List of works - Tohru Yamakuni

A New Regulatory Protein of Catecholamine Synthesizing-Enzyme Expression

scientific article published on 01 January 1998

A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Abeta-inhibition of the cascade in cultured rat CNS neurons.

scientific article

A novel mechanism of depression: role for connexins

scientific article published on 5 March 2018

A novel protein containing Cdc10/SWI6 motifs regulates expression of mRNA encoding catecholamine biosynthesizing enzymes.

scientific article published on October 1998

Acidosis-induced protein tyrosine phosphorylation depends on Ca2+ influx via voltage-dependent Ca2+ channels in SHR aorta.

scientific article published in November 2004

Beneficial effects of Ajuga decumbens on osteoporosis and arthritis.

scientific article

Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana

scientific article published on 01 February 2006

Ca2+ channel activating action of maitotoxin in cultured brainstem neurons.

scientific article published on 10 March 2006

Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana ⬇️

scientific article published on 01 October 2007

Development and migration of Purkinje cells in the mouse cerebellar primordium ⬇️

scientific article published on January 1, 1991

Dopamine or biopterin deficiency potentiates phosphorylation at (40)Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system

scientific article published on 27 July 2015

Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine secretion in cultured bovine adrenal medullary cells.

scientific article published in June 2010

Ephedorae herba decreases lipopolysaccharide-induced cyclooxgenase-2 protein expression and NF-kappaB-dependent transcription in C6 rat glioma cells.

scientific article published on 9 July 2005

Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis

scientific article published on 18 June 2019

Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4'-demethylnobiletin prevents MK801-induced memory impairment.

scientific article

Four new myrsinol diterpenes from Euphorbia prolifera.

scientific article published on 31 July 2012

Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells.

scientific article published on 2 November 2005

Ginsenoside Rg1 alleviates corticosterone-induced dysfunction of gap junctions in astrocytes.

scientific article

Heterogeneity of the ciliary epithelium of the rat eye as revealed by spot 35 protein (a Purkinje cell specific protein)-like immunoreactivity ⬇️

scientific article published on 01 January 1988

High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound

scientific article published on 11 May 2011

IC101 induces apoptosis by Akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with Akt in L1210 cells.

scientific article published on 25 May 2004

Imidacloprid, a neonicotinoid insecticide, facilitates tyrosine hydroxylase transcription and phenylethanolamine N-methyltransferase mRNA expression to enhance catecholamine synthesis and its nicotine-evoked elevation in PC12D cells

scientific article

Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei ⬇️

scientific article published on 01 January 2006

Isolation and immunohistochemical localization of a cerebellar protein ⬇️

scientific article published on April 6, 1984

Isolation, Structural Elucidation, and Neuroprotective Effects of Iridoids fromValeriana jatamansi ⬇️

scientific article published on July 7, 2012

Metronomic scheduling of a cyclic hexapeptide Ra-VII for anti-angiogenesis, tumor vessel maturation and anti-tumor activity.

scientific article

Nardosinone enhances nerve growth factor-induced neurite outgrowth in a mitogen-activated protein kinase- and protein kinase C-dependent manner in PC12D cells

scientific article published on 01 September 2003

Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells ⬇️

scientific article published on November 12, 2003

Neurobehavioral effects of tetrabromobisphenol A, a brominated flame retardant, in mice.

scientific article published on 20 May 2009

Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis.

scientific article published on 7 July 2011

New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production

scientific article published on April 18, 2012

Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities.

scientific article published on 10 October 2005

Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells.

scientific article published on January 2013

Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats.

scientific article published on 3 April 2006

Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.

scientific article published in September 2007

Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.

scientific article

Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease.

scientific article published on 10 June 2008

Nobiletin-rich Citrus reticulata peels, a kampo medicine for Alzheimer's disease: a case series.

scientific article

Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological acti

scientific article

Preventive action of nobiletin, a constituent of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, against amyloid-beta peptide-induced neurotoxicity expression and memory impairment

scientific article published in April 2010

Production and secretion of nerve growth factor by clonal striated muscle cell line, G8-1

scientific article published on September 1, 1992

Regulation of nerve growth factor and nerve growth factor receptor production by NMDA in C6 glioma cells

scientific article published on June 1, 1992

Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization.

scientific article published on 20 July 2012

SLC10A4 is a protease-activated transporter that transports bile acids.

scientific article published on 14 April 2013

Stimulated tyrosine phosphorylation of phosphatidylinositol 3-kinase causes acidic pH-induced contraction in spontaneously hypertensive rat aorta.

scientific article published in December 2002

Three new iridoids from the roots of Valeriana jatamansi

scientific article published on 14 February 2012

Three-membered ring sesquiterpenoids with NGF-potentiating activity from the roots of Valeriana fauriei

scientific article published on 01 March 2006

Two Distinct Mechanisms for Actin Capping Protein Regulation—Steric and Allosteric Inhibition

scientific article

Two steroidal saponins from Camassia cusickii induce L1210 cell death through the apoptotic mechanism.

scientific article published in November 2001

[Elucidation of mechanism underlying amyloid-beta peptide aggregation and its neurotoxicity expression and inhibition of these molecular processes by beneficial synthetic and natural compounds with low-molecular weights-new approaches to fundamental

scientific article published in April 2010

[Pharmacological superiority of nobiletin-rich Citrus reticulata peel, a multicomponent drug, over nobiletin alone regarding anti-dementia action].

scientific article published in May 2015

List of works by Tohru Yamakuni

A New Regulatory Protein of Catecholamine Synthesizing-Enzyme Expression

A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Abeta-inhibition of the cascade in cultured rat CNS neurons.

A novel mechanism of depression: role for connexins

A novel protein containing Cdc10/SWI6 motifs regulates expression of mRNA encoding catecholamine biosynthesizing enzymes.

Acidosis-induced protein tyrosine phosphorylation depends on Ca2+ influx via voltage-dependent Ca2+ channels in SHR aorta.

Beneficial effects of Ajuga decumbens on osteoporosis and arthritis.

Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana

Ca2+ channel activating action of maitotoxin in cultured brainstem neurons.

Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana ⬇️

Development and migration of Purkinje cells in the mouse cerebellar primordium ⬇️

Dopamine or biopterin deficiency potentiates phosphorylation at (40)Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system

Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine secretion in cultured bovine adrenal medullary cells.

Ephedorae herba decreases lipopolysaccharide-induced cyclooxgenase-2 protein expression and NF-kappaB-dependent transcription in C6 rat glioma cells.

Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis

Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4'-demethylnobiletin prevents MK801-induced memory impairment.

Four new myrsinol diterpenes from Euphorbia prolifera.

Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells.

Ginsenoside Rg1 alleviates corticosterone-induced dysfunction of gap junctions in astrocytes.

Heterogeneity of the ciliary epithelium of the rat eye as revealed by spot 35 protein (a Purkinje cell specific protein)-like immunoreactivity ⬇️

High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound

IC101 induces apoptosis by Akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with Akt in L1210 cells.

Imidacloprid, a neonicotinoid insecticide, facilitates tyrosine hydroxylase transcription and phenylethanolamine N-methyltransferase mRNA expression to enhance catecholamine synthesis and its nicotine-evoked elevation in PC12D cells

Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei ⬇️

Isolation and immunohistochemical localization of a cerebellar protein ⬇️

Isolation, Structural Elucidation, and Neuroprotective Effects of Iridoids fromValeriana jatamansi ⬇️

Metronomic scheduling of a cyclic hexapeptide Ra-VII for anti-angiogenesis, tumor vessel maturation and anti-tumor activity.

Nardosinone enhances nerve growth factor-induced neurite outgrowth in a mitogen-activated protein kinase- and protein kinase C-dependent manner in PC12D cells

Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells ⬇️

Neurobehavioral effects of tetrabromobisphenol A, a brominated flame retardant, in mice.

Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis.

New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production

Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities.

Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells.

Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats.

Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.

Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.

Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease.

Nobiletin-rich Citrus reticulata peels, a kampo medicine for Alzheimer's disease: a case series.

Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological acti

Preventive action of nobiletin, a constituent of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, against amyloid-beta peptide-induced neurotoxicity expression and memory impairment

Production and secretion of nerve growth factor by clonal striated muscle cell line, G8-1

Regulation of nerve growth factor and nerve growth factor receptor production by NMDA in C6 glioma cells

Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization.

SLC10A4 is a protease-activated transporter that transports bile acids.

Stimulated tyrosine phosphorylation of phosphatidylinositol 3-kinase causes acidic pH-induced contraction in spontaneously hypertensive rat aorta.

Three new iridoids from the roots of Valeriana jatamansi

Three-membered ring sesquiterpenoids with NGF-potentiating activity from the roots of Valeriana fauriei

Two Distinct Mechanisms for Actin Capping Protein Regulation—Steric and Allosteric Inhibition

Two steroidal saponins from Camassia cusickii induce L1210 cell death through the apoptotic mechanism.

[Elucidation of mechanism underlying amyloid-beta peptide aggregation and its neurotoxicity expression and inhibition of these molecular processes by beneficial synthetic and natural compounds with low-molecular weights-new approaches to fundamental

[Pharmacological superiority of nobiletin-rich Citrus reticulata peel, a multicomponent drug, over nobiletin alone regarding anti-dementia action].