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List of works by Rafael Roesler

3'3-ditrifluoromethyldiphenyl diselenide: a new organoselenium compound with interesting antigenotoxic and antimutagenic activities.

scientific article published on 3 February 2009

A Placebo-Controlled Crossover Trial of Gastrin-Releasing Peptide in Childhood Autism.

scientific article published on 27 April 2017

A Valepotriate Fraction of Valeriana glechomifolia Shows Sedative and Anxiolytic Properties and Impairs Recognition But Not Aversive Memory in Mice.

scientific article

A phosphodiesterase 4-controlled switch between memory extinction and strengthening in the hippocampus.

scientific article published on 17 March 2014

A randomized, double-blind, placebo-controlled trial of deprenyl and thiotic acid in HIV-associated cognitive impairment

scientific article published on 01 June 1999

A synaptic reinforcement-based model for transient amnesia following disruptions of memory consolidation and reconsolidation.

scientific article published on January 2008

Activation of BDNF/TrkB/Akt pathway is associated with aggressiveness and unfavorable survival in oral squamous cell carcinoma

scientific article published on 02 October 2019

Administration of a Histone Deacetylase Inhibitor into the Basolateral Amygdala Enhances Memory Consolidation, Delays Extinction, and Increases Hippocampal BDNF Levels.

scientific article

Administration of the phosphodiesterase type 4 inhibitor rolipram into the amygdala at a specific time interval after learning increases recognition memory persistence ⬇️

scientific article published on September 19, 2012

Adrenergic enhancement of consolidation of object recognition memory

scientific article

Age-related effects of diazepam on retention of inhibitory avoidance and shuttle avoidance tasks in rats

scientific article published on January 1, 1997

Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats.

scientific article

An organic selenium compound attenuates apomorphine-induced stereotypy in mice.

scientific article published on 18 October 2006

Analysis of KIR gene frequencies and HLA class I genotypes in prostate cancer and control group.

scientific article published on 10 April 2012

Anti-EGFR therapy combined with neuromedin B receptor blockade induces the death of DAOY medulloblastoma cells.

scientific article published on 3 October 2013

Anti-proliferative effect of the gastrin-release peptide receptor antagonist RC-3095 plus temozolomide in experimental glioblastoma models.

scientific article

Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma

scientific article published on 26 June 2019

Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes

scientific article published on 16 May 2010

BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells

scientific article published on 27 November 2015

BDNF/TrkB signaling protects HT-29 human colon cancer cells from EGFR inhibition.

scientific article

Basolateral amygdala activity is required for enhancement of memory consolidation produced by histone deacetylase inhibition in the hippocampus.

scientific article published on 28 February 2014

Basolateral amygdala lesions block the memory-enhancing effect of 8-Br-cAMP infused into the entorhinal cortex of rats after training.

scientific article published in March 2002

Bombesin protection against FK506 neurotoxicity

scientific article published on 01 April 2007

Bombesin receptor regulation of emotional memory.

scientific article published on January 2012

Bombesin/gastrin-releasing peptide receptors in the basolateral amygdala regulate memory consolidation.

scientific article published in February 2004

Brazil launches an innovative program to develop the National Institutes for Science and Technology (INCTs): the INCT for Translational Medicine

scientific article published on 01 September 2009

CXCR2 +1208 CT genotype may predict earlier clinical stage at diagnosis in patients with prostate cancer.

scientific article published on 29 June 2017

Cancer chemotherapy and cognitive function in rodent models: memory impairment induced by cyclophosphamide in mice.

scientific article published in August 2006

Cancer stem cells and the biology of brain tumors.

scientific article published on December 2009

Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients

scientific article

Characterization of ectonucleotidases in human medulloblastoma cell lines: ecto-5'NT/CD73 in metastasis as potential prognostic factor

scientific article

Cisplatin induces Bmi-1 and enhances the stem cell fraction in head and neck cancer.

scientific article published on February 2014

Cognitive enhancers: focus on modulatory signaling influencing memory consolidation.

scientific article published on 12 January 2011

Combined Inhibition of HDAC and EGFR Reduces Viability and Proliferation and Enhances STAT3 mRNA Expression in Glioblastoma Cells

scientific article published on 18 March 2019

Combined Treatments with a Retinoid Receptor Agonist and Epigenetic Modulators in Human Neuroblastoma Cells

scientific article published on 10 November 2016

Correction: Characterization of Ectonucleotidases in Human Medulloblastoma Cell Lines: ecto-5′NT/CD73 in Metastasis as Potential Prognostic Factor.

scientific article published on 6 November 2012

DEFB1 gene 5′ untranslated region (UTR) polymorphisms are marginally involved in inflammatory bowel disease in south Brazilians

article

DNA damage response in patients with pediatric Acute Lymphoid Leukemia during induction therapy.

scientific article published on 11 January 2017

Differential effects of post-training muscimol and AP5 infusions into different regions of the cingulate cortex on retention for inhibitory avoidance in rats.

scientific article published on September 1999

Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation.

scientific article published on 18 January 2005

Early life stress decreases hippocampal BDNF content and exacerbates recognition memory deficits induced by repeated D-amphetamine exposure

scientific article published on 27 May 2011

Early life stress exacerbates cognitive dysfunction induced by d-amphetamine: amelioration by valproic acid

scientific article

Ecto-5'-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model

scientific article (publication date: 2015)

Ecto-5'-nucleotidase/CD73 contributes to the radiosensitivity of T24 human bladder cancer cell line.

scientific article published on 5 January 2018

Effect of a gastrin-releasing peptide receptor antagonist and a proton pump inhibitor association in an animal model of gastritis.

scientific article

Effect of mangiferin, a naturally occurring glucoxylxanthone, on fear memory in rats

scientific article published on January 1, 2011

Effects of Lonomia obliqua caterpillar venom upon the proliferation and viability of cell lines.

scientific article published on 22 January 2013

Effects of N-acetylcysteine/deferoxamine, taurine and RC-3095 on respiratory chain complexes and creatine kinase activities in rat brain after sepsis.

scientific article published in April 2010

Effects of an antagonist of the gastrin-releasing peptide receptor in an animal model of uveitis.

scientific article

Effects of beta-carboline alkaloids on the object recognition task in mice.

scientific article published on 12 July 2006

Effects of chronic haloperidol and/or clozapine on oxidative stress parameters in rat brain.

scientific article published on 31 March 2007

Effects of the gastrin-releasing peptide antagonist RC-3095 in a rat model of ulcerative colitis.

scientific article published on 6 November 2009

Effects of thyroid hormones on memory and on Na(+), K(+)-ATPase activity in rat brain.

scientific article published in August 2007

Emerging therapeutic agents for cervical cancer.

scientific article

Enhancement of memory consolidation by the histone deacetylase inhibitor sodium butyrate in aged rats

scientific article published on 30 March 2015

Environmental and health risk assessments of genetically modified eucalypts in Brazil

scientific article published on 13 September 2011

Epidermal Growth Factor Receptor Regulation of Ewing Sarcoma Cell Function.

scientific article published on 14 March 2018

Erythropoietin, glutamate, and neuroprotection.

scientific article published in September 2004

Ewing Sarcoma: influence of TP53 Arg72Pro and MDM2 T309G SNPs.

scientific article published on 10 May 2013

Ewing's sarcoma: Analysis of single nucleotide polymorphism in the EWS gene

article

Expression and pharmacological inhibition of TrkB and EGFR in glioblastoma

scientific article published on 29 August 2020

Expression of neurotrophins and their receptors in primary osteosarcoma

scientific article published on 01 May 2019

Failure of anti-EGFR therapy in p16-positive head and neck cancer

scientific article published on 01 October 2013

Fingolimod (FTY720) reduces viability and survival and increases histone H3 acetylation in medulloblastoma cells

scientific article published on 11 December 2019

Fructose-1,6-bisphosphate inhibits in vitro and ex vivo platelet aggregation induced by ADP and ameliorates coagulation alterations in experimental sepsis in rats.

scientific article

GRPR antagonists for prostate cancer--prospects and caveats.

scientific article published on 25 June 2013

Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells.

scientific article published on 16 January 2016

Gastrin-releasing peptide as a molecular target for inflammatory diseases: an update.

scientific article published on June 2013

Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils

scientific article published on 27 December 2011

Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: involvement of toll-like receptor 4 signaling.

scientific article

Gastrin-releasing peptide receptor antagonist induces a protection from lethal sepsis: involvement of toll-like receptor 4 signaling.

scientific article

Gastrin-releasing peptide receptor as a molecular target for inflammatory diseases.

scientific article published on December 2007

Gastrin-releasing peptide receptor expression in cervical cancer

scientific article published on 01 January 2007

Gastrin-releasing peptide receptor expression in lung cancer.

scientific article published on January 2014

Gastrin-releasing peptide receptor signaling in the integration of stress and memory.

scientific article published on 31 August 2013

Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target.

scientific article

Gene expression changes associated with chemotherapy resistance in Ewing sarcoma cells.

scientific article

Glioma revisited: from neurogenesis and cancer stem cells to the epigenetic regulation of the niche ⬇️

scientific article

HDAC and MAPK/ERK Inhibitors Cooperate To Reduce Viability and Stemness in Medulloblastoma

scientific article published on 13 February 2020

HER2 as a cancer stem-cell target.

scientific article published in March 2010

Histone deacetylase inhibition prevents the impairing effects of hippocampal gastrin-releasing peptide receptor antagonism on memory consolidation and extinction.

scientific article published on 26 March 2016

Impairing effects of chronic haloperidol and clozapine treatment on recognition memory: possible relation to oxidative stress.

scientific article published in March 2005

Impairment of object recognition memory by rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation.

scientific article published on 9 December 2011

Impairments of social behavior and memory after neonatal gastrin-releasing peptide receptor blockade in rats: Implications for an animal model of neurodevelopmental disorders

scientific journal article

Improvement in Symptoms of Autism Spectrum Disorder in Children With the Use of Gastrin-Releasing Peptide: An Open Trial.

scientific article published on 21 June 2016

Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide.

scientific article published on 15 February 2016

In reference to Fu et al. (neuro-Oncology 2008:10139-152)

scientific article published on 25 November 2008

In vitro antitumor effect of sodium butyrate and zoledronic acid combined with traditional chemotherapeutic drugs: a paradigm of synergistic molecular targeting in the treatment of Ewing sarcoma.

scientific article published on 6 December 2013

Influence of GRPR and BDNF/TrkB signaling on the viability of breast and gynecologic cancer cells

scientific article published on 07 August 2012

Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory.

scientific article published on 19 October 2011

Inhibition of protein synthesis or mTOR in the basolateral amygdala blocks retrieval-induced memory strengthening ⬇️

scientific article published on May 7, 2013

Inhibitory activities of trichostatin a in U87 glioblastoma cells and tumorsphere-derived cells.

scientific article published on 25 January 2014

International scientific collaboration in HIV and HPV: a network analysis

scientific article

Interplay between neural stem cells and glioblastoma: possible role of neurotrophin signaling

scientific article published on 30 September 2019

Involvement of hippocampal NMDA receptors in retention of shuttle avoidance conditioning in rats.

scientific article published in December 1998

Involvement of mechanisms dependent on NMDA receptors, nitric oxide and protein kinase A in the hippocampus but not in the caudate nucleus in memory.

scientific article published in December 1997

KIR gene haplotype A is associated with hospital mortality in patients with sepsis

scientific article published on 30 January 2019

KIR genes and HLA class I ligands in a Caucasian Brazilian population with colorectal cancer

scientific article published on 11 January 2017

Ketamine impairs recognition memory consolidation and prevents learning-induced increase in hippocampal brain-derived neurotrophic factor levels.

scientific article published on 22 March 2010

Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of southern Brazil.

scientific article published on 14 January 2010

Letter to the Editor: MicroRNA levels and anti-VEGF therapy in glioblastoma

scientific article published on 10 June 2016

Long-term behavioral effects of neonatal blockade of gastrin-releasing peptide receptors in rats: similarities to autism spectrum disorders.

scientific article

Long-term memory for aversive training is impaired in Idua(-/-) mice, a genetic model of mucopolysaccharidosis type I.

scientific article published on 13 February 2006

Low brain-derived neurotrophic factor levels are associated with active disease and poor prognosis in childhood acute leukemia.

scientific article

MAPK pathway activation in colorectal cancer: a therapeutic opportunity for GRP receptor antagonists

scientific article published on 01 July 2005

Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats.

scientific article published on 19 March 2010

Memory consolidation and posttraumatic stress disorder

scientific article published in June 2003

Memory impairment induced by brain iron overload is accompanied by reduced H3K9 acetylation and ameliorated by sodium butyrate ⬇️

scientific article published on October 28, 2011

Modulatory influence of dopamine receptors on consolidation of object recognition memory.

scientific article

Molecular Basis of Distant Medulloblastoma Recurrence.

scientific article

Molecular mechanisms controlling protein synthesis in memory reconsolidation.

scientific article published on 2 May 2017

Molecular mechanisms mediating gastrin-releasing peptide receptor modulation of memory consolidation in the hippocampus.

scientific article

N-methyl-D-aspartate glutamate receptor blockade attenuates lung injury associated with experimental sepsis.

scientific article published on 16 October 2009

NMDA receptors mediate consolidation of contextual memory in the hippocampus after context preexposure.

scientific article

NMDA receptors might be involved in the impairing effects of procyclidine on cognition.

scientific article published in December 2003

Neuro-Behçet disease mimicking brain tumor: A case report.

scientific article published on 5 June 2017

Neurochemical and behavioural effects of acute and chronic memantine administration in rats: Further support for NMDA as a new pharmacological target for the treatment of depression?

scientific article published on 30 November 2009

Neuropeptides and anxiety disorders: bombesin receptors as novel therapeutic targets.

scientific article

Neutrality of miniSTR D22S1045 marker by Ewing's sarcoma phenotype

scientific article published on 10 September 2013

No alternative to animal tests for behaviour

scientific article published in Nature

Normal inhibitory avoidance learning and anxiety, but increased locomotor activity in mice devoid of PrP(C)

scientific article (publication date: 25 August 1999)

Opposite effects of low and high doses of the gastrin-releasing peptide receptor antagonist RC-3095 on memory consolidation in the hippocampus: possible involvement of the GABAergic system.

scientific article published on 2 May 2006

P2X7 receptor as predictor gene for glioma radiosensitivity and median survival

scientific article published on 7 September 2015

PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines

scientific article published on 20 May 2014

Pharmacology and toxicology of diphenyl diselenide in several biological models

scientific article published on October 2007

Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats

scientific article

Protective effect of RC-3095, an antagonist of the gastrin-releasing peptide receptor, in experimental arthritis

scientific article published on 01 October 2011

Protein synthesis, PKA, and MAP kinase are differentially involved in short- and long-term memory in rats.

scientific article

Recent therapeutic advances for treating medulloblastoma: focus on new molecular targets.

scientific article published on July 2010

Reduced NGF Secretion by HT-29 Human Colon Cancer Cells Treated with a GRPR Antagonist

scientific article published on 01 January 2009

Reduced frequency of two activating KIR genes in patients with sepsis.

scientific article published on 14 February 2017

Regulation of E-cadherin expression by growth factor receptors in cancer cells

scientific article published on 28 February 2011

Regulation of Fear Memory by Glucocorticoid and Cholinergic Receptors within the Dorsal Striatum ⬇️

scientific article published on June 19, 2012

Retrieval mediated by hippocampal extracellular signal-regulated kinase/mitogen-activated protein kinase is required for memory strengthening.

scientific article published on 17 March 2009

Reversal of age-related deficits in object recognition memory in rats with l-deprenyl.

scientific article published on 2 April 2005

Reverse Engineering of Ewing Sarcoma Regulatory Network Uncovers PAX7 and RUNX3 as Master Regulators Associated with Good Prognosis

scientific article published on 13 April 2021

Short- and long-term memory are differentialy modulated by hippocampal nerve growth factor and fibroblast growth factor.

scientific article published in February 2005

Sodium butyrate enhances the cytotoxic effect of antineoplastic drugs in human lymphoblastic T-cells.

scientific article published on 9 August 2008

Stem cells and the origin of different glioma subtypes.

scientific article

Stimulation of proliferation of U138-MG glioblastoma cells by gastrin-releasing peptide in combination with agents that enhance cAMP signaling.

scientific article

Systemic administration of doxorubicin impairs aversively motivated memory in rats.

scientific article published in 2009

Targeting Histone Deacetylase Activity to Arrest Cell Growth and Promote Neural Differentiation in Ewing Sarcoma.

scientific article

Targeting the NMDA receptor for fear-related disorders.

scientific article

Targeting the bombesin/gastrin-releasing peptide receptor to treat sepsis.

scientific article

Targeting the epidermal growth factor receptor in colorectal cancer: a potential therapeutic role for gastrin-releasing peptide receptor antagonists

scientific article published on 21 December 2007

Targeting the gastrin-releasing peptide receptor pathway to treat cognitive dysfunctionassociated with Alzheimer's Disease

scientific article published in April 2007

Targeting tyrosine receptor kinase B in gliomas.

scientific article

The N-methyl-D-aspartate receptor blocker MK-801 prevents the facilitatory effects of naloxone and epinephrine on retention of inhibitory avoidance task in rats

scientific article published on 01 October 1997

The anticancer estrogen receptor antagonist tamoxifen impairs consolidation of inhibitory avoidance memory through estrogen receptor alpha.

scientific article published on 2 September 2017

The bombesin/gastrin releasing peptide receptor antagonist RC-3095 blocks apomorphine but not MK-801-induced stereotypy in mice.

scientific article

The gastrin-releasing peptide receptor as a marker of dysplastic alterations in cervical epithelial cells.

scientific article published on 9 February 2012

The gastrin-releasing peptide receptor as a therapeutic target in central nervous system disorders.

scientific article published on June 2007

The histone deacetylase inhibitor sodium butyrate in combination with brain-derived neurotrophic factor reduces the viability of DAOY human medulloblastoma cells.

scientific article published on 6 April 2011

The histone deacetylase inhibitor sodium butyrate promotes cell death and differentiation and reduces neurosphere formation in human medulloblastoma cells.

scientific article published on 21 March 2013

The interaction between prion protein and laminin modulates memory consolidation

scientific article

Treadmill exercise alters histone acetyltransferases and histone deacetylases activities in frontal cortices from wistar rats

scientific article published on 24 August 2014

Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma.

scientific article published on 26 April 2016

TrkB blockade in the hippocampus after training or retrieval impairs memory: protection from consolidation impairment by histone deacetylase inhibition.

scientific article published in October 2015

Tropomyosin-Related Kinase Receptor and Neurotrophin Expression in Cutaneous Melanoma Is Associated with a Poor Prognosis and Decreased Survival

scientific article published on 09 May 2019

Two waves of proteasome-dependent protein degradation in the hippocampus are required for recognition memory consolidation

scientific article published on 14 February 2015

Uncovering the role of brain-derived neurotrophic factor/tyrosine kinase receptor B signaling in head and neck malignancies.

scientific article

Viability of D283 medulloblastoma cells treated with a histone deacetylase inhibitor combined with bombesin receptor antagonists.

scientific article published on 20 November 2015

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