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List of works by Masakiyo Hosokawa

A new methodology for functionalization at the 3-position of indoles by a combination of boron Lewis acid with nitriles

scientific article published on 01 January 2015

A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy.

scientific article

Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.

scientific article published on 30 September 2004

Analysis of a child who developed abnormal neuropsychiatric symptoms after administration of oseltamivir: a case report.

scientific article published on 5 August 2015

Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver

scientific article published on 31 January 2018

Are non-human primates useful experimental animals for pre-clinical study?

scientific article published on 01 January 2010

Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients

scientific article

Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1

scientific article published on 21 February 2018

Current progress on esterases: from molecular structure to function

scientific article (publication date: May 2002)

Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies

scientific article published on 01 January 2018

Dexamethasone-induced methylprednisolone hemisuccinate hydrolase: its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma.

scientific article published on April 2005

Dexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 gene

scientific article published on 11 January 2012

Differential catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells ⬇️

scientific article published on May 8, 1998

Effects of carbamazepine on the first ovulation in gonadotropin‐primed immature female rats ⬇️

scientific article published on November 1, 2001

Evidence for the involvement of a pulmonary first-pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration.

scientific article published on 8 October 2003

Fawcettimine-related alkaloids from Lycopodium serratum

scientific article published on 16 May 2007

Functional analysis of carboxylesterase in human induced pluripotent stem cell-derived enterocytes

scientific article published on 8 March 2017

Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites.

scientific article published on 6 March 2008

Gly143Glu polymorphism of the human carboxylesterase1 gene in an Asian population.

scientific article published on 27 July 2012

Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver

scientific journal article

Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor.

scientific article

Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques

scientific article published on 7 February 2015

Key structural features of ligands for activation of human pregnane X receptor.

scientific article

Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic a

scientific article published on 24 November 2008

Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo.

scientific article published in November 2003

Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques

scientific article published on 24 March 2018

Species-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesterase

scientific article published on 25 August 2006

Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes.

scientific article

Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases

scientific article published on 19 June 2019

Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases

scientific article published on 19 December 2015

Synthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesterase

scientific article published on 14 March 2019

Synthesis of a new class of camptothecin derivatives, the long-chain fatty acid esters of 10-hydroxycamptothecin, as a potent prodrug candidate, and their in vitro metabolic conversion by carboxylesterases

scientific article published on 01 March 1998

Systematic identification and characterization of carboxylesterases in cynomolgus macaques

scientific article published on 25 September 2014

The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.

scientific article

Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotec

scientific article

cDNA Cloning and Genomic Organization of Peroxisome Proliferator-Inducible Long-Chain Acyl-CoA Hydrolase from Rat Liver Cytosol ⬇️

scientific article published on July 30, 1998

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