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List of works by Chris Pugh

A cross-sectional study exploring levels of physical activity and motivators and barriers towards physical activity in haemodialysis patients to inform intervention development

scientific article published on 24 October 2019

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

scientific journal article

Academic postgraduate medical education -- an Oxford view.

scientific article published in February 2014

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

scientific article published in 2015

Cerebral ischemia during hemodialysis-finding the signal in the noise.

scientific article published on 11 February 2018

Characterisation of functional domains within the mouse erythropoietin 3' enhancer conveying oxygen-regulated responses in different cell lines

scientific article published on April 1994

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

scientific article

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

scientific article

Detection of BK virus in urine from renal transplant subjects by mass spectrometry.

scientific article

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

scientific journal article

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

scientific article published on 21 July 2010

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

scientific article

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

scientific article published in July 2006

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

scientific article

Hypoxia and HIF pathway in cancer and the placenta.

scientific article published on 16 March 2017

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.

scientific article published on 12 September 2009

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

scientific article

Hypoxia-inducible factors: where, when and why?

scientific article published in January 2006

Imaging of haemodialysis-associated amyloidosis with 123I-serum amyloid P component

scientific article published on 01 August 1991

Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.

scientific article

Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation

article

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

scientific article

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

scientific article published on 23 March 2020

Modulation of the Hypoxic Response.

scientific article published on January 2016

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

scientific article published on 11 September 2017

Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology.

scientific article

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.

scientific article published on 21 April 2010

New horizons in hypoxia signaling pathways

scientific article published on 14 March 2017

Non-contact video-based vital sign monitoring using ambient light and auto-regressive models.

scientific article

Non-lymphoid cells from rat intestinal lymph

scientific article published on 01 January 1982

Oxygen sensing

scientific article published on 01 January 2005

Oxygen sensing in cancer

scientific article published on January 2003

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

scientific article published on January 1999

PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies

scientific article published on 19 June 2018

Photoplethysmographic derivation of respiratory rate: a review of relevant physiology.

scientific article published on 20 December 2011

Postdoctoral progression is needed for doctors taking up clinical academic careers

scientific article published on 23 December 2015

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

scientific article

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

scientific article

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

scientific article published on 14 August 2017

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

scientific article published on 7 February 2011

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.

scientific article

Regulation of growth differentiation factor 15 expression by intracellular iron.

scientific article

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway

scientific article published on 04 September 2015

Relationship between Hypotension and Cerebral Ischemia during Hemodialysis

scientific article published on 7 March 2017

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

scientific article

Systemic silencing of PHD2 causes reversible immune regulatory dysfunction

scientific article published on 04 June 2019

Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

scientific article published on 27 March 2007

Targeting tumors through the HIF system.

scientific article published in December 2000

The HIF pathway: implications for patterns of gene expression in cancer.

scientific article

The Oxford Renal (OxRen) cross-sectional study of chronic kidney disease in the UK.

scientific article published on 17 December 2013

The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma

scientific article published on 07 May 2007

The clinical academic workforce of the future: a cross-sectional study of factors influencing career decision-making among clinical PhD students at two research-intensive UK universities

scientific article published on 28 August 2017

The impact of renin–angiotensin–aldosterone system inhibitors on Type 1 and Type 2 diabetic patients with and without early diabetic nephropathy

scientific article published on 21 December 2011

The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.

scientific article

The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha

scientific article

The relationship between symptoms and blood pressure during maintenance hemodialysis

scientific article

The role of hypoxia-inducible factors in organ donation and transplantation: the current perspective and future opportunities

scientific article

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

scientific article

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

scientific article

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

scientific article published on 8 August 2016

Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues.

scientific article published on December 2005

Using an Integrated -Omics Approach to Identify Key Cellular Processes That Are Disturbed in the Kidney After Brain Death.

scientific article published on 25 November 2015

What lies downstream: Cellular oxygen delivery during hemodialysis

scientific article published on 04 December 2018

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

scientific article published on 17 December 2002

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