List of works by Michael P. Lisanti

"Energetic" Cancer Stem Cells (e-CSCs): A New Hyper-Metabolic and Proliferative Tumor Cell Phenotype, Driven by Mitochondrial Energy

17β-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells

scientific article

A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer

scientific article published on 18 November 2010

A biphasic response of hepatobiliary cholesterol metabolism to dietary fat at the onset of obesity in the mouse

scientific article published in April 2005

A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death

scientific article

A mitochondrial based oncology platform for targeting cancer stem cells (CSCs): MITO-ONC-RX

scholarly article by Federica Sotgia published in September 2018

A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis

scientific article published on 27 October 2017

A novel role for caveolin-1 in B lymphocyte function and the development of thymus-independent immune responses.

scientific article

A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1.

scientific article published on 14 May 2009

A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4.

scientific article

ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer

scientific article

ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection

scientific article

Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases

scientific article published on 20 December 2012

Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation

scientific article published on June 2003

Accelerated aging in the tumor microenvironment: connecting aging, inflammation and cancer metabolism with personalized medicine

scientific article published on July 2011

Acetylation in hormone signaling and the cell cycle

scientific article

Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer

scientific article published on June 2013

Activation of Transcription Factors AP-1 and NF-κB in Murine Chagasic Myocarditis

scientific article published on May 1, 2003

Adipocyte differentiation induces dynamic changes in NF-kappaB expression and activity

scientific article published on 13 July 2004

Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment

scientific article

Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment

Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization

scientific article published on September 25, 2003

Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure

scientific article published on 19 March 2010

Akt1 governs breast cancer progression in vivo

scientific article

Alterations in membrane caveolae and BKCa channel activity in skin fibroblasts in Smith-Lemli-Opitz syndrome

scientific article published on 27 May 2011

Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice

scientific article

Altered expression of DACH1 and cyclin D1 in endometrial cancer.

scientific article

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

scientific article

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation

scientific article

Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis.

scientific article published on 7 March 2007

Anti-CTLA-4 therapy for malignant mesothelioma

scientific article published on March 2017

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

scientific article published on 15 November 2011

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease

scientific article published on March 2015

Atherosclerosis, caveolae and caveolin-1.

scientific article published on January 2012

Attenuation of Forkhead signaling by the retinal determination factor DACH1.

scientific article

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production

scientific article

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

scientific article

Azithromycin and Roxithromycin define a new family of "senolytic" drugs that target senescent human fibroblasts

BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies

scientific article published on 21 November 2012

Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs).

scientific article published on 22 June 2016

Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase

scientific article published on 13 May 2021

Bortezomib (PS-341) treatment decreases inflammation and partially rescues the expression of the dystrophin-glycoprotein complex in GRMD dogs

scientific article

CAPER, a novel regulator of human breast cancer progression

scientific article

CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway

scientific article

CCR5 antagonist blocks metastasis of basal breast cancer cells

scientific article

CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines.

scientific article

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis

scientific article

COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

scientific article published on 30 March 2020

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.

scientific article

Caloric restriction augments radiation efficacy in breast cancer

scientific article published on 21 May 2013

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors

scientific article

Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer

scientific article published on 10 April 2013

Cancer metabolism: a therapeutic perspective

scientific article published on 4 May 2016

Cancer metabolism: new validated targets for drug discovery

scientific article published on August 2013

Cancer stem cell metabolism

scientific article

Cancer stem cells (CSCs): metabolic strategies for their identification and eradication.

scientific article published on 9 May 2018

Carbonic anhydrase 9 (CA9) and redox signaling in cancer-associated fibroblasts: therapeutic implications

scientific article published on 30 July 2013

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

scientific article published on 28 January 2014

Cav1 inhibits benign skin tumor development in a two-stage carcinogenesis model by suppressing epidermal proliferation.

scientific article published on 21 January 2013

Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation

scientific article published on 22 December 2012

Caveolae and caveolin-1: novel potential targets for the treatment of cardiovascular disease

scientific article published on January 2007

Caveolae and signalling in cancer

scientific article published on April 2015

Caveolae and transcytosis in endothelial cells: role in atherosclerosis

scientific article published on 08 August 2008

Caveolae-deficient Endothelial Cells Show Defects in the Uptake and Transport of Albuminin Vivo

scientific article published in Journal of Biological Chemistry

Caveolae: from cell biology to animal physiology

scientific article

Caveolin, caveolae, and endothelial cell function

scientific article

Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature

scientific article published on May 2009

Caveolin-1 Null (−/−) Mice Show Dramatic Reductions in Life Span†

scientific article published on 01 December 2003

Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug

scientific article

Caveolin-1 and breast cancer: a new clinical perspective

scientific article published on January 2012

Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms

scientific article

Caveolin-1 and caveolae in atherosclerosis: differential roles in fatty streak formation and neointimal hyperplasia

scientific article

Caveolin-1 and liver regeneration: role in proliferation and lipogenesis

scientific article

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts

scientific article

Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness

scientific article

Caveolin-1 deficiency exacerbates cardiac dysfunction and reduces survival in mice with myocardial infarction

scientific article

Caveolin-1 deficiency increases cerebral ischemic injury

scientific journal article

Caveolin-1 deficiency induces spontaneous endothelial-to-mesenchymal transition in murine pulmonary endothelial cells in vitro

scientific article published on 27 November 2012

Caveolin-1 deficiency stimulates neointima formation during vascular injury

scientific article

Caveolin-1 expression determines the route of neutrophil extravasation through skin microvasculature

scientific article published on February 2009

Caveolin-1 expression enhances endothelial capillary tubule formation

scientific article published on 17 December 2001

Caveolin-1 expression is essential for proper nonshivering thermogenesis in brown adipose tissue

scientific article published in March 2005

Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion

scientific article published on 7 September 2004

Caveolin-1 in breast cancer

scientific article

Caveolin-1 in oncogenic transformation, cancer, and metastasis

scientific article

Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase

scientific article

Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide

scientific article published on 17 April 2013

Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli

scientific journal article

Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia

scientific article published on October 2002

Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status

scientific article

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

scientific journal article

Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate.

scientific article published on 12 May 2011

Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition

scientific article published on November 2011

Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice

scientific article

Caveolin-1 tumor-promoting role in human melanoma

scientific article

Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation

scientific journal article

Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers

scientific article published on November 2006

Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosis

scientific article published in November 2008

Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts

scientific article published on March 2009

Caveolin-1-deficient aortic smooth muscle cells show cell autonomous abnormalities in proliferation, migration, and endothelin-based signal transduction

scientific article published on 13 January 2006

Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities

scientific article published on 5 December 2001

Caveolin-1-deficient mice have an increased mammary stem cell population with upregulation of Wnt/beta-catenin signaling.

scientific article

Caveolin-1-deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar Typhimurium infection

scientific article

Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue

scientific article published on 26 March 2003

Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.

scientific article published on June 2002

Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae

scientific article

Caveolin-2-deficient mice show increased sensitivity to endotoxemia

scientific article

Caveolin-3 Promotes a Vascular Smooth Muscle Contractile Phenotype

scientific article

Caveolin-3 T78M and T78K missense mutations lead to different phenotypes in vivo and in vitro

scientific article published on 4 February 2008

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

scientific article (publication date: 11 October 2002)

Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle

scientific article published on 2 February 2005

Caveolinopathies: from the biology of caveolin-3 to human diseases

scientific article

Caveolinopathies: from the biology of caveolin-3 to human diseases.

scientific article published on 19 November 2009

Cell cycle regulatory proteins in the liver in murine Trypanosoma cruzi infection

scientific article

Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth

scientific journal article

Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation

scientific article published on 12 December 2013

Cerebral malaria: we have come a long way

scientific article published on 25 September 2012

Chagas disease, adipose tissue and the metabolic syndrome

scientific article published on July 2009

Chagas heart disease: report on recent developments

scientific article published on March 2012

Chapter 10 Caveolae and Caveolins in the Vascular System: Functional Roles in Endothelia, Macrophages, and Smooth Muscle Cells

article published in 2005

Chapter 11 Caveolin Proteins in Cardiopulmonary Disease and Lung Cancers

article

Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells

scientific article published on May 2015

Cholesterol and Mevalonate: Two Metabolites Involved in Breast Cancer Progression and Drug Resistance through the ERRα Pathway

scientific article published on 31 July 2020

Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment.

scientific article published on 6 February 2013

Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders

scientific article published on 30 March 2009

Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome

scientific article

Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer

scientific article

Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia

scientific article published on 25 March 2004

Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis

scientific article published on 10 April 2013

Connexin family members target to lipid raft domains and interact with caveolin-1

scientific article (publication date: 7 May 2002)

Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette

scientific article

Contrast-enhanced in vivo imaging of breast and prostate cancer cells by MRI.

scientific article published on 4 January 2006

Creating a tumor-resistant microenvironment: cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo.

scientific article published on February 2012

Cyclin D1 Promotes Androgen-Dependent DNA Damage Repair in Prostate Cancer Cells

scientific article published on 18 November 2015

Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity

scientific article

Cyclin D1 determines estrogen signaling in the mammary gland in vivo

scientific article

Cyclin D1 induction of cellular migration requires p27(KIP1).

scientific article published on October 2006

Cyclin D1 integrates estrogen-mediated DNA damage repair signaling

scientific article

Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism

scientific article

Cyclin and caveolin expression in an acute model of murine Chagasic myocarditis.

scientific article

Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator

scientific article

DACH1 inhibits transforming growth factor-beta signaling through binding Smad4

scientific article

DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth

scientific article

Dachshund binds p53 to block the growth of lung adenocarcinoma cells

scientific article published on 14 March 2013

Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8.

scientific article

Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis

scientific article published on September 2008

Deficiency of hyccin, a newly identified membrane protein, causes hypomyelination and congenital cataract

scientific article

Defining lipid raft structure and function with proximity imaging

article published in 2006

Development of a high-affinity inhibitor of the prostaglandin transporter

scientific article

Dietary n-3 polyunsaturated fatty acids fail to reduce prostate tumorigenesis in the PB-ErbB-2 x Pten(+/-) preclinical mouse model

scientific article published on 15 May 2010

Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase

scientific article

Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells

scientific article

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

scientific article

Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production

scientific article

Doxycycline and therapeutic targeting of the DNA damage response in cancer cells: old drug, new purpose

scientific article published on 24 August 2015

Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy

scientific article

Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)

Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study

Ectopic expression of murine diphosphoinositol polyphosphate phosphohydrolase 1 attenuates signaling through the ERK1/2 pathway

scientific article published on September 2004

Endothelial caveolin-1 plays a major role in the development of atherosclerosis

scientific article published on 7 January 2014

Energy transfer in "parasitic" cancer metabolism: mitochondria are the powerhouse and Achilles' heel of tumor cells

scientific article

Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking

scientific article published on 3 January 2006

ErbB-2 induces bilateral adrenal pheochromocytoma formation in mice.

scientific article published on 31 May 2007

ErbB2 induces Notch1 activity and function in breast cancer cells

scientific article published on September 2008

Erratum

scholarly article published in Autophagy

Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection

scientific article published on 9 February 2012

Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC)

scientific article

Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism: implications for breast cancer prevention

scientific article (publication date: 15 January 2013)

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

scientific article

Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D

scientific article

Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs).

scientific article published on 19 February 2018

Expression and Characterization of Recombinant Caveolin

scientific article published in Journal of Biological Chemistry

Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation.

scientific article

Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts

scientific article

Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival.

scientific article published on 15 June 2009

G Protein-Coupled Receptors at the Crossroad between Physiologic and Pathologic Angiogenesis: Old Paradigms and Emerging Concepts

scientific article published on 14 December 2017

GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment

scientific article published on 6 December 2017

Genes contributing to prion pathogenesis

scientific article

Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration

scientific article published on 6 March 2012

Genetic ablation of caveolin-1 confers protection against atherosclerosis

scientific article published on 16 October 2003

Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions

scientific article published on April 2009

Genetic ablation of caveolin-1 in mammary epithelial cells increases milk production and hyper-activates STAT5a signaling

scientific article published on 9 March 2006

Genetic ablation of caveolin-1 increases neural stem cell proliferation in the subventricular zone (SVZ) of the adult mouse brain

scientific article published on 28 December 2009

Genetic ablation of caveolin-2 sensitizes mice to bleomycin-induced injury

scientific article published on July 2013

Genetic induction of the Warburg effect inhibits tumor growth

scientific article published in November 2012

Glomerular endothelial fenestrae in vivo are not formed from caveolae

scientific article published in November 2002

Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance

scientific article published on 15 December 2011

Glutamine supplementation alleviates vasculopathy and corrects metabolic profile in an in vivo model of endothelial cell dysfunction

scientific article

Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling

scientific article published on 15 June 2010

Graphene oxide selectively targets cancer stem cells, across multiple tumor types: implications for non-toxic cancer treatment, via "differentiation-based nano-therapy".

scientific article published on February 2015

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis

scientific article

Hallmarks of the cancer cell of origin: Comparisons with "energetic" cancer stem cells (e-CSCs)

Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism

scientific article

Hereditary ovarian cancer and two-compartment tumor metabolism: epithelial loss of BRCA1 induces hydrogen peroxide production, driving oxidative stress and NFκB activation in the tumor stroma

scientific article

High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant

scientific article published on 30 September 2015

Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment.

scientific article published in June 2017

Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy

scientific article published on 30 August 2008

Hyccin, the molecule mutated in the leukodystrophy hypomyelination and congenital cataract (HCC), is a neuronal protein

scientific journal article

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs "fertilizer".

scientific article

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue

scientific article published on December 2011

ICAM-1: role in inflammation and in the regulation of vascular permeability

scientific article published on 8 August 2008

Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis

scientific article

Identification of a cyclin D1 network in prostate cancer that antagonizes epithelial-mesenchymal restraint

scientific article published on 26 November 2013

Identification of a functional prostanoid-like receptor in the protozoan parasite, Trypanosoma cruzi

scientific article published on 13 February 2013

Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate

scientific article

Imaging of small-animal models of infectious diseases

scientific article

Immune dysfunction in caveolin-1 null mice following infection with Trypanosoma cruzi (Tulahuen strain).

scientific article published on 09 January 2007

Impaired phagocytosis in caveolin-1 deficient macrophages

scientific article

Impairment of caveolae formation and T-system disorganization in human muscular dystrophy with caveolin-3 deficiency

scientific article published on January 2002

Inhibition of cyclin D1 gene transcription by Brg-1.

scientific article published on 12 December 2007

Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence

scientific article published on May 2013

Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice

scientific article published on 29 June 2015

Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism

scientific article published on 15 January 2012

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: connecting fibrosis, inflammation, and stemness for cancer prevention.

scientific article published on 05 December 2013

Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells

scientific article

Ketone body utilization drives tumor growth and metastasis

scientific article

Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

scientific article

Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics

scientific article

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis

scientific article

Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease

scientific article

Left ventricular dysfunction in murine models of heart failure and in failing human heart is associated with a selective decrease in the expression of caveolin-3.

scientific article

Localization of phospho-beta-dystroglycan (pY892) to an intracellular vesicular compartment in cultured cells and skeletal muscle fibers in vivo

scientific article

Localization of the human caveolin-3 gene to the D3S18/D3S4163/D3S4539 locus (3p25), in close proximity to the human oxytocin receptor gene

article

Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria

scientific article

Loss of caveolin-1 causes the hyper-proliferation of intestinal crypt stem cells, with increased sensitivity to whole body gamma-radiation

scientific article

Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice

scientific article

Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression

scientific article published on 08 July 2013

Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation

scientific journal article

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

scientific article

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation

scientific article published in June 2010

Lung remodeling and pulmonary hypertension after myocardial infarction: pathogenic role of reduced caveolin expression.

scientific article

MR imaging of caveolin gene-specific alterations in right ventricular wall thickness.

scientific article

Mammary gland selective excision of c-jun identifies its role in mRNA splicing

scientific article

Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways

article by Gloria Bonuccelli et al published 23 August 2018 in Aging

Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis

scientific article

Mechanisms of Trypanosoma cruzi persistence in Chagas disease

scientific article

Mesenchymal stem cells, used as bait, disclose tissue binding sites: a tool in the search for the niche?

scientific article

Metabolic asymmetry in cancer: a "balancing act" that promotes tumor growth.

scientific article

Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth

scientific article

Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells

scientific article

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.

scientific article

Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?

scientific article published in December 2015

MicroRNA-203 regulates caveolin-1 in breast tissue during caloric restriction

scientific article

Microarray analysis of the mammalian thromboxane receptor-Trypanosoma cruzi interaction

scientific article

Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice

scientific article published on 7 August 2002

MitoTracker Deep Red (MTDR) Is a Metabolic Inhibitor for Targeting Mitochondria and Eradicating Cancer Stem Cells (CSCs), With Anti-Tumor and Anti-Metastatic Activity <i>In Vivo</i>

scientific article published on 30 July 2021

Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells

scientific article published on 21 November 2012

Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition

scientific article

Mitochondrial "power" drives tamoxifen resistance: NQO1 and GCLC are new therapeutic targets in breast cancer

scientific article

Mitochondrial biogenesis drives tumor cell proliferation

scientific article published on May 2011

Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance

scientific article

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

scientific article

Mitochondrial biomarkers predict tumor progression and poor overall survival in gastric cancers: Companion diagnostics for personalized medicine

scientific article published on 5 August 2017

Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin.

scientific article published on 20 December 2012

Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling.

scientific article published on 19 January 2018

Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth

scientific article

Mitochondrial impairment is a critical event in anthrax lethal toxin-induced cytolysis of murine macrophages

scientific article published on 28 January 2006

Mitochondrial mRNA transcripts predict overall survival, tumor recurrence and progression in serous ovarian cancer: Companion diagnostics for cancer therapy

scientific article published on 6 August 2017

Mitochondrial markers predict recurrence, metastasis and tamoxifen-resistance in breast cancer patients: Early detection of treatment failure with companion diagnostics

scientific article published on 27 July 2017

Mitochondrial markers predict survival and progression in non-small cell lung cancer (NSCLC) patients: Use as companion diagnostics

scientific article published on 28 July 2017

Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue

scientific article

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

scientific article

Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection

scientific article published on December 2011

Mitoketoscins: Novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs).

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Mitoriboscins: Mitochondrial-based therapeutics targeting cancer stem cells (CSCs), bacteria and pathogenic yeast

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Molecular cloning and characterization of mitogen-activated protein kinase 2 in Toxoplasma gondii

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Molecular cloning and characterization of mitogen-activated protein kinase 2 in Trypanosoma cruzi

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Molecular cloning and developmental expression of the caveolin gene family in the amphibian Xenopus laevis

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Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

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Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment

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Muscle-specific interaction of caveolin isoforms: differential complex formation between caveolins in fibroblastic vs. muscle cells

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Mutational analysis identifies a short atypical membrane attachment sequence (KYWFYR) within caveolin-1.

scientific article published on March 2002

N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation

scientific article published on April 2007

NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting "stemness".

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Novel oncogene-induced metastatic prostate cancer cell lines define human prostate cancer progression signatures

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Nutrient restriction and radiation therapy for cancer treatment: when less is more

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Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4.

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Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery

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Overexpression of caveolin-1 inhibits endothelial cell proliferation by arresting the cell cycle at G0/G1 phase

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Oxidative Stress and Reprogramming of Mitochondrial Function and Dynamics as Targets to Modulate Cancer Cell Behavior and Chemoresistance

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Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

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PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b

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PPARgamma activation induces autophagy in breast cancer cells

scientific article published on 26 June 2009

PV-1 is negatively regulated by VEGF in the lung of caveolin-1, but not caveolin-2, null mice.

scientific article published in September 2006

PV-1 labels trans-cellular openings in mouse endothelial cells and is negatively regulated by VEGF.

scientific article published on September 2006

Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes

scientific article published on 2 August 2004

Pharmacological rescue of the dystrophin-glycoprotein complex in Duchenne and Becker skeletal muscle explants by proteasome inhibitor treatment

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Phenotypic behavior of caveolin-3 R26Q, a mutant associated with hyperCKemia, distal myopathy, and rippling muscle disease

scientific article published on 2 July 2003

Phenotypic characterization of hypomyelination and congenital cataract.

scientific article published in August 2007

Phosphofructokinase muscle-specific isoform requires caveolin-3 expression for plasma membrane recruitment and caveolar targeting: implications for the pathogenesis of caveolin-related muscle diseases

scientific article published in December 2003

Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer

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Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the heart modulates enzyme stimulation

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Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins

scientific article published on October 2003

Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts

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Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

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Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI.

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Recent developments in the interactions between caveolin and pathogens

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Regulation of Cripto-1 signaling and biological activity by caveolin-1 in mammary epithelial cells

scientific article published on 17 January 2008

Regulation of host cell cyclin D1 by Trypanosoma cruzi in myoblasts

scientific article published on 18 November 2007

Regulation of insulin receptor substrate-1 expression levels by caveolin-1.

scientific article published in October 2008

Repurposing atovaquone: targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells

scientific article published on 30 April 2016

Repurposing of FDA-approved drugs against cancer - focus on metastasis

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Requirement of transcription factor NFAT in developing atrial myocardium

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Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain).

scientific article published on 31 January 2012

Reverse Warburg effect in a patient with aggressive B-cell lymphoma: is lactic acidosis a paraneoplastic syndrome?

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Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells

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Reviewing once more the c-myc and Ras collaboration: converging at the cyclin D1-CDK4 complex and challenging basic concepts of cancer biology

scientific article published on January 2011

Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease.

scientific article published on 29 May 2012

Role of caveolae and caveolins in health and disease

scientific article published in October 2004

Role of caveolin and caveolae in insulin signaling and diabetes

scientific article published on December 1, 2003

Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation

scientific article published in May 2004

Role of caveolin-1 in the regulation of lipoprotein metabolism

scientific article published on 28 May 2008

Role of caveolin-1 in the regulation of the vascular shear stress response

scientific article published on May 2006

Role of cholesterol in the development and progression of breast cancer

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Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

scientific article published on 20 May 2013

SOCS proteins and caveolin-1 as negative regulators of endocrine signaling

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Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development

scientific article published on January 2013

Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis

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Segregation of micron-scale membrane sub-domains in live murine sperm

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Selective cytotoxicity of synthesized procyanidin 3-O-galloylepicatechin-4b, 8-3-O-galloylcatechin to human cancer cells

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Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1)

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Short-Term Administration of a Cell-Permeable Caveolin-1 Peptide Prevents the Development of Monocrotaline-Induced Pulmonary Hypertension and Right Ventricular Hypertrophy

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Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor

scientific article published on 4 December 2006

Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1

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Stabilization of caveolin-1 by cellular cholesterol and scavenger receptor class B type I.

scientific article published on October 2002

Stromal CD10 and SPARC expression in ductal carcinoma in situ (DCIS) patients predicts disease recurrence

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Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells

scientific article published on November 2006

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

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Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth

scientific article published on 4 August 2017

Stromal glycolysis and MCT4 are hallmarks of DCIS progression to invasive breast cancer

scientific article published on 27 August 2013

Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment

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Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts

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Switch to oral hypoglycemic agent therapy from insulin injection in patients with type 2 diabetes

scientific article published in December 2008

TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen

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Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity

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Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy

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Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy

scientific article published on 12 June 2017

Targeting tumor-initiating cells: eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction

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The Caveolin genes: from cell biology to medicine

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The ER-alpha mutation Y537S confers Tamoxifen-resistance via enhanced mitochondrial metabolism, glycolysis and Rho-GDI/PTEN signaling: Implicating TIGAR in somatic resistance to endocrine therapy

The adipocyte as an important target cell for Trypanosoma cruzi infection

scientific article published on 18 April 2005

The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox

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The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism

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The biology of caveolae: lessons from caveolin knockout mice and implications for human disease

scientific article published on December 2003

The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion

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The caveolin proteins

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The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module

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The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis

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The reverse Warburg effect in osteosarcoma

scientific article published in September 2014

The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

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The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

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The role of breast cancer stem cells in metastasis and therapeutic implications

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Therapeutic potential of proteasome inhibition in Duchenne and Becker muscular dystrophies

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Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy

scientific article published in June 2009

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

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Transgenic overexpression of caveolin-3 in the heart induces a cardiomyopathic phenotype

scientific article (publication date: November 2003)

Translational discoveries, personalized medicine, and living biobanks of the future.

scientific article published in April 2012

Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells

scientific article published on September 2004

Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells

scientific article published in January 2006

Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype

scientific article published on September 2008

Trypanosoma cruzi infection results in the reduced expression of caveolin-3 in the heart

scientific article published on 15 April 2010

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors

scientific article published on 15 June 2010

Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function

scientific article published on 05 March 2014

Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

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Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).

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Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment

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Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment

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Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells

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Urogenital alterations in aged male caveolin-1 knockout mice

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Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation

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Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers

scientific article published on 15 March 2012

VMY-1-103, a dansylated analog of purvalanol B, induces caspase-3-dependent apoptosis in LNCaP prostate cancer cells

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Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs).

scientific article published on 9 June 2017

Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis

scientific article published on 17 November 2011

Zebrafish as a novel model system to study the function of caveolae and caveolin-1 in organismal biology

scientific article published on December 2006

c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion

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c-Jun is required for TGF-β-mediated cellular migration via nuclear Ca²⁺ signaling

scientific article published on 5 April 2011

c-Myc induction of programmed cell death may contribute to carcinogenesis: a perspective inspired by several concepts of chemical carcinogenesis

scientific article published on April 2011

microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling

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microRNA, cell cycle, and human breast cancer

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p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling

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v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1.

scientific article published on 15 September 2016