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List of works by Alexander Vinks

1543. Ceftaroline Model-based Dose Individualization in an Infant with Kidney Disease and Mediastinitis

A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses.

scientific article published on 3 August 2016

A Prospective Study of Alemtuzumab as a Second-Line Agent for Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric and Young Adult Allogeneic Hematopoietic Stem Cell Transplantation.

scientific article

A Theoretical Physiologically-Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition

scientific article published on 07 March 2019

ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children

scientific article

ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children

scientific article published on 26 January 2016

Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery

scientific article published on 01 April 2018

Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1.

scientific article

Alternate-day micafungin antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study.

scientific article published on 20 June 2010

An integrated population pharmacokinetic meta-analysis of propofol in morbidly obese and nonobese adults, adolescents, and children.

scientific article

Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values

scientific article published on 26 December 2018

Better medicines for 300 million children in China: report on recent progress.

scientific article published in June 2011

Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial

scientific article published on 14 November 2017

Busulfan Pharmacokinetics and Precision Dosing: Are Patients with Fanconi Anemia Different?

scientific article published on 18 July 2019

CYP2D6 pharmacogenetic and oxycodone pharmacokinetic association study in pediatric surgical patients

scientific article published on 17 February 2017

Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter.

scientific article published on 09 December 2016

Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants

scientific article published on 08 August 2016

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing.

scientific article published on 3 June 2015

Clinical Pharmacokinetics and Pharmacodynamics of Biologic Therapeutics for Treatment of Systemic Lupus Erythematosus

scientific article

Clinical Trial Simulations and Pharmacometric Analysis in Pediatrics: Application to Inhaled Loxapine in Children and Adolescents

scientific article published on 15 February 2017

Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care

scientific article published on 11 June 2020

Clinical trial simulations in pediatric patients using realistic covariates: application to teduglutide, a glucagon-like peptide-2 analog in neonates and infants with short-bowel syndrome

scientific article published on 21 October 2009

Coma due to an overdose of valnoctamide

scientific article published on April 18, 1992

Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo.

scientific article published on 18 June 2007

Continuous infusion of beta-lactams.

scientific article published on October 2007

Continuous infusion of ceftazidime in cystic fibrosis patients during home treatment: clinical outcome, microbiology and pharmacokinetics ⬇️

scientific article published on 01 July 1997

Cost-effectiveness of therapeutic drug monitoring: a systematic review.

scientific article

Current management of neonatal abstinence syndrome secondary to intrauterine opioid exposure

scientific article

Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib

scientific article published on 24 January 2019

Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems

scientific article

Determination of risperidone and enantiomers of 9-hydroxyrisperidone in plasma by LC-MS/MS.

scientific article published on 15 February 2007

Development and Implementation of Electronic Health Record-Integrated Model-Informed Clinical Decision Support Tools for the Precision Dosing of Drugs

scientific article published on 16 October 2019

Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants.

scientific article

Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content.

scientific article published on 24 July 2013

Development of a pharmacokinetic-guided dose individualization strategy for hydroxyurea treatment in children with sickle cell anaemia

scientific article published on 28 November 2015

Development of an optimal sampling strategy for clinical pharmacokinetic studies of the novel anthracycline disaccharide analogue MEN-10755.

scientific article published on 7 April 2004

Development of population PK model with enterohepatic circulation for mycophenolic acid in patients with childhood-onset systemic lupus erythematosus.

scientific article

Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children.

scientific article

Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery

scientific article published on 01 June 2019

Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model.

scientific article published in July 2013

Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies.

scientific article published on 16 February 2017

Developmental trajectory of intestinal MDR1/ABCB1 mRNA expression in children

scientific article published on May 2014

Do not give paraffin to packers.

scientific article published in October 1998

Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study

scientific article published on 13 March 2018

Dose modifications and pharmacokinetics of adjuvant cisplatin monotherapy while on hemodialysis for patients with hepatoblastoma

scientific article published on 30 August 2018

Dose optimisation of antibiotics in children: application of pharmacokinetics/pharmacodynamics in paediatrics

scientific article

Drug Dosing in Obese Children: Challenges and Evidence-Based Strategies

scientific article published in December 2017

Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients.

scientific article

Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy.

scientific article

Effects of unbound mycophenolic acid on inosine monophosphate dehydrogenase inhibition in pediatric kidney transplant patients

scientific article

Efficacy and Safety of Sirolimus in the Treatment of Complicated Vascular Anomalies

scientific article published on 18 January 2016

Electronic Health Record-Embedded Decision Support Platform for Morphine Precision Dosing in Neonates

scientific article published on 16 October 2019

Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients

scientific article published on 15 April 2019

Evaluation of Target Attainment of Vancomycin Area Under the Curve in Children With Methicillin-Resistant Staphylococcus Aureus Bacteremia

scientific article

Evidence of a clinically significant drug-drug interaction between cannabidiol and tacrolimus

scientific article published on 21 May 2019

Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children.

scientific article

Federal legislation and the advancement of neonatal drug studies

scientific article published on 27 October 2012

From Molecule to Patient and Ways to Get the Dose Precisely Right

scientific article published on 01 March 2019

Genotype-Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplantation.

scientific article published on 23 November 2015

Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation

scientific article published on 07 October 2020

Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine

scientific article published on 29 July 2018

Important role of population pharmacokinetic/pharmacodynamic modeling in pediatric therapeutics

scientific article published on 20 July 2011

Improved Population Pharmacokinetic Model for Predicting Optimized Infliximab Exposure in Pediatric Inflammatory Bowel Disease

scientific article published on 01 February 2020

Increased Vancomycin Exposure and Nephrotoxicity in Children: Therapeutic Does Not Mean Safe

scientific article published on 29 December 2014

Individually Tailored Immunosuppression: Is There a Role for Biomarkers?

scientific article published on 12 January 2011

Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study

scientific article published on 08 November 2018

Inosine monophosphate dehydrogenase (IMPDH) activity as a pharmacodynamic biomarker of mycophenolic acid effects in pediatric kidney transplant recipients.

scientific article published on 23 April 2010

Intermediate term thrombotic risk in contemporary total cavo-pulmonary connection for single ventricle circulations.

scientific article published on 31 July 2017

Learning Health Systems as Facilitators of Precision Medicine.

scientific article published on 16 December 2016

Letter: stool adalimumab detection in ulcerative colitis and Crohn's disease--authors' reply

scientific article published on 01 July 2015

Longitudinal comparison of thyroxine pharmacokinetics between pregnant and nonpregnant women: a stable isotope study.

scientific article published on December 2010

Lower vancomycin serum trough concentrations might not be the answer.

scientific article published on December 2013

Measuring Medication Adherence in Pediatric Cancer: An Approach to Validation.

scientific article published on 16 May 2016

Meropenem in children receiving continuous renal replacement therapy: clinical trial simulations using realistic covariates

scientific article published on 16 July 2014

Micafungin antifungal prophylaxis in children undergoing HSCT: can we give higher doses, less frequently? A pharmacokinetic study

scientific article published on 01 June 2018

Milrinone Dosing Issues in Critically Ill Children With Kidney Injury: A Review.

scientific article published on 06 October 2015

Model-based dosing with concentration feedback as an integral part of personalized hydroxycarbamide management

scientific article published on 17 April 2018

Model-based precision dosing of sirolimus in pediatric patients with vascular anomalies.

scientific article published on 16 May 2017

Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children

scientific article published on 13 June 2015

Monitoring of inosine monophosphate dehydrogenase activity as a biomarker for mycophenolic acid effect: potential clinical implications.

scientific article published on April 2007

Morphine clearance in children: does race or genetics matter?

scientific article published in July 2012

Mycophenolate mofetil-related leukopenia in children and young adults following kidney transplantation: Influence of genes and drugs

scientific article published on 4 September 2017

Mycophenolate, clinical pharmacokinetics, formulations, and methods for assessing drug exposure.

scientific article published on 28 December 2010

NFM-06. NF106: PHASE 2 TRIAL OF THE MEK INHIBITOR PD-0325901 IN ADOLESCENTS AND ADULTS WITH NF1-RELATED PLEXIFORM NEUROFIBROMAS: AN NF CLINICAL TRIALS CONSORTIUM STUDY

Next Challenge From the Variance in Individual Physiologically-Based Pharmacokinetic Model-Predicted to Observed Morphine Concentration in Critically Ill Neonates

scientific article published on 12 September 2019

OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children

scientific article published on 4 May 2017

OCT1 genetic variants influence the pharmacokinetics of morphine in children.

scientific article

Obesity and overweight as CAE comorbidities and differential drug response modifiers

scientific article published on 30 March 2016

Opportunities for model-based precision dosing in the treatment of sickle cell anemia

scientific article published on 09 August 2017

Optimization of mycophenolic acid therapy using clinical pharmacometrics

scientific article published on 17 December 2013

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants

scientific article published on 19 June 2018

Personalizing Drug Selection Using Advanced Clinical Decision Support

scientific article published on June 2009

Pharmacogenetics in perioperative medicine.

scientific article published on August 2012

Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy

scientific article published on 25 March 2017

Pharmacokinetic modeling of therapies for systemic lupus erythematosus.

scientific article published on 05 July 2015

Pharmacokinetic modelling of intravenous tobramycin in adolescent and adult patients with cystic fibrosis using the nonparametric expectation maximization (NPEM) algorithm

scientific article published on June 1, 1997

Pharmacokinetic optimisation of antibacterial treatment in patients with cystic fibrosis. Current practice and suggestions for future directions.

scientific article

Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: the minimum inhibitory concentration versus stationary concentration.

scientific article published in January 2005

Pharmacokinetics and Safety of Single-Dose Inhaled Loxapine in Children and Adolescents.

scientific article published on 16 May 2017

Pharmacokinetics and pharmacogenomics of β-lactam-induced neutropenia

scientific article

Pharmacokinetics of IGF-1 in PAPP-A2-Deficient Patients, Growth Response, and Effects on Glucose and Bone Density.

scientific article

Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study

scientific article

Pharmacokinetics of amantadine in children with impaired consciousness due to acquired brain injury: preliminary findings using a sparse-sampling technique.

scientific article published in January 2010

Pharmacokinetics of glycerol phenylbutyrate in pediatric patients 2 months to 2 years of age with urea cycle disorders

scientific article published on 04 September 2018

Pharmacokinetics of levetiracetam in neonates with seizures

scientific article published on 18 May 2011

Pharmacokinetics of meropenem in children receiving continuous renal replacement therapy: Validation of clinical trial simulations

scientific article published on 21 September 2015

Pharmacokinetics of prednisolone at steady state in young patients with systemic lupus erythematosus on prednisone therapy: an open-label, single-dose study.

scientific article published on 07 October 2011

Pharmacokinetics of ranitidine in a homogeneous population of intensive care unit patients during intermittent and continuous administration

scientific article published on 01 January 1992

Phase 1 safety and pharmacokinetic study on the use of pioglitazone in critically ill patients with sepsis: a randomized clinical trial

scientific article published on 25 September 2018

Population Pharmacokinetics and Optimal Sampling Strategy for Model-Based Precision Dosing of Melphalan in Patients Undergoing Hematopoietic Stem Cell Transplantation

scientific article published on 16 September 2017

Population pharmacokinetic analysis of nonlinear behavior of piperacillin during intermittent or continuous infusion in patients with cystic fibrosis.

scientific article

Population pharmacokinetic modeling of risperidone and 9-hydroxyrisperidone to estimate CYP2D6 subpopulations in children and adolescents.

scientific article

Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients

scientific article published on 23 January 2020

Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents

scientific article published on 13 May 2015

Population pharmacokinetic-pharmacodynamic modelling of mycophenolic acid in paediatric renal transplant recipients in the early post-transplant period

scientific article

Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1-Erratum

scientific article published on 21 January 2016

Precision Medicine-Nobody Is Average.

scientific article published in March 2017

Pretransplant Absolute Lymphocyte Counts Impact the Pharmacokinetics of Alemtuzumab.

scientific article published on 12 January 2017

Propofol Clearance in Morbidly Obese Children and Adolescents : Influence of Age and Body Size.

scientific article

Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model

scientific article

Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry

scientific article published on 28 August 2013

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS.

scientific article published on 8 November 2015

Recommendations for the design of therapeutic trials for neonatal seizures

scientific article published on 24 December 2018

Relationship between minimum inhibitory concentration and stationary concentration revisited: growth rates and minimum bactericidal concentrations

scientific article published on 01 January 2005

Retrospective Evaluation of Milrinone Pharmacokinetics in Children With Kidney Injury

scientific article published on 09 April 2015

Review article: applying pharmacokinetics to optimise dosing of anti-TNF biologics in acute severe ulcerative colitis

scientific article

Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients

scientific article published on 14 June 2016

Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation

scientific article published on 01 April 2012

Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia

scientific article published on 12 June 2019

Safety and Dose Escalation Study of Intravenous Zinc Supplementation in Pediatric Critical Illness.

scientific article published on 19 February 2015

Significant effect of infection and food intake on sirolimus pharmacokinetics and exposure in pediatric patients with acute lymphoblastic leukemia

scientific article published on 08 December 2018

Similar MPA exposure on modified release and regular tacrolimus

scientific article published on 01 June 2014

Sirolimus for non-progressive NF1-associated plexiform neurofibromas: an NF clinical trials consortium phase II study.

scientific article published in June 2014

Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study.

scientific article published on 14 October 2014

Some international approaches to aminoglycoside monitoring in the extended dosing interval era.

scientific article

Suggestions for Model-Informed Precision Dosing to Optimize Neonatal Drug Therapy

scientific article published on 11 September 2018

The application of population pharmacokinetic modeling to individualized antibiotic therapy.

scientific article published in April 2002

The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma.

scientific article published in June 2014

The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease

scientific article published on January 2011

The future of physiologically based pharmacokinetic modeling to predict drug exposure in pregnant women.

scientific article published on 6 March 2013

The impact of CYP3A5*3 polymorphism on sirolimus pharmacokinetics: insights from predictions with a physiologically-based pharmacokinetic model

scientific article

Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report

scientific article published on 01 June 2019

Therapeutic Optimization as Part of the Precision Medicine Paradigm

scientific article published on 01 April 2016

Time in therapeutic range as a marker for thrombotic and bleeding outcomes in Fontan patients.

scientific article

Trend in therapeutic monitoring of immunosuppressive drugs

scientific article published on 01 July 2007

UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients

scientific article

Update in fetal anesthesia for the ex utero intrapartum treatment (EXIT) procedure

scientific article published on January 2012

Urinary kidney injury biomarkers and tobramycin clearance among children and young adults with cystic fibrosis: a population pharmacokinetic analysis.

scientific article

Using a vancomycin PBPK model in special populations to elucidate case-based clinical PK observations

scientific article published on 15 February 2018

Utilization of optimal study design for maternal and fetal sheep propofol pharmacokinetics study: a preliminary study

scientific article published on February 2014

Validation of a pediatric population pharmacokinetic model for vancomycin.

scientific article published on June 2015

Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation.

scientific article

Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.

scientific article published on 9 February 2017

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