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List of works by Kai Tan

4DGenome: a comprehensive database of chromatin interactions.

scientific article

A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution

scientific article published on 05 September 2019

A microfluidic device for epigenomic profiling using 100 cells.

scientific article

A systems approach to delineate functions of paralogous transcription factors: role of the Yap family in the DNA damage response.

scientific article

CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells.

scientific article published on 6 June 2017

CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections.

scientific article published on 10 December 2016

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation

scientific article published on 03 September 2020

Coevolution within a transcriptional network by compensatory trans and cis mutations.

scientific article

Combinatorial chromatin modification patterns in the human genome revealed by subspace clustering. ⬇️

scientific article

Correction: Functional screen identifies regulators of murine hematopoietic stem cell repopulation.

scientific article published on 27 September 2016

Discover context-specific combinatorial transcription factor interactions by integrating diverse ChIP-Seq data sets

scientific article

Discover protein complexes in protein-protein interaction networks using parametric local modularity

scientific article

Discover regulatory DNA elements using chromatin signatures and artificial neural network.

scientific article

Dissecting the tumor-immune landscape in chimeric antigen receptor T-cell therapy: key challenges and opportunities for a systems immunology approach

scientific article published on 03 March 2020

Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers

scientific article published on 24 July 2020

Dynamic HoxB4-regulatory network during embryonic stem cell differentiation to hematopoietic cells.

scientific article

EnhancerAtlas: a resource for enhancer annotation and analysis in 105 human cell/tissue types

scientific article

Enhancers in embryonic stem cells are enriched for transposable elements and genetic variations associated with cancers ⬇️

scientific article published on June 17, 2011

Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility.

scientific article published on 22 February 2018

FLAGS: A Flexible and Adaptive Association Test for Gene Sets Using Summary Statistics.

scientific article published on 15 January 2016

Finding combinatorial histone code by semi-supervised biclustering

scientific article

Functional screen identifies regulators of murine hematopoietic stem cell repopulation

scientific article published on 15 February 2016

Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary ⬇️

scientific article published on March 9, 2012

Global view of enhancer-promoter interactome in human cells.

scientific article

H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification

scientific article published on 03 January 2019

Identifying noncoding risk variants using disease-relevant gene regulatory networks

scientific article published on 16 February 2018

Identifying topologically associating domains and subdomains by Gaussian Mixture model And Proportion test

scientific article

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production.

scientific article

Making connections between novel transcription factors and their DNA motifs.

scientific article

Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.

scientific article published on 27 December 2017

Mechanisms of Entrectinib Resistance in a Neuroblastoma Xenograft Model

scientific article published on 23 December 2019

Mining genome databases to identify and understand new gene regulatory systems.

scientific article

Modeling disease progression using dynamics of pathway connectivity

scientific article

Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia

publication published on 01 July 2021

Optimal control nodes in disease-perturbed networks as targets for combination therapy

scientific article published on 16 May 2019

Predictive modeling of single-cell DNA methylome data enhances integration with transcriptome data

scientific article published on 20 November 2020

Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1.

scientific article published on 21 August 2017

RUNX1 and the endothelial origin of blood

scientific article published on 31 October 2018

Risk variants disrupting enhancers of T1 and T cells in type 1 diabetes

scientific article published on 25 March 2019

Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells

scientific article published on 9 July 2015

SCRABBLE: single-cell RNA-seq imputation constrained by bulk RNA-seq data

scientific article published on 06 May 2019

TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells

scientific article

The Human Cell Atlas White Paper ⬇️

journal article from 'arXiv:1810.05192 [q-bio]' published in 2018

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

scientific article published on 28 March 2019

The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women

scientific article

Transcriptional regulation of protein complexes within and across species

scholarly article

Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells

scientific article published on 04 June 2020

Understanding transcriptional regulatory networks using computational models.

scientific article published on 04 March 2016

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