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List of works by Paul T. Wingfield

3D NMR experiments for measuring 15N relaxation data of large proteins: application to the 44 kDa ectodomain of SIV gp41.

scientific article

A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV

scientific article

A cell-penetrating antibody fragment against HIV-1 Rev has high antiviral activity: characterization of the paratope

scientific article

A new HIV-1 Rev structure optimizes interaction with target RNA (RRE) for nuclear export.

scientific article published on 29 March 2018

A powerful method of sequential proton resonance assignment in proteins using relayed 15 N-1 H multiple quantum coherence spectroscopy

scientific article published on 01 January 1989

A recombinant Chinese hamster ovary cell line containing a 300-fold amplified tetramer of the hepatitis B genome together with a double selection marker expresses high levels of viral protein

scientific article published on 01 June 1986

Activated STING in a vascular and pulmonary syndrome

scientific article

Activation of virus uptake through induction of macropinocytosis with a novel polymerizing peptide.

scientific article published on 04 October 2013

Activator Gcn4 employs multiple segments of Med15/Gal11, including the KIX domain, to recruit mediator to target genes in vivo

scientific article

Albinism-causing mutations in recombinant human tyrosinase alter intrinsic enzymatic activity.

scientific article

An Investigation of Patient Preferences for Music Played Before Electroconvulsive Therapy.

scientific article

An easy way to include weak alignment constraints into NMR structure calculations.

scientific article published in November 2001

An unusual topological structure of the HIV-1 Rev response element

scientific article published on 24 October 2013

Analysis and characterization of dimerization inhibition of a multi-drug-resistant human immunodeficiency virus type 1 protease using a novel size-exclusion chromatographic approach

scientific article published on April 2009

Antigenic Switching of Hepatitis B Virus by Alternative Dimerization of the Capsid Protein

scientific article

Assessment of differences in the conformational flexibility of hepatitis B virus core-antigen and e-antigen by hydrogen deuterium exchange-mass spectrometry.

scientific article

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

scientific article published on 22 May 2017

Biophysical and functional characterization of full-length, recombinant human tissue inhibitor of metalloproteinases-2 (TIMP-2) produced in Escherichia coli. Comparison of wild type and amino-terminal alanine appended variant with implications for t

scientific article published on 01 July 1999

Capsids of hepatitis B virus e antigen with authentic C termini are stabilized by electrostatic interactions

scientific article published on 16 December 2019

Characterization of a conformational epitope on hepatitis B virus core antigen and quasiequivalent variations in antibody binding

scientific article

Chimeric Rabbit/Human Fab Antibodies Against the Hepatitis B e-antigen and Their Potential Applications in Assay, Characterization and Therapy.

scientific article

Commentary on the article: Purification and characterization of the Ner repressor of bacteriophage Mu (1989) FEBS Lett. 244, 369-375 G. Kukolj, P.P. Tolias and M.S. DuBow

scientific article published on 01 July 1989

Cross-Linking of Isolated Oligomycin-Insensitive Adenosine Triphosphatase from Ox Heart Mitochondria ⬇️

scientific article published on January 1, 1975

Cryo-EM study of Hepatitis B virus core antigen capsids decorated with antibodies from a human patient.

scientific article published on 25 October 2011

Determination of the secondary structure of the DNA binding protein Ner from phage .mu. using proton homonuclear and nitrogen-15-proton heteronuclear NMR spectroscopy

scientific article published in 1989

Enzymology of Ubiquinone-Utilizing Electron Transfer Complexes in Nonionic Detergent ⬇️

scientific article published on August 15, 1979

Epitope diversity of hepatitis B virus capsids: quasi-equivalent variations in spike epitopes and binding of different antibodies to the same epitope.

scientific article published on 8 November 2005

Epitope-distal effects accompany the binding of two distinct antibodies to hepatitis B virus capsids.

scientific article published on 18 April 2013

Expression of quasi-equivalence and capsid dimorphism in the Hepadnaviridae

scientific article published on 20 April 2020

Folding and Purification of Insoluble (Inclusion Body) Proteins from Escherichia coli.

scientific article

Functional and biophysical characterization of recombinant human hepatocyte growth factor isoforms produced in Escherichia coli ⬇️

scientific article published on September 15, 1997

Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev.

scientific article

Generation and use of antibody fragments for structural studies of proteins refractory to crystallization

scientific article

HIV-1 Rev expressed in recombinant Escherichia coli: purification, polymerization, and conformational properties ⬇️

scientific article published on July 30, 1991

HIV-1 envelope protein gp41: an NMR study of dodecyl phosphocholine embedded gp41 reveals a dynamic prefusion intermediate conformation.

scientific article

HIV-1 gp41 transmembrane oligomerization monitored by FRET and FCS.

scientific article published on 17 February 2018

Hepatitis B virus antigens made in microbial cells immunise against viral infection ⬇️

scientific article published on March 1, 1984

High-resolution mass spectrometry of viral assemblies: molecular composition and stability of dimorphic hepatitis B virus capsids.

scholarly article

Human immunodeficiency virus (HIV) gp41 escape mutants: cross-resistance to peptide inhibitors of HIV fusion and altered receptor activation of gp120.

scientific article

IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease

scientific article published on 28 September 2017

Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element

scientific article

Inhibition of HIV-1 replication by a peptide dimerization inhibitor of HIV-1 protease.

scientific article published on 21 April 2006

Interleukin-35 induces regulatory B cells that suppress autoimmune disease.

scientific article

Internal dynamics of the homotrimeric HIV-1 viral coat protein gp41 on multiple time scales

scientific article published on 2 April 2013

Localization of the N terminus of hepatitis B virus capsid protein by peptide-based difference mapping from cryoelectron microscopy.

scientific article published on December 1998

Long-range 15N-1H correlation as an aid to sequential proton resonance assignment of proteins. Application to the DNA-binding protein ner from phage Mu.

scientific article published in September 1988

Membrane crystals of ubiquinone:cytochrome c reductase from Neurospora mitochondria ⬇️

scientific article published on August 23, 1979

Membrane-associated human tyrosinase is an enzymatically active monomeric glycoprotein.

scientific article

Micelle-induced curvature in a water-insoluble HIV-1 Env peptide revealed by NMR dipolar coupling measurement in stretched polyacrylamide gel.

scientific article

Molecular basis for the high degree of antigenic cross-reactivity between hepatitis B virus capsids (HBcAg) and dimeric capsid-related protein (HBeAg): insights into the enigmatic nature of the e-antigen

scientific article

N-Terminal Methionine Processing.

scientific article published on 3 April 2017

N-terminal extension of beta B1-crystallin: identification of a critical region that modulates protein interaction with beta A3-crystallin.

scientific article published on October 2009

N-terminal-methionylated interleukin-1 beta has reduced receptor-binding affinity.

scientific article

Native cytokines do not bind to uromodulin (Tamm-Horsfall glycoprotein)

scientific article published on 01 January 1988

Non-canonical binding of an antibody resembling a naïve B cell receptor immunoglobulin to hepatitis B virus capsids.

scientific article published on 9 April 2008

Oculocutaneous albinism type 1: link between mutations, tyrosinase conformational stability, and enzymatic activity.

scientific article

Overview of the characterization of recombinant proteins

scientific article published on 01 May 2001

Overview of the purification of recombinant proteins produced in Escherichia coli.

scientific article published on February 2003

Overview of the purification of recombinant proteins.

scientific article published on April 2015

P2' Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety

scientific article

Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein

scientific article

Point mutations of human interleukin-1 with decreased receptor binding affinity

scientific article

Preparation and extraction of insoluble (inclusion-body) proteins from Escherichia coli

scientific article published on 01 November 2012

Preparation and extraction of insoluble (inclusion-body) proteins from Escherichia coli.

scientific article

Preparation of Soluble Proteins from Escherichia coli

scientific article

Preparation of soluble proteins from Escherichia coli.

scientific article

Protein Stability and Functional Characterization of Intra-Melanosomal Domain of Human Recombinant Tyrosinase-Related Protein 1

scientific article published on 03 January 2020

Protein precipitation using ammonium sulfate.

scientific article

Purification and characterization of the DNA-binding protein Ner of bacteriophage Mu.

scientific article

Purification of Recombinant Human Tyrosinase from Insect Larvae Infected with the Baculovirus Vector.

scientific article

Pyruvic acid is attached through its central carbon atom to the amino terminus of the recombinant DNA-derived DNA-binding protein Ner of bacteriophage Mu ⬇️

scientific article published in Journal of Biological Chemistry

Reversible oxidative modification as a mechanism for regulating retroviral protease dimerization and activation

scientific article

Secondary structure of the ribonuclease H domain of the human immunodeficiency virus reverse transcriptase in solution using three-dimensional double and triple resonance heteronuclear magnetic resonance spectroscopy

scientific article published in October 1991

Site directed mutants of human interleukin-1 alpha: a 1H-NMR and receptor binding study

scientific article published on April 1988

Sizing up large protein complexes by electrospray ionisation-based electrophoretic mobility and native mass spectrometry: morphology selective binding of Fabs to hepatitis B virus capsids

scientific article

Squeezing protein shells: how continuum elastic models, molecular dynamics simulations, and experiments coalesce at the nanoscale.

scientific article

Structural Biophysics of the NusB:NusE Antitermination Complex

scientific article

Structure and dynamics of micelle-associated human immunodeficiency virus gp41 fusion domain.

scientific article

Structure of an RNA Aptamer that Can Inhibit HIV-1 by Blocking Rev-Cognate RNA (RRE) Binding and Rev-Rev Association

article

Structure, assembly, and antigenicity of hepatitis B virus capsid proteins.

scientific article

Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition

scientific article published on 09 August 2018

Subunit exchange rates in Hepatitis B virus capsids are geometry- and temperature-dependent.

scientific article

The G18V CRYGS mutation associated with human cataracts increases gammaS-crystallin sensitivity to thermal and chemical stress

scientific article published on August 2009

The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly

scientific article published on 31 May 2016

The TYRP1-mediated protection of human tyrosinase activity does not involve stable interactions of tyrosinase domains

scientific article published on 03 June 2019

The UL36 tegument protein of herpes simplex virus 1 has a composite binding site at the capsid vertices

scientific article

The initial step in human immunodeficiency virus type 1 GagProPol processing can be regulated by reversible oxidation ⬇️

scientific article published on October 22, 2010

The polypeptides of the ox heart mitochondrial inner membrane: isolation of the major component

scientific article published on 01 January 1975

The state of the N-terminus of recombinant proteins: determination of N-terminal methionine (formylated, acetylated, or free)

scientific article published on 01 August 1987

The structure of the transcriptional antiterminator NusB from Escherichia coli

scientific article published in June 2000

Thermodynamic analysis of weak protein interactions using sedimentation equilibrium.

scientific article

Three-dimensional structure of ubiquinol:cytochrome c reductase from Neurospora mitochondria determined by electron microscopy of membrane crystals

scientific article published on 01 June 1981

Tumour necrosis factor is a compact trimer

scientific article published on 01 January 1987

Use of protein folding reagents.

scientific article published on May 2001

Z-disc-associated, alternatively spliced, PDZ motif-containing protein (ZASP) mutations in the actin-binding domain cause disruption of skeletal muscle actin filaments in myofibrillar myopathy.

scientific article

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