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List of works by Anna Orlova

(99m)Tc-maEEE-Z(HER2:342), an Affibody molecule-based tracer for the detection of HER2 expression in malignant tumors.

scientific article

111InBz-DTPA-hEGF: Preparation andIn VitroCharacterization of a Potential Anti-Glioblastoma Targeting Agent

scientific article published on August 1, 2003

188Re-ZHER2:V2, a promising affibody-based targeting agent against HER2-expressing tumors: preclinical assessment.

scientific article published on 2 October 2014

99mTc(CO)3+-(HE)3-ZIGF1R:4551, a new Affibody conjugate for visualization of insulin-like growth factor-1 receptor expression in malignant tumours

scientific article published on November 21, 2012

99mTc-chelator engineering to improve tumour targeting properties of a HER2-specific Affibody molecule.

scientific article published on 13 June 2007

A HER2-binding Affibody molecule labelled with 68Ga for PET imaging: direct in vivo comparison with the 111In-labelled analogue.

scientific article

ADAPT, a Novel Scaffold Protein-Based Probe for Radionuclide Imaging of Molecular Targets That Are Expressed in Disseminated Cancers

scientific article published on 21 August 2015

Affibody Molecules as Targeting Vectors for PET Imaging

scientific article published on 11 March 2020

Affibody-derived drug conjugates: Potent cytotoxic molecules for treatment of HER2 over-expressing tumors

scientific article published on 30 August 2018

Affibody-mediated PET imaging of HER3 expression in malignant tumours.

scientific article

Affibody-mediated tumour targeting of HER-2 expressing xenografts in mice.

scientific article published on 15 March 2006

Affibody‑mediated imaging of EGFR expression in prostate cancer using radiocobalt‑labeled DOTA‑ZEGFR:2377

scientific article published on 15 October 2018

Approaches to improve cellular retention of radiohalogen labels delivered by internalising tumour-targeting proteins and peptides.

scientific article published on November 2003

Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules

scientific article published on 13 March 2020

Biodistribution and Radiation Dosimetry of the Anti-HER2 Affibody Molecule 68Ga-ABY-025 in Breast Cancer Patients.

scientific article published on 9 February 2016

Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer

scientific article published on 14 September 2019

Closo-dodecaborate(2-) as a linker for iodination of macromolecules. Aspects on conjugation chemistry and biodistribution

scientific article published on 01 May 1999

Comparative Evaluation of Affibody Molecules for Radionuclide Imaging of in Vivo Expression of Carbonic Anhydrase IX.

scientific article published on 16 August 2016

Comparative Evaluation of Anti-HER2 Affibody Molecules Labeled with 64Cu Using NOTA and NODAGA.

scientific article published on 28 February 2017

Comparative Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Radionuclide Molecular Imaging of HER2 Expression in Malignant Tumors.

scientific article

Comparative Evaluation of Two DARPin Variants: Effect of Affinity, Size, and Label on Tumor Targeting Properties

scientific article published on 08 February 2019

Comparative biodistribution of imaging agents for in vivo molecular profiling of disseminated prostate cancer in mice bearing prostate cancer xenografts: focus on 111In- and 125I-labeled anti-HER2 humanized monoclonal trastuzumab and ABY-025 affibod

scientific article

Comparative evaluation of 111In-labeled NOTA‑conjugated affibody molecules for visualization of HER3 expression in malignant tumors.

scientific article published on 9 June 2015

Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

scientific article published on 17 October 2019

Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours

scientific article published on 05 November 2018

Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with 111In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts

scientific article published on November 30, 2011

Comparative evaluation of tumor targeting using the anti-HER2 ADAPT scaffold protein labeled at the C-terminus with indium-111 or technetium-99m

scientific article

Comparison of tumor‑targeting properties of directly and indirectly radioiodinated designed ankyrin repeat protein (DARPin) G3 variants for molecular imaging of HER2

scientific article published on 11 February 2019

Cyclic versus Noncyclic Chelating Scaffold for 89Zr-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression

scientific article published on 21 November 2017

Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands

scientific article published on 20 May 2022

Design, synthesis and biological evaluation of a multifunctional HER2-specific Affibody molecule for molecular imaging.

scientific article

Detecting ligand interactions with G protein-coupled receptors in real-time on living cells

scientific article

Development and preclinical characterisation of 99mTc-labelled Affibody molecules with reduced renal uptake.

scientific article

Development of a 124I-labeled version of the anti-PSMA monoclonal antibody capromab for immunoPET staging of prostate cancer: Aspects of labeling chemistry and biodistribution

scientific article published on 10 April 2014

Development of an optimal imaging strategy for selection of patients for affibody-based PNA-mediated radionuclide therapy

scientific article published on 25 June 2018

Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model

scientific article published on 30 December 2020

Effects of lysine-containing mercaptoacetyl-based chelators on the biodistribution of 99mTc-labeled anti-HER2 Affibody molecules.

scientific article

Evaluating the Therapeutic Efficacy of Mono- and Bivalent Affibody-Based Fusion Proteins Targeting HER3 in a Pancreatic Cancer Xenograft Model

scientific article published on 13 June 2020

Evaluation of ((4-hydroxyphenyl)ethyl)maleimide for site-specific radiobromination of anti-HER2 affibody.

scientific article published in November 2005

Evaluation of 99mTc-Z IGF1R:4551-GGGC affibody molecule, a new probe for imaging of insulin-like growth factor type 1 receptor expression

scientific article

Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe.

scientific article published on 14 February 2018

Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart

scientific article published on 02 August 2019

Evaluation of a HER2-targeting affibody molecule combining an N-terminal HEHEHE-tag with a GGGC chelator for 99mTc-labelling at the C terminus

scientific article published on 17 January 2012

Evaluation of a maleimido derivative of CHX-A'' DTPA for site-specific labeling of affibody molecules

scientific article published on 12 July 2008

Evaluation of a maleimido derivative of NOTA for site-specific labeling of affibody molecules

scientific article published on 12 April 2011

Evaluation of a radiocobalt-labelled affibody molecule for imaging of human epidermal growth factor receptor 3 expression

scientific article published on 11 October 2017

Evaluation of backbone-cyclized HER2-binding 2-helix affibody molecule for in vivo molecular imaging.

scientific article published on 26 January 2013

Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab

scientific article published on 25 July 2018

Feasibility of Affibody Molecule-Based PNA-Mediated Radionuclide Pretargeting of Malignant Tumors

scientific article

Feasibility of Affibody-Based Bioorthogonal Chemistry-Mediated Radionuclide Pretargeting.

scientific article published on 10 December 2015

Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1

scientific article published on 07 May 2020

Feasibility of imaging of epidermal growth factor receptor expression with ZEGFR:2377 affibody molecule labeled with 99mTc using a peptide-based cysteine-containing chelator.

scientific article published on 05 October 2016

Gallium-68-labeled affibody molecule for PET imaging of PDGFRβ expression in vivo

scientific article

HAHAHA, HEHEHE, HIHIHI, or HKHKHK: influence of position and composition of histidine containing tags on biodistribution of [(99m)Tc(CO)3](+)-labeled affibody molecules.

scientific article published on 14 June 2013

HEHEHE-tagged affibody molecule may be purified by IMAC, is conveniently labeled with [⁹⁹(m)Tc(CO)₃](+), and shows improved biodistribution with reduced hepatic radioactivity accumulation.

scientific article published on 22 October 2010

HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution

scientific article published on 24 April 2020

Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model

scientific article published on 01 July 2020

High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26.

scientific article published on 10 August 2017

Histidine-rich glycoprotein uptake and turnover is mediated by mononuclear phagocytes

scientific article

Imaging agents for in vivo molecular profiling of disseminated prostate cancer--targeting EGFR receptors in prostate cancer: comparison of cellular processing of [111In]-labeled affibody molecule Z(EGFR:2377) and cetuximab.

scientific article published on 20 January 2011

Imaging of HER2 may improve the outcome of external irradiation therapy for prostate cancer patients.

scientific article published on 3 December 2014

Imaging of HER2-expressing tumours using a synthetic Affibody molecule containing the 99mTc-chelating mercaptoacetyl-glycyl-glycyl-glycyl (MAG3) sequence.

scientific article published on 5 December 2006

Imaging of HER3-expressing xenografts in mice using a (99m)Tc(CO) 3-HEHEHE-Z HER3:08699 affibody molecule.

scientific article published on 13 March 2014

Imaging of insulinlike growth factor type 1 receptor in prostate cancer xenografts using the affibody molecule 111In-DOTA-ZIGF1R:4551.

scientific article

Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591.

scientific article published on 9 January 2014

Improved contrast of affibody-mediated imaging of HER3 expression in mouse xenograft model through co-injection of a trivalent affibody for in vivo blocking of hepatic uptake

scientific article published on 01 May 2019

In Vivo and In Vitro Studies on Renal Uptake of Radiolabeled Affibody Molecules for Imaging of HER2 Expression in Tumors

scientific article published on March 5, 2013

In vitro and in vivo evaluation of a (18)F-labeled high affinity NOTA conjugated bombesin antagonist as a PET ligand for GRPR-targeted tumor imaging

scientific article (publication date: 2013)

In vitro characterization of 211 At-labeled antibody A33--a potential therapeutic agent against metastatic colorectal carcinoma.

scientific article published on October 2005

In vitro modeling of HER2-targeting therapy in disseminated prostate cancer.

scientific article published on 29 August 2014

In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin-binding therapeutic affibody construct.

scientific article published on 23 February 2017

Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody-DM1 Drug Conjugates

scientific article published on 14 August 2019

Incorporation of a triglutamyl spacer improves the biodistribution of synthetic affibody molecules radiofluorinated at the N-terminus via oxime formation with (18)F-4-fluorobenzaldehyde.

scientific article published on 27 December 2013

Increase in negative charge of 68Ga/chelator complex reduces unspecific hepatic uptake but does not improve imaging properties of HER3-targeting affibody molecules

scientific article published on 27 November 2019

Increasing the Net Negative Charge by Replacement of DOTA Chelator with DOTAGA Improves the Biodistribution of Radiolabeled Second-Generation Synthetic Affibody Molecules

scientific article published on 23 March 2016

Indirect Radioiodination of DARPin G3 Using N-succinimidyl-Para-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging

scientific article published on 21 June 2019

Influence of DOTA chelator position on biodistribution and targeting properties of (111)In-labeled synthetic anti-HER2 affibody molecules.

scientific article

Influence of Histidine-Containing Tags on the Biodistribution of ADAPT Scaffold Proteins

scientific article published on 29 January 2016

Influence of Molecular Design on the Targeting Properties of ABD-Fused Mono- and Bi-Valent Anti-HER3 Affibody Therapeutic Constructs

scientific article published on 11 October 2018

Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules

scientific article published on 15 February 2020

Influence of an aliphatic linker between DOTA and synthetic Z(HER2:342) Affibody molecule on targeting properties of the (111)In-labeled conjugate.

scientific article published on 3 March 2011

Influence of composition of cysteine-containing peptide-based chelators on biodistribution of 99mTc-labeled anti-EGFR affibody molecules.

scientific article

Influence of labelling methods on biodistribution and imaging properties of radiolabelled peptides for visualisation of molecular therapeutic targets.

scientific article published on January 2010

Influence of macrocyclic chelators on the targeting properties of (68)Ga-labeled synthetic affibody molecules: comparison with (111)In-labeled counterparts

scientific article (publication date: 2013)

Influence of molecular design on biodistribution and targeting properties of an Affibody-fused HER2-recognising anticancer toxin

scientific article published on 6 July 2016

Influence of nuclides and chelators on imaging using affibody molecules: comparative evaluation of recombinant affibody molecules site-specifically labeled with ⁶⁸Ga and ¹¹¹In via maleimido derivatives of DOTA and NODAGA.

scientific article published on 5 June 2013

Influence of the N-Terminal Composition on Targeting Properties of Radiometal-Labeled Anti-HER2 Scaffold Protein ADAPT6.

scientific article published on 14 October 2016

Influence of valency and labelling chemistry on in vivo targeting using radioiodinated HER2-binding Affibody molecules.

scientific article

Inhibiting HER3-mediated tumor cell growth with affibody molecules engineered to low picomolar affinity by position-directed error-prone PCR-like diversification

scientific article

Liver uptake of radiolabeled targeting proteins and peptides: considerations for targeting peptide conjugate design

scientific article published on 08 July 2012

Locally delivered CD40 agonist antibody accumulates in secondary lymphoid organs and eradicates experimental disseminated bladder cancer.

scientific article published on 21 October 2013

Measuring HER2-Receptor Expression In Metastatic Breast Cancer Using [68Ga]ABY-025 Affibody PET/CT.

scientific article published on January 2016

Methods for Radiolabelling of Monoclonal Antibodies

scientific article published on 01 January 2014

Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of Ga-Labeled Tracers

scientific article published on 02 March 2019

Molecular design and optimization of 99mTc-labeled recombinant affibody molecules improves their biodistribution and imaging properties

scientific article published on 14 February 2011

Molecular design of radiocopper-labelled Affibody molecules.

scientific article

Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In- or 68Ga-labeled affibody molecules.

scientific article published on 19 May 2010

On the selection of a tracer for PET imaging of HER2-expressing tumors: direct comparison of a 124I-labeled affibody molecule and trastuzumab in a murine xenograft model.

scientific article

Optimal composition and position of histidine-containing tags improves biodistribution of 99mTc-labeled DARPin G3

scientific article published on 28 June 2019

Optimal specific radioactivity of anti-HER2 Affibody molecules enables discrimination between xenografts with high and low HER2 expression levels.

scientific article published on 11 November 2010

Optimization of HER3 expression imaging using affibody molecules: Influence of chelator for labeling with indium-111

scientific article published in Scientific Reports

Optimized Molecular Design of ADAPT-Based HER2-Imaging Probes Labeled with 111In and 68Ga

scientific article published on 20 June 2018

Order of amino acids in C-terminal cysteine-containing peptide-based chelators influences cellular processing and biodistribution of 99mTc-labeled recombinant Affibody molecules.

scientific article

PET imaging of epidermal growth factor receptor expression in tumours using 89Zr-labelled ZEGFR:2377 affibody molecules.

scientific article published on 2 February 2016

Position for site-specific attachment of a DOTA chelator to synthetic affibody molecules has a different influence on the targeting properties of 68Ga- compared to 111in-labeled conjugates.

scientific article published on January 2014

Positioning of 99mTc-chelators influences radiolabeling, stability and biodistribution of Affibody molecules.

scientific article published on 25 March 2009

Preclinical Evaluation of [Ga]Ga-DFO-ZEGFR:2377: A Promising Affibody-Based Probe for Noninvasive PET Imaging of EGFR Expression in Tumors

scientific article published on 18 September 2018

Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer

scientific article published on 18 December 2020

Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer

scientific article published on 16 October 2020

Protein interactions with HER-family receptors can have different characteristics depending on the hosting cell line

scientific article

Radiolabeled GRPR Antagonists for Imaging of Disseminated Prostate Cancer. Influence of Labeling Chemistry on Targeting Properties

scientific article published on 12 March 2020

Radiolabeled probes targeting tyrosine-kinase receptors for personalized medicine.

scientific article published on January 2014

Radiolabelled receptor-tyrosine-kinase targeting drugs for patient stratification and monitoring of therapy response: prospects and pitfalls.

scientific article published on 26 July 2010

Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1

scientific article published on 14 October 2020

Radionuclide Tumor Targeting Using ADAPT Scaffold Proteins: Aspects of Label Positioning and Residualizing Properties of the Label

scientific article published in September 2017

Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model

scientific article published on 07 August 2018

Radionuclide therapy of HER2-expressing human xenografts using an affibody molecule-based PNA-mediated pretargeting: in vivo proof-of-principle

scientific article published on 9 February 2018

Radionuclide therapy of HER2-positive microxenografts using a 177Lu-labeled HER2-specific Affibody molecule.

scientific article published on March 2007

Same-Day Imaging Using Small Proteins: Clinical Experience and Translational Prospects in Oncology

scientific article published on 15 March 2018

Selection of an optimal cysteine-containing peptide-based chelator for labeling of affibody molecules with (188)Re.

scientific article published on 26 September 2014

Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26

scientific article published on 19 November 2019

Selection of optimal chelator improves the contrast of GRPR imaging using bombesin analogue RM26.

scientific article published on 09 March 2016

Selection of the optimal macrocyclic chelators for labeling with 111In and 68Ga improves contrast of HER2 imaging using engineered scaffold protein ADAPT6

scientific article published on 10 May 2019

Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity

scientific article published on 12 January 2015

Site-specific conjugation of recognition tags to trastuzumab for peptide nucleic acid-mediated radionuclide HER2 pretargeting

scientific article published on 14 February 2019

Site-specific radiometal labeling and improved biodistribution using ABY-027, a novel HER2-targeting affibody molecule-albumin-binding domain fusion protein.

scientific article published on 25 March 2013

Slow internalization of anti-HER2 synthetic affibody monomer 111In-DOTA-ZHER2:342-pep2: implications for development of labeled tracers.

scientific article published on August 2008

Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer

scientific article published on 23 July 2019

Synthesis and characterization of a high-affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging.

scientific article published on 2 July 2013

Synthesis and chemoselective intramolecular crosslinking of a HER2-binding affibody.

scientific article published in January 2009

Synthesis of 11C-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [11C]CO.

scientific article published on 05 October 2016

Synthetic affibody molecules: a novel class of affinity ligands for molecular imaging of HER2-expressing malignant tumors

scientific article published on 01 March 2007

Targeting of HER2-expressing tumors using 111In-ABY-025, a second-generation affibody molecule with a fundamentally reengineered scaffold.

scientific article

Targeting of HER2-expressing tumors with a site-specifically 99mTc-labeled recombinant affibody molecule, ZHER2:2395, with C-terminally engineered cysteine.

scientific article

The effect of macrocyclic chelators on the targeting properties of the 68Ga-labeled gastrin releasing peptide receptor antagonist PEG2-RM26.

scientific article

The effect of mini-PEG-based spacer length on binding and pharmacokinetic properties of a 68Ga-labeled NOTA-conjugated antagonistic analog of bombesin.

scientific article published on 17 July 2014

The influence of Bz-DOTA and CHX-A''-DTPA on the biodistribution of ABD-fused anti-HER2 Affibody molecules: implications for (114m)In-mediated targeting therapy.

scientific article

The use of radiocobalt as a label improves imaging of EGFR using DOTA-conjugated Affibody molecule.

scientific article

Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177 Lu-DOTAGA-PEG2 -RM26.

scientific article published on 11 May 2019

Tumor targeting using affibody molecules: interplay of affinity, target expression level, and binding site composition.

scientific article

Update: affibody molecules for molecular imaging and therapy for cancer.

scientific article

Use of a HEHEHE purification tag instead of a hexahistidine tag improves biodistribution of affibody molecules site-specifically labeled with (99m)Tc, (111)In, and (125)I.

scientific article published on 12 May 2011

[177Lu]Bz-DTPA-EGF: Preclinical characterization of a potential radionuclide targeting agent against glioma.

scientific article published on April 2004