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List of works by Ian Jacobs

A Perl toolkit for LIMS development

scientific article

A combined biomarker panel shows improved sensitivity for the early detection of ovarian cancer allowing the identification of the most aggressive type II tumours.

scientific article published on 29 June 2017

A modified medium that significantly improves the growth of human normal ovarian surface epithelial (OSE) cells in vitro.

scientific article published in July 2004

A molecular genetic and statistical approach for the diagnosis of dual-site cancers.

scientific article published in October 2004

A quantitative performance study of two automatic methods for the diagnosis of ovarian cancer

scientific article published on 01 September 2018

A suite of Perl modules for handling microarray data.

scientific article

A well-characterised peak identification list of MALDI MS profile peaks for human blood serum.

scientific article published in September 2010

Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer

scientific article published on 18 December 2016

Academic health science systems

scientific article published on 01 May 2010

Acceptance of transvaginal sonography by postmenopausal women participating in the United Kingdom Collaborative Trial of Ovarian Cancer Screening.

scientific article published on 11 December 2012

Age related trends in the incidence of endometrial cancer in South East England 1962-1997.

scientific article

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.

scientific article

Annual outpatient hysteroscopy and endometrial sampling (OHES) in HNPCC/Lynch syndrome (LS).

scientific article published on 4 August 2012

Ascites and a raised serum Ca 125--confusing combination

scientific article published on 01 November 2001

Assessing the malignant potential of ovarian inclusion cysts in postmenopausal women within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a prospective cohort study.

scientific article published on 15 July 2011

Assessment of the depth of myometrial invasion in stage I endometrioid endometrial cancer using pancytokeratin immunohistochemistry.

scientific article

Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study

scientific article

Association of serum sex steroid receptor bioactivity and sex steroid hormones with breast cancer risk in postmenopausal women

scientific article published on 10 April 2012

Attitude towards and factors affecting uptake of population-based BRCA testing in the Ashkenazi Jewish population: a cohort study

scientific article published on 18 March 2019

Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer

scientific article published on 7 May 2013

Can MRI rule out bladder and rectal invasion in cervical cancer to help select patients for limited EUA?

scientific article published on 28 November 2005

Can Ovarian Cancer Screening Save Lives? The Question Remains Unanswered

scientific article published in December 2011

Changing trends in reproductive/lifestyle factors in UK women: descriptive study within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

scientific article published on 06 March 2017

Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells.

scientific article

Clinical Value of Immunohistochemically Detected Lymphatic and Vascular Invasions in Clinically Staged Endometrioid Endometrial Cancer

scientific article published on 01 August 2009

Clinical value of immunohistochemically detected lymphovascular space invasion in early stage cervical carcinoma

scientific article published on 12 July 2008

Combining multiple serum tumor markers improves detection of stage I epithelial ovarian cancer

scientific article

Comment on Elit et al.: prophylactic oophorectomy in Ontario

scientific article published on 01 January 2001

Comparison of Longitudinal CA125 Algorithms as a First-Line Screen for Ovarian Cancer in the General Population

scientific article published in October 2018

Complementary Longitudinal Serum Biomarkers to CA125 for Early Detection of Ovarian Cancer

scientific article published on 09 April 2019

Concordance of National Cancer Registration with self-reported breast, bowel and lung cancer in England and Wales: a prospective cohort study within the UK Collaborative Trial of Ovarian Cancer Screening

scientific article published on 15 October 2013

Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population

scientific article published on 10 September 2015

Contribution ofBRCA1andBRCA2mutations to inherited ovarian cancer

scientific article published on 01 December 2007

Correction: The Dynamics and Prognostic Potential of DNA Methylation Changes at Stem Cell Gene Loci in Women's Cancer

article

Corrigendum to "Sex hormone measurements using mass spectrometry and sensitive extraction radioimmunoassay and risk of estrogen receptor negative and positive breast cancer: Case control study in UK Collaborative Cancer Trial of Ovarian Cancer Scree

scientific article published in September 2016

DNA methylation analysis in liquid-based cytology for cervical cancer screening.

scientific article published in December 2009

DNA methylation of polycomb group target genes in cores taken from breast cancer centre and periphery.

scientific article published on 8 April 2009

Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus

scientific article published on 16 November 2015

Detection of tumour lymphovascular space invasion using dual cytokeratin and CD31 immunohistochemistry.

scientific article published on October 2003

Development of a multimarker assay for early detection of ovarian cancer

scientific article published on 5 April 2010

Diagnosis of epithelial ovarian cancer using a combined protein biomarker panel

scientific article published on 07 August 2019

Diagnostic performance of nanoparticle-enhanced magnetic resonance imaging in the diagnosis of lymph node metastases in patients with endometrial and cervical cancer

scientific article published on 01 April 2005

Diathermy-Induced Injury May Affect Detection of Occult Tubal Lesions at Risk-Reducing Salpingo-Oophorectomy

scientific article published in June 2012

Differential diagnosis of adnexal masses: risk of malignancy index, ultrasonography, magnetic resonance imaging, and radioimmunoscintigraphy

scientific article published on 01 January 2007

Discovery of serum biomarkers of ovarian cancer using complementary proteomic profiling strategies.

scientific article

Distribution of microsatellite instability in Danish ovarian tumor patients and the prognostic value in ovarian cancer patients.

scientific article published in January 2008

Distribution of p53 expression in tissue from 774 Danish ovarian tumour patients and its prognostic significance in ovarian carcinomas.

scientific article published in May 2008

ESGO statement on cervical cancer vaccination

scientific article published on 01 November 2007

Early detection of cancer in the general population: a blinded case-control study of p53 autoantibodies in colorectal cancer.

scientific article published on 20 November 2012

Early detection of ovarian cancer in samples pre-diagnosis using CA125 and MALDI-MS peaks.

scientific article

Elevation of TP53 Autoantibody Before CA125 in Preclinical Invasive Epithelial Ovarian Cancer

scientific article published on 21 June 2017

Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study

scientific article

Evaluation in pre-diagnosis samples discounts ICAM-1 and TIMP-1 as biomarkers for earlier diagnosis of pancreatic cancer

scientific article published on 01 January 2015

Evaluation of endometrial carcinoma on magnetic resonance imaging

scientific article published on 01 January 2007

Evaluation of serum CEA, CYFRA21-1 and CA125 for the early detection of colorectal cancer using longitudinal preclinical samples.

scientific article published on 2 June 2015

Evidence of Stage Shift in Women Diagnosed With Ovarian Cancer During Phase II of the United Kingdom Familial Ovarian Cancer Screening Study.

scientific article published on 27 February 2017

Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis

scientific article published on 01 December 2003

Factors affecting visualization of postmenopausal ovaries: descriptive study from the multicenter United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).

scientific article published in October 2013

Familial ovarian cancer

scientific article published on 01 January 2001

Feasibility of screening for ovarian cancer using symptoms as selection criteria

scientific article published in January 2007

Genetic intra-tumour heterogeneity in epithelial ovarian cancer and its implications for molecular diagnosis of tumours

scientific article published on 01 February 2007

Genetic screening for gynecological cancer: where are we heading?

scientific article

Grading of serous ovarian carcinoma: further evidence of a lack of agreement between conventional grading systems.

scientific article published on 13 December 2007

HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study.

scientific article published in November 2009

HOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer

scientific article published on 01 August 2008

Health care professionals' attitudes towards population-based genetic testing and risk-stratification for ovarian cancer: a cross-sectional survey

scientific article published on 16 December 2017

Hereditary non-polyposis colorectal cancer or Lynch syndrome: the gynaecological perspective.

scientific article published on February 2009

High-risk premenopausal women's experiences of undergoing prophylactic oophorectomy: a descriptive study

scientific article published on 01 January 2004

Histological confirmation of breast cancer registration and self-reporting in England and Wales: a cohort study within the UK Collaborative Trial of Ovarian Cancer Screening.

scientific article published on 17 May 2012

Histopathologic features of genetically determined ovarian cancer

scientific article published on 01 October 2002

Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression.

scientific article

Impact of a decision aid about stratified ovarian cancer risk-management on women's knowledge and intentions: a randomised online experimental survey study.

scientific article published on 16 November 2017

In vitro three-dimensional modeling of fallopian tube secretory epithelial cells.

scientific article

In vitro three-dimensional modelling of human ovarian surface epithelial cells.

scientific article published on 24 April 2009

Increased mortality in postmenopausal women with serum CA125 elevation

scientific article published on 01 May 1999

International Conference on Ovarian Cancer Screening

scientific article published in May 2012

Laparoscopic extraperitoneal paraaortic lymphadenectomy: a study of its applications in gynecological malignancies

scientific article published in April 2004

MR Imaging of Uterine Sarcomas ⬇️

scientific article published on 01 December 2001

Methylated NEUROD1 promoter is a marker for chemosensitivity in breast cancer.

scientific article published in June 2008

Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers.

scientific article

Model for the Molecular Genetic Diagnosis of Endometrial Cancer Using K-ras Mutation Analysis ⬇️

scientific article published on 01 April 1998

Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.

scientific article

Molecular assessment of depth of myometrial invasion in stage I endometrial cancer: a model based on K-ras mutation analysis

scientific article published on 01 October 2003

Molecular differences between RER+ and RER- sporadic endometrial carcinomas in a large population-based series

scientific article published on 01 September 2004

Molecular evidence for putative tumour suppressor genes on chromosome 13q specific to BRCA1 related ovarian and fallopian tube cancer.

scientific article

Molecular evidence of a common clonal origin and subsequent divergent clonal evolution in vulval intraepithelial neoplasia, vulval squamous cell carcinoma and lymph node metastases.

scientific article

New tumor markers: CA125 and beyond.

scientific article

No Evidence Exists for Methylation Inactivation of thep16Tumor Suppressor Gene in Ovarian Carcinogenesis ⬇️

scientific article published on 01 January 1998

OSPACS: Ultrasound image management system.

scientific article published on 20 June 2008

Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-κB Ligand (RANKL), is Dysregulated in BRCA Mutation Carriers

scientific article

Outcome of risk-reducing salpingo-oophorectomy in BRCA carriers and women of unknown mutation status

scientific article published on 10 March 2011

Ovarian Cancer Screening and Mortality

scientific article published in The Journal of the American Medical Association

Ovarian cancer screening

scientific article published in April 2002

Ovarian cancer screening

scientific article published in January 2001

Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial.

scientific article published on 16 December 2015

Ovarian cancer screening in the general population

scientific article

Ovarian cancer screening was feasible but did not decrease incidence of index cancer or mortality.

scientific article

Ovarian cancer screening: UKCTOCS trial - Authors' reply.

scientific article published in June 2016

Performance of ultrasound as a second line test to serum CA125 in ovarian cancer screening.

scientific article published in December 2014

Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium

scientific article

Postmenopausal women undergoing transvaginal ultrasound screening prefer not to have chaperones.

scientific article published on 7 July 2006

Preanalytic influence of sample handling on SELDI-TOF serum protein profiles.

scientific article published on 15 February 2007

Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancer.

scientific article published in September 2008

Predictive Value of Symptoms for Ovarian Cancer: Comparison of Symptoms Reported by Questionnaire, Interview, and General Practitioner Notes

scientific article published on 13 January 2012

Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions.

scientific article published on 20 September 2004

Prevalence and predictors of complementary and alternative medicine/non-pharmacological interventions use for menopausal symptoms within the UK Collaborative Trial of Ovarian Cancer Screening

scientific article published on 22 March 2017

Prevalence, frequency and problem rating of hot flushes persist in older postmenopausal women: impact of age, body mass index, hysterectomy, hormone therapy use, lifestyle and mood in a cross-sectional cohort study of 10,418 British women aged 54-65

scientific article published on 19 October 2011

Prognostic value of estrogen receptor and progesterone receptor tumor expression in Danish ovarian cancer patients: from the 'MALOVA' ovarian cancer study.

scientific article published in November 2007

Protein expression levels of carcinoembryonic antigen (CEA) in Danish ovarian cancer patients: from the Danish 'MALOVA'ovarian cancer study.

scientific article published in August 2008

Psychological morbidity associated with ovarian cancer screening: results from more than 23,000 women in the randomised trial of ovarian cancer screening (UKCTOCS).

scientific article published on 28 May 2014

Psychosocial Factors Associated With Withdrawal From the United Kingdom Collaborative Trial of Ovarian Cancer Screening After 1 Episode of Repeat Screening.

scientific article published on 28 July 2015

Quality assurance and its impact on ovarian visualization rates in the multicenter United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

scientific article published on 19 June 2015

Radioimmunoscintigraphy with Tc‐99m‐labelled SM3 in differentiating malignant from benign adnexal masses ⬇️

scientific article published on 01 May 2003

Randomised trial of population-based BRCA testing in Ashkenazi Jews: long-term outcomes

scientific article published on 10 September 2019

Recent developments in ovarian cancer screening

scientific article

Recruitment of newly diagnosed ovarian cancer patients proved challenging in a multicentre biobanking study.

scientific article published on 13 November 2010

Recruitment to multicentre trials--lessons from UKCTOCS: descriptive study

scientific article published on 13 November 2008

Registration of ovarian cancer in England and Wales

scientific article published in July 2000

Reply

scientific article published in May 2014

Reply to P.F. Pinsky, C.P. Crum, and M.W. McIntosh et al

scientific article published on 10 January 2016

Results of annual screening in phase I of the United Kingdom familial ovarian cancer screening study highlight the need for strict adherence to screening schedule

scientific article published on 3 December 2012

Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening.

scientific article published on 11 May 2015

Risk of epithelial ovarian cancer in asymptomatic women with ultrasound-detected ovarian masses: a prospective cohort study within the UK collaborative trial of ovarian cancer screening (UKCTOCS).

scientific article

Risks of ovarian, breast, and corpus uteri cancer in women treated with assisted reproductive technology in Great Britain, 1991-2010: data linkage study including 2.2 million person years of observation

scientific article published on 11 July 2018

Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development

scientific journal article

Role of MR imaging in the selection of patients with early cervical carcinoma for fertility-preserving surgery: initial experience

scientific article published on 01 August 1999

STK15 polymorphisms and association with risk of invasive ovarian cancer.

scientific article published in October 2004

Screening for Ovarian Cancer

scientific article published in September 2006

Screening for familial ovarian cancer: the need for well-designed prospective studies

scientific article published on 01 August 2005

Screening for ovarian cancer

scientific article published on 01 September 1998

Screening for ovarian cancer in women with varying levels of risk, using annual tests, results in high recall for repeat screening tests.

scientific article published on 23 November 2011

Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort.

scientific article

Serial Patterns of Ovarian Cancer Biomarkers in a Prediagnosis Longitudinal Dataset

scientific article published on 24 December 2015

Serum CA19-9 is significantly upregulated up to 2 years before diagnosis with pancreatic cancer: implications for early disease detection.

scientific article

Serum HE4 and diagnosis of ovarian cancer in postmenopausal women with adnexal masses

scientific article published on 24 July 2019

Serum oestrogen receptor alpha and beta bioactivity are independently associated with breast cancer: a proof of principle study.

scientific article published on 02 June 2009

Serum peptide profiling using MALDI mass spectrometry: avoiding the pitfalls of coated magnetic beads using well-established ZipTip technology.

scientific article published in September 2007

Sex hormone measurements using mass spectrometry and sensitive extraction radioimmunoassay and risk of estrogen receptor negative and positive breast cancer: Case control study in UK Collaborative Cancer Trial of Ovarian Cancer Screening (UKCTOCS).

scientific article published on 15 April 2016

Sexual functioning in 4,418 postmenopausal women participating in UKCTOCS: a qualitative free-text analysis

scientific article published on 01 October 2019

Significance of PTEN alterations in endometrial carcinoma: a population-based study of mutations, promoter methylation and PTEN protein expression

scientific article published on 01 December 2004

Simultaneous autoradiography and line immunoelectrophoresis (ARLIE): a novel combination to identify de novo protein synthesis by pregnancy tissues

scientific article published on 01 November 1989

Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer

scientific article published on 10 March 2009

Somatic mitochondrial DNA mutations in primary and metastatic ovarian cancer

scientific article published on 30 August 2006

Sonographers' self-reported visualization of normal postmenopausal ovaries on transvaginal ultrasound is not reliable: results of expert review of archived images from UKCTOCS.

scientific article published in March 2018

Steady, relentless progress towards effective, safe screening for early detection of cancer of the ovary

scientific article published on 21 August 2017

Strategies for improving the specificity of screening for ovarian cancer with tumor-associated antigens CA 125, CA 15-3, and TAG 72.3 ⬇️

scientific article published on 01 September 1992

Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancer

scientific article published on 24 February 2009

Testing breast cancer serum biomarkers for early detection and prognosis in pre-diagnosis samples.

scientific article published on 12 January 2017

The UKCTOCS experience--reasons for hope?

scientific article published in May 2012

The effect of ovarian cancer screening on sexual activity and functioning: results from the UK collaborative trial of ovarian cancer screening RCT.

scientific article published on 21 March 2017

The role of magnetic resonance imaging and ultrasound in patients with adnexal masses

scientific article published on 01 March 2005

The role of peritoneal cytology at risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of familial ovarian/tubal cancer ⬇️

scientific article published on October 20, 2011

The sex hormone system in carriers of BRCA1/2 mutations: a case-control study.

scientific article published on 17 October 2013

Three Biomarkers Identified from Serum Proteomic Analysis for the Detection of Early Stage Ovarian Cancer

scientific article published on 01 August 2004

Three-dimensional in vitro cell biology models of ovarian and endometrial cancer.

scientific article

Time to diagnosis of Type I or II invasive epithelial ovarian cancers: a multicentre observational study using patient questionnaire and primary care records.

scientific article published on 29 May 2015

Tumor markers in screening for ovarian cancer

scientific article published on 01 January 2001

Two fetal antigens (FA-1 and FA-2) and endometrial proteins (PP12 and PP14) isolated from amniotic fluid; preliminary observations in fetal and maternal tissues

scientific article published on 01 September 1988

Use and perceived efficacy of complementary and alternative medicines after discontinuation of hormone therapy: a nested United Kingdom Collaborative Trial of Ovarian Cancer Screening cohort study

scientific article published on April 2015

Validity of self-reported hysterectomy: a prospective cohort study within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).

scientific article published on 03 March 2014

Withdrawal from familial ovarian cancer screening for surgery: findings from a psychological evaluation study (PsyFOCS).

scientific article published on 15 October 2011

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