on 10 November 2010

MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways

scientific article published on April 2014

Novel antibacterial class.

scientific article

Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres

scientific article

Rational design and binding mode duality of MDM2-p53 inhibitors

scientific article

Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction

scientific article

Solution structure and function of an essential CMP kinase of Streptococcus pneumoniae

scientific article

Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction ⬇️

scientific article published on May 9, 2012

The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

scientific article

The Role of MDM2 Amplification and Overexpression in Tumorigenesis

scientific article published on 18 May 2016

List of works by Anne Y Saiki

DNA cleavage activities of Staphylococcus aureus gyrase and topoisomerase IV stimulated by quinolones and 2-pyridones.

Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development

Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C

Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction

From bacterial genomes to novel antibacterial agents: discovery, characterization, and antibacterial activity of compounds that bind to HI0065 (YjeE) from Haemophilus influenzae

Identifying the determinants of response to MDM2 inhibition.

Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors.

MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways

Novel antibacterial class.

Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres

Rational design and binding mode duality of MDM2-p53 inhibitors

Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction

Solution structure and function of an essential CMP kinase of Streptococcus pneumoniae

Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction ⬇️

The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

The Role of MDM2 Amplification and Overexpression in Tumorigenesis